Real-time differential labeling of blood, interstitium, and lymphatic and single-field analysis of vasculature dynamics in vivo

American Journal of Physiology - Cell Physiology

Volumn 302, Issue 10, 2012, Pages

  Sarkisyan, Gor ^a   Cahalan, Stuart M ^a   Gonzalez Cabrera, Pedro J ^a   Leaf, Nora B ^a   Rosen, Hugh ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Fluorescence labeling; Intravital two photon excitation microscopy; Lymph node; Microfluidic dynamics

Indexed keywords

DEXTRAN; QUANTUM DOT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CELL MIGRATION; CONTROLLED STUDY; DIFFERENTIAL VASCULAR LABELING; IN VIVO STUDY; INTERSTITIUM; LYMPHATIC SYSTEM; LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROCEDURES;

ANIMALS; COMPUTER SYSTEMS; ENDOTHELIAL CELLS; EXTRACELLULAR FLUID; LYMPH NODES; LYMPHATIC VESSELS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, LYSOSPHINGOLIPID; REGIONAL BLOOD FLOW; STAINING AND LABELING;

EID: 84861156914     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00382.2011     Document Type: Article

References (44)

1. Bernsen HJ, Rijken PF, Peters JP, Bakker JH, Boerman RH, Wesseling P, van der Kogel AJ. Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status. J Neurooncol 44: 129-136, 1999.
2. 1-eGFP knock-in mice. Nat Chem Biol 7: 254-256, 2011.
3. Cohen-Jonathan E, Evans SM, Koch CJ, Muschel RJ, McKenna WG, Wu J, Bernhard EJ. The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras. Cancer Res 61: 2289-2293, 2001.
4. Delmas C, End D, Rochaix P, Favre G, Toulas C, Cohen-Jonathan E. The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft. Clin Cancer Res 9: 6062-6068, 2003.
5. Eichhorn ME, Strieth S, Luedemann S, Kleespies A, Nöth U, Passon A, Brix G, Jauch KW, Bruns CJ, Dellian M. Contrast enhanced MRI and intravital fluorescence microscopy indicate improved tumor microcirculation in highly vascularized melanomas upon short-term anti-VEGFR treatment. Cancer Biol Ther 7: 1006-1013, 2008.
6. Girard JP, Springer TA. High endothelial venules (HEVs): specialized endothelium for lymphocyte migration. Immunol Today 16: 449-457, 1995.
7. Goetzl EJ, Rosen H. Regulation of immunity by lysosphingolipids and their G protein-coupled receptors. J Clin Invest 114: 1531-1537, 2004.
8. Grigorova IL, Panteleev M, Cyster JG. Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure. Proc Natl Acad Sci U S A 107: 20447-20452, 2010.
9. Grigorova IL, Schwab SR, Phan TG, Pham THM, Okada T, Cyster JG. Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells. Nat Immunol 10: 58-65, 2009.
10. Halin C, Mora JR, Sumen C, von Andrian UH. In vivo imaging of lymphocyte trafficking. Annu Rev Cell Dev Biol 21: 581-603, 2005.
11. Halin C, Scimone ML, Bonasio R, Gauguet JM, Mempel TR, Quackenbush E, Proia RL, Mandala S, von Andrian UH. The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. Blood 106: 1314-1322, 2005.
12. Hansen-Algenstaedt N, Stoll BR, Padera TP, Dolmans DE, Hicklin DJ, Fukumura D, Jain RK. Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy. Cancer Res 60: 4556-4560, 2000.
13. Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, Peixoto A, Flynn M, Senman B, Junt T, Wong HC, Chakraborty AK, von Andrian UH. In vivo imaging of T cell priming. Sci Signal 1: pt2, 2008.
14. Hunt PS, Reeve TS. Experimental arterial thrombus prevention and renal function in sheep after infusion with low molecular weight dextran and dextran 70,000. Ann Surg 166: 51-58, 1967.
15. Koekenberg LJ. [Blood thinning with dextran (Macrodex) in prevention of postoperative thrombosis]. Ned Tijdschr Geneeskd 105: 2433-2437, 1961.
16. Lynch PM, Delano FA, Schmid-Schönbein GW. The primary valves in the initial lymphatics during inflammation. Lymphat Res Biol 5: 3-10, 2007.
17. MacCallum GW. On the mechanism of absorption of granular materials from the peritoneum. Bull Johns Hopkins Hosp 14: 105-115, 1903.
18. MacLennan IC, Gulbranson-Judge A, Toellner KM, Casamayor-Palleja M, Chan E, Sze DM, Luther SA, Orbea HA. The changing preference of T and B cells for partners as T-dependent antibody responses develop. Immunol Rev 156: 53-66, 1997.
19. Mandala S, Hajdu R, Bergstrom J, Quackenbush E, Xie J, Milligan J, Thornton R, Shei GJ, Card D, Keohane C, Rosenbach M, Hale J, Lynch CL, Rupprecht K, Parsons W, Rosen H. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296: 346-349, 2002.
20. Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427: 355-360, 2004.
21. Mayerson HS, Patterson RM, McKee A, Lebrie SJ, Mayerson P. Permeability of lymphatic vessels. Am J Physiol 203: 98-106, 1962.
22. Mayerson HS. Observations and reflections on the lymphatic system. Trans Stud Coll Physicians Phila 28: 109-127, 1961.
23. Mayerson HS. Lymph and lymphatics. Heart Bull 12: 8-12, 1963.
24. Mempel TR, Junt T, von Andrian UH. Rulers over randomness: stroma cells guide lymphocyte migration in lymph nodes. Immunity 25: 867-869, 2006.
25. Miller MJ, Wei SH, Cahalan MD, Parker I. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci U S A 100: 2604-2609, 2003.
26. Mora JR, Von Andrian UH. Specificity and plasticity of memory lymphocyte migration. Curr Top Microbiol Immunol 308: 83-116, 2006.
27. Nombela-Arrieta C, Mempel TR, Soriano SF, Mazo I, Wymann MP, Hirsch E, Martínez-AC, Fukui Y, von Andrian UH, Stein JV. A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J Exp Med 204: 497-510, 2007.
28. Reed MA, Randall JN, Aggarwal RJ, Matyi RJ, Moore TM, Wetsel AE. Observation of discrete electronic states in a zero-dimensional semiconductor nanostructure. Phys Rev Lett 60: 535-537, 1988.
29. Renkin EM, Tucker VL, Wiig H, Kaysen G, Sibley L, DeCarlo M, Simanonok K, Wong M. Blood-tissue transport of exogenous albumin and immunoglobulin G in genetically analbuminemic rats. J Appl Physiol 74: 559-566, 1993.
30. Renkin EM, Wiig H. Limits to steady-state lymph flow rates derived from plasma-to-tissue uptake measurements. Microvasc Res 47: 318-328, 1994.
31. Renkin EM. Evaluation of capillary perfusion. Am J Physiol Heart Circ Physiol 282: H1172-H1173, 2002.
32. Rosen H, Goetzl EJ. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat Rev Immunol 5: 560-570, 2005.
33. Rosen H, Gonzalez-Cabrera P, Marsolais D, Cahalan S, Don AS, Sanna MG. Modulating tone: the overture of S1P receptor immunotherapeutics. Immunol Rev 223: 221-235, 2008.
34. Rosen H, Gonzalez-Cabrera P, Marsolais D, Cahalan S, Don AS, Sanna MG. Modulating tone: the overture of S1P receptor immunotherapeutics. Immunol Rev 223: 221-235, 2008.
35. Rosen H, Gonzalez-Cabrera PJ, Sanna MG, Brown S. Sphingosine 1-phosphate receptor signaling. Annu Rev Biochem 78: 743-768, 2009.
36. Rosen H, Sanna G, Alfonso C. Egress: a receptor-regulated step in lymphocyte trafficking. Immunol Rev 195: 160-177, 2003.
37. Rosen H, Sanna MG, Cahalan SM, Gonzalez-Cabrera PJ. Tipping the gatekeeper: S1P regulation of endothelial barrier function. Trends Immunol 28: 102-107, 2007.
38. Rosen H. Chemical approaches to the lysophospholipid receptors. Prostaglandins Other Lipid Mediat 77: 179-184, 2005.
39. Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH, Rosen H. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol 2: 434-441, 2006.
40. Schwab SR, Cyster JG. Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol 8: 1295-1301, 2007.
41. Sensken SC, Nagarajan M, Bode C, Gräler MH. Local inactivation of sphingosine 1-phosphate in lymph nodes induces lymphopenia. J Immunol 186: 3432-3440, 2011.
42. Thangada S, Khanna KM, Blaho VA, Oo ML, Im DS, Guo C, Lefrancois L, Hla T. Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. J Exp Med 207: 1475-1483, 2010.
43. Wei SH, Rosen H, Matheu MP, Sanna MG, Wang SK, Jo E, Wong CH, Parker I, Cahalan MD. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol 6: 1228-1235, 2005.
44. Wright CS. Structural comparison of the two distinct sugar binding sites in wheat germ agglutinin isolectin II. J Mol Biol 178: 91-104, 1984.