Model-based therapeutic correction of hypothalamic-pituitary-adrenal axis dysfunction

PLoS Computational Biology

Volumn 5, Issue 1, 2009, Pages

  Ben Zvi, Amos ^a   Vernon, Suzanne D ^b   Broderick, Gordon ^c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CFIDS Association of America   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CURRICULA; MODEL PREDICTIVE CONTROL; PREDICTIVE CONTROL SYSTEMS; UNCERTAINTY ANALYSIS;

CHRONIC FATIGUE SYNDROMES; COMPLEX DYNAMICS; HOMOEOSTASIS; HORMONE LEVELS; HYPOTHALAMIC-PITUITARY-ADRENAL AXIS; IMMUNE FUNCTION; MODEL-BASED OPC; STABLE STEADY STATE; STEADY STATE; SYMPATHETIC NERVOUS SYSTEMS;

CORTISOL;

CORTICOTROPIN; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; SERPIN A6; SERPIN-A6; TRANSCORTIN;

ARTICLE; CONCEPTUAL FRAMEWORK; HYPOPHYSIS DISEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; PROCESS MODEL; STEADY STATE; TREATMENT PLANNING; ADRENAL INSUFFICIENCY; BIOLOGICAL MODEL; CHRONIC FATIGUE SYNDROME; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FEEDBACK SYSTEM; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; METHODOLOGY; PATHOPHYSIOLOGY; SYSTEMS BIOLOGY;

ADRENAL INSUFFICIENCY; ADRENOCORTICOTROPIC HORMONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FATIGUE SYNDROME, CHRONIC; FEEDBACK, BIOCHEMICAL; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MODELS, BIOLOGICAL; PITUITARY-ADRENAL SYSTEM; RECEPTORS, GLUCOCORTICOID; SYSTEMS BIOLOGY; TRANSCORTIN;

EID: 59149084187     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000273     Document Type: Article

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