Reduction of insulin resistance in HepG2 cells by knockdown of LITAF expression in human THP-1 macrophages

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 32, Issue 1, 2012, Pages 53-58

  Huang, Yan ^a   Liu, Jie ^a   Xu, Yancheng ^a   Dai, Zhe ^a   Alves, Martins Hedson ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Diabetes; Inflammation; Insulin resistance; Lipopolysaccharide induced tumor necrosis factor; Obesity

Indexed keywords

LITAF PROTEIN, HUMAN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL LINE; COCULTURE; CYTOLOGY; GENE SILENCING; HEPG2 CELL LINE; HUMAN; INSULIN RESISTANCE; MACROPHAGE; METABOLISM; PHYSIOLOGY;

CELL COMMUNICATION; CELL DIFFERENTIATION; CELL LINE; COCULTURE TECHNIQUES; GENE KNOCKDOWN TECHNIQUES; HEP G2 CELLS; HUMANS; INSULIN RESISTANCE; MACROPHAGES; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS;

EID: 84861133711     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-012-0009-7     Document Type: Article

References (14)

1. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest, 2006, 116(8):1793-1801
2. Myokai F, Takashiba S, Lebo R, et al. A novel lipopolysaccharide- induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment. Proc Natl Acad Sci USA, 1999, 96(3):4518-4523
3. Tang X, Metzger D, Leeman S, et al. LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LI-TAF-dependent LPS signaling pathways. Proc Natl Acad Sci USA, 2006, 103(4):13 777-13 782
4. Kosaka C, Masuda J, Shimokado K, et al. Interferon- gamma suppresses PDGF production from THP-1 cells and blood monocyte-derived macrophages. Atherosclerosis, 1992, 97(4):75-87
5. Dietze D, Koenen M, Rohrig K, et al. Impairment of insulin signaling in human skeletal muscle cells by co-culture with human adipocytes. Diabetes, 2002, 51(4):2369-2376
6. Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology, 2007, 132(2): 2169-2180
7. Tang X, Marciano DL, Leeman SE, et al. LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines. Proc Natl Acad Sci USA, 2005, 102(6): 5132-5137
8. Ji Ozinsky A, Underhill DM, Fontenot JD, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA, 2000, 97(1): 13 766-13 771
9. Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science, 1998, 282(3):2085-2088
10. Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature, 2001, 411(7):494-498
11. Le Roith D, Zick Y. Recent advances in our under- standing of insulin action and insulin resistance. Diabetes Care, 2001, 24(8):588-597
12. Paz K, Hemi R, LeRoith D, et al. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J Biol Chem, 1997, 272(4):29 911-29 918
13. Hotamisligil GS. Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord, 2003, 27(Suppl 3):S53-S55
14. Wang M, Tafuri S. Modulation of PPARgamma activity with pharmaceutical agents: treatment of insulin resistance and atherosclerosis. J Cell Biochem, 2003, 89(1):38-47