Chloride secretion by cultures of pig tracheal gland cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 302, Issue 10, 2012, Pages

  Widdicombe, J H ^a   Borthwell, Rachel M ^a   Hajighasemi Ossareh, Mohammad ^a   Lachowicz Scroggins, Marrah E ^a   Finkbeiner, W E ^b   Stevens, Jeremy E ^a   Modlin, Sara ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Airway mucous gland; Anion secretion; Cystic fibrosis

Indexed keywords

AMILORIDE; ANION; CHLORIDE; CYCLIC AMP; LACTOFERRIN; LYSOZYME; MUCIN 5B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CELL CULTURE; CYSTIC FIBROSIS; FEMALE; MALE; MUCUS GLAND; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; SHORT CIRCUIT CURRENT; TIGHT JUNCTION; TRACHEA;

AMILORIDE; ANIMALS; BIOLOGICAL MARKERS; CALCIUM; CELLS, CULTURED; CHLORIDES; CYCLIC AMP; CYSTIC FIBROSIS; DIFFUSION CHAMBERS, CULTURE; DISEASE MODELS, ANIMAL; ELECTRIC IMPEDANCE; EPITHELIAL CELLS; EXOCRINE GLANDS; HUMANS; ION TRANSPORT; LACTOFERRIN; METHACHOLINE CHLORIDE; MUCIN-5B; MURAMIDASE; SWINE; TIGHT JUNCTIONS; TRACHEA;

EID: 84861108867     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00253.2011     Document Type: Article

References (41)

1. Bedrossian CW, Greenberg SD, Singer DB, Hansen JJ, Rosenberg HS. The lung in cystic fibrosis. A quantitative study including prevalence of pathologic findings among different age groups. Hum Pathol 7: 195-204, 1976.
2. Bowes D, Clark AE, Corrin B. Ultrastructural localisation of lactoferrin and glycoprotein in human bronchial glands. Thorax 36: 108-115, 1981.
3. Bowes D, Corrin B. Ultrastructural immunocytochemical localisation of lysozyme in human bronchial glands. Thorax 32: 163-170, 1977.
4. Cesarone CF, Bolognesi C, Santi L. Improved microfluorometric DNA determination in biological material using Hoechst 33258. Anal Biochem 100: 188-197, 1979.
5. Choi HK, Finkbeiner WE, Widdicombe JH. A comparative study of mammalian tracheal mucous glands. J Anat 197: 361-372, 2000.
6. Choi JY, Joo NS, Krouse ME, Wu JV, Robbins RC, Ianowski JP, Hanrahan JW, Wine JJ. Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis. J Clin Invest 117: 3118-3127, 2007.
7. Coleman DL, Tuet IK, Widdicombe JH. Electrical properties of dog tracheal epithelial cells grown in monolayer culture. Am J Physiol Cell Physiol 246: C355-C359, 1984.
8. Dubin RF, Robinson SK, Widdicombe JH. Secretion of lactoferrin and lysozyme by cultures of human airway epithelium. Am J Physiol Lung Cell Mol Physiol 286: L750-L755, 2004.
9. Finkbeiner WE, Widdicombe JH. Control of nasal airway secretions, ion transport, and water movement. In: Treatise on Pulmonary Toxicology. Comparative Biology of the Normal Lung, edited by Parent RA. Boca Raton, FL: CRC, 1992, vol. 1, p. 633-657.
10. Finkbeiner WE, Zlock LT, Mehdi I, Widdicombe JH. Cultures of human tracheal gland cells of mucous or serous phenotype. In Vitro Cell Dev Biol Anim 46: 450-456, 2010.
11. Finkbeiner WE, Zlock LT, Morikawa M, Dasari V, Widdicombe JH. Cystic fibrosis and the relationship between mucin and chloride secretion by differentiated cultures of human airway gland mucous cells. Am J Physiol Lung Cell Mol Physiol 301: L402-L414, 2011.
12. Fischer H, Illek B, Sachs L, Finkbeiner WE, Widdicombe JH. CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype. Am J Physiol Lung Cell Mol Physiol 299: L585-L594, 2010.
13. Gruenert DC, Finkbeiner WE, Widdicombe JH. Culture and transformation of human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 268: L347-L360, 1995.
14. Guilbault C, Saeed Z, Downey GP, Radzioch D. Cystic fibrosis mouse models. Am J Respir Cell Mol Biol 36: 1-7, 2007.
15. Hartzell C, Putzier I, Arreola J. Calcium-activated chloride channels. Annu Rev Physiol 67: 719-758, 2005.
16. Hays SR, Fahy JV. Characterizing mucous cell remodeling in cystic fibrosis: relationship to neutrophils. Am J Respir Crit Care Med 174: 1018-1024, 2006.
17. Inoue D, Kubo H, Watanabe M, Sasaki T, Yasuda H, Numasaki M, Sasaki H, Yamaya M. Submucosal gland cells in human lower airways produce MUC5AC protein. Respirology 13: 285-287, 2008.
18. Jayaraman S, Joo NS, Reitz B, Wine JJ, Verkman AS. Submucosal gland secretions in airways from cystic fibrosis patients have normal [Na ] and pH but elevated viscosity. Proc Natl Acad Sci USA 98: 8119-8123, 2001.
19. Jiang C, Finkbeiner WE, Widdicombe JH, McCray PB Jr, Miller SS. Altered fluid transport across airway epithelium in cystic fibrosis. Science 262: 424-427, 1993.
20. Jiang C, Finkbeiner WE, Widdicombe JH, Miller SS. Fluid transport across cultures of human tracheal glands is altered in cystic fibrosis. J Physiol 501: 637-647, 1997.
21. Joo NS, Irokawa T, Wu JV, Robbins RC, Whyte RI, Wine JJ. Absent secretion to vasoactive intestinal peptide in cystic fibrosis airway glands. J Biol Chem 277: 50710-50715, 2002.
22. Joo NS, Lee DJ, Winges KM, Rustagi A, Wine JJ. Regulation of antiprotease and antimicrobial protein secretion by airway submucosal gland serous cells. J Biol Chem 279: 38854-38860, 2004.
23. Joo NS, Saenz Y, Krouse ME, Wine JJ. Mucus secretion from single submucosal glands of pig. Stimulation by carbachol and vasoactive intestinal peptide. J Biol Chem 277: 28167-28175, 2002.
24. Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, Verkman AS. Thiazolidinone CFTR inhibitor identified by high-through-put screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest 110: 1651-1658, 2002.
25. McCarty NA, McDonough S, Cohen BN, Riordan JR, Davidson N, Lester HA. Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl channel by two closely related arylaminobenzoates. J Gen Physiol 102: 1-23, 1993.
26. Merten MD, Figarella C. Constitutive hypersecretion and insensitivity to neurotransmitters by cystic fibrosis tracheal gland cells. Am J Physiol Lung Cell Mol Physiol 264: L98-L99, 1993.
27. Ostedgaard LS, Meyerholz DK, Chen JH, Pezzulo AA, Karp PH, Rokhlina T, Ernst SE, Hanfland RA, Reznikov LR, Ludwig PS, Rogan MP, Davis GJ, Dohrn CL, Wohlford-Lenane C, Taft PJ, Rector MV, Hornick E, Nassar BS, Samuel M, Zhang Y, Richter SS, Uc A, Shilyansky J, Prather RS, McCray PB Jr, Zabner J, Welsh MJ, Stoltz DA. The F508 mutation causes CFTR misprocessing and cystic fibrosislike disease in pigs. Sci Transl Med 3: 74-84, 2011.
28. Reid L. Measurement of the bronchial mucous gland layer: a diagnostic yardstick in chronic bronchitis. Thorax 15: 132-141, 1960.
29. Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray PB Jr, Zabner J, Prather RS, Welsh MJ. Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science 321: 1837-1841, 2008.
30. Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 86: 245-278, 2006.
31. Sachs LA, Finkbeiner WE, Widdicombe JH. Effects of media on differentiation of cultured human tracheal epithelium. In Vitro 39A: 56-62, 2003.
32. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC. Measurement of protein using bicinchoninic acid. Anal Biochem 71: 1392-1401, 1985.
33. Sommerhoff CP, Finkbeiner WE. Human tracheobronchial submucosal gland cells in culture. Am J Respir Cell Mol Biol 2: 41-50, 1990.
34. Tos M. Development of the tracheal glands in man. Acta Pathol Microbiol Scand Suppl 185: 1-130, 1966.
35. Ueki I, German VF, Nadel J. Micropipette measurement of airway submucosal gland secretion: autonomic effects. Am Rev Respir Dis 121: 351-357, 1980.
36. Widdicombe JH, Basbaum CB, Highland E. Ion contents and other properties of isolated cells from dog tracheal epithelium. Am J Physiol Cell Physiol 241: C184-C192, 1981.
37. Wu DX, Lee CY, Uyekubo SN, Choi HK, Bastacky SJ, Widdicombe JH. Regulation of the depth of surface liquid in bovine trachea. Am J Physiol Lung Cell Mol Physiol 274: L388-L395, 1998.
38. Yamaya M, Finkbeiner WE, Chun SY, Widdicombe JH. Differentiated structure and function of cultures from human tracheal epithelium. Am J Physiol Lung Cell Mol Physiol 262: L713-L724, 1992.
39. Yamaya M, Finkbeiner WE, Widdicombe JH. Altered ion transport by tracheal glands in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 261: L491-L494, 1991.
40. Yamaya M, Finkbeiner WE, Widdicombe JH. Ion transport by cultures of human tracheobronchial submucosal glands. Am J Physiol Lung Cell Mol Physiol 261: L485-L490, 1991.
41. Yeates DB, Sturgess J, Kahn S, Levison H, Aspin N. Mucociliary transport in the trachea of patients with cystic fibrosis. Arch Dis Child 51: 28-33, 1976.