Is myocardial recovery possible and how do you measure it?

Current Cardiology Reports

Volumn 14, Issue 3, 2012, Pages 293-298

  Mann, Douglas L ^a,c   Burkhoff, Daniel ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c Division of Cardiology   (United States)

Author keywords

Cardiac remodeling; Heart failure; Myocardial recovery; Reverse remodeling

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

ASSISTED CIRCULATION; CARDIOPULMONARY EXERCISE TEST; CARDIOVASCULAR PARAMETERS; CONGESTIVE CARDIOMYOPATHY; DISEASE COURSE; ECHOCARDIOGRAPHY; EXTRACELLULAR MATRIX; HEART ASSIST DEVICE; HEART FAILURE; HEART HEMODYNAMICS; HEART LEFT VENTRICLE FUNCTION; HUMAN; MORPHOLOGY; MYOCARDIAL RECOVERY; REVIEW;

HEART FAILURE; HEART-ASSIST DEVICES; HUMANS; PROGNOSIS; TREATMENT OUTCOME; VENTRICULAR REMODELING;

EID: 84861101916     PISSN: 15233782     EISSN: 15343170     Source Type: Journal    
DOI: 10.1007/s11886-012-0264-z     Document Type: Review

References (31)

1. Kass DA, Baughman KL, Pak PH, Cho PW, Levin HR, Gardner TJ, Halperin HR, Tsitlik JE, Acker MA. Reverse remodeling from cardiomyoplasty in human heart failure. External constraint versus active assist. Circulation. 1995;91:2314-8.
2. Levin HR, Oz MC, Chen JM, Packer M, Rose EA, Burkhoff D. Reversal of chronic ventricular dilation in patients with end-stage cardiomyopathy by prolonged mechanical unloading. Circulation. 1995;91:2717-20.
3. Westaby S, Jin XY, Katsumata T, Taggart DP, Coats AJ, Frazier OH: Mechanical support in dilated cardiomyopathy: signs of early left ventricular recovery; 1997, pp 1303-1308.
4. Frazier OH. First use of an untethered, vented electric left ventricular assist device for long-term support. Circulation. 1994;89:2908-14.
5. Levin HR, Oz MC, Catanese KA, Rose EA, Burkhoff D. Transient normalization of systolic and diastolic function after support with a left ventricular assist device in a patient with dilated cardiomyopathy. J Heart Lung Transplant. 1996;15:840-2.
6. Konstam MA, Kronenberg MW, Rousseau MF, Udelson JE, Melin J, Stewart D, Dolan N, Edens TR, Ahn S, Kinan D. Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dilatation in patients with asymptomatic systolic dysfunction. SOLVD (Studies of Left Ventricular Dysfunction) Investigators. Circulation. 1993;88:2277-83.
7. Lindpaintner K, Lee MA, Larson MG, Rao S, Pfeffer MA, Ordovas JM, Schaefer EJ, Wilson AF, Wilson P W F, Vasan RS, Myers RH, Levy D. Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass. N Engl J Med. 1996;334:1023-8.
8. Kirklin JK, Naftel DC, Kormos RL, Stevenson LW, Pagani FD, Miller MA, Ulisney KL, Baldwin JT, Young JB: Third INTER-MACS Annual Report: the evolution of destination therapy in the United States. J Heart Lung Transplant 2011, 30:115-23. This is the most recent report from the INTERMACS registry that shows that 1 % of VAD patients were explanted for myocardial recovery.
9. Mann DL, Burkhoff D: Myocardial expression levels of microribonucleic acids in patients with left ventricular assist devices signature of myocardial recovery, signature of reverse remodeling, or signature with no name? J Am Coll Cardiol 2011, 58:2279-81. This is an editorial that provides the first working definition of myocardial recovery.
10. Margulies KB, Matiwala S, Cornejo C, Olsen H, Craven WA, Bednarik D. Mixed messages: transcription patterns in failing and recovering human myocardium. Circ Res. 2005;96:592-9.
11. Rodrigue-Way A, Burkhoff D, Geesaman BJ, Golden S, Xu J, Pollman MJ, Donoghue M, Jeyaseelan R, Houser S, Breitbart RE, Marks A, Acton S. Sarcomeric genes involved in reverse remodeling of the heart during left ventricular assist device support. J Heart Lung Transplant. 2005;24:73-80.
12. Schwientek P, Ellinghaus P, Steppan S, D'Urso D, Seewald M, Kassner A, Cebulla R, Schulte-Eistrup S, Morshuis M, Rofe D, El BA, Korfer R, Milting H: Global gene expression analysis in nonfailing and failing myocardium pre-and postpulsatile and nonpulsatile ventricular assist device support. Physiol Genomics 2010, 42:397-405. This is a recent microarray analysis showing that the heart failure gene program is not reversed following pulsatile and nonpulsatile VADs.
13. Lowes BD, Zolty R, Shakar SF, Brieke A, Gray N, Reed M, Calalb M, Minobe W, Lindenfeld J, Wolfel EE, Geraci M, Bristow MR, Cleveland Jr J. Assist devices fail to reverse patterns of fetal gene expression despite beta-blockers. J Heart Lung Transplant. 2007;26:1170-6.
14. Barbone A, Oz MC, Burkhoff D, Holmes JW. Normalized diastolic properties after left ventricular assist result from reverse remodeling of chamber geometry. Circulation. 2001;104:I229-32.
15. Birks EJ, Tansley PD, Hardy J, George RS, Bowles CT, Burke M, Banner NR, Khaghani A, Yacoub MH. Left ventricular assist device and drug therapy for the reversal of heart failure. N Engl J Med. 2006;355:1873-84.
16. Hall JL, Birks EJ, Grindle S, Cullen ME, Barton PJ, Rider JE, Lee S, Harwalker S, Mariash A, Adhikari N, Charles NJ, Felkin LE, Polster S, George RS, Miller LW, Yacoub MH. Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy. Eur Heart J. 2007;28:613-27.
17. Mancini DM, Beniaminovitz A, Levin H, Catanese K, Flannery M, DiTullio M, Savin S, Cordisco ME, Rose E, Oz M. Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure. Circulation. 1998;98:2383-9.
18. Birks EJ, George RS, Hedger M, Bahrami T, Wilton P, Bowles CT, Webb C, Bougard R, Amrani M, Yacoub MH, Dreyfus G, Khaghani A: Reversal of Severe Heart Failure With a Continuous-Flow Left Ventricular Assist Device and Pharmacological Therapy: A Prospective Study. Circulation 2011, 123:381-390. This is a recent prospective study that shows that the a combination of medical therapy and VAD support resulted in recovery in 60 % of the patients that were studied.
19. Mann DL. Mechanisms and models in heart failure: a combinatorial approach. Circulation. 1999;100:999-1088.
20. Maybaum S, Mancini D, Xydas S, Starling RC, Aaronson K, Pagani FD, Miller LW, Margulies K, McRee S, Frazier OH, Torre-Amione G. Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group. Circulation. 2007;115:2497-505.
21. Dandel M, Weng Y, Siniawski H, Potapov E, Drews T, Lehmkuhl HB, Knosalla C, Hetzer R. Prediction of cardiac stability after weaning from left ventricular assist devices in patients with idiopathic dilated cardiomyopathy. Circulation. 2008;118:S94-S105.
22. Dandel M, Weng Y, Siniawski H, Stepanenko A, Krabatsch T, Potapov E, Lehmkuhl HB, Knosalla C, Hetzer R. Heart failure reversal by ventricular unloading in patients with chronic cardiomyopathy: criteria for weaning from ventricular assist devices. Eur Heart J. 2011;32:1148-60.
23. Drakos SG, Terrovitis JV, Nastasiou-Nana MI, Nanas JN. Reverse remodeling during long-term mechanical unloading of the left ventricle. J Mol Cell Cardiol. 2007;43:231-42.
24. Drakos SG, Charitos EI, Nanas SN, Nanas JN. Ventricular-assist devices for the treatment of chronic heart failure. Expert Rev Cardiovasc Ther. 2007;5:571-84.
25. Liden H, Karason K, Bergh CH, Nilsson F, Koul B, Wiklund L. The feasibility of left ventricular mechanical support as a bridge to cardiac recovery. Eur J Heart Fail. 2007;9:525-30.
26. Gorcsan III J, Severyn D, Murali S, Kormos RL. Non-invasive assessment of myocardial recovery on chronic left ventricular assist device: results associated with successful device removal. J Heart Lung Transplant. 2003;22:1304-13.
27. Matsumiya G, Monta O, Fukushima N, Sawa Y, Funatsu T, Toda K, Matsuda H. Who would be a candidate for bridge to recovery during prolonged mechanical left ventricular support in idiopathic dilated cardiomyopathy? J Thorac Cardiovasc Surg. 2005;130:699-704.
28. Simon MA, Primack BA, Teuteberg J, Kormos RL, Bermudez C, Toyoda Y, Shah H, Gorcsan III J, McNamara DM. Left ventricular remodeling and myocardial recovery on mechanical circulatory support. J Card Fail. 2010;16:99-105.
29. Farrar DJ, Holman WR, McBride LR, Kormos RL, Icenogle TB, Hendry PJ, Moore CH, Loisance DY, El Banayosy A, Frazier H. Long-term follow-up of Thoratec ventricular assist device bridgeto-recovery patients successfully removed from support after recovery of ventricular function. J Heart Lung Transplant. 2002;21:516-21.
30. Drakos SG, Kfoury AG, Selzman CH, Verma DR, Nanas JN, Li DY, Stehlik J. Left ventricular assist device unloading effects on myocardial structure and function: current status of the field and call for action. Curr Opin Cardiol. 2011;26:245-55.
31. Mann DL, Burkhoff D. Myocardial expression levels of microribonucleic acids in patients with left ventricular assist devices signature of myocardial recovery, signature of reverse remodeling, or signature with no name? J Am Coll Cardiol. 2011;58:2279-81.