Monoamine concentrations changes in the PTU-induced hypothyroid rat brain and the ameliorating role of folic acid

Human and Experimental Toxicology

Volumn 31, Issue 3, 2012, Pages 282-289

  Tousson, E ^a   Ibrahim, W ^b   Arafa, N ^c   Akela, M A ^a  

^a Tanta University   (Egypt)

^b TANTA UNIVERSITY   (Egypt)

^c National Authority for Control and Pharmaceutical Research   (Egypt)

Author keywords

brain monoamines; HPLC; hypothyroidism; neurotransmitters; PTU

Indexed keywords

DOPAMINE; DRINKING WATER; FOLIC ACID; LIOTHYRONINE; LIOTRIX; MONOAMINE; NEUROTRANSMITTER; NORADRENALIN; PROPYLTHIOURACIL; SEROTONIN; THYROTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; HYPOTHALAMUS; HYPOTHYROIDISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VISUAL CORTEX;

ANIMALS; BRAIN; BRAIN CHEMISTRY; CEREBRAL CORTEX; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; FOLIC ACID; HYPOTHALAMUS; HYPOTHYROIDISM; MALE; NOREPINEPHRINE; PROPYLTHIOURACIL; RATS; SEROTONIN; THYROTROPIN; TRIIODOTHYRONINE; VITAMIN B COMPLEX;

RATTUS;

EID: 84861083485     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327111405863     Document Type: Conference Paper

References (38)

1. Toshihiro I.. Thyroid hormone and atherosclerosis. Vascul Pharmacol J. 2009 ;:
2. Gong J, Dong J, Wang Y, Xu H, Wei W, et al. Developmental iodine deficiency and hypothyroidism impair neural development, up-regulate caveolin-1, and down-regulate synaptophysin in rat hippocampus. BMC Neurosci. 2010 ; 50: 11
3. Ahmed OM, Abd El-Tawab SM, Ahmed RG.. Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: I. The development of the thyroid hormones-neurotransmitters and adenosinergic system interactions. Int J Dev Neurosci. 2010 ; 28: 437-454
4. Dong J, Liu W, Wang Y, Hou Y, Xi Q, Chen J.. Developmental iodine deficiency resulting in hypothyroidism reduces hippocampal ERK1/2 and CREB in lactational and adolescent rats. BMC Neurosci. 2009 ; 10: 149
5. Ahmed OM, El-Gareib AW, El-Bakry AM, El-Tawab SMA, Ahmed RG.. Thyroid hormones states and brain development interactions. Int J Dev Neurosci. 2008 ; 26: 147-209 (Pubitemid 351215070)
6. Sandrini M, Vitale G, Vergoni AV, Ottani A, Bertolini A.. Effect of acute and chronic treatment with triiodothyronine on serotonin levels and serotonergic receptor subtypes in the rat brain. Life Sci. 1996 ; 58: 1551-1559 (Pubitemid 26130525)
7. Newman M, Agid O, Gur E, Lerer B.. Pharmacological mechanisms of T3 augmentation of antidepressant action. Int J Neuropsychopharmacol. 2003 ; 3: 187-191
8. Viquerie N, Langin D.. Effects of thyroid hormone and gene expression. Curr Opin Clin Nutr Metab Care. 2003 ; 6: 377-381 (Pubitemid 40684587)
9. Oppenheimer JH, Schwartz HL.. Molecular basis of thyroid hormone-dependent brain development. Endocr Rev. 1997 ; 18: 462-475 (Pubitemid 27349552)
10. Bernal J, Guadaño-Ferraz A, Morte B.. Perspectives in the study of thyroid hormone in brain development and function. Thyroid. 2003 ; 13: 1005-1012 (Pubitemid 37464553)
11. De Escobar GM, Obregón MJ, del Rey FE.. Iodine deficiency and brain development in the first half of pregnancy. Public Health Nutr. 2007 ; 10: 1554-1570 (Pubitemid 350224313)
12. Galton VA, Wood ET, St Germain EA, Withrow CA, et al.. Thyroid hormone homeostasis and action in the type 2 deiodinase-deficient rodent brain during development. Endocrinology. 2007 ; 148: 3080-3088 (Pubitemid 46997018)
13. Schmidt M, Huff W, Dietlein M, Kobe C, Schicha H.. Interactions between brain, psyche and thyroid. Nuklearmedizin. 2008 ; 47: 225-234
14. Ito JM, Valcana T, Timiras PS.. Effect of hypo- and hyperthyroidism on regional monoamine metabolism in the adult rat brain. Neuroendocrinology. 1977 ; 24: 55-64 (Pubitemid 8264807)
15. Nedrebù BG, Ericsson UB, Nygaard O, et al. Plasma total homocysteine levels in hyperthyroid and hypothyroid patients. Metabolism. 1998 ; 47: 89-93
16. Brosnan JT, Jacobs RL, Stead LM, Brosnan ME.. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim. 2004 ; 51: 405-413 (Pubitemid 38969303)
17. Au-Yeung KW, Yip CW, Siow YL, Karmin O.. Folic acid inhibits homocysteine-induced superoxide anion production and nuclear factor kappa B activation in macrophages. Can J Physiol Pharmacol. 2006 ; 84: 141-147 (Pubitemid 44017619)
18. Fenech M, Baghurst P, Luderer W, et al. Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, b-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability-results from a dietary intake and micronucleus index survey in South Australia. Carcinogenesis. 2005 ; 26: 991-999 (Pubitemid 41214329)
19. Matte C, Scherer EB, Stefanello FM, Barschak AG, et al. Concurrent folate treatment prevents Na+, K+-ATPase activity inhibition and memory impairments caused by chronic hyperhomocysteinemia during rat development. Int J Dev Neurosci. 2007 ; 25: 545-552 (Pubitemid 350184247)
20. Salvati S, Attorri L, Campeggi LM.. Effect of propylthiouracil induced hypothyroidism on cerebral cortex of young and aged rats: Lipid composition of synaptosomes, muscarinic receptor sites, and acetylcholinesterase activity. Neurochem Res. 1994 ; 19: 1181-1186 (Pubitemid 24284794)
21. Pagel P, Blome J, Wolf HU.. High-performance liquid chromatographic separation and measurement of various biogenic compounds possibly involved in the pathomechanism of Parkinson's disease. J Chromatogr B. 2000 ; 746: 297-304 (Pubitemid 30657946)
22. Gilbert ME, Paczkowski C.. Propylthiouracil (PTU)-induced hypothyroidism in the developing rat impairs synaptic transmission and plasticity in the dentate gyrus of the adult hippocampus. Dev Brain Res. 2003 ; 145: 19-29 (Pubitemid 38368638)
23. Vaccari A., Rossetti ZL, De Ontis G, Stefanini E, Martino E, Gessa GL.. Neonatal hypothyroidism induces striatal dopaminergic dysfunction. Neuroscience. 1990 ; 35: 699-706 (Pubitemid 20198401)
24. Gur E, Lerer B, Newman ME.. Chronic clomipramine and triiodothyronine increase serotonin levels in rat frontal cortex in vivo: relationship to serotonin autoreceptor activity. J Pharmacol Exp Therap. 1999 ; 288: 81-87 (Pubitemid 29113476)
25. Atterwill CK.. Effect of acute and chronic tri-iodothyronine (T3) administration to rats on central 5-HT and dopamine-mediated behavioural responses and related brain biochemistry. Neuropharmacology. 1981 ; 20: 131-144 (Pubitemid 11138080)
26. Portela-Gomes MG, Albquerque J, Bchir MB, Ferra M.. Serotonin and gastrin cells in rat gastrointestinal tract after thyroparathyroidectomy and induced hyperthyroidism. Digest Dis Sci. 2000 ; 45: 730-735 (Pubitemid 30186056)
27. Schatzberg AF, Schildkraut JJ. Psychopharmacology the fourth generation of progress. Bloom FE Kupfer DJ, ed. Raven Press: New York ; 1995: 911-920.
28. Coulombe P, Dussault JH, Walker P.. Catecholamine metabolism in thyroid disease. II. Norepinephrine secretion rate in hyperthyroidism and hypothyroidism. J Clin Endocrinol Metab. 1977 ; 44: 1185-1189 (Pubitemid 8104308)
29. Velasco M, Luchsinger A.. Dopamine pharmacologic and therapeutic aspects. Am J Therapeut. 1998 ; 5: 37-43
30. Crocker AD.. Hypothyroidism leads to increased dopamine receptor sensitivity and concentration. Pharmacol Biochem Behav. 1986 ; 24: 1593-1597 (Pubitemid 16066620)
31. Eshchenko ND. Biokhimiya psikhicheskikh I nervnykh boleznei. Biochemistry of psychic and neurological Sdiseases). St. Petersburg: Sankt-Peterburgskii universitet ; 2004:
32. Fedotova O, Masalova O.. Specific monoamine exchange in the brains of young and aged male rats with hypothyroidism. Neurochem J. 2010 ; 4: 19-24
33. Cousens G. Depression-free for life. New York: William Morrow ; 2000:
34. Bottiglieri T, Laundry M, Crellin R, Toone BK, Carney MWP, Reynolds EH.. Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry. 2000 ; 69: 228-232 (Pubitemid 30466029)
35. Zhu X, Smith MA, Honda K, et al. Vascular oxidative stress in Alzheimer disease. J Neurol Sci. 2007 ; 257: 240-246 (Pubitemid 46856513)
36. Morris MS.. Homocysteine and Alzheimer's disease. Lancet Neurol. 2003 ; 2: 425-428 (Pubitemid 36793935)
37. Ventura P,, Panini R, Verlato C, Scarpetta G, Salvioli G.. Peroxidation indices and total antioxidant capacity in plasma during hyperhomocysteinaemia induced by methionine oral loading. Metabolism. 2000 ; 49: 225-228 (Pubitemid 30090888)
38. Streck EL, Matté C, Vieira PS, et al. Reduction of Na+, K+-ATPase activity in hippocampus of rats subjected to chemically induced hyperhomocysteinemia. Neurochem Res. 2002 ; 27: 1585-1590