An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model

Blood

Volumn 119, Issue 19, 2012, Pages 4512-4523

  Bergerson, Rachel J ^a   Collier, Lara S ^b   Sarver, Aaron L ^a   Been, Raha A ^a   Lugthart, Sanne ^c   Diers, Miechaleen D ^a   Zuber, Johannes ^d   Rappaport, Amy R ^d,e   Nixon, Molly J ^a   Silverstein, Kevin A T ^a   Fan, Danhua ^a   Lamblin, Anne Francoise J ^a   Wolff, Linda ^f   Kersey, John H ^a   Delwel, Ruud ^c   Lowe, Scott W ^d,e,g   O'Sullivan, M Gerard ^a   Kogan, Scott C ^h   Adams, David J ⁱ   Largaespada, David A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^e WATSON SCHOOL OF BIOLOGICAL SCIENCES   (United States)

^f NATIONAL CANCER INSTITUTE   (United States)

^g HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; BCL11A PROTEIN; CYCLIN D1; FIBROBLAST GROWTH FACTOR RECEPTOR 3; GMFG PROTEIN; IKAROS TRANSCRIPTION FACTOR; MIXED LINEAGE LEUKEMIA AF9 FUSION PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; MN1 PROTEIN; MYC PROTEIN; NOTCH1 RECEPTOR; ONCOPROTEIN; PROTEIN MYB; RASGRP1 PROTEIN; RRAS2 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR DELTA FOSB; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SURVIVAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE REARRANGEMENT; GENOTYPE; HUMAN; HUMAN CELL; LEUKEMOGENESIS; LEUKOCYTE COUNT; MALE; MOLONEY LEUKEMIA ONCOVIRUS; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; SPLEEN WEIGHT; UPREGULATION; VIRUS CARCINOGENESIS; WILD TYPE;

EID: 84861073904     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-04-281428     Document Type: Article

References (41)

1. Rowley JD. The role of chromosome translocations in leukemogenesis. Semin Hematol. 1999; 36(4 suppl 7):59-72.
2. Felix CA, Kolaris CP, Osheroff N. Topoisomerase II and the etiology of chromosomal translocations. DNA Repair. 2006;5(9-10):1093-1108. (Pubitemid 44291622)
3. Daser A, Rabbitts TH. The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis. Semin Cancer Biol. 2005;15(3):175-188.
4. Nakamura T, Alder H, Gu Y, et al. Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proc Natl Acad Sci U S A. 1993;90(10):4631-4635. (Pubitemid 23148959)
5. Huret JL, Senon S, Bernheim A, Dessen P. An Atlas on genes and chromosomes in oncology and haematology. Cell Mol Biol. 2004;50(7):805-807.
6. Corral J, Lavenir I, Impey H, et al. An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. Cell. 1996; 85(6):853-861. (Pubitemid 26192136)
7. Dobson CL, Warren AJ, Pannell R, et al. The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis. EMBO J. 1999;18(13):3564-3574. (Pubitemid 29308837)
8. Johnson JJ, Chen W, Hudson W, et al. Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia. Blood. 2003;101(8):3229-3235. (Pubitemid 36858019)
9. Mikkers H, Berns A. Retroviral insertional mutagenesis: tagging cancer pathways. Adv Cancer Res. 2003;88:53-99. (Pubitemid 36343279)
10. Lund AH, Turner G, Trubetskoy A, et al. Genomewide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Nat Genet. 2002;32(1):160-165. (Pubitemid 34977212)
11. Blaydes SM, Kogan SC, Truong BT, et al. Retroviral integration at the Epi1 locus cooperates with Nf1 gene loss in the progression to acute myeloid leukemia. J Virol. 2001;75(19):9427-9434. (Pubitemid 32851946)
12. Wolff L, Koller R, Hu X, Anver MR. A Moloney murine leukemia virus-based retrovirus with 4070A long terminal repeat sequences induces a high incidence of myeloid as well as lymphoid neoplasms. J Virol. 2003;77(8):4965-4971. (Pubitemid 36402845)
13. Wolff L, Garin MT, Koller R, et al. Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice. Oncogene. 2003; 22(58):9265-9274. (Pubitemid 38122038)
14. Slape C, Hartung H, Lin YW, Bies J, Wolff L, Aplan PD. Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation. Cancer Res. 2007;67(11):5148-5155. (Pubitemid 46997251)
15. Starr TK, Allaei R, Silverstein KA, et al. A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science. 2009;323(5922):1747-1750.
16. Stabenau A, McVicker G, Melsopp C, Proctor G, Clamp M, Birney E. The Ensembl core software libraries. Genome Res. 2004;14(5):929-933. (Pubitemid 38660512)
17. Sundstrom C, Nilsson K. Establishment and characterization of a human histiocytic lymphoma cell line (U-937). Int J Cancer. 1976;17(5):565-577.
18. Harris P, Ralph P. Human leukemic models of myelomonocytic development: a review of the HL-60 and U937 cell lines. J Leukoc Biol. 1985;37(4): 407-422. (Pubitemid 15147523)
19. Zuber J, McJunkin K, Fellmann C, et al. Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat Biotechnol. 2011;29(1):79-83.
20. Heuser M, Argiropoulos B, Kuchenbauer F, et al. MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML. Blood. 2007;110(5):1639-1647. (Pubitemid 47443982)
21. Castilla LH, Perrat P, Martinez NJ, et al. Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia. Proc Natl Acad Sci U S A. 2004;101(14):4924-4929. (Pubitemid 38469179)
22. Ross JA, Robison LL. MLL rearrangements in infant leukemia: is there a higher frequency in females? Leuk Res. 1997;21(8):793-795. (Pubitemid 27458633)
23. Akagi K, Suzuki T, Stephens RM, Jenkins NA, Copeland NG. RTCGD: retroviral tagged cancer gene database. Nucleic Acids Res. 2004;32(database issue):D523-D527. (Pubitemid 38081713)
24. Forbes SA, Bhamra G, Bamford S, et al. The catalogue of somatic mutations in cancer (COSMIC). Curr Protoc Hum Genet. 2008;Chapter 10: Unit 10.11.
25. Futreal PA, Coin L, Marshall M, et al. A census of human cancer genes. Nat Rev Cancer. 2004; 4(3):177-183. (Pubitemid 38337497)
26. Valk PJ, Verhaak RG, Beijen MA, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med. 2004;350(16): 1617-1628. (Pubitemid 38528701)
27. Verhaak RG, Wouters BJ, Erpelinck CA, et al. Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling. Haematologica. 2009;94(1):131-134.
28. Carella C, Bonten J, Sirma S, et al. MN1 overexpression is an important step in the development of inv(16) AML. Leukemia. 2007;21(8):1679-1690. (Pubitemid 47086758)
29. Mullighan CG, Goorha S, Radtke I, et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature. 2007; 446(7137):758-764. (Pubitemid 46582031)
30. Ferrari S, Torelli U, Selleri L, et al. Study of the levels of expression of two oncogenes, c-myc and c-myb, in acute and chronic leukemias of both lymphoid and myeloid lineage. Leuk Res. 1985;9(7):833-842. (Pubitemid 15030811)
31. Wolff L. Myb-induced transformation. Crit Rev Oncog. 1996;7(3-4):245-260. (Pubitemid 27362414)
32. Walter MJ, Payton JE, Ries RE, et al. Acquired copy number alterations in adult acute myeloid leukemia genomes. Proc Natl Acad Sci U S A. 2009;106(31):12950-12955.
33. Lawrence HJ, Rozenfeld S, Cruz C, et al. Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias. Leukemia. 1999;13(12):1993-1999.
34. Sitwala KV, Dandekar MN, Hess JL. HOX proteins and leukemia. Int J Clin Exp Pathol. 2008; 1(6):461-474.
35. Liu T, Jankovic D, Brault L, et al. Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia. Leukemia. 2010;24(3):601-612.
36. Wolff L, Garin MT, Koller R, et al. A novel retrovirus provides the cooperating oncogenic event(s) required to demonstrate the tumor suppressor activity of p15Ink4b in myeloid cells in vivo. Blood Cells Mol Dis. 2004;32(1):226-231. (Pubitemid 38147721)
37. Nitta T, Takahama Y. The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins. Trends Immunol. 2007;28(2):58-65. (Pubitemid 46176732)
38. Cebrat M, Miazek A, Kisielow P. Identification of a third evolutionarily conserved gene within the RAG locus and its RAG1-dependent and-independent regulation. Eur J Immunol. 2005;35(7): 2230-2238. (Pubitemid 41015062)
39. Caudell D, Harper DP, Novak RL, et al. Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice. Blood. 2010; 115(6):1194-1203.
40. Grosveld GC. MN1, a novel player in human AML. Blood Cells Mol Dis. 2007;39(3):336-339. (Pubitemid 47484474)
41. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402-408. (Pubitemid 34164012)