Retroviral integration at the Epi1 locus cooperates with Nf1 gene loss in the progression to acute myeloid leukemia

Journal of Virology

Volumn 75, Issue 19, 2001, Pages 9427-9434

  Blaydes, S M ^a   Kogan, S C ^a   Truong, B T H ^a   Gilbert, D J ^a   Jenkins, N A ^a   Copeland, N G ^a   Largaespada, D A ^a   Brannan, C I ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DISEASE COURSE; GENE LOCUS; GENE LOSS; HEMATOPOIETIC STEM CELL; JUVENILE MYELOMONOCYTIC LEUKEMIA; MOUSE; MYELOMONOCYTIC LEUKEMIA; NEUROFIBROMATOSIS; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS;

ACUTE DISEASE; ANIMALS; GENE DELETION; GENES, MYB; GENES, NEUROFIBROMATOSIS 1; GENETIC PREDISPOSITION TO DISEASE; LEUKEMIA, EXPERIMENTAL; LEUKEMIA, MYELOID; MICE; RETROVIRIDAE; VIRUS INTEGRATION;

EID: 0034856180     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.19.9427-9434.2001     Document Type: Article

References (38)

1. Neurofibromatosis and childhood leukemia
2. Spontaneous and induced leukemias of myeloid origin in recombinant inbred BXH mice
3. Transplacental transmission of a leukemogenic murine leukemia virus
4. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues
5. Effects of X-ray on lymphoid and hemopoietic tissues of albino mice
6. Evi-2, a common integration site involved in murine myeloid leukemogenesis
7. Subacute and chronic myelomonocytic leukemia in children (juvenile CML)
8. cDNA sequence and genomic structure of EV12B, a gene lying within an intron of the neurofibromatosis type 1 gene
9. The genomic sequencing technique
10. Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation
11. Development and applications of a molecular genetic linkage map of the mouse genome
12. Only the DNA binding and transactivation domains of c-Myb are required to block terminal differentiation of murine erythroleukemia cells
13. Use of National Institutes of Health criteria for diagnosis of neurofibromatosis 1 in children
14. The neurofibromatosis type 1 gene and its protein product, neurofibromin
15. Genetic profile of insertion mutations in mouse leukemias and lymphomas
16. Somatically acquired recombinant murine leukemia proviruses in thymic leukemias of AKR/J mice
17. Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus
18. The Myb and Ahi-1 genes are physically very closely linked on mouse chromosome 10
19. Retroviral insertional mutagenesis as a strategy to identify cancer genes
20. Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras
21. Retroviral insertion at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levels
22. Nf1 deficiency causes Ras-mediated granulocyte/macrophage stimulating factor hypersensitivity and chronic myeloid leukemia
23. Leukemia disease genes: Large-scale cloning and pathway predictions
24. Differentiation of mouse erythroleukemia cells is blocked by late up-regulation of a c-myb transgene
25. Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice
26. Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukemias
27. The myb gene family in cell growth, differentiation and apoptosis
28. The pathology of murine myelogenous leukemias
29. Epicardin: A novel basic helix-loophelix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads
30. Deregulated c-myb disrupts interleukin-6- or leukemia inhibitory factorinduced myeloid differentiation prior to c-myc: Role in leukemogenesis
31. Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders
32. Monosomy 7 myeloproliferative disease in children with neurofibromatosis, type 1: Epidemiology and molecular analysis
33. Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1
34. Neurofibromatosis and childhood leukaemia/lymphoma: A population-based UKCCSG study
35. Down-regulation of c-myb gene expression is a prerequisite for erythropoietin-induced erythroid differentiation
36. Myb-induced transformation
37. Constitutive expression of exogenous c-myb gene causes maturation block in monocyte-macrophage differentiation