Dynamic HoxB4-regulatory network during embryonic stem cell differentiation to hematopoietic cells

Blood

Volumn 119, Issue 19, 2012, Pages

  Fan, Rong ^a   Bonde, Sabrina ^a   Gao, Peng ^a   Sotomayor, Brendan ^a   Chen, Changya ^b   Mouw, Tyler ^a   Zavazava, Nicholas ^a,b,c   Tan, Kai ^a,b,d  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d University of Iowa   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; DLL1 PROTEIN; HLX PROTEIN; IKAROS TRANSCRIPTION FACTOR; IKZF1 PROTEIN; INHIBITOR OF DIFFERENTIATION 2; LYL1 PROTEIN; MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR 4; PROGRAMMED DEATH 1 LIGAND 1; PROTEIN BCL 6; PROTEIN KINASE ZAP 70; PROTEIN NODAL; SIM2 PROTEIN; SMAD2 PROTEIN; SPACER DNA; STAT5 PROTEIN; TBX3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FLI1; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR HOXB4; TRANSCRIPTION FACTOR MEIS1; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR SALL4; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR TAL1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYOID BODY; EMBRYONIC STEM CELL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LYMPHOID CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UPREGULATION;

EID: 84861053031     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-12-396754     Document Type: Article

References (46)

1. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5): 861-872. (Pubitemid 350138099)
2. Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007;318(5858):1917-1920.
3. Doetschman TC, Eistetter H, Katz M, Schmidt W, Kemler R. The in vitro development of blastocystderived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol. 1985;87:27-45. (Pubitemid 15029925)
4. Mikkola HK, Orkin SH. The journey of developing hematopoietic stem cells. Development. 2006; 133(19):3733-3744. (Pubitemid 44650952)
5. Kyba M, Perlingeiro RC, Daley GQ. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell. 2002;109(1):29-37. (Pubitemid 34327514)
6. Pilat S, Carotta S, Schiedlmeier B, et al. HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells. Proc Natl Acad Sci U S A. 2005;102(34):12101-12106. (Pubitemid 41291135)
7. Chan KM, Bonde S, Klump H, Zavazava N. Hematopoiesis and immunity of HOXB4-transduced embryonic stem cell-derived hematopoietic progenitor cells. Blood. 2008;111(6):2953-2961.
8. Wang Y, Yates F, Naveiras O, Ernst P, Daley GQ. Embryonic stem cell-derived hematopoietic stem cells. Proc Natl Acad Sci U S A. 2005;102(52): 19081-19086. (Pubitemid 43049569)
9. Lensch MW, Daley GQ. Origins of mammalian hematopoiesis: in vivo paradigms and in vitro models. Curr Top Dev Biol. 2004;60:127-196. (Pubitemid 39752361)
10. Hills D, Gribi R, Ure J, et al. Hoxb4-YFP reporter mouse model: a novel tool for tracking HSC development and studying the role of Hoxb4 in hematopoiesis. Blood. 2011;117(13):3521-3528.
11. Schiedlmeier B, Santos AC, Ribeiro A, et al. HOXB4's road map to stem cell expansion. Proc Natl Acad Sci U S A. 2007;104(43):16952-16957. (Pubitemid 350210971)
12. Oshima M, Endoh M, Endo TA, et al. Genomewide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells. Blood. 2011; 117(15):e142-e150.
13. Lee HM, Zhang H, Schulz V, Tuck DP, Forget BG. Downstream targets of HOXB4 in a cell line model of primitive hematopoietic progenitor cells. Blood. 2010;116(5):720-730.
14. Klump H, Schiedlmeier B, Vogt B, Ryan M, Ostertag W, Baum C. Retroviral vector-mediated expression of HoxB4 in hematopoietic cells using a novel coexpression strategy. Gene Ther. 2001; 8(10):811-817. (Pubitemid 32509796)
15. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res. 2003;31(4):e15.
16. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004;3:Article 3.
17. McKinney-Freeman SL, Naveiras O, Yates F, et al. Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells. Blood. 2009;114(2):268-278.
18. Berger MF, Badis G, Gehrke AR, et al. Variation in homeodomain DNA binding revealed by highresolution analysis of sequence preferences. Cell. 2008;133(7):1266-1276. (Pubitemid 351852913)
19. Ravasi T, Suzuki H, Cannistraci CV, et al. An atlas of combinatorial transcriptional regulation in mouse and man. Cell. 2010;140(5):744-752.
20. Taoudi S, Bee T, Hilton A, et al. ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev. 2011;25(3):251-262.
21. Kranc KR, Schepers H, Rodrigues NP, et al. Cited2 is an essential regulator of adult hematopoietic stem cells. Cell Stem Cell. 2009;5(6):659-665.
22. Scheller M, Huelsken J, Rosenbauer F, et al. Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nat Immunol. 2006;7(10):1037-1047. (Pubitemid 44420648)
23. Spyropoulos DD, Pharr PN, Lavenburg KR, et al. Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Mol Cell Biol. 2000;20(15):5643-5652. (Pubitemid 30482898)
24. Tsai FY, Keller G, Kuo FC, et al. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 1994;371(6494):221-226. (Pubitemid 24293019)
25. Ji M, Li H, Suh HC, Klarmann KD, Yokota Y, Keller JR. Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins. Blood. 2008;112(4):1068-1077.
26. Nogueira MM, Mitjavila-Garcia MT, Le Pesteur F, et al. Regulation of Id gene expression during embryonic stem cell-derived hematopoietic differentiation. Biochem Biophys Res Commun. 2000; 276(2):803-812.
27. Ng SY, Yoshida T, Zhang J, Georgopoulos K. Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity. 2009;30(4):493-507.
28. Pimanda JE, Ottersbach K, Knezevic K, et al. Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc Natl Acad Sci U S A. 2007; 104(45):17692-17697. (Pubitemid 350210896)
29. Azcoitia V, Aracil M, Martinez AC, Torres M. The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Dev Biol. 2005;280(2):307-320. (Pubitemid 40692134)
30. Beslu N, Krosl J, Laurin M, Mayotte N, Humphries KR, Sauvageau G. Molecular interactions involved in HOXB4-induced activation of HSC selfrenewal. Blood. 2004;104(8):2307-2314. (Pubitemid 39331827)
31. Sanyal M, Tung JW, Karsunky H, et al. B-cell development fails in the absence of the Pbx1 protooncogene. Blood. 2007;109(10):4191-4199. (Pubitemid 46743383)
32. Cai Z, de Bruijn M, Ma X, et al. Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo. Immunity. 2000;13(4):423-431.
33. Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996;84(2):321-330. (Pubitemid 26042836)
34. Fatrai S, Wierenga AT, Daenen SM, Vellenga E, Schuringa JJ. Identification of HIF2alpha as an important STAT5 target gene in human hematopoietic stem cells. Blood. 2011;117(12):3320-3330.
35. Hattori N, Kawamoto H, Fujimoto S, Kuno K, Katsura Y. Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus. J Exp Med. 1996;184(3):1137-1147. (Pubitemid 26313570)
36. Welch JS, Yuan W, Ley TJ. PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice. J Clin Invest. 2011;121(4):1636-1645.
37. Wilson NK, Foster SD, Wang X, et al. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell. 2010;7(4): 532-544.
38. Park PJ. ChIP-seq: advantages and challenges of a maturing technology. Nat Rev Genet. 2009; 10(10):669-680.
39. Martin CH, Woll PS, Ni Z, Zuniga-Pflucker JC, Kaufman DS. Differences in lymphocyte developmental potential between human embryonic stem cell and umbilical cord blood-derived hematopoietic progenitor cells. Blood. 2008;112(7):2730-2737.
40. Vodyanik MA, Bork JA, Thomson JA, Slukvin II. Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential. Blood. 2005;105(2):617-626. (Pubitemid 40070744)
41. Lengerke C, Daley GQ. Autologous blood cell therapies from pluripotent stem cells. Blood Rev. 2010;24(1):27-37.
42. Challen GA, Boles NC, Chambers SM, Goodell MA. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell. 2010;6(3):265-278.
43. Norddahl GL, Pronk CJ, Wahlestedt M, et al. Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. Cell Stem Cell. 2011;8(5):499-510.
44. Hu M, Krause D, Greaves M, et al. Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev. 1997;11(6):774-785. (Pubitemid 27157165)
45. Mercer EM, Lin YC, Benner C, et al. Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors. Immunity. 2011;35(3): 413-425.
46. McLean CY, Bristor D, Hiller M, et al. GREAT improves functional interpretation of cis-regulatory regions. Nat Biotechnol. 2010;28(5):495-501.