Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells

Blood

Volumn 117, Issue 15, 2011, Pages

  Oshima, Motohiko ^a,b   Endoh, Mitsuhiro ^b,c   Endo, Takaho A ^d   Toyoda, Tetsuro ^d   Nakajima Takagi, Yaeko ^a,b   Sugiyama, Fumihiro ^e   Koseki, Haruhiko ^b,c   Kyba, Michael ^f   Iwama, Atsushi ^a,b,g   Osawa, Mitsujiro ^a,b,g  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c Institute of Physical and Chemical Research   (Japan)

^d RIKEN   (Japan)

^e UNIVERSITY OF TSUKUBA   (Japan)

^f UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^g NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLHYDROCARBON RECEPTOR; CELL PROTEIN; HEMOGEN; HOX PROTEIN; HOXB4 PROTEIN; LIM DOMAIN ONLY 2; MEIS HOMEOBOX 1; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; TRANSCRIPTION FACTOR ERG; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR PBX1; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR TAL1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; GENE CONTROL; GENETIC ASSOCIATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 79954595962     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-12-323212     Document Type: Article

References (35)

1. Oguro H, Iwama A. Life and death in hematopoietic stem cells. Curr Opin Immunol. 2007;19(5):503-509. (Pubitemid 47464911)
2. Sorrentino BP. Clinical strategies for expansion of haematopoietic stem cells. Nat Rev Immunol. 2004;4(11):878-888. (Pubitemid 39490763)
3. Kim PG, Daley GQ. Application of induced pluripotent stem cells to hematologic disease. Cytotherapy. 2009;11(8):980-989.
4. Conneally E, Cashman J, Petzer A, Eaves C. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc Natl Acad Sci U S A. 1997;94(18):9836-9841. (Pubitemid 27408151)
5. Miller CL, Eaves CJ. Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability. Proc Natl Acad Sci U S A. 1997;94(25):13648-13653. (Pubitemid 28009637)
6. Bhardwaj G, Murdoch B, Wu D, et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol. 2001;2(2):172-180. (Pubitemid 33707938)
7. Lawrence HJ, Largman C. Homeobox genes in normal hematopoiesis and leukemia. Blood. 1992;80(10):2445-2453.
8. Antonchuk J, Sauvageau G, Humphries RK. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell. 2002;109(1):39-45. (Pubitemid 34327515)
9. Sauvageau G, Thorsteinsdottir U, Eaves CJ, et al. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev. 1995;9(14):1753-1765.
10. Antonchuk J, Sauvageau G, Humphries RK. HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation. Exp Hematol. 2001;29(9):1125-1134. (Pubitemid 32781004)
11. Kyba M, Perlingeiro RC, Daley GQ. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell. 2002;109(1):29-37. (Pubitemid 34327514)
12. Jiang J, Yu H, Shou Y, et al. Hemgn is a direct transcriptional target of HOXB4 and induces expansion of murine myeloid progenitor cells. Blood. 2010;116(5):711-719.
13. Lee HM, Zhang H, Schulz V, Tuck DP, Forget BG. Downstream targets of HOXB4 in a cell line model of primitive hematopoietic progenitor cells. Blood. 2010;116(5):720-730.
14. Schiedlmeier B, Santos AC, Ribeiro A, et al. HOXB4's road map to stem cell expansion. Proc Natl Acad Sci U S A. 2007;104(43):16952-16957. (Pubitemid 350210971)
15. Tanimoto Y, Iijima S, Hasegawa Y, et al. Embryonic stem cells derived from C57BL/6J and C57BL/6N mice. Comp Med. 2008;58(4):347-352.
16. Iwama A, Oguro H, Negishi M, et al. Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity. 2004;21(6):843-851. (Pubitemid 39626674)
17. Fujimura Y, Isono K, Vidal M, et al. Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development. 2006;133(12):2371-2381. (Pubitemid 44044558)
18. van Bakel H, van Werven FJ, Radonjic M, et al. Improved genome-wide localization by ChIP-chip using double-round T7 RNA polymerase-based amplification. Nucleic Acids Res. 2008;36(4):e21.
19. Pilat S, Carotta S, Schiedlmeier B, et al. HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells. Proc Natl Acad Sci U S A. 2005;102(34):12101-12106. (Pubitemid 41291135)
20. Mikkola HK, Klintman J, Yang H, et al. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stemcell leukaemia SCL/tal-1 gene. Nature. 2003;421(6922):547-551. (Pubitemid 36168449)
21. Hall MA, Curtis DJ, Metcalf D, et al. The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A. 2003;100(3):992-997. (Pubitemid 36183943)
22. Souroullas GP, Salmon JM, Sablitzky F, Curtis DJ, Goodell MA. Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell. 2009;4(2):180-186.
23. North T, Gu TL, Stacy T, et al. Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. Development. 1999;126(11):2563-2575. (Pubitemid 29299024)
24. Chen MJ, Yokomizo T, Zeigler BM, Dzierzak E, Speck NA. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature. 2009;457(7231):887-891.
25. Tsai FY, Orkin SH. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood. 1997;89(10):3636-3643. (Pubitemid 27227086)
26. Kitajima K, Masuhara M, Era T, Enver T, Nakano T. GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitors. EMBO J. 2002;21(12):3060-3069. (Pubitemid 34670390)
27. Zeng H, Yucel R, Kosan C, Klein-Hitpass L, Moroy T. Transcription factor Gfi1 regulates selfrenewal and engraftment of hematopoietic stem cells. EMBO J. 2004;23(20):4116-4125. (Pubitemid 39472432)
28. Hock H, Hamblen MJ, Rooke HM, et al. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature. 2004;431(7011):1002-1007. (Pubitemid 39434423)
29. Capron C, Lacout C, Lecluse Y, et al. A major role of TGF-beta1 in the homing capacities of murine hematopoietic stem cell/progenitors. Blood. 2010;116(8):1244-1253.
30. Deneault E, Cellot S, Faubert A, et al. A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell. 2009;137(2):369-379.
31. Li FX, Zhu JW, Hogan CJ, DeGregori J. Defective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice. Mol Cell Biol. 2003;23(10):3607-3622. (Pubitemid 36539193)
32. Iwase S, Furukawa Y, Kikuchi J, et al. Modulation of E2F activity is linked to interferon-induced growth suppression of hematopoietic cells. J Biol Chem. 1997;272(19):12406-12414. (Pubitemid 27203328)
33. Tsai S, Bartelmez S, Sitnicka E, Collins S. Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development. Genes Dev. 1994;8(23):2831-2841. (Pubitemid 24374668)
34. Gupta R, Hong D, Iborra F, Sarno S, Enver T. NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells. Science. 2007;316(5824):590-593. (Pubitemid 46683143)
35. Boitano AE, Wang J, Romeo R, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010;329(5997):1345-1348.