Effect of a new prokinetic agent DA-9701 formulated with corydalis tuber and pharbitidis semen on cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Ji, Hye Young ^a   Liu, Kwang Hyeon ^b   Jeong, Ji Hyeon ^a   Lee, Dae Young ^c   Shim, Hyun Joo ^c   Son, Miwon ^c   Lee, Hye Suk ^a  

^a The Catholic University of Korea   (South Korea)

^b Kyungpook National University   (South Korea)

^c Dong A Pharmaceutical Company   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BUFURALOL; CORYDALIS TUBER EXTRACT; CYTOCHROME P450; CYTOCHROME P450 2D6; DA 9701; ETOPOSIDE; GLUCURONOSYLTRANSFERASE; PHARBITIDIS SEMEN EXTRACT; PLANT EXTRACT; PROKINETIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; CORYDALIS TUBER; DRUG GLUCURONIDATION; ENZYME ACTIVITY; HERB; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; PHARBITIDIS SEMEN; PRIORITY JOURNAL;

EID: 84861028053     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/650718     Document Type: Article

References (28)

1. El-Serag H. B., Talley N. J., Systematic review: the prevalence and clinical course of functional dyspepsia Alimentary Pharmacology and Therapeutics 2004 19 6 643 654 (Pubitemid 38445425)
2. Boeckxstaens G. E., Hirsch D. P., Kuiken S. D., Heisterkamp S. H., Tytgat G. N. J., The proximal stomach and postprandial symptoms in functional dyspeptics The American Journal of Gastroenterology 2002 97 1 40 48 (Pubitemid 34059762)
3. Maes B. D., Ghoos Y. F., Hiele M. I., Rutgeerts P. J., Gastric emptying rate of solids in patients with nonulcer dyspepsia Digestive Diseases and Sciences 1997 42 6 1158 1162 (Pubitemid 27343439)
4. Sarnelli G., Caenepeel P., Geypens B., Janssens J., Tack J., Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia The American Journal of Gastroenterology 2003 98 4 783 788 (Pubitemid 36576302)
5. van den Elzen B. D. J., Boeckxstaens G. E. E., Review article: a critical view on impaired accommodation as therapeutic target for functional dyspepsia Alimentary Pharmacology and Therapeutics 2006 23 11 1499 1510 (Pubitemid 43727457)
6. Choi S., Choi J. J., Jun J. Y., Koh J. W., Kim S. H., Kim D. H., Pyo M. Y., Choi S., Son J. P., Lee I., Son M., Jin M., Induction of pacemaker currents by DA-9701, a prokinetic agent, in interstitial cells of Cajal from murine small intestine Molecules and Cells 2009 27 3 307 312
7. R. Kim E., H. Min B., O. Lee S., H. Lee T., Son M., L. Rhee P., The effects of DA-9701, a novel prokinetic agent, on gastric accommodation in conscious dogs. Journal of Gastroenterology and Hepatology. In press
8. Lee T. H., Choi J. J., Kim D. H., Choi S., Lee K. R., Son M., Jin M., Gastroprokinetic effects of DA-9701, a new prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber Phytomedicine 2008 15 10 836 843
9. Kubo M., Matsuda H., Tokuoka K., Ma S., Shiomoto H., Anti-inflammatory activities of methanolic extract and alkaloidal components from Corydalis tuber Biological and Pharmaceutical Bulletin 1994 17 2 262 265 (Pubitemid 24112347)
10. Matsuda H., Tokuoka K., Wu J., Tanaka T., Kubo M., Inhibitory effects of methanolic extract from corydalis tuber against types I-IV allergic models Biological and Pharmaceutical Bulletin 1995 18 7 963 967
11. Yuan C. S., Mehendale S. R., Wang C. Z., Aung H. H., Jiang T., Guan X., Shoyama Y., Effects of Corydalis yanhusuo and Angelicae dahuricae on cold pressor-induced pain in humans: a controlled trial Journal of Clinical Pharmacology 2004 44 11 1323 1327 (Pubitemid 39391491)
12. Lee T. H., Kim K. H., Lee S. O., Lee K. R., Son M., Jin M., Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function Journal of Pharmacology and Experimental Therapeutics 2011 338 3 917 924
13. Lee T. H., Son M., Kim S. Y., Effects of corydaline from corydalis tuber on gastric motor function in an animal model Biological and Pharmaceutical Bulletin 2010 33 6 958 962
14. Mohamed M.-E. F., Frye R. F., Effects of herbal supplements on drug glucuronidationreview of clinical, animal, and in vitro studies Planta Medica 2011 77 4 311 321
15. Na D. H., Ji H. Y., Park E. J., Kim M. S., Liu K.-H., Lee H. S., Evaluation of metabolism-mediated herb-drug interactions Archives of Pharmacal Research 2011 34 11 1829 1842
16. Zhou S. F., Zhou Z. W., Li C. G., Chen X., Yu X., Xue C. C., Herington A., Identification of drugs that interact with herbs in drug development Drug Discovery Today 2007 12 15-16 664 673 (Pubitemid 47238642)
17. He S.-M., Chan E., Zhou S.-F., ADME properties of herbal medicines in humans: evidence, challenges andstrategies Current Pharmaceutical Design 2011 17 4 357 407
18. He S. M., Yang A. K., Li X. T., Du Y. M., Zhou S. F., Effects of herbal products on the metabolism and transport of anticancer agents Expert Opinion on Drug Metabolism and Toxicology 2010 6 10 1195 1213
19. Kim H., Kim K. B., Ku H. Y., Soo J. P., Choi H., Moon J. K., Park B. S., Sung S. Y., Lee C. H., Hye S. L., Shin J. G., Liu K. H., Identification and characterization of potent CYP2B6 inhibitors in Woohwangcheongsimwon suspension, an herbal preparation used in the treatment and prevention of apoplexy in Korea and China Drug Metabolism and Disposition 2008 36 6 1010 1015 (Pubitemid 351717457)
20. Sevior D. K., Hokkanen J., Tolonen A., Abass K., Tursas L., Pelkonen O., Ahokas J. T., Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail Xenobiotica 2010 40 4 245 254
21. Chen X.-W., Serag E. S., Sneed K. B., Liang J., Chew H., Pan S.-Y., Zhou S.-F., Clinical herbal interactions with conventional drugs: from molecules to maladies Current Medicinal Chemistry 2011 18 31 4836 4850
22. Ji H. Y., Kim S. Y., Kim D. K., Jeong J. H., Lee H. S., Effects of eupatilin and jaceosidin on cytochrome P450 enzyme activities in human liver microsomes Molecules 2010 15 9 6466 6474
23. Ji H. Y., Liu K. H., Lee H., Im S. R., Shim H. J., Son M., Lee H. S., Corydaline inhibits multiple cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes Molecules 2011 16 8 6591 6602
24. Strandell J., Neil A., Carlin G., An approach to the in vitro evaluation of potential for cytochrome P450 enzyme inhibition from herbals and other natural remedies Phytomedicine 2004 11 2-3 98 104 (Pubitemid 38314048)
25. Dierks E. A., Stams K. R., Lim H. K., Cornelius G., Zhang H., Ball S. E., A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry Drug Metabolism and Disposition 2001 29 1 23 29 (Pubitemid 32041675)
26. Kim M. J., Kim H., Cha I. J., Park J. S., Shon J. H., Liu K. H., Shin J. G., High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry Rapid Communications in Mass Spectrometry 2005 19 18 2651 2658 (Pubitemid 41338608)
27. Zhou J., Tracy T. S., Remmel R. P., Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors Drug Metabolism and Disposition 2011 39 2 322 329
28. Newton D. J., Wang R. W., Lu A. Y. H., Cytochrome P450 inhibitors: evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes Drug Metabolism and Disposition 1995 23 1 154 158