Corydaline inhibits multiple cytochrome P450 and UDP- glucuronosyltransferase enzyme activities in human liver microsomes

Molecules

Volumn 16, Issue 8, 2011, Pages 6591-6602

  Ji, Hye Young ^a   Liu, Kwang Hyeon ^b   Lee, Hyeri ^a,c   Im, Sae Rom ^a   Shim, Hyun Joo ^d   Son, Miwon ^d   Lee, Hye Suk ^a  

^a The Catholic University of Korea   (South Korea)

^b Kyungpook National University   (South Korea)

^c Seoul National University   (South Korea)

^d Dong A Pharmaceutical Company   (South Korea)

Author keywords

Corydaline; Cytochrome P450 inhibition; Drug drug interaction; Human liver microsomes; UDP glucuronosyltransferase inhibition

Indexed keywords

ANALGESIC AGENT; ANTIALLERGIC AGENT; BERBERINE DERIVATIVE; CORYDALINE; CYP2C19 PROTEIN, HUMAN; CYP2C9 PROTEIN, HUMAN; CYP3A PROTEIN, HUMAN; CYTOCHROME P450 3A; ENZYME INHIBITOR; GLUCURONOSYLTRANSFERASE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CHEMISTRY; CORYDALIS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; HYDROXYLATION; KINETICS; LIQUID CHROMATOGRAPHY; LIVER; LIVER MICROSOME; METABOLISM; TANDEM MASS SPECTROMETRY;

ANALGESICS; ANTI-ALLERGIC AGENTS; ARYL HYDROCARBON HYDROXYLASES; BERBERINE ALKALOIDS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, LIQUID; CORYDALIS; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUCURONOSYLTRANSFERASE; HUMANS; HYDROXYLATION; KINETICS; LIVER; MICROSOMES, LIVER; TANDEM MASS SPECTROMETRY;

EID: 80052230944     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules16086591     Document Type: Article

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