Novel steroid inhibitors of glucose 6-phosphate dehydrogenase

Journal of Medicinal Chemistry

Volumn 55, Issue 9, 2012, Pages 4431-4445

  Hamilton, Niall M ^a   Dawson, Martin ^a   Fairweather, Emma E ^a   Hamilton, Nicola S ^a   Hitchin, James R ^a   James, Dominic I ^a   Jones, Stuart D ^a   Jordan, Allan M ^a   Lyons, Amanda J ^a   Small, Helen F ^a   Thomson, Graeme J ^a   Waddell, Ian D ^a   Ogilvie, Donald J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

(3BETA,5ALPHA) 3 AMINOANDROSTAN 17 ONE; (3BETA,5ALPHA) 3 AMINOANDROSTAN 17 ONE,CYCLIC 1,2 ETHANEDIYL ACETAL; (3BETA,5ALPHA) 3 AMINOPREGNAN 20 ONE,CYCLIC 1,2 ETHANEDIYL ACETAL; 2 [(3ALPHA,5ALPHA) 17 OXOANDROSTAN 3 YL,17 CYCLIC 1,2 ETHANEDIYL ACETAL] 1H ISOINDOLE 1,3(2H)DIONE; 2 [(3BETA,5ALPHA) 17 OXOANDROSTAN 3 YL,17 CYCLIC 1,2 ETHANEDIYL ACETAL] 1H ISOINDOLE 1,3(2H)DIONE; 2 [(3BETA,5ALPHA) 20 OXOPREGNAN 3 YL, 20 CYCLIC 1,2 ETHANEDIYL ACETAL]; [(3BETA,5ALPHA) 17 OXOANDROSTAN 3 YL]CARBAMIC ACID,METHYL ESTER; [(3BETA,5ALPHA) 20 OXOPREGNAN 3 YL]CARBAMIC ACID,METHYL ESTER; [(3BETA,5ALPHA) 21 HYDROXY 20 OXOPREGNAN 3 YL]CARBAMIC ACID,METHYL ESTER; ENZYME INHIBITOR; GLUCOSE 6 PHOSPHATE DEHYDROGENASE INHIBITOR; N [(3BETA,5ALPHA) 17 OXOANDROSTAN 3 YL]BENZENESULFONAMIDE; N BUTYL N' [(3BETA,5ALPLHA) 17 OXOANDROSTAN 3 YL]UREA; N ETHYL N' [(3BETA,5ALPHA) 17 OXOANDROSTAN 3 YL]UREA; N ETHYL N' [(5ALPHA) 21 HYDROXY 20 OXOPREGNAN 3 YL]UREA; N METHYL N' [(3BETA,5ALPHA) 17 OXOANDROSTAN 3 YL]UREA; N,N DIMETHYL N' [(3BETA,5ALPHA) 17 OXOANDROSTAN 3 YL]UREA; N,N DIMETHYL N' [(3BETA,5ALPHA) 20 OXOPREGNAN 3 YL]SULFAMIDE; N,N DIMETHYL N' [(3BETA,5ALPHA) 20 OXOPREGNAN 3 YL]UREA; N[(3BETA,5ALPA) 20 OXOPREGNAN 3 YL]UREA; N[(3BETA,5ALPHA) 17 OXOANDROSTAN 3 YL]ACETAMIDE; N[(3BETA,5ALPHA) 17 OXOANDROSTAN 3 YL]ETHANESULFONAMIDE; N[(3BETA,5ALPHA) 17 OXOANDROSTAN 3 YL]METHANESULFONAMIDE; N[(3BETA,5ALPHA) 17 OXOANDROSTAN 3 YL]SULFAMIDE; N[(3BETA,5ALPHA) 17 OXOANDROSTAN 3 YL]UREA; N[(3BETA,5ALPHA) 20 OXOPREGNAN 3 YL]ETHANESULFONAMIDE; N[(3BETA,5ALPHA) 20 OXOPREGNAN 3 YL]METHANESULFONAMIDE; N[(3BETA,5ALPHA) 20 OXOPREGNAN 3 YL]SULFAMIDE; STEROID; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; ENZYME INHIBITORS; GLUCOSEPHOSPHATE DEHYDROGENASE; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PREGNANES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861027291     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300317k     Document Type: Article

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