CGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Plano, Santiago A ^a   Agostino, Patricia V ^a   de la Iglesia, Horacio O ^b   Golombek, Diego A ^a  

^a UNIVERSIDAD NACIONAL DE QUILMES   (Argentina)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP PHOSPHODIESTERASE; GUANYLATE CYCLASE; PROTEIN KINASE; SILDENAFIL; TADALAFIL; VARDENAFIL; CARBOLINE DERIVATIVE; CIRCADIAN RHYTHM SIGNALING PROTEIN; IMIDAZOLE DERIVATIVE; PER1 PROTEIN, MOUSE; PER2 PROTEIN, MOUSE; PHOSPHODIESTERASE; PHOSPHODIESTERASE V INHIBITOR; PIPERAZINE DERIVATIVE; SULFONE; TRIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL MOUSE; CIRCADIAN RHYTHM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EVOKED VISUAL RESPONSE; FEMALE; GENE; GENE EXPRESSION; HAMSTER; LIGHT DARK CYCLE; LIGHT INTENSITY; LOCOMOTION; MALE; MOLECULAR CLOCK; NONHUMAN; OPTICAL DENSITY; PER1 GENE; PER2 GENE; PHARMACOLOGICAL BLOCKING; PROTEIN TARGETING; RODENT; SIGNAL TRANSDUCTION; SUPRACHIASMATIC NUCLEUS; VISUAL ACUITY; VISUAL STIMULATION; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; HUMAN; METABOLISM; MOUSE; SPECIES DIFFERENCE; SYRIAN HAMSTER;

CRICETINAE; MAMMALIA; RODENTIA;

ANIMALS; CARBOLINES; CIRCADIAN RHYTHM; CRICETINAE; FEMALE; GUANYLATE CYCLASE; HUMANS; IMIDAZOLES; MALE; MESOCRICETUS; MICE; PERIOD CIRCADIAN PROTEINS; PHOSPHODIESTERASE 5 INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PIPERAZINES; SPECIES SPECIFICITY; SULFONES; TRIAZINES;

EID: 84861014717     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037121     Document Type: Article

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