Diacylglycerol kinase β knockout mice exhibit attention-deficit behavior and an abnormal response on methylphenidate-induced hyperactivity

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Ishisaka, Mitsue ^a   Kakefuda, Kenichi ^a   Oyagi, Atsushi ^a   Ono, Yoko ^a   Tsuruma, Kazuhiro ^a   Shimazawa, Masamitsu ^a   Kitaichi, Kiyoyuki ^b   Hara, Hideaki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b GIFU UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL KINASE; DIACYLGLYCEROL KINASE BETA; DIZOCILPINE; METHYLPHENIDATE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; UNCLASSIFIED DRUG; CENTRAL STIMULANT AGENT; NERVE PROTEIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENTION DEFICIT DISORDER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HYPERACTIVITY; KNOCKOUT MOUSE; LOCOMOTION; MOUSE; NONHUMAN; OPEN FIELD TEST; PATHOPHYSIOLOGY; TASK PERFORMANCE; TREATMENT RESPONSE; WILD TYPE; AKATHISIA; ANIMAL; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHENOTYPE; SIGNAL TRANSDUCTION;

MUS;

AKATHISIA, DRUG-INDUCED; ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; CORPUS STRIATUM; DIACYLGLYCEROL KINASE; MAP KINASE SIGNALING SYSTEM; METHYLPHENIDATE; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 3; NERVE TISSUE PROTEINS; PHENOTYPE;

EID: 84861008821     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037058     Document Type: Article

References (46)

1. Rhee SG, Bae YS, (1997) Regulation of phosphoinositide-specific phospholipase C isozymes. J Biol Chem 272: 15045-15048.
2. Nishizuka Y, (1995) Protein kinase C and lipid signaling for sustained cellular responses. Faseb J 9: 484-496.
3. Merida I, Avila-Flores A, Merino E, (2008) Diacylglycerol kinases: at the hub of cell signalling. Biochem J 409: 1-18.
4. Ghosh S, Strum JC, Sciorra VA, Daniel L, Bell RM, (1996) Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells. J Biol Chem 271: 8472-8480.
5. Kanoh H, Yamada K, Sakane F, (1990) Diacylglycerol kinase: a key modulator of signal transduction? Trends Biochem Sci 15: 47-50.
6. Topham MK, (2006) Signaling roles of diacylglycerol kinases. J Cell Biochem 97: 474-484.
7. Goto K, Hozumi Y, Nakano T, Saino SS, Kondo H, (2007) Cell biology and pathophysiology of the diacylglycerol kinase family: morphological aspects in tissues and organs. Int Rev Cytol 264: 25-63.
8. Sakane F, Imai S, Kai M, Yasuda S, Kanoh H, (2007) Diacylglycerol kinases: why so many of them? Biochim Biophys Acta 1771: 793-806.
9. Goto K, Kondo H, (1999) Diacylglycerol kinase in the central nervous system-molecular heterogeneity and gene expression. Chem Phys Lipids 98: 109-117.
10. Goto K, Kondo H, (1993) Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons. Proc Natl Acad Sci U S A 90: 7598-7602.
11. Hozumi Y, Fukaya M, Adachi N, Saito N, Otani K, et al. (2008) Diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum. Eur J Neurosci 28: 2409-2422.
12. Caricasole A, Bettini E, Sala C, Roncarati R, Kobayashi N, et al. (2002) Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties. J Biol Chem 277: 4790-4796.
13. Kakefuda K, Oyagi A, Ishisaka M, Tsuruma K, Shimazawa M, et al. (2010) Diacylglycerol kinase beta knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS One 5: e13447.
14. Shirai Y, Kouzuki T, Kakefuda K, Moriguchi S, Oyagi A, et al. (2010) Essential role of neuron-enriched diacylglycerol kinase (DGK), DGK beta in neurite spine formation, contributing to cognitive function. PLoS One 5: e11602.
15. Hozumi Y, Watanabe M, Otani K, Goto K, (2009) Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neurons. BMC Neurosci 10: 99.
16. Reich W, Neuman RJ, Volk HE, Joyner CA, Todd RD, (2005) Comorbidity between ADHD and symptoms of bipolar disorder in a community sample of children and adolescents. Twin Res Hum Genet 8: 459-466.
17. Nierenberg AA, Miyahara S, Spencer T, Wisniewski SR, Otto MW, et al. (2005) Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants. Biol Psychiatry 57: 1467-1473.
18. Beaulieu JM, Sotnikova TD, Gainetdinov RR, Caron MG, (2006) Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice. J Biol Chem 281: 32072-32080.
19. Zhou M, Rebholz H, Brocia C, Warner-Schmidt JL, Fienberg AA, et al. (2010) Forebrain overexpression of CK1delta leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD. Proc Natl Acad Sci U S A 107: 4401-4406.
20. Krapacher FA, Mlewski EC, Ferreras S, Pisano V, Paolorossi M, et al. (2010) Mice lacking p35 display hyperactivity and paradoxical response to psychostimulants. J Neurochem 114: 203-214.
21. Alkam T, Hiramatsu M, Mamiya T, Aoyama Y, Nitta A, et al. (2011) Evaluation of object-based attention in mice. Behav Brain Res 220: 185-193.
22. Segal DS, Kuczenski R, (1997) Repeated binge exposures to amphetamine and methamphetamine: behavioral and neurochemical characterization. J Pharmacol Exp Ther 282: 561-573.
23. Carlsson M, Carlsson A, (1989) The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice. J Neural Transm 75: 221-226.
24. Gainetdinov RR, Mohn AR, Bohn LM, Caron MG, (2001) Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter. Proc Natl Acad Sci U S A 98: 11047-11054.
25. Shioda N, Yamamoto Y, Watanabe M, Binas B, Owada Y, et al. (2009) Heart-type fatty acid binding protein regulates dopamine D2 receptor function in mouse brain. J Neurosci 30: 3146-3155.
26. Pascoli V, Valjent E, Corbille AG, Corvol JC, Tassin JP, et al. (2005) cAMP and extracellular signal-regulated kinase signaling in response to d-amphetamine and methylphenidate in the prefrontal cortex in vivo: role of beta 1-adrenoceptors. Mol Pharmacol 68: 421-429.
27. Arime Y, Kubo Y, Sora I, (2011) Animal models of attention-deficit/hyperactivity disorder. Biol Pharm Bull 34: 1373-1376.
28. Bari A, Dalley JW, Robbins TW, (2008) The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats. Nat Protoc 3: 759-767.
29. Volkow ND, Wang GJ, Fowler JS, Gatley SJ, Logan J, et al. (1998) Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate. Am J Psychiatry 155: 1325-1331.
30. Verebey K, Kogan MJ, Mule SJ, (1981) Phencyclidine-induced stereotype in rats: effects of methadone, apomorphine, and naloxone. Psychopharmacology (Berl) 75: 44-47.
31. Kiguchi M, Fujita S, Oki H, Shimizu N, Cools AR, et al. (2008) Behavioural characterisation of rats exposed neonatally to bisphenol-A: responses to a novel environment and to methylphenidate challenge in a putative model of attention-deficit hyperactivity disorder. J Neural Transm 115: 1079-1085.
32. Park SW, Shen X, Tien LT, Roman R, Ma T, (2011) Methamphetamine-induced changes in the striatal dopamine pathway in mu-opioid receptor knockout mice. J Biomed Sci 18: 83.
33. Fienberg AA, Hiroi N, Mermelstein PG, Song W, Snyder GL, et al. (1998) DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science 281: 838-842.
34. Greengard P, Allen PB, Nairn AC, (1999) Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron 23: 435-447.
35. Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, et al. (2005) An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122: 261-273.
36. Zhang L, Lou D, Jiao H, Zhang D, Wang X, et al. (2004) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. J Neurosci 24: 3344-3354.
37. Valjent E, Corvol JC, Pages C, Besson MJ, Maldonado R, et al. (2000) Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. J Neurosci 20: 8701-8709.
38. Fukui R, Svenningsson P, Matsuishi T, Higashi H, Nairn AC, et al. (2003) Effect of methylphenidate on dopamine/DARPP signalling in adult, but not young, mice. J Neurochem 87: 1391-1401.
39. Valjent E, Pascoli V, Svenningsson P, Paul S, Enslen H, et al. (2005) Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proc Natl Acad Sci U S A 102: 491-496.
40. Yan Z, Feng J, Fienberg AA, Greengard P, (1999) D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons. Proc Natl Acad Sci U S A 96: 11607-11612.
41. Gerfen CR, Engber TM, Mahan LC, Susel Z, Chase TN, et al. (1990) D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 250: 1429-1432.
42. Pan D, Gatley SJ, Dewey SL, Chen R, Alexoff DA, et al. (1994) Binding of bromine-substituted analogs of methylphenidate to monoamine transporters. Eur J Pharmacol 264: 177-182.
43. Sanjuan MA, Pradet-Balade B, Jones DR, Martinez AC, Stone JC, et al. (2003) T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation. J Immunol 170: 2877-2883.
44. Topham MK, Prescott SM, (2001) Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. J Cell Biol 152: 1135-1143.
45. Regier DS, Higbee J, Lund KM, Sakane F, Prescott SM, et al. (2005) Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling. Proc Natl Acad Sci U S A 102: 7595-7600.
46. Yasuda S, Kai M, Imai S, Takeishi K, Taketomi A, et al. (2009) Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization. J Biol Chem 284: 29559-29570.