메뉴 건너뛰기




Volumn 28, Issue 3, 2012, Pages 296-304

Genetics and Hypertension: Is It Time to Change My Practice?

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 17; CYTOCHROME P450 1A2; FIBROBLAST GROWTH FACTOR 5; PROTEIN SH2; TAMM HORSFALL GLYCOPROTEIN; VOLTAGE GATED CALCIUM CHANNEL;

EID: 84860920071     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cjca.2012.02.004     Document Type: Review
Times cited : (17)

References (78)
  • 1
    • 0037079309 scopus 로고    scopus 로고
    • Age-specific relevance of usual BP to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
    • Lewington S., Clarke R., Qizilbash N., Peto R., Collins R. Age-specific relevance of usual BP to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002, 360:1903-1913.
    • (2002) Lancet , vol.360 , pp. 1903-1913
    • Lewington, S.1    Clarke, R.2    Qizilbash, N.3    Peto, R.4    Collins, R.5
  • 2
    • 12344282783 scopus 로고    scopus 로고
    • Global burden of hypertension: analysis of worldwide data
    • Kearney P.M., Whelton M., Reynolds K., et al. Global burden of hypertension: analysis of worldwide data. Lancet 2005, 365:217-223.
    • (2005) Lancet , vol.365 , pp. 217-223
    • Kearney, P.M.1    Whelton, M.2    Reynolds, K.3
  • 3
    • 36448950113 scopus 로고    scopus 로고
    • The burden of blood pressure-related disease: a neglected priority for global health
    • Perkovic V., Huxley R., Wu Y., Prabhakaran D., MacMahon S. The burden of blood pressure-related disease: a neglected priority for global health. Hypertension 2007, 50:991-997.
    • (2007) Hypertension , vol.50 , pp. 991-997
    • Perkovic, V.1    Huxley, R.2    Wu, Y.3    Prabhakaran, D.4    MacMahon, S.5
  • 4
    • 0017761036 scopus 로고
    • The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results
    • Feinleib M., Garrison R.J., Fabsitz R., et al. The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results. Am J Epidemiol 1977, 106:284-285.
    • (1977) Am J Epidemiol , vol.106 , pp. 284-285
    • Feinleib, M.1    Garrison, R.J.2    Fabsitz, R.3
  • 5
    • 0022502168 scopus 로고
    • The influence of genetics and household environment upon the variability of normal blood pressure: the Montreal Adoption Survey
    • Mongeau J.G., Biron P., Sing C.F. The influence of genetics and household environment upon the variability of normal blood pressure: the Montreal Adoption Survey. Clin Exp Hypertens A 1986, 8:653-660.
    • (1986) Clin Exp Hypertens A , vol.8 , pp. 653-660
    • Mongeau, J.G.1    Biron, P.2    Sing, C.F.3
  • 7
    • 0038375052 scopus 로고    scopus 로고
    • Genome-wide mapping of human loci for essential hypertension
    • Caulfield M., Munroe P., Pembroke J., et al. Genome-wide mapping of human loci for essential hypertension. Lancet 2003, 361:2118-2123.
    • (2003) Lancet , vol.361 , pp. 2118-2123
    • Caulfield, M.1    Munroe, P.2    Pembroke, J.3
  • 9
    • 84858798943 scopus 로고    scopus 로고
    • Implications of discoveries from genome-wide association studies in current cardiovascular practice
    • Jeemon P., Pettigrew K., Sainsbury C., Prabhakaran D., Padmanabhan S. Implications of discoveries from genome-wide association studies in current cardiovascular practice. World J Cardiol 2011, 3:230-247.
    • (2011) World J Cardiol , vol.3 , pp. 230-247
    • Jeemon, P.1    Pettigrew, K.2    Sainsbury, C.3    Prabhakaran, D.4    Padmanabhan, S.5
  • 10
    • 0021957675 scopus 로고
    • A comparison of sib-pair linkage tests for disease susceptibility loci
    • Blackwelder W.C., Elston R.C. A comparison of sib-pair linkage tests for disease susceptibility loci. Genet Epidemiol 1985, 2:85-97.
    • (1985) Genet Epidemiol , vol.2 , pp. 85-97
    • Blackwelder, W.C.1    Elston, R.C.2
  • 11
    • 34147216956 scopus 로고    scopus 로고
    • A review of the genetics of essential hypertension
    • Binder A. A review of the genetics of essential hypertension. Curr Opin Cardiol 2007, 22:176-184.
    • (2007) Curr Opin Cardiol , vol.22 , pp. 176-184
    • Binder, A.1
  • 12
    • 5444222846 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3
    • Koivukoski L., Fisher S.A., Kanninen T., et al. Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3. Hum Mol Genet 2004, 13:2325-2332.
    • (2004) Hum Mol Genet , vol.13 , pp. 2325-2332
    • Koivukoski, L.1    Fisher, S.A.2    Kanninen, T.3
  • 13
    • 33644980079 scopus 로고    scopus 로고
    • Chromosome 2p shows significant linkage to antihypertensive response in the British Genetics of Hypertension Study
    • Padmanabhan S., Wallace C., Munroe P.B., et al. Chromosome 2p shows significant linkage to antihypertensive response in the British Genetics of Hypertension Study. Hypertension 2006, 47:603-608.
    • (2006) Hypertension , vol.47 , pp. 603-608
    • Padmanabhan, S.1    Wallace, C.2    Munroe, P.B.3
  • 14
    • 0842332610 scopus 로고    scopus 로고
    • Positional identification of hypertension susceptibility genes on chromosome 2
    • Barkley R.A., Chakravarti A., Cooper R.S., et al. Positional identification of hypertension susceptibility genes on chromosome 2. Hypertension 2004, 43:477-482.
    • (2004) Hypertension , vol.43 , pp. 477-482
    • Barkley, R.A.1    Chakravarti, A.2    Cooper, R.S.3
  • 15
    • 20844455582 scopus 로고    scopus 로고
    • Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays
    • Matsuzaki H., Dong S., Loi H., et al. Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays. Nat Methods 2004, 1:109-111.
    • (2004) Nat Methods , vol.1 , pp. 109-111
    • Matsuzaki, H.1    Dong, S.2    Loi, H.3
  • 16
    • 18144425478 scopus 로고    scopus 로고
    • A genome-wide scalable SNP genotyping assay using microarray technology
    • Gunderson K.L., Steemers F.J., Lee G., Mendoza L.G., Chee M.S. A genome-wide scalable SNP genotyping assay using microarray technology. Nat Genet 2005, 37:549-554.
    • (2005) Nat Genet , vol.37 , pp. 549-554
    • Gunderson, K.L.1    Steemers, F.J.2    Lee, G.3    Mendoza, L.G.4    Chee, M.S.5
  • 17
    • 35748962317 scopus 로고    scopus 로고
    • Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    • Levy D., Larson M.G., Benjamin E.J., et al. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. BMC Med Genet 2007, 8(suppl 1):S3.
    • (2007) BMC Med Genet , vol.8 , Issue.SUPPL. 1
    • Levy, D.1    Larson, M.G.2    Benjamin, E.J.3
  • 18
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007, 447:661-678. Wellcome Trust Case Control Consortium.
    • (2007) Nature , vol.447 , pp. 661-678
  • 19
    • 67349085063 scopus 로고    scopus 로고
    • Genome-wide association study identifies eight loci associated with blood pressure
    • Newton-Cheh C., Johnson T., Gateva V., et al. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009, 41:666-676.
    • (2009) Nat Genet , vol.41 , pp. 666-676
    • Newton-Cheh, C.1    Johnson, T.2    Gateva, V.3
  • 20
    • 67349208839 scopus 로고    scopus 로고
    • Genome-wide association study of blood pressure and hypertension
    • Levy D., Ehret G.B., Rice K., et al. Genome-wide association study of blood pressure and hypertension. Nat Genet 2009, 41:677-687.
    • (2009) Nat Genet , vol.41 , pp. 677-687
    • Levy, D.1    Ehret, G.B.2    Rice, K.3
  • 21
    • 80053383403 scopus 로고    scopus 로고
    • Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
    • Wain L.V., Verwoert G.C., O'Reilly P.F., et al. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet 2011, 43:1005-1011.
    • (2011) Nat Genet , vol.43 , pp. 1005-1011
    • Wain, L.V.1    Verwoert, G.C.2    O'Reilly, P.F.3
  • 22
    • 67349188883 scopus 로고    scopus 로고
    • A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
    • Cho Y.S., Go M.J., Kim Y.J., et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 2009, 41:527-534.
    • (2009) Nat Genet , vol.41 , pp. 527-534
    • Cho, Y.S.1    Go, M.J.2    Kim, Y.J.3
  • 23
    • 80053907554 scopus 로고    scopus 로고
    • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
    • Ehret G.B., Munroe P.B., Rice K.M., et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011, 478:103-109.
    • (2011) Nature , vol.478 , pp. 103-109
    • Ehret, G.B.1    Munroe, P.B.2    Rice, K.M.3
  • 24
    • 78449233580 scopus 로고    scopus 로고
    • Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension
    • Padmanabhan S., Melander O., Johnson T., et al. Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genet 2010, 6:e1001177.
    • (2010) PLoS Genet , vol.6
    • Padmanabhan, S.1    Melander, O.2    Johnson, T.3
  • 25
    • 79955482101 scopus 로고    scopus 로고
    • Genome-wide association studies of hypertension: light at the end of the tunnel
    • Hastie C.E., Padmanabhan S., Dominiczak A.F. Genome-wide association studies of hypertension: light at the end of the tunnel. Int J Hypertens 2010, 2010:509581.
    • (2010) Int J Hypertens , vol.2010 , pp. 509581
    • Hastie, C.E.1    Padmanabhan, S.2    Dominiczak, A.F.3
  • 26
    • 0033755028 scopus 로고    scopus 로고
    • Genetics of hypertension: from experimental models to clinical applications
    • Lee W.K., Padmanabhan S., Dominiczak A.F. Genetics of hypertension: from experimental models to clinical applications. J Hum Hypertens 2000, 14:631-647.
    • (2000) J Hum Hypertens , vol.14 , pp. 631-647
    • Lee, W.K.1    Padmanabhan, S.2    Dominiczak, A.F.3
  • 28
    • 43449087893 scopus 로고    scopus 로고
    • Genetics of the human renin angiotensin system
    • Jeunemaitre X. Genetics of the human renin angiotensin system. J Mol Med 2008, 86:637-641.
    • (2008) J Mol Med , vol.86 , pp. 637-641
    • Jeunemaitre, X.1
  • 29
    • 65649108517 scopus 로고    scopus 로고
    • Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease
    • Rudnicki M., Mayer G. Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease. Pharmacogenomics 2009, 10:463-476.
    • (2009) Pharmacogenomics , vol.10 , pp. 463-476
    • Rudnicki, M.1    Mayer, G.2
  • 30
    • 39749113160 scopus 로고    scopus 로고
    • Meta-analysis of the association of 4 angiotensinogen polymorphisms with essential hypertension: a role beyond M235T?
    • Pereira T.V., Nunes A.C., Rudnicki M., et al. Meta-analysis of the association of 4 angiotensinogen polymorphisms with essential hypertension: a role beyond M235T?. Hypertension 2008, 51:778-783.
    • (2008) Hypertension , vol.51 , pp. 778-783
    • Pereira, T.V.1    Nunes, A.C.2    Rudnicki, M.3
  • 31
    • 33646047704 scopus 로고    scopus 로고
    • Update on G-protein polymorphisms in hypertension
    • Zhu H., Wang X., Lu Y., et al. Update on G-protein polymorphisms in hypertension. Curr Hypertens Rep 2006, 8:23-29.
    • (2006) Curr Hypertens Rep , vol.8 , pp. 23-29
    • Zhu, H.1    Wang, X.2    Lu, Y.3
  • 32
    • 14644401770 scopus 로고    scopus 로고
    • Adducin polymorphism: detection and impact on hypertension and related disorders
    • Bianchi G., Ferrari P., Staessen J.A. Adducin polymorphism: detection and impact on hypertension and related disorders. Hypertension 2005, 45:331-340.
    • (2005) Hypertension , vol.45 , pp. 331-340
    • Bianchi, G.1    Ferrari, P.2    Staessen, J.A.3
  • 33
    • 34547890304 scopus 로고    scopus 로고
    • Functional genomics of the oxidative stress pathway
    • Delles C., Moreno M.U., Padmanabhan S., et al. Functional genomics of the oxidative stress pathway. Curr Hypertens Rev 2009, 3:156-165.
    • (2009) Curr Hypertens Rev , vol.3 , pp. 156-165
    • Delles, C.1    Moreno, M.U.2    Padmanabhan, S.3
  • 34
    • 38949165231 scopus 로고    scopus 로고
    • NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases
    • San Jose G., Fortuno A., Beloqui O., Diez J., Zalba G. NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases. Clin Sci (Lond) 2008, 114:173-182.
    • (2008) Clin Sci (Lond) , vol.114 , pp. 173-182
    • San Jose, G.1    Fortuno, A.2    Beloqui, O.3    Diez, J.4    Zalba, G.5
  • 35
    • 83555162484 scopus 로고    scopus 로고
    • Blood pressure loci identified with a gene-centric array
    • Johnson T., Gaunt T.R., Newhouse S.J., et al. Blood pressure loci identified with a gene-centric array. Am J Hum Genet 2011, 89:688-700.
    • (2011) Am J Hum Genet , vol.89 , pp. 688-700
    • Johnson, T.1    Gaunt, T.R.2    Newhouse, S.J.3
  • 36
    • 77149127075 scopus 로고    scopus 로고
    • The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study
    • Padmanabhan S., Menni C., Lee W.K., et al. The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. J Hypertens 2010, 28:465-477.
    • (2010) J Hypertens , vol.28 , pp. 465-477
    • Padmanabhan, S.1    Menni, C.2    Lee, W.K.3
  • 37
    • 78650415464 scopus 로고    scopus 로고
    • Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array
    • Tomaszewski M., Debiec R., Braund P.S., et al. Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array. Hypertension 2010, 56:1069-1076.
    • (2010) Hypertension , vol.56 , pp. 1069-1076
    • Tomaszewski, M.1    Debiec, R.2    Braund, P.S.3
  • 38
    • 67650665283 scopus 로고    scopus 로고
    • Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array
    • Sober S., Org E., Kepp K., et al. Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. PLoS One 2009, 4:e6034.
    • (2009) PLoS One , vol.4
    • Sober, S.1    Org, E.2    Kepp, K.3
  • 39
    • 42649084334 scopus 로고    scopus 로고
    • Rare independent mutations in renal salt handling genes contribute to blood pressure variation
    • Ji W., Foo J.N., O'Roak B.J., et al. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet 2008, 40:592-599.
    • (2008) Nat Genet , vol.40 , pp. 592-599
    • Ji, W.1    Foo, J.N.2    O'Roak, B.J.3
  • 40
    • 78650923596 scopus 로고    scopus 로고
    • Whole-exome sequencing: a powerful technique for identifying novel genes of complex disorders
    • Sanders S. Whole-exome sequencing: a powerful technique for identifying novel genes of complex disorders. Clin Genet 2011, 79:132-133.
    • (2011) Clin Genet , vol.79 , pp. 132-133
    • Sanders, S.1
  • 41
    • 0037862904 scopus 로고    scopus 로고
    • Where are all the blood-pressure genes?
    • Harrap S.B. Where are all the blood-pressure genes?. Lancet 2003, 361:2149-2151.
    • (2003) Lancet , vol.361 , pp. 2149-2151
    • Harrap, S.B.1
  • 42
    • 78650419995 scopus 로고    scopus 로고
    • Genome-wide association studies will unlock the genetic basis of hypertension.: con side of the argument
    • Kurtz T.W. Genome-wide association studies will unlock the genetic basis of hypertension.: con side of the argument. Hypertension 2010, 56:1021-1025.
    • (2010) Hypertension , vol.56 , pp. 1021-1025
    • Kurtz, T.W.1
  • 43
    • 78650418521 scopus 로고    scopus 로고
    • Genome-wide association studies will unlock the genetic basis of hypertension: pro side of the argument
    • Dominiczak A.F., Munroe P.B. Genome-wide association studies will unlock the genetic basis of hypertension: pro side of the argument. Hypertension 2010, 56:1017-1020.
    • (2010) Hypertension , vol.56 , pp. 1017-1020
    • Dominiczak, A.F.1    Munroe, P.B.2
  • 44
    • 0032554222 scopus 로고    scopus 로고
    • The new genetics in clinical practice
    • Bell J. The new genetics in clinical practice. BMJ 1998, 316:618-620.
    • (1998) BMJ , vol.316 , pp. 618-620
    • Bell, J.1
  • 45
    • 33845355513 scopus 로고    scopus 로고
    • Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis
    • Sookoian S., Gianotti T.F., Gonzalez C.D., Pirola C.J. Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis. J Hypertens 2007, 25:5-13.
    • (2007) J Hypertens , vol.25 , pp. 5-13
    • Sookoian, S.1    Gianotti, T.F.2    Gonzalez, C.D.3    Pirola, C.J.4
  • 46
  • 47
    • 77952991746 scopus 로고    scopus 로고
    • Evidence for a role of uromodulin in chronic kidney disease progression
    • Prajczer S., Heidenreich U., Pfaller W., et al. Evidence for a role of uromodulin in chronic kidney disease progression. Nephrol Dial Transplant 2010, 25:1896-1903.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 1896-1903
    • Prajczer, S.1    Heidenreich, U.2    Pfaller, W.3
  • 48
    • 79955695682 scopus 로고    scopus 로고
    • Scraping fibrosis: UMODulating renal fibrosis
    • Eddy A.A. Scraping fibrosis: UMODulating renal fibrosis. Nat Med 2011, 17:553-555.
    • (2011) Nat Med , vol.17 , pp. 553-555
    • Eddy, A.A.1
  • 49
    • 78149291420 scopus 로고    scopus 로고
    • Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease
    • Good D.M., Zurbig P., Argiles A., et al. Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease. Mol Cell Proteomics 2010, 9:2424-2437.
    • (2010) Mol Cell Proteomics , vol.9 , pp. 2424-2437
    • Good, D.M.1    Zurbig, P.2    Argiles, A.3
  • 50
    • 67349175651 scopus 로고    scopus 로고
    • Multiple loci associated with indices of renal function and chronic kidney disease
    • Kottgen A., Glazer N.L., Dehghan A., et al. Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet 2009, 41:712-717.
    • (2009) Nat Genet , vol.41 , pp. 712-717
    • Kottgen, A.1    Glazer, N.L.2    Dehghan, A.3
  • 51
    • 80053483147 scopus 로고    scopus 로고
    • Genetic association for renal traits among participants of African ancestry reveals new loci for renal function
    • Liu C.T., Garnaas M.K., Tin A., et al. Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genet 2011, 7:e1002264.
    • (2011) PLoS Genet , vol.7
    • Liu, C.T.1    Garnaas, M.K.2    Tin, A.3
  • 52
    • 77957326576 scopus 로고    scopus 로고
    • Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases
    • Gudbjartsson D.F., Holm H., Indridason O.S., et al. Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases. PLoS Genet 2010, 6:e1001039.
    • (2010) PLoS Genet , vol.6
    • Gudbjartsson, D.F.1    Holm, H.2    Indridason, O.S.3
  • 53
    • 80053457834 scopus 로고    scopus 로고
    • Association of eGFR-related loci identified by GWAS with incident CKD and ESRD
    • Boger C.A., Gorski M., Li M., et al. Association of eGFR-related loci identified by GWAS with incident CKD and ESRD. PLoS Genet 2011, 7:e1002292.
    • (2011) PLoS Genet , vol.7
    • Boger, C.A.1    Gorski, M.2    Li, M.3
  • 54
    • 20044368467 scopus 로고    scopus 로고
    • Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice
    • Bachmann S., Mutig K., Bates J., et al. Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice. Am J Physiol Renal Physiol 2005, 288:F559-F567.
    • (2005) Am J Physiol Renal Physiol , vol.288
    • Bachmann, S.1    Mutig, K.2    Bates, J.3
  • 55
    • 77949346577 scopus 로고    scopus 로고
    • Uromodulin levels associate with a common UMOD variant and risk for incident CKD
    • Kottgen A., Hwang S.J., Larson M.G., et al. Uromodulin levels associate with a common UMOD variant and risk for incident CKD. J Am Soc Nephrol 2010, 21:337-344.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 337-344
    • Kottgen, A.1    Hwang, S.J.2    Larson, M.G.3
  • 56
    • 70349251478 scopus 로고    scopus 로고
    • Blood pressure is a major risk factor for renal death: an analysis of 560 352 participants from the Asia-Pacific region
    • O'Seaghdha C.M., Perkovic V., Lam T.H., et al. Blood pressure is a major risk factor for renal death: an analysis of 560 352 participants from the Asia-Pacific region. Hypertension 2009, 54:509-515.
    • (2009) Hypertension , vol.54 , pp. 509-515
    • O'Seaghdha, C.M.1    Perkovic, V.2    Lam, T.H.3
  • 57
    • 0015890890 scopus 로고
    • Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol
    • Goldstein J.L., Brown M.S. Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. Proc Natl Acad Sci U S A 1973, 70:2804-2808.
    • (1973) Proc Natl Acad Sci U S A , vol.70 , pp. 2804-2808
    • Goldstein, J.L.1    Brown, M.S.2
  • 58
    • 0037490080 scopus 로고    scopus 로고
    • Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis
    • Law M.R., Wald N.J., Rudnicka A.R. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ 2003, 326:1423.
    • (2003) BMJ , vol.326 , pp. 1423
    • Law, M.R.1    Wald, N.J.2    Rudnicka, A.R.3
  • 59
    • 38649132270 scopus 로고    scopus 로고
    • Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    • Kathiresan S., Melander O., Guiducci C., et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 2008, 40:189-197.
    • (2008) Nat Genet , vol.40 , pp. 189-197
    • Kathiresan, S.1    Melander, O.2    Guiducci, C.3
  • 60
    • 33645653691 scopus 로고    scopus 로고
    • Are development times for pharmaceuticals increasing or decreasing?
    • Keyhani S., Diener-West M., Powe N. Are development times for pharmaceuticals increasing or decreasing?. Health Aff (Millwood) 2006, 25:461-468.
    • (2006) Health Aff (Millwood) , vol.25 , pp. 461-468
    • Keyhani, S.1    Diener-West, M.2    Powe, N.3
  • 61
    • 81855211733 scopus 로고    scopus 로고
    • Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease
    • Mega J.L., Hochholzer W., Frelinger A.L., et al. Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease. JAMA 2011, 306:2221-2228.
    • (2011) JAMA , vol.306 , pp. 2221-2228
    • Mega, J.L.1    Hochholzer, W.2    Frelinger, A.L.3
  • 62
    • 49949104757 scopus 로고    scopus 로고
    • SLCO1B1 variants and statin-induced myopathy-a genomewide study
    • Link E., Parish S., Armitage J., et al. SLCO1B1 variants and statin-induced myopathy-a genomewide study. N Engl J Med 2008, 359:789-799.
    • (2008) N Engl J Med , vol.359 , pp. 789-799
    • Link, E.1    Parish, S.2    Armitage, J.3
  • 63
    • 78651511585 scopus 로고    scopus 로고
    • Clinical implications of pharmacogenetic variation on the effects of statins
    • Maggo S.D., Kennedy M.A., Clark D.W. Clinical implications of pharmacogenetic variation on the effects of statins. Drug Saf 2011, 34:1-19.
    • (2011) Drug Saf , vol.34 , pp. 1-19
    • Maggo, S.D.1    Kennedy, M.A.2    Clark, D.W.3
  • 64
    • 3042710748 scopus 로고    scopus 로고
    • Pharmacogenetics of antihypertensive drug responses
    • Schwartz G.L., Turner S.T. Pharmacogenetics of antihypertensive drug responses. Am J Pharmacogenomics 2004, 4:151-160.
    • (2004) Am J Pharmacogenomics , vol.4 , pp. 151-160
    • Schwartz, G.L.1    Turner, S.T.2
  • 65
    • 49849084134 scopus 로고    scopus 로고
    • Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic
    • Turner S.T., Bailey K.R., Fridley B.L., et al. Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic. Hypertension 2008, 52:359-365.
    • (2008) Hypertension , vol.52 , pp. 359-365
    • Turner, S.T.1    Bailey, K.R.2    Fridley, B.L.3
  • 66
    • 66349111734 scopus 로고    scopus 로고
    • Criteria for evaluation of novel markers of cardiovascular risk: a scientific statement from the American Heart Association
    • Hlatky M.A., Greenland P., Arnett D.K., et al. Criteria for evaluation of novel markers of cardiovascular risk: a scientific statement from the American Heart Association. Circulation 2009, 119:2408-2416.
    • (2009) Circulation , vol.119 , pp. 2408-2416
    • Hlatky, M.A.1    Greenland, P.2    Arnett, D.K.3
  • 67
    • 85015054307 scopus 로고    scopus 로고
    • Nature, nurture and human disease
    • Chakravarti A., Little P. Nature, nurture and human disease. Nature 2003, 421:412-414.
    • (2003) Nature , vol.421 , pp. 412-414
    • Chakravarti, A.1    Little, P.2
  • 68
    • 33748797136 scopus 로고    scopus 로고
    • Genes, environment and the value of prospective cohort studies
    • Manolio T.A., Bailey-Wilson J.E., Collins F.S. Genes, environment and the value of prospective cohort studies. Nat Rev Genet 2006, 7:812-820.
    • (2006) Nat Rev Genet , vol.7 , pp. 812-820
    • Manolio, T.A.1    Bailey-Wilson, J.E.2    Collins, F.S.3
  • 69
    • 2442639385 scopus 로고    scopus 로고
    • Urinary excretion rate of Tamm-Horsfall protein is related to salt intake in humans
    • Torffvit O., Melander O., Hulten U.L. Urinary excretion rate of Tamm-Horsfall protein is related to salt intake in humans. Nephron Physiol 2004, 97:31-36.
    • (2004) Nephron Physiol , vol.97 , pp. 31-36
    • Torffvit, O.1    Melander, O.2    Hulten, U.L.3
  • 70
    • 0031688685 scopus 로고    scopus 로고
    • Dietary salt regulates expression of Tamm-Horsfall glycoprotein in rats
    • Ying W.Z., Sanders P.W. Dietary salt regulates expression of Tamm-Horsfall glycoprotein in rats. Kidney Int 1998, 54:1150-1156.
    • (1998) Kidney Int , vol.54 , pp. 1150-1156
    • Ying, W.Z.1    Sanders, P.W.2
  • 71
    • 40849142430 scopus 로고    scopus 로고
    • Systematic, genome-wide, sex-specific linkage of cardiovascular traits in French Canadians
    • Seda O., Tremblay J., Gaudet D., et al. Systematic, genome-wide, sex-specific linkage of cardiovascular traits in French Canadians. Hypertension 2008, 51:1156-1162.
    • (2008) Hypertension , vol.51 , pp. 1156-1162
    • Seda, O.1    Tremblay, J.2    Gaudet, D.3
  • 72
    • 31944435805 scopus 로고    scopus 로고
    • Genome-wide scan for linkage to obesity-associated hypertension in French Canadians
    • Pausova Z., Gaudet D., Gossard F., et al. Genome-wide scan for linkage to obesity-associated hypertension in French Canadians. Hypertension 2005, 46:1280-1285.
    • (2005) Hypertension , vol.46 , pp. 1280-1285
    • Pausova, Z.1    Gaudet, D.2    Gossard, F.3
  • 73
    • 31944450739 scopus 로고    scopus 로고
    • Dissecting hypertension by obesity identifies a locus at 1p36
    • Morris B.J. Dissecting hypertension by obesity identifies a locus at 1p36. Hypertension 2005, 46:1256-1258.
    • (2005) Hypertension , vol.46 , pp. 1256-1258
    • Morris, B.J.1
  • 74
    • 77950405093 scopus 로고    scopus 로고
    • Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
    • Craddock N., Hurles M.E., Cardin N., et al. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 2010, 464:713-720.
    • (2010) Nature , vol.464 , pp. 713-720
    • Craddock, N.1    Hurles, M.E.2    Cardin, N.3
  • 75
    • 70749096913 scopus 로고    scopus 로고
    • Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    • Kathiresan S., Voight B.F., Purcell S., et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 2009, 41:334-341.
    • (2009) Nat Genet , vol.41 , pp. 334-341
    • Kathiresan, S.1    Voight, B.F.2    Purcell, S.3
  • 76
    • 83555160904 scopus 로고    scopus 로고
    • Genome-wide association of copy-number variation reveals an association between short stature and the presence of low-frequency genomic deletions
    • Dauber A., Yu Y., Turchin M.C., et al. Genome-wide association of copy-number variation reveals an association between short stature and the presence of low-frequency genomic deletions. Am J Hum Genet 2011, 89:751-759.
    • (2011) Am J Hum Genet , vol.89 , pp. 751-759
    • Dauber, A.1    Yu, Y.2    Turchin, M.C.3
  • 77
    • 84655176643 scopus 로고    scopus 로고
    • Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder
    • Elia J., Glessner J.T., Wang K., et al. Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nat Genet 2011, 44:78-84.
    • (2011) Nat Genet , vol.44 , pp. 78-84
    • Elia, J.1    Glessner, J.T.2    Wang, K.3
  • 78
    • 84863012766 scopus 로고    scopus 로고
    • Genome-wide association study of copy number variation identified gremlin1 as a candidate gene for lean body mass
    • Hai R., Pei Y.F., Shen H., et al. Genome-wide association study of copy number variation identified gremlin1 as a candidate gene for lean body mass. J Hum Genet 2012, 57:33-37.
    • (2012) J Hum Genet , vol.57 , pp. 33-37
    • Hai, R.1    Pei, Y.F.2    Shen, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.