Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection

PLoS Pathogens

Volumn 8, Issue 2, 2012, Pages

  Raju, Ravikiran M ^a   Unnikrishnan, Meera ^a   Rubin, Daniel H F ^a   Krishnamoorthy, Vidhya ^a   Kandror, Olga ^b   Akopian, Tatos N ^b   Goldberg, Alfred L ^b   Rubin, Eric J ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ENZYME; CLP PROTEASE 1; CLP PROTEASE 2; ENDOPEPTIDASE CLP; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CLPP2 PROTEIN, BACTERIA; SERINE PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL SURVIVAL; CELL DEATH; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION AND TRANSLATION; IN VITRO STUDY; MISSENSE MUTATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN MOTIF; TUBERCULOSIS; ANIMAL; C57BL MOUSE; GENETICS; METABOLISM; MICROBIAL VIABILITY; PHYSIOLOGY;

BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MUS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; PROKARYOTA;

ANIMALS; BACTERIAL PROTEINS; MICE; MICE, INBRED C57BL; MICROBIAL VIABILITY; MYCOBACTERIUM TUBERCULOSIS; PROTEOLYSIS; SERINE ENDOPEPTIDASES; TUBERCULOSIS;

EID: 84860909929     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002511     Document Type: Article

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