-
1
-
-
0025895769
-
Molecular biology of the human immunodeficiency virus type 1
-
W. A. Haseltine, Molecular biology of the human immunodeficiency virus type 1, FASEB J. 1991, 5, 2349-2360.
-
(1991)
FASEB J.
, vol.5
, pp. 2349-2360
-
-
Haseltine, W.A.1
-
2
-
-
0023852121
-
The human immunodeficiency virus: Infectivity and mechanisms of pathogenesis
-
A. S. Fauci, The human immunodeficiency virus: infectivity and mechanisms of pathogenesis, Science, 1988, 239, 617-622.
-
(1988)
Science
, vol.239
, pp. 617-622
-
-
Fauci, A.S.1
-
3
-
-
0023770927
-
HIV causes AIDS
-
W. Blattner, R. C. Gallo, H. M. Temin, HIV causes AIDS, Science, 1988, 241, 515-516.
-
(1988)
Science
, vol.241
, pp. 515-516
-
-
Blattner, W.1
Gallo, R.C.2
Temin, H.M.3
-
4
-
-
0026510316
-
Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction
-
O. Bagasra, S. P. Hauptman, H. W. Lischner, M. Sachs, R. J. Pomerantz, Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction, N. Engl. J. Med. 1992, 326, 1385-1391.
-
(1992)
N. Engl. J. Med.
, vol.326
, pp. 1385-1391
-
-
Bagasra, O.1
Hauptman, S.P.2
Lischner, H.W.3
Sachs, M.4
Pomerantz, R.J.5
-
5
-
-
0025800401
-
Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection
-
A. S. Fauci, Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection, Ann. Intern. Med. 1991, 114, 678-693.
-
(1991)
Ann. Intern. Med.
, vol.114
, pp. 678-693
-
-
Fauci, A.S.1
-
6
-
-
0025238899
-
Zidovudine in asymptomatic human immunodeficiency virus infection: A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimetre
-
P. A. Volberding, S. W. Lagakos, M. A. Koch, et al., Zidovudine in asymptomatic human immunodeficiency virus infection: a controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimetre, N. Engl. J. Med. 1990, 322, 941-949.
-
(1990)
N. Engl. J. Med.
, vol.322
, pp. 941-949
-
-
Volberding, P.A.1
Lagakos, S.W.2
Koch, M.A.3
-
7
-
-
0026507775
-
The effect of antiviral therapy on the natural history of human immunodeficiency virus infection in a cohort of hemophiliacs
-
M. V. Ragni, L. A. Kingsley, S. J. Zhou, The effect of antiviral therapy on the natural history of human immunodeficiency virus infection in a cohort of hemophiliacs, J. Acquir. Immune. Defic. Syndr. 1992, 5, 120-126.
-
(1992)
J. Acquir. Immune. Defic. Syndr.
, vol.5
, pp. 120-126
-
-
Ragni, M.V.1
Kingsley, L.A.2
Zhou, S.J.3
-
8
-
-
0025912401
-
Effect of zidovudine and Pneumocystis carinii pneumonia prophylaxis on progression of HIV-1 infection to AIDS
-
N. M. H Graham, S. L Zeger, L. P. Park, et al., Effect of zidovudine and Pneumocystis carinii pneumonia prophylaxis on progression of HIV-1 infection to AIDS, Lancet 1991, 338, 265-269.
-
(1991)
Lancet
, vol.338
, pp. 265-269
-
-
Graham, N.M.H.1
Zeger, S.L.2
Park, L.P.3
-
9
-
-
0025173899
-
Survival trends for patients with AIDS
-
G. F Lemp, S. F Payne, D. Neal, T. Temelso, G. W. Rutherford, Survival trends for patients with AIDS, JAMA, 1990, 263, 402-406.
-
(1990)
JAMA
, vol.263
, pp. 402-406
-
-
Lemp, G.F.1
Payne, S.F.2
Neal, D.3
Temelso, T.4
Rutherford, G.W.5
-
10
-
-
0025980126
-
Primary HIV infection: Host responses and intervention strategies
-
B. Tindall, D. A. Cooper, Primary HIV infection: host responses and intervention strategies, AIDS 1991, 5, 1-14.
-
(1991)
AIDS
, vol.5
, pp. 1-14
-
-
Tindall, B.1
Cooper, D.A.2
-
11
-
-
0029775166
-
What can be expected from non-nucleoside reverse transcriptase inhibitors in the treatment of human immunodeficiency virus type 1 infection?
-
E. De Clercq, What can be expected from non-nucleoside reverse transcriptase inhibitors in the treatment of human immunodeficiency virus type 1 infection? Rev. Med. Virol. 1996, 97-117.
-
(1996)
Rev. Med. Virol.
, pp. 97-117
-
-
de Clercq, E.1
-
12
-
-
0032918170
-
Perspectives of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection
-
E. De Clercq, Perspectives of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection, Farmaco 1999, 54, 26-45.
-
(1999)
Farmaco
, vol.54
, pp. 26-45
-
-
de Clercq, E.1
-
13
-
-
0036104758
-
Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: Past, present, and future perspectives
-
G. Campiani, A. Ramunno, G. Maga, V. Nacci, C. Fattorusso, B. Catalanotti, B. Morelli, E. Novellino, Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives, Curr. Pharm. Des. 2002, 8, 615-657.
-
(2002)
Curr. Pharm. Des.
, vol.8
, pp. 615-657
-
-
Campiani, G.1
Ramunno, A.2
Maga, G.3
Nacci, V.4
Fattorusso, C.5
Catalanotti, B.6
Morelli, B.7
Novellino, E.8
-
14
-
-
0024832408
-
Highly specific inhibition of human immunodeficiency virus type-1 by a novel 6-substituted acyclouridine derivative
-
M. Baba, H. Tanakas, E. De Clercq, R. Pauwels, J. Balzarini, D. Schols, H. Nakashima, C. F. Perno, R. T. Walker, T. Miyasaka, Highly specific inhibition of human immunodeficiency virus type-1 by a novel 6-substituted acyclouridine derivative, Biochem Biophys. Res. Commun. 1989, 165, 1375-1381.
-
(1989)
Biochem Biophys. Res. Commun.
, vol.165
, pp. 1375-1381
-
-
Baba, M.1
Tanakas, H.2
de Clercq, E.3
Pauwels, R.4
Balzarini, J.5
Schols, D.6
Nakashima, H.7
Perno, C.F.8
Walker, R.T.9
Miyasaka, T.10
-
15
-
-
33644683832
-
Effects of Efavirenz Binding on the Subunit Equilibria of HIV-1 Reverse Transcriptase
-
C. F. Venezia, K. J. Howard, M. E. Ignatov, L. A. Holladay, M. D. Barkley, Effects of Efavirenz Binding on the Subunit Equilibria of HIV-1 Reverse Transcriptase, Biochemistry 2006, 45, 2779-2789.
-
(2006)
Biochemistry
, vol.45
, pp. 2779-2789
-
-
Venezia, C.F.1
Howard, K.J.2
Ignatov, M.E.3
Holladay, L.A.4
Barkley, M.D.5
-
16
-
-
0027407551
-
Potent and Highly Selective Human Immunodeficiency Virus Type 1 (HIV-1) Inhibition by a Series of-Anilinophenylacetamide derivatives targeted at HIV-1 Reverse Transcriptase
-
R. Pauwels, K. Andries, Z. Debyser, P. Van Daele, D. Schols, A. M. Vandamme, C. G. M. Janssen, J. Anne, G. Cauwenbergh, J. Desmyter, J. Heykants, M. A. C. Janssen, E. De Clercq, P. A. J. Janssen, Potent and Highly Selective Human Immunodeficiency Virus Type 1 (HIV-1) Inhibition by a Series of-Anilinophenylacetamide derivatives targeted at HIV-1 Reverse Transcriptase, Proc. Natl. Acad. Sci. USA 1993, 90, 1711-1715.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 1711-1715
-
-
Pauwels, R.1
Andries, K.2
Debyser, Z.3
van Daele, P.4
Schols, D.5
Vandamme, A.M.6
Janssen, C.G.M.7
Anne, J.8
Cauwenbergh, G.9
Desmyter, J.10
Heykants, J.11
Janssen, M.A.C.12
de Clercq, E.13
Janssen, P.A.J.14
-
17
-
-
0026606044
-
2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2"-oxathiole-2'',2'-dioxide) pyrimidine (TSAO) nucleoside analogues: Highly selective inhibitors of human immunodeficiency virus type 1 that targeted at the viral reverse transcriptase
-
J. Balzarini, M. J. Pérez-Pérez, A. San-Felix, D. C. F. Schols, Perno, A. Vandamme, M. J. Camarasa, E. De Clercq, 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2"-oxathiole-2'',2'-dioxide) pyrimidine (TSAO) nucleoside analogues: highly selective inhibitors of human immunodeficiency virus type 1 that targeted at the viral reverse transcriptase, Proc. Natl. Acad. Sci. USA 1992, 89, 4392-4396.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 4392-4396
-
-
Balzarini, J.1
Pérez-Pérez, M.J.2
San-Felix, A.3
Schols, D.C.F.4
Perno5
Vandamme, A.6
Camarasa, M.J.7
de Clercq, E.8
-
18
-
-
0025996983
-
Nonnucleoside Reverse Transcriptase Inhibitors that Potently and Specifically Block Human Immunodeficiency Virus Type 1 replication
-
D. L. Romero, M. Busso, C. K. Tan, F. Reusser, J. R. Palmer, S. M. Poppe, P. F. Aristoff, K. M. Downey, A. G. So, L. Resnick; W. G. Tarpley, Nonnucleoside Reverse Transcriptase Inhibitors that Potently and Specifically Block Human Immunodeficiency Virus Type 1 replication, Proc. Natl. Acad. Sci. USA 1991, 88, 8806-8810.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 8806-8810
-
-
Romero, D.L.1
Busso, M.2
Tan, C.K.3
Reusser, F.4
Palmer, J.R.5
Poppe, S.M.6
Aristoff, P.F.7
Downey, K.M.8
So, A.G.9
Resnick, L.10
Tarpley, W.G.11
-
19
-
-
0025679303
-
Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor
-
V.J. Merluzzi, K.D. Hargrave, M. Labadia, K. Grozinger, M. Skoog, J.C. Wu, C.K. Shih, K. Eckner, S. Hattox, J. Adams, Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor, Science, 1990, 250, 1411-1413.
-
(1990)
Science
, vol.250
, pp. 1411-1413
-
-
Merluzzi, V.J.1
Hargrave, K.D.2
Labadia, M.3
Grozinger, K.4
Skoog, M.5
Wu, J.C.6
Shih, C.K.7
Eckner, K.8
Hattox, S.9
Adams, J.10
-
20
-
-
0025014499
-
Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivative
-
R. Pauwels, K. Andries, J. Desmyter, D. Schols, M. J. Kukla, H. J. Breslin, A. Raeymaeckers, J. Van Gelder, R. Woestenborghs, J. Heykants, Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivative, Nature, 1990, 343, 470-474.
-
(1990)
Nature
, vol.343
, pp. 470-474
-
-
Pauwels, R.1
Andries, K.2
Desmyter, J.3
Schols, D.4
Kukla, M.J.5
Breslin, H.J.6
Raeymaeckers, A.7
van Gelder, J.8
Woestenborghs, R.9
Heykants, J.10
-
21
-
-
0028998825
-
The PETT series, a new class of potent non-nucleoside inhibitors of human immunodeficiency virus type-1 reverse transcriptase
-
C. Ahgren, K. Backro, F. W. Bell, A. S. Cantrell, M. Clemens, J. M. Colacino, J. B. Deeter, J. A. Engelhardt, M. Hogberg, S. R. Jaskunas, N. G. Johanssons, The PETT series, a new class of potent non-nucleoside inhibitors of human immunodeficiency virus type-1 reverse transcriptase, Antimicrob. Agents Chemother. 1995, 39, 1329-1335.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 1329-1335
-
-
Ahgren, C.1
Backro, K.2
Bell, F.W.3
Cantrell, A.S.4
Clemens, M.5
Colacino, J.M.6
Deeter, J.B.7
Engelhardt, J.A.8
Hogberg, M.9
Jaskunas, S.R.10
Johanssons, N.G.11
-
22
-
-
84871382257
-
-
To date six nucleosides have been approved by the FDA: AZT, 3TC, d4T, ddI, ddC, and abacavir.
-
To date six nucleosides have been approved by the FDA: AZT, 3TC, d4T, ddI, ddC, and abacavir.
-
-
-
23
-
-
0030887575
-
A check on rational drug design: Molecular simulation of the allosteric inhibition of HIV-1 reverse transcriptase
-
P. P. Mager, A check on rational drug design: Molecular simulation of the allosteric inhibition of HIV-1 reverse transcriptase, Med. Res. Rev. 1997, 17, 235-276.
-
(1997)
Med. Res. Rev.
, vol.17
, pp. 235-276
-
-
Mager, P.P.1
-
24
-
-
0029977510
-
Targeting HIV reverse transcriptase for anti-AIDS drug design: Structural and biological considerations for chemotherapeutic strategies
-
E. Arnold, K. Das, J. Ding, P.N. Yadav, Y. Hsiou, P.L. Boyer, S. H. Hughes, Targeting HIV reverse transcriptase for anti-AIDS drug design: structural and biological considerations for chemotherapeutic strategies, Drug. Des. Discov. 1996, 13, 29-47.
-
(1996)
Drug. Des. Discov.
, vol.13
, pp. 29-47
-
-
Arnold, E.1
Das, K.2
Ding, J.3
Yadav, P.N.4
Hsiou, Y.5
Boyer, P.L.6
Hughes, S.H.7
-
25
-
-
0034059835
-
The HIV-1 reverse transcription (RT) process as target for RT inhibitors
-
H. Jonckheere, J. Anne, E. De Clercq, The HIV-1 reverse transcription (RT) process as target for RT inhibitors, Med. Res. Rev. 2000, 20, 129-154.
-
(2000)
Med. Res. Rev.
, vol.20
, pp. 129-154
-
-
Jonckheere, H.1
Anne, J.2
de Clercq, E.3
-
26
-
-
0026318387
-
Human Immunodeficiency Virus Type 1 Mutants Resistant to Nonnucleoside Inhibitors of Reverse Transcriptase arises in Tissue Culture
-
D. Richman, C. K. Shih, I. Lowy, J. Rose, P. Prodanovich, S. Goff, and Griffin, Human Immunodeficiency Virus Type 1 Mutants Resistant to Nonnucleoside Inhibitors of Reverse Transcriptase arises in Tissue Culture, Proc. Natl. Acad. Sci. USA 1991, 88, 11241-11245.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 11241-11245
-
-
Richman, D.1
Shih, C.K.2
Lowy, I.3
Rose, J.4
Prodanovich, P.5
Goff, S.6
Griffin7
-
27
-
-
0035821597
-
2-Amino-6-arylsulfonylbenzonitriles as Non-nucleoside Reverse Transcriptase Inhibitors of HIV-1
-
H. Chan. Joseph, 2-Amino-6-arylsulfonylbenzonitriles as Non-nucleoside Reverse Transcriptase Inhibitors of HIV-1, J. Med. Chem. 2001, 44, 1866-1882.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 1866-1882
-
-
Chan, H.J.1
-
29
-
-
84913723369
-
Molecular Shape as a Critical Factor in Structure-Property-Activity Studies
-
M. Randic, P. G. Seybold, Molecular Shape as a Critical Factor in Structure-Property-Activity Studies, SAR QSAR Environ. Res. 1993, 1, 77-85.
-
(1993)
SAR QSAR Environ. Res.
, vol.1
, pp. 77-85
-
-
Randic, M.1
Seybold, P.G.2
-
30
-
-
0002225001
-
In Search of Structural Invariants
-
M. Randić, In Search of Structural Invariants, J. Math. Chem. 1992, 9, 97-146.
-
(1992)
J. Math. Chem.
, vol.9
, pp. 97-146
-
-
Randić, M.1
-
32
-
-
5344262585
-
Molecular Structure-Property Relationships
-
P. G. Seybold, M. May, U. A. Bagal, Molecular Structure-Property Relationships, J. Chem. Educ. 1987, 64, 575-581.
-
(1987)
J. Chem. Educ.
, vol.64
, pp. 575-581
-
-
Seybold, P.G.1
May, M.2
Bagal, U.A.3
-
34
-
-
33751386067
-
Design of molecules from quantitative structure-activity relationship models. III. Role of higher order path counts: Path Three
-
L. B. Kier, L. H. Hall, Design of molecules from quantitative structure-activity relationship models. III. Role of higher order path counts: Path Three, J. Chem. Inf. Comput. Sci. 1993, 33, 598-603.
-
(1993)
J. Chem. Inf. Comput. Sci.
, vol.33
, pp. 598-603
-
-
Kier, L.B.1
Hall, L.H.2
-
35
-
-
0026035062
-
The electro-topological state: An atom index for QSAR
-
L. B. Kier, L. H. Hall, B. K. Mohney, The electro-topological state: An atom index for QSAR, Quant. Struct.-Act. Relat. 1991, 10, 43-51.
-
(1991)
Quant. Struct.-Act. Relat.
, vol.10
, pp. 43-51
-
-
Kier, L.B.1
Hall, L.H.2
Mohney, B.K.3
-
36
-
-
0025977916
-
The concept of structure in structure-activity relations by studies and drug design
-
B. Testa, L. B. Kier, The concept of structure in structure-activity relations by studies and drug design, Med. Res. Rev, 1991, 11, 35-48.
-
(1991)
Med. Res. Rev
, vol.11
, pp. 35-48
-
-
Testa, B.1
Kier, L.B.2
-
37
-
-
0027769667
-
The generation of molecular structures for a graph based equations
-
L. B. Kier, L. H. Hall, The generation of molecular structures for a graph based equations, Quant. Struct.-Act. Relat. 1994, 12, 383-388.
-
(1994)
Quant. Struct.-Act. Relat.
, vol.12
, pp. 383-388
-
-
Kier, L.B.1
Hall, L.H.2
-
38
-
-
0042184608
-
Quantitative information analysis: The new center of gravity in medicinal chemistry
-
L. B. Kier, L. H. Hall, Quantitative information analysis: The new center of gravity in medicinal chemistry, Med. Chem. Res. 1997, 7,335-339.
-
(1997)
Med. Chem. Res.
, vol.7
, pp. 335-339
-
-
Kier, L.B.1
Hall, L.H.2
-
39
-
-
0000672441
-
Design of molecules from quantitative structure-activity relationship models. I. Information transfer between path and vertex degree counts
-
L. B. Kier, L. H. Hall, J. W. Frazer, Design of molecules from quantitative structure-activity relationship models. I. Information transfer between path and vertex degree counts, J. Chem. Inf. Comput. Sci. 1993, 33, 143-147.
-
(1993)
J. Chem. Inf. Comput. Sci.
, vol.33
, pp. 143-147
-
-
Kier, L.B.1
Hall, L.H.2
Frazer, J.W.3
-
40
-
-
0242677271
-
A quantitative approach to biochemical structure-activity relationships
-
C. Hansch, A quantitative approach to biochemical structure-activity relationships, Acc. Chem. Res. 1969, 2, 232-239.
-
(1969)
Acc. Chem. Res.
, vol.2
, pp. 232-239
-
-
Hansch, C.1
-
41
-
-
84871397373
-
-
Sagata Regression ver. 1.0
-
Sagata Regression ver. 1.0, Sagata Regression ver. 1.0, http://www.sagata.com.
-
Sagata Regression ver. 1.0
-
-
-
42
-
-
84871375921
-
-
July
-
WinIDAMS 1.2, http://www.unesco.org/idams, July 2004.
-
(2004)
WinIDAMS 1.2
-
-
|