Kinetics and molecular docking studies of kaempferol and its prenylated derivatives as aldose reductase inhibitors

Chemico-Biological Interactions

Volumn 197, Issue 2-3, 2012, Pages 110-118

  Jung, Hyun Ah ^a   Moon, Hye Eun ^b   Oh, Sang Ho ^c   Kim, Byung Woo ^d   Sohn, Hee Sook ^a   Choi, Jae Sue ^b,d  

^a Chonbuk National University   (South Korea)

^b Pukyong National University   (South Korea)

^c Korean Bio Information Center (KOBIC)   (South Korea)

^d Dong Eui University   (South Korea)

Author keywords

Diabetic complications; Enzyme kinetic; Molecular docking; Prenylated flavonoid

Indexed keywords

ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; DESMETHYLANHYDROICARITIN; FLAVONOID; KAEMPFEROL; SOPHOFLAVESCENOL; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG POTENTIATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STRUCTURE; HUMAN; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; NONHUMAN; PREDICTION; RAT; SIMULATION;

ALDEHYDE REDUCTASE; ANIMALS; BINDING SITES; ENZYME INHIBITORS; FLAVONES; FLAVONOIDS; HUMANS; KAEMPFEROLS; KINETICS; MODELS, MOLECULAR; PRENYLATION; PROTEIN CONFORMATION; RATS;

RATTUS;

EID: 84860871742     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.04.004     Document Type: Article

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