Antidiabetic complications and anti-alzheimer activities of sophoflavescenol, a prenylated flavonol from Sophora flavescens, and its structure-activity relationship

Phytotherapy Research

Volumn 25, Issue 5, 2011, Pages 709-715

  Jung, Hyun Ah ^a   Jin, Seong Eun ^b   Park, Jun Seong ^c   Choi, Jae Sue ^b,d  

^a Chonbuk National University   (South Korea)

^b Pukyong National University   (South Korea)

^c AmorePacific Corporation   (South Korea)

^d Dong Eui University   (South Korea)

Author keywords

Alzheimer disease; diabetic complication; sophoflavescenol; Sophora flavescens; structure activity relationship

Indexed keywords

8 C LAVANDURYLKAEMPFEROL; ADVANCED GLYCATION END PRODUCT; ALDEHYDE REDUCTASE; BETA SECRETASE 1; CHOLINESTERASE; DESMETHYLANHYDROICARITIN; DICHLOROMETHANE; ENZYME INHIBITOR; FLAVONOL; HYDROXYL GROUP; ICARITIN; KAEMPFEROL; QUERCETIN; RECOMBINANT ENZYME; SILICA GEL; SOPHOFLAVESCENOL; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; NONHUMAN; PHYTOCHEMISTRY; PRENYLATION; RAT; SOPHORA; SOPHORA FLAVESCENS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ALDEHYDE REDUCTASE; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CHOLINESTERASES; ENZYME INHIBITORS; FLAVONOIDS; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; INHIBITORY CONCENTRATION 50; MEDICINE, TRADITIONAL; PLANT EXTRACTS; PRENYLATION; RATS; RECOMBINANT PROTEINS; SOPHORA; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS; SOPHORA FLAVESCENS;

EID: 79955525480     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3326     Document Type: Article

References (18)

1. Ellman GL, Courtney KD, Andres V Jr, Featherstone RM,. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7: 88-95.
2. Hayman S, Kinoshita JH,. 1965. Isolation and properties of lens aldose reductase. J Biol Chem 240: 877-882.
3. Huang KC,. 1993. The Pharmacology of Chinese Herbs. CRC Press Inc.: Boca Raton, FL, 63-66.
4. Jung HA, Yokozawa T, Kim BW, Jung JH, Choi JS,. 2010. Selective inhibition of prenylated flavonoids from Sophora flavescens against BACE1 and cholinesterases. Am J Chin Med 38: 1-15.
5. Jung HA, Yoon NY, Kang SS, Kim YS, Choi JS,. 2008. Inhibitory activities of prenylated flavonoids from Sophora flavescens against aldose reductase and generation of advanced glycation endproducts. J Pharm Pharmacol 60: 1227-1236.
6. Lee NK, Son KH, Chang HW, et al. 2004. Prenylated flavonoids as tyrosinase inhibitors. Arch Pharm Res 27: 1132-1135.
7. Nishimura C, Yamaoka T, Mizutani M, Yamashita K, Akera T, Tanimoto T,. 1991. Purification and characterization of the recombinant human aldose reductase expressed in baculovirus system. Biochim Biophys Acta 1078: 171-178.
8. Parihar MS, Hemnani T,. 2004. Alzheimer's disease pathogenesis and therapeutic interventions. J Clin Neurosci 11: 456-467. (Pubitemid 38869470)
9. Peyrou J, Sternberg M,. 2006. Advanced glycation endproducts (AGEs): pharmacological inhibition diabetes. Pathol Biol 54: 409-419.
10. Rao AA, Sridhar GR, Das UN,. 2007. Elevated butyrylcholinesterase and acetylcholinesterase may predict the development of type 2 diabetes mellitus and Alzheimer's disease. Med Hypotheses 69: 1272-1276. (Pubitemid 47633064)
11. Rickles R, Pierce L, Lee MS,. 2009. Combinations for the treatment of B-cell proliferative disorders. PCT Int Appl WO 2009011897 A1 20090122.
12. Shin HJ, Kim HJ, Kwak JH, et al. 2002. A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett 12: 2313-2316. (Pubitemid 34879856)
13. Singh M, Arseneault M, Sanderson T, Murthy V, Ramassamy C,. 2008. Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms. J Agric Food Chem 56: 4855-4873. (Pubitemid 352039080)
14. Tang W, Eisenbrand G,. 1992. Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine. Springer-Verlag: Berlin, 931-943.
15. Vassar R., 2002. β-Secretase (BACE) as a drug target for Alzheimer's disease. Adv Drug Deliv Rev 54: 1589-1602. (Pubitemid 35346833)
16. Vinson JA, Howard III, TB,. 1996. Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients. J Nutr Biochem 7: 659-663. (Pubitemid 27019421)
17. Woo ER, Kwak JH, Kim HJ, Park HK,. 1998. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod 61: 1552-1554.
18. Yan R, Bienkowski MJ, Shuck ME, et al. 1999. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity. Nature 402: 533-537.