Functional and structural analysis of the siderophore synthetase AsbB through reconstitution of the petrobactin biosynthetic pathway from Bacillus anthracis

Journal of Biological Chemistry

Volumn 287, Issue 19, 2012, Pages 16058-16072

  Nusca, Tyler D ^a,b   Kim, Youngchang ^c   Maltseva, Natalia ^c   Lee, Jung Yeop ^a   Eschenfeldt, William ^c   Stols, Lucy ^c   Schofield, Michael M ^a   Scaglione, Jamie B ^a   Dixon, Shandee D ^b   Oves Costales, Daniel ^d   Challis, Gregory L ^d   Hanna, Philip C ^b   Pfleger, Brian F ^a,e   Joachimiak, Andrzej ^c,f   Sherman, David H ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c ARGONNE NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF WARWICK   (United Kingdom)

^e University of Wisconsin Madison   (United States)

^f UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE; AMIDE BOND; ANTHRACIS; BACILLUS ANTHRACIS; BIFUNCTIONAL; BIOSYNTHETIC PATHWAY; CAUSATIVE AGENTS; CHEMO-ENZYMATIC SYNTHESIS; ENZYMATIC ASSAY; FINAL ASSEMBLY; GENE PRODUCTS; IN-VITRO; NONRIBOSOMAL PEPTIDE; NONRIBOSOMAL PEPTIDE SYNTHETASES; PATHOGENIC BACTERIUM; POLYAMINES; PRIMARY METABOLITE; SECONDARY METABOLITES; SIDEROPHORES; STRUCTURAL CHARACTERISTICS; SYNTHETASES; THERAPEUTIC TARGETS; THREE-DIMENSIONAL MODEL;

AMIDES; BACTERIA; BIOCHEMISTRY; CARBOXYLATION; GENES; MACHINERY; METABOLITES; PHENOLS; POLYPEPTIDES; THREE DIMENSIONAL;

BIOSYNTHESIS;

BACILLUS ANTHRACIS SIDEROPHORE BIOSYNTHESIS PROTEIN B; BACILLUS ANTHRACIS SIDEROPHORE BIOSYNTHESIS PROTEIN C; BACILLUS ANTHRACIS SIDEROPHORE BIOSYNTHESIS PROTEIN D; BACILLUS ANTHRACIS SIDEROPHORE BIOSYNTHESIS PROTEIN E; BACTERIAL PROTEIN; CARBOXYLIC ACID; NUCLEOPHILE; PETROBACTIN; SIDEROPHORE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS ANTHRACIS; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME STRUCTURE; ENZYME SUBSTRATE; IN VITRO STUDY; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN TARGETING;

AMINO ACID SEQUENCE; BACILLUS ANTHRACIS; BACTERIAL PROTEINS; BENZAMIDES; BIOCATALYSIS; BIOSYNTHETIC PATHWAYS; CARBON-NITROGEN LIGASES; CRYSTALLOGRAPHY, X-RAY; LIGASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; POLYAMINES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIDEROPHORES; SUBSTRATE SPECIFICITY;

BACILLUS ANTHRACIS;

EID: 84860852544     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.359349     Document Type: Article

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