Inflammatory muscle pain is dependent on the activation of kinin B 1 and B 2 receptors and intracellular kinase pathways

British Journal of Pharmacology

Volumn 166, Issue 3, 2012, Pages 1127-1139

  Meotti, F C ^a,b   Campos, R ^a   Da Silva, K A B S ^a   Paszcuk, A F ^a   Costa, R ^a   Calixto, J B ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

cytokines; hyperalgesia; inflammation; intracellular kinases; kinin B 1 and B 2 receptors; muscle pain

Indexed keywords

3 (6 ACETAMIDO 3 PYRIDYL) N [N [2,4 DICHLORO 3 [(2 METHYL 8 QUINOLINYL)OXYMETHYL]PHENYL] N METHYLAMINOCARBONYLMETHYL]ACRYLAMIDE; ANALGESIC AGENT; BRADYKININ B1 RECEPTOR; BRADYKININ B1 RECEPTOR ANTAGONIST; BRADYKININ B2 RECEPTOR; DESARGININE 9 [LEUCINE 8] BRADYKININ; FORMALDEHYDE; HO 140; ICATIBANT; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOPEROXIDASE; PROTEIN KINASE C; SSR 240612; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GASTROCNEMIUS MUSCLE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HYPERALGESIA; INFLAMMATORY MUSCLE PAIN; MALE; MOUSE; MYALGIA; NONHUMAN; PAIN ASSESSMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; CYTOKINES; ENZYME INHIBITORS; FORMALDEHYDE; GENE EXPRESSION; HYPERALGESIA; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MUSCLE, SKELETAL; MYOSITIS; OLIGOPEPTIDES; PAIN MEASUREMENT; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, BRADYKININ B1; RECEPTOR, BRADYKININ B2; UP-REGULATION;

EID: 84860851269     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01830.x     Document Type: Article

References (68)

1. Angers M, Drouin R, Bachvarova M, Paradis I, Marceau F, Bachvarov DR, (2000). In vivo protein-DNA interactions at the kinin B(1) receptor gene promoter: no modification on interleukin-1 beta or lipopolysaccharide induction. J Cell Biochem 78: 278-296.
2. Babenko V, Graven-Nielsen T, Svensson P, Drewes AM, Jensen TS, Arendt-Nielsen L, (1999). Experimental human muscle pain and muscular hyperalgesia induced by combinations of serotonin and bradykinin. Pain 82: 1-8.
3. Barnes PJ, (1992). Bradykinin and asthma. Thorax 47: 979-983.
4. Boix F, Roe C, Rosenborg L, Knardahl S, (2005). Kinin peptides in human trapezius muscle during sustained isometric contraction and their relation to pain. J Appl Physiol 98: 534-540.
5. Bradley PP, Priebat DA, Christensen RD, Rothstein G, (1982). Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78: 206-209.
6. Brechter AB, Lerner UH, (2002). Characterization of bradykinin receptors in a human osteoblastic cell line. Regul Pept 103: 39-51.
7. Calixto JB, Cabrini DA, Ferreira J, Campos MM, (2000). Kinins in pain and inflammation. Pain 87: 1-5.
8. Calixto JB, Medeiros R, Fernandes ES, Ferreira J, Cabrini DA, Campos MM, (2004). Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes. Br J Pharmacol 143: 803-818.
9. Campos MM, Calixto JB, (1995). Involvement of B1 and B2 receptors in bradykinin-induced rat paw oedema. Br J Pharmacol 114: 1005-1013.
10. Cesare P, Dekker LV, Sardini A, Parker PJ, McNaughton PA, (1999). Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. Neuron 23: 617-624.
11. Cloutier F, Couture R, (2000). Pharmacological characterization of the cardiovascular responses elicited by kinin B(1) and B(2) receptor agonists in the spinal cord of streptozotocin-diabetic rats. Br J Pharmacol 130: 375-385.
12. Correa CR, Calixto JB, (1993). Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouse. Br J Pharmacol 110: 193-198.
13. Costa-Neto CM, Dillenburg-Pilla P, Heinrich TA, Parreiras-e-Silva LT, Pereira MG, Reis RI, et al,. (2008). Participation of kallikrein-kinin system in different pathologies. Int Immunopharmacol 8: 135-142.
14. Couture R, Harrisson M, Vianna RM, Cloutier F, (2001). Kinin receptors in pain and inflammation. Eur J Pharmacol 429: 161-176.
15. Dina OA, Green PG, Levine JD, (2008a). Role of interleukin-6 in chronic muscle hyperalgesic priming. Neuroscience 152: 521-525.
16. Dina OA, Levine JD, Green PG, (2008b). Muscle inflammation induces a protein kinase C epsilon-dependent chronic-latent muscle pain. J Pain 9: 457-462.
17. Dray A, Perkins M, (1997). Kinins and pain. In:, Farmer SG, (ed.). The Handbook of Immunopharmacology: The Kinin System. Academic Press: London, pp. 157-172.
18. Ferreira J, Campos MM, Araujo R, Bader M, Pesquero JB, Calixto JB, (2002). The use of kinin B1 and B2 receptor knockout mice and selective antagonists to characterize the nociceptive responses caused by kinins at the spinal level. Neuropharmacology 43: 1188-1197.
19. Ferreira J, da Silva GL, Calixto JB, (2004). Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice. Br J Pharmacol 141: 787-794.
20. Ferreira J, Triches KM, Medeiros R, Calixto JB, (2005). Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice. Pain 117: 171-181.
21. Ferreira J, Triches KM, Medeiros R, Cabrini DA, Mori MA, Pesquero JB, et al,. (2008). The role of kinin B1 receptors in the nociception produced by peripheral protein kinase C activation in mice. Neuropharmacology 54: 597-604.
22. Figueroa CD, Dietze G, Muller-Esterl W, (1996). Immunolocalization of bradykinin B2 receptors on skeletal muscle cells. Diabetes 45 (Suppl. 1): S24-S28.
23. Gerdle B, Hilgenfeldt U, Larsson B, Kristiansen J, Sogaard K, Rosendal L, (2008). Bradykinin and kallidin levels in the trapezius muscle in patients with work-related trapezius myalgia, in patients with whiplash associated pain, and in healthy controls-a microdialysis study of women. Pain 139: 578-587.
24. Gougat J, Ferrari B, Sarran L, Planchenault C, Poncelet M, Maruani J, et al,. (2004). SSR240612 [(2R)-2-[((3R)-3-(1,3-benzodioxol-5-yl)-3-[[(6-methoxy-2- naphthyl)sulfonyl]amino]propanoyl)amino]-3-(4-[[2R,6S)-2,6-dimethylpiperidinyl] methyl]pheny l)-N-isopropyl-N-methylpropanamide hydrochloride], a new nonpeptide antagonist of the bradykinin B1 receptor: biochemical and pharmacological characterization. J Pharmacol Exp Ther 309: 661-669.
25. Hunskaar S, Hole K, (1987). The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30: 103-114.
26. Jensen K, Tuxen C, Pedersen-Bjergaard U, Jansen I, Edvinsson L, Olesen J, (1990). Pain and tenderness in human temporal muscle induced by bradykinin and 5-hydroxytryptamine. Peptides 11: 1127-1132.
27. Khan MN, Lee YS, (2011). Cyclooxygenase inhibitors: scope of their use and development in cancer chemotherapy. Med Res Rev 31: 161-201.
28. Klebanoff S, (1991). Myeloperoxidase: occurence and biological function. In:, Everse J, Everse KE, Grisham MB, (eds). Peroxidases in Chemistry and Biology. CRC Press: Boca Raton, pp. 1-35.
29. Lopes P, Regoli D, Couture R, (1993). Cardiovascular effects of intrathecally administered bradykinin in the rat: characterization of receptors with antagonists. Br J Pharmacol 110: 1369-1374.
30. Mackenzie IS, MacDonald TM, (2010). Treatment of osteoarthritis in hypertensive patients. Expert Opin Pharmacother 11: 393-403.
31. Manjavachi MN, Motta EM, Marotta DM, Leite DF, Calixto JB, (2010). Mechanisms involved in IL-6-induced muscular mechanical hyperalgesia in mice. Pain 151: 345-355.
32. Marceau F, Bachvarov DR, (1998). Kinin receptors. Clin Rev Allergy Immunol 16: 385-401.
33. Marceau F, Regoli D, (2004). Bradykinin receptor ligands: therapeutic perspectives. Nat Rev Drug Discov 3: 845-852.
34. Medeiros R, Cabrini DA, Ferreira J, Fernandes ES, Mori MA, Pesquero JB, et al,. (2004). Bradykinin B1 receptor expression induced by tissue damage in the rat portal vein: a critical role for mitogen-activated protein kinase and nuclear factor-kappaB signaling pathways. Circ Res 94: 1375-1382.
35. Meini S, Maggi CA, (2008). Knee osteoarthritis: a role for bradykinin? Inflamm Res 57: 351-361.
36. Mense S, (2009). Algesic agents exciting muscle nociceptors. Exp Brain Res 196: 89-100.
37. Mizumura K, Sugiura T, Katanosaka K, Banik RK, Kozaki Y, (2009). Excitation and sensitization of nociceptors by bradykinin: what do we know? Exp Brain Res 196: 53-65.
38. Mork H, Ashina M, Bendtsen L, Olesen J, Jensen R, (2003). Experimental muscle pain and tenderness following infusion of endogenous substances in humans. Eur J Pain 7: 145-153.
39. Motta EM, Calixto JB, Rae GA, (2006). Mechanical hyperalgesia induced by endothelin-1 in rats is mediated via phospholipase C, protein kinase C, and MAP kinases. Exp Biol Med 231: 1141-1145.
40. Murase S, Terazawa E, Queme F, Ota H, Matsuda T, Hirate K, et al,. (2010). Bradykinin and nerve growth factor play pivotal roles in muscular mechanical hyperalgesia after exercise (delayed-onset muscle soreness). J Neurosci 30: 3752-3761.
41. Pan ZK, Christiansen SC, Ptasznik A, Zuraw BL, (1999). Requirement of phosphatidylinositol 3-kinase activity for bradykinin stimulation of NF-kappaB activation in cultured human epithelial cells. J Biol Chem 274: 9918-9922.
42. Paszcuk AF, Quintao NL, Fernandes ES, Juliano L, Chapman K, Andrade-Gordon P, et al,. (2008). Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw. Eur J Pharmacol 581: 204-215.
43. Pesquero JB, Araujo RC, Heppenstall PA, Stucky CL, Silva JA Jr, Walther T, et al,. (2000). Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors. Proc Natl Acad Sci U S A 97: 8140-8145.
44. Phagoo SB, Poole S, Leeb-Lundberg LM, (1999). Autoregulation of bradykinin receptors: agonists in the presence of interleukin-1beta shift the repertoire of receptor subtypes from B2 to B1 in human lung fibroblasts. Mol Pharmacol 56: 325-333.
45. Polosa R, (1993). Role of the kinin-kallikrein pathway in allergic diseases. Allergy 48: 217-225.
46. Prichett W, Hand A, Sheilds J, Dunnington D, (1995). Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha. J Inflamm 45: 97-105.
47. 2 release in airway smooth muscle. Biochem J 328 (Pt 2): 689-694.
48. Quintao NL, Passos GF, Medeiros R, Paszcuk AF, Motta FL, Pesquero JB, et al,. (2008). Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. J Neurosci 28: 2856-2863.
49. Rainsford KD, (2009). Ibuprofen: pharmacology, efficacy and safety. Inflammopharmacology 17: 275-342.
50. Regoli D, Barabe J, (1980). Pharmacology of bradykinin and related kinins. Pharmacol Rev 32: 1-46.
51. Regoli D, Nsa Allogho S, Rizzi A, Gobeil FJ, (1998). Bradykinin receptors and their antagonists. Eur J Pharmacol 348: 1-10.
52. Ritchie RH, Marsh JD, Schiebinger RJ, (1999). Bradykinin-stimulated protein synthesis by myocytes is dependent on the MAP kinase pathway and p70(S6K). Am J Physiol 276: H1393-H1398.
53. Rooks DS, (2007). Fibromyalgia treatment update. Curr Opin Rheumatol 19: 111-117.
54. Rosendal L, Sogaard K, Kjaer M, Sjogaard G, Langberg H, Kristiansen J, (2005). Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise. J Appl Physiol 98: 477-481.
55. Sawamura S, Fujinaga M, Kingery WS, Belanger N, Davies MF, Maze M, (1999). Opioidergic and adrenergic modulation of formalin-evoked spinal c-fos mRNA expression and nocifensive behavior in the rat. Eur J Pharmacol 379: 141-149.
56. Schafers M, Sorkin LS, Sommer C, (2003). Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats. Pain 104: 579-588.
57. Schanstra JP, Bataille E, Marin Castano ME, Barascud Y, Hirtz C, Pesquero JB, et al,. (1998). The B1-agonist [des-Arg10]-kallidin activates transcription factor NF-kappaB and induces homologous upregulation of the bradykinin B1-receptor in cultured human lung fibroblasts. J Clin Invest 101: 2080-2091.
58. Sugiyama S, Okada Y, Sukhova GK, Virmani R, Heinecke JW, Libby P, (2001). Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes. Am J Pathol 158: 879-891.
59. Tian LJ, Du YR, Xiao Y, Lv ZM, Yu YQ, Cui XY, et al,. (2009). Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde. Sheng Li Xue Bao 61: 404-416.
60. Tjolsen A, Berge OG, Hunskaar S, Rosland JH, Hole K, (1992). The formalin test: an evaluation of the method. Pain 51: 5-17.
61. Vadakkan KI, Wang H, Ko SW, Zastepa E, Petrovic MJ, Sluka KA, et al,. (2006). Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases. Mol Pain 2: 7-17.
62. Wallace DJ, Linker-Israeli M, Hallegua D, Silverman S, Silver D, Weisman MH, (2001). Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study. Rheumatology (Oxford) 40: 743-749.
63. Werner MF, Kassuya CA, Ferreira J, Zampronio AR, Calixto JB, Rae GA, (2007). Peripheral kinin B(1) and B(2) receptor-operated mechanisms are implicated in neuropathic nociception induced by spinal nerve ligation in rats. Neuropharmacology 53: 48-57.
64. Wirth K, Hock FJ, Albus U, Linz W, Alpermann HG, Anagnostopoulos H, et al,. (1991). Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies. Br J Pharmacol 102: 774-777.
65. Young P, McDonnell P, Dunnington D, Hand A, Laydon J, Lee J, (1993). Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level. Agents Actions 39: Spec No: C67-C69.
66. Zhao WQ, Ravindranath L, Mohamed AS, Zohar O, Chen GH, Lyketsos CG, et al,. (2002). MAP kinase signaling cascade dysfunction specific to Alzheimer's disease in fibroblasts. Neurobiol Dis 11: 166-183.
67. Ziltener JL, Leal S, Fournier PE, (2010). Non-steroidal anti-inflammatory drugs for athletes: an update. Ann Phys Rehabil Med 53: 278-282, 282-288.
68. Zimmermann M, (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110.