Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis

Journal of Biological Chemistry

Volumn 287, Issue 20, 2012, Pages 16390-16398

  Liu, Changxuan ^a,b   Bai, Yan ^a   Chen, Yiliang ^a   Wang, Yu ^a,b   Sottejeau, Yoann ^a   Liu, Lijun ^a   Li, Xiaomei ^b   Lingrel, Jerry B ^c   Malhotra, Deepak ^a   Cooper, Christopher J ^a   Shapiro, Joseph I ^a   Xie, Zi Jian ^a   Tian, Jiang ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b PEKING UNIVERSITY FIRST HOSPITAL   (China)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; BASAL LEVELS; CARDIAC CONTRACTILITY; CARDIAC MYOCYTES; CARDIOTONIC STEROIDS; CASPASES; GROWTH INHIBITION; HEART FAILURE; HEART FUNCTION; IN-VITRO; KNOCK OUTS; LEFT VENTRICLES; MYOCYTES; RAPAMYCIN; S6 KINASE; SIGNALING PATHWAYS; WILD TYPES;

ACTIVATION ANALYSIS; ANTIBIOTICS; CARDIOLOGY; CELL CULTURE; HEART; MAMMALS; PHOSPHORYLATION;

CELL DEATH;

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CASPASE 8; CASPASE 9; MAMMALIAN TARGET OF RAPAMYCIN; MARINOBUFAGENIN; PROTEIN BAD; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; S6 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; HEART CELL CULTURE; HEART DILATATION; HEART DISEASE; HEART LEFT VENTRICLE; HEART MUSCLE CELL; IN VITRO STUDY; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; BUFANOLIDES; CASPASE 8; CASPASE 9; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; HEART DISEASES; MICE; MICE, MUTANT STRAINS; MUSCLE PROTEINS; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIROLIMUS; SODIUM-POTASSIUM-EXCHANGING ATPASE; SRC-FAMILY KINASES; TOR SERINE-THREONINE KINASES;

ANIMALIA; LAKE VICTORIA MARBURGVIRUS; MUS;

EID: 84860849880     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.304451     Document Type: Article

References (37)

1. Nørgaard, A., Bagger, J. P., Bjerregaard, P., Baandrup, U., Kjeldsen, K., and Thomsen, P. E. (1988) Relation of left ventricular function and Na,K-pump concentration in suspected idiopathic dilated cardiomyopathy. Am. J. Cardiol. 61, 1312-1315
2. +-pump capacity in congestive heart failure following myocardial infarction in rats. J. Mol. Cell Cardiol. 30, 1311-1328
3. Fraser, C. L., and Arieff, A. I. (2001) Na-K-ATPase activity decreases with aging in female rat brain synaptosomes. Am. J. Physiol. Renal Physiol. 281, F674-678
4. Kawamoto, E. M., Munhoz, C. D., Lepsch, L. B., de Sá Lima, L., Glezer, I., Markus, R. P., de Silva, C. L., Camarini, R., Marcourakis, T., and Scavone, C. (2008) Age-related changes in cerebellar phosphatase-1 reduce Na,KATPase activity. Neurobiol. Aging 29, 1712-1720
5. +-ATPase gene expression by insulin in vascular smooth muscle cells. Am. J. Hypertens. 6, 626-629
6. Chen, S., Yuan, C., Clough, D., Schooley, J., Haddy, F. J., and Pamnani, M. B. (1993) Role of digitalis-like substance in the hypertension of streptozotocin- induced diabetes in reduced renal mass rats. Am. J. Hypertens. 6, 397-406 (Pubitemid 23161691)
7. Clerico, A., and Giampietro, O. (1990) Is the endogenous digitalis-like factor the link between hypertension and metabolic disorders as diabetes mellitus, obesity, and acromegaly? Clin. Physiol. Biochem. 8, 153-168 (Pubitemid 20290790)
8. Harik, S. I., Mitchell, M. J., and Kalaria, R. N. (1989) Ouabain binding in the human brain. Effects of Alzheimer disease and aging. Arch. Neurol. 46, 951-954 (Pubitemid 19227216)
9. 2+-ATPase and some soluble enzymes related to energy metabolism in brains of patients with Alzheimer disease. Neurosci. Lett. 112, 338-342
10. James, P. F., Grupp, I. L., Grupp, G., Woo, A. L., Askew, G. R., Croyle, M. L., Walsh, R. A., and Lingrel, J. B. (1999) Identification of a specific role for the Na,K-ATPase α2 isoform as a regulator of calcium in the heart. Mol. Cell 3, 555-563 (Pubitemid 29268439)
11. Moseley, A. E., Cougnon, M. H., Grupp, I. L., El Schultz, J., and Lingrel, J. B. (2004) Attenuation of cardiac contractility in Na,K-ATPase α1 isoform-deficient hearts under reduced calcium conditions. J. Mol. Cell Cardiol. 37, 913-919 (Pubitemid 39446816)
12. Schoner, W., and Scheiner-Bobis, G. (2007) Endogenous and exogenous cardiac glycosides: Their roles in hypertension, salt metabolism, and cell growth. Am. J. Physiol. Cell Physiol. 293, C509-C536 (Pubitemid 47235171)
13. Aydemir-Koksoy, A., Abramowitz, J., and Allen, J. C. (2001) Ouabain-induced signaling and vascular smooth muscle cell proliferation. J. Biol. Chem. 276, 46605-46611
14. Liu, L., Abramowitz, J., Askari, A., and Allen, J. C. (2004) Role of caveolae in ouabain-induced proliferation of cultured vascular smooth muscle cells of the synthetic phenotype. Am. J. Physiol. Heart Circ. Physiol. 287, H2173-2182 (Pubitemid 39433392)
15. Tian, J., Li, X., Liang, M., Liu, L., Xie, J. X., Ye, Q., Kometiani, P., Tillekeratne, M., Jin, R., and Xie, Z. (2009) Changes in sodium pump expression dictate the effects of ouabain on cell growth. J. Biol. Chem. 284, 14921-14929
16. Komiyama, Y., Dong, X. H., Nishimura, N., Masaki, H., Yoshika, M., Masuda, M., and Takahashi, H. (2005) A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure. Clin. Biochem. 38, 36-45 (Pubitemid 39647654)
17. Kashkin, V. A., Bagrov, A. Y., Fedorova, O. V., Bagrov, Y. Y., Agalakova, N. I., Patkina, N. A., and Zvartau, E. E. (2002) Marinobufagenin (MBG) suppression of ethanol-seeking behavior is associated with inhibition of brain cortex Na/K-ATPase in mice. Eur. Neuropsychopharmacol. 12, 217-223 (Pubitemid 34462214)
18. Hamlyn, J. M., and Manunta, P. (1992) Ouabain, digitalis-like factors and hypertension. J. Hypertens. Suppl. 10, S99-111
19. Balzan, S., Neglia, D., Ghione, S., D'Urso, G., Baldacchino, M. C., Montali, U., and L'Abbate, A. (2001) Increased circulating levels of ouabain-like factor in patients with asymptomatic left ventricular dysfunction. Eur. J. Heart Fail 3, 165-171 (Pubitemid 32216656)
20. Nadal-Ginard, B., Kajstura, J., Leri, A., and Anversa, P. (2003) Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ. Res. 92, 139-150 (Pubitemid 36254270)
21. Kennedy, D. J., Elkareh, J., Shidyak, A., Shapiro, A. P., Smaili, S., Mutgi, K., Gupta, S., Tian, J., Morgan, E., Khouri, S., Cooper, C. J., Periyasamy, S. M., Xie, Z., Malhotra, D., Fedorova, O. V., Bagrov, A. Y., and Shapiro, J. I. (2008) Partial nephrectomy as a model for uremic cardiomyopathy in the mouse. Am. J. Physiol. Renal Physiol. 294, F450-454 (Pubitemid 351199411)
22. O'Connell, T. D., Rodrigo, M. C., and Simpson, P. C. (2007) Isolation and culture of adult mouse cardiac myocytes. Methods Mol. Biol. 357, 271-296 (Pubitemid 350183253)
23. Peng, M., Huang, L., Xie, Z., Huang, W. H., and Askari, A. (1996) Partial inhibition of Na+/K+-ATPase by ouabain induces the Ca2+-dependent expressions of early-response genes in cardiac myocytes. J. Biol. Chem. 271, 10372-10378
24. Elkareh, J., Kennedy, D. J., Yashaswi, B., Vetteth, S., Shidyak, A., Kim, E. G. R., Smaili, S., Periyasamy, S. M., Hariri, I. M., Fedorova, L., Liu, J., Wu, L., Kahaleh, M. B., Xie, Z., Malhotra, D., Fedorova, O. V., Kashkin, V. A., Bagrov, A. Y., and Shapiro, J. I. (2007) Hypertension %R 10.1161/01.HYP. 0000252409.36927.05 49, 215-224
25. Tian, J., Shidyak, A., Periyasamy, S. M., Haller, S., Taleb, M., El-Okdi, N., Elkareh, J., Gupta, S., Gohara, S., Fedorova, O. V., Cooper, C. J., Xie, Z., Malhotra, D., Bagrov, A. Y., and Shapiro, J. I. (2009) Spironolactone attenuates experimental uremic cardiomyopathy by antagonizing marinobufagenin. Hypertension 54, 1313-1320
26. Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C., and Kitsis, R. N. (2003) A mechanistic role for cardiac myocyte apoptosis in heart failure. J. Clin. Invest. 111, 1497-1504 (Pubitemid 38063282)
27. Li, Q., Li, B., Wang, X., Leri, A., Jana, K. P., Liu, Y., Kajstura, J., Baserga, R., and Anversa, P. (1997) Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. The J. Clin. Invest. 100, 1991-1999 (Pubitemid 27459352)
28. Haunstetter, A., and Izumo, S. (1998) Apoptosis: Basic mechanisms and implications for cardiovascular disease. Circulation research 82, 1111-1129 (Pubitemid 28311120)
29. Harada, H., Andersen, J. S., Mann, M., Terada, N., and Korsmeyer, S. J. (2001) p70S6 kinase signals cell survival as well as growth, inactivating the proapoptotic molecule BAD. Proc. Natl. Acad. Sci. U.S.A. 98, 9666-9670 (Pubitemid 32769360)
30. Rathore, S. S., Curtis, J. P., Wang, Y., Bristow, M. R., and Krumholz, H. M. (2003) Association of serum digoxin concentration and outcomes in patients with heart failure. Jama 289, 871-878 (Pubitemid 37430346)
31. Basset, O., Boittin, F. X., Cognard, C., Constantin, B., and Ruegg, U. T. (2006) Bcl-2 overexpression prevents calcium overload and subsequent apoptosis in dystrophic myotubes. Biochem. J. 395, 267-276
32. Cho, S. Y., Lee, J. H., Bae, H. D., Jeong, E. M., Jang, G. Y., Kim, C. W., Shin, D. M., Jeon, J. H., and Kim, I. G. (2010) Transglutaminase 2 inhibits apoptosis induced by calcium- overload through down-regulation of Bax. Exp. Mol. Med. 42, 639-650
33. Liang, M., Tian, J., Liu, L., Pierre, S., Liu, J., Shapiro, J., and Xie, Z. J. (2007) Identification of a pool of non-pumping Na/K-ATPase. J. Biol. Chem. 282, 10585-10593 (Pubitemid 47093457)
34. Liang, M., Cai, T., Tian, J., Qu, W., and Xie, Z. J. (2006) Functional characterization of Src-interacting Na/K-ATPase using RNA interference assay. J. Biol. Chem. 281, 19709-19719 (Pubitemid 44035473)
35. +- ATPase. J. Biol. Chem. 275, 27832-27837
36. Cheung, E. C., and Slack, R. S. (2004) Emerging role for ERK as a key regulator of neuronal apoptosis. Sci. STKE 2004, PE45
37. Fink, S. L., and Cookson, B. T. (2005) Apoptosis, pyroptosis, and necrosis: Mechanistic description of dead and dying eukaryotic cells. Infect Immun. 73, 1907-1916 (Pubitemid 40470787)