Attenuation of cardiac contractility in Na,K-ATPase α1 isoform-deficient hearts under reduced calcium conditions

Journal of Molecular and Cellular Cardiology

Volumn 37, Issue 5, 2004, Pages 913-919

  Moseley, Amy E ^a   Cougnon, Marc H ^a   Grupp, Ingrid L ^a   El Schultz, Jo ^a   Lingrel, Jerry B ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BUFFER; CALCIUM; ISOENZYME; OUABAIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME DEFICIENCY; ENZYME INHIBITION; EXAMINATION; EXTRACELLULAR CALCIUM; HEART MUSCLE CONTRACTILITY; HEART MUSCLE RELAXATION; HEART PERFORMANCE; HEART PERFUSION; HEART VENTRICLE OVERLOAD; MALE; MOUSE; NONHUMAN; OBSERVATION; PHENOTYPE; PRIORITY JOURNAL; UPREGULATION; WILD TYPE;

ANIMALS; CALCIUM; MICE; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; MYOSIN HEAVY CHAINS; NA(+)-K(+)-EXCHANGING ATPASE; OUABAIN; TROPOMYOSIN; TROPONIN I; UP-REGULATION; VENTRICULAR PRESSURE;

STROPHANTHUS GRATUS;

EID: 7444270766     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2004.06.005     Document Type: Article

References (18)

1. Glitsch H.G. Electrophysiology of the sodium-potassium-ATPase in cardiac cells Physiol Rev 81 4 2001 1791 1826
2. Clausen T. The sodium pump keeps us going Ann NY Acad Sci 986 2003 595 602
3. +-ATPase (NKA) Prog Clin Biol Res 258 1988 215 222
4. Adams R.J., Schwartz A., Grupp G., Grupp I., Lee S.W., and Wallick E.T. High-affinity ouabain binding site and low-dose positive inotropic effect in rat myocardium Nature 296 5853 1982 167 169
5. 2+ transients in the human heart J Appl Physiol 83 2 1997 652 660
6. Hasenfuss G., Mulieri L.A., Allen P.D., Just H., and Alpert N.R. Influence of isoproterenol and ouabain on excitation-contraction coupling, cross-bridge function, and energetics in failing human myocardium Circulation 94 12 1996 3155 3160
7. McDonough A.A., Velotta J.B., Schwinger R.H., Philipson K.D., and Farley R.A. The cardiac sodium pump: structure and function Basic Res Cardiol 97 Suppl 1 2002 I19 I24
8. Dostanic I., Lorenz J.N., Schultz J.J., Grupp I.L., Neumann J.C., and Wani M.A. The alpha2 isoform of Na,K-ATPase mediates ouabain-induced cardiac inotropy in mice J Biol Chem 278 52 2003 53026 53034
9. James P.F., Grupp I.L., Grupp G., Woo A.L., Askew G.R., and Croyle M.L. Identification of a specific role for the Na,K-ATPase alpha2 isoform as a regulator of calcium in the heart Mol Cell 3 5 1999 555 563
10. 2+ exchanger is essential for the action of cardiac glycosides Circ Res 90 3 2002 305 308
11. Schwartz A., and Petrashevskaya N.N. The importance of calcium in interpretation of NaK-ATPase isoform function in the mouse heart Cardiovasc Res 51 1 2001 9 12
12. Moseley A.E., Lieske S.P., Wetzel R.K., James P.F., He S., and Shelly D.A. The Na,K-ATPase alpha2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice J Biol Chem 278 7 2003 5317 5324
13. Bronson D.D., and Schachat F.H. Heterogeneity of contractile proteins. Differences in tropomyosin in fast, mixed, and slow skeletal muscles of the rabbit J Biol Chem 257 7 1982 3937 3944
14. Li T., and Vassalle M. The negative inotropic effect of calcium overload in cardiac Purkinje fibers J Mol Cell Cardiol 16 1 1984 65 77
15. i transients in mouse ventricular myocytes Biophys J 80 3 2001 1230 1237
16. Hartford A.K., Messer M.L., Moseley A.E., Lingrel J.B., and Delamere N.A. Na,K-ATPase alpha2 inhibition alters calcium responses in optic nerve astrocytes Glia 45 3 2004 229 237
17. 2+ signaling Am J Physiol Cell Physiol 284 2 2003 C475 C486
18. Lencesova L., O'Neill A., Resneck W.G., Bloch R.J., and Blaustein M.P. Plasma membrane-cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes J Biol Chem 279 4 2004 2885 2893