Marinobufagenin (MBG) suppression of ethanol-seeking behavior is associated with inhibition of brain cortex Na/K-ATPase in mice

European Neuropsychopharmacology

Volumn 12, Issue 3, 2002, Pages 217-223

  Kashkin, Vladimir A ^a   Bagrov, Alexei Y ^b,c   Fedorova, Olga V ^b,c   Bagrov, Yakov Y ^b   Agalakova, Natalia I ^c   Patkina, Nadezhda A ^a   Zvartau, Edwin E ^a  

^a PAVLOV FIRST SAINT PETERSBURG STATE MEDICAL UNIVERSITY   (Russian Federation)

^b SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Ethanol; Marinobufagenin; Na K ATPase; Ouabain; Self administration

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALCOHOL; DIGITALIS LIKE FACTOR; LIGAND; MARINOBUFAGENIN; STEROID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BEHAVIOR; BLOOD LEVEL; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVITY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL;

ALCOHOL DRINKING; ANIMALS; BEHAVIOR, ADDICTIVE; BUFANOLIDES; CARDENOLIDES; CEREBRAL CORTEX; DIGOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MALE; MICE; MICE, INBRED DBA; NA(+)-K(+)-EXCHANGING ATPASE; SAPONINS;

EID: 0036238165     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(02)00026-3     Document Type: Article

References (36)

1. Inhibition of Na/K ATPase from rat aorta by two endogenous Na/K pump inhibitors, ouabain and marinobufagenin. Evidence of interaction with different alpha-subunit isoforms
2. Endogenous marinobufagenin-like immunoreactive factor and Na, K-ATPase inhibition during voluntary hypoventilation
3. Competition of ethanol with endogenous digoxin-like factor as a possible mechanism of addiction
4. Characterization of a urinary bufodienolide Na, K-ATPase inhibitor in patients after acute myocardial infarction
5. Involvement of endogenous digitalis-like factors in voluntary selection of alcohol by rats
6. Digitalis-like factors and ethanol consumption and reward
7. Endogenous digitalis-like ligands of the sodium pump: Possible involvement in mood control and ethanol addiction
8. 2+ stores and cell responsiveness
9. A concept of natriuretic hormone
10. The Na, K-ATPase hypothesis for bipolar illness
11. Endogenous Na, K pump ligands are differentially regulated during acute NaCl loading of Dahl rats
12. Nanomolar concentrations of ouabain block ethanol-inducible Na, K-ATPase activity in brain
13. Stimulation of Na, K-ATPase by ethanol: Possible involvement of an isozyme-specific inhibitor of Na/K-ATPase
14. Ethanol may stimulate or inhibit Na, K-ATPase, depending upon Na and K concentrations
15. Immunoreactivity of endogenous digitalis-like factors
16. Stress-induced elevation of ouabain-like compound in rat plasma and adrenal
17. Endogenous digoxin-like immunoreactive factor (DLIF) serum concentrations are decreased in manic bipolar patients compared to normal controls
18. An inhibitor of the sodium pump obtained from human placenta
19. Intravenous heroin and ethanol self-administration by alcohol-preferring AA and alcohol-avoiding ANA rats
20. Effects of calcium channel blockade on intravenous self-administration of ethanol in rats
21. Lithium prevents ouabain-induced behavioral changes. Toward an animal model for manic depression
22. Identification of digitalis-like compounds in human cataractous lenses
23. Purification of an endogenous digitalis-like factor from human plasma for structural analysis
24. Neurobiological similarities in depression and drug dependence: A self-medication hypothesis
25. Erythrocyte membrane cation carrier in depressive illness
26. Effects of ethanol on ouabain inhibition of mouse brain Na, K-ATPase activity
27. How many endobains are there?
28. Persistent hyperreactivity following a single intracerebroventricular dose of ouabain
29. Decreased activity of erythrocyte membrane ATPases in depression and schizophrenia
30. Pulse pressure correlates in humans with a proscillaridin A immunoreactive compound
31. Sodium pump isoform specificity for the digitalis-like factor isolated from human peritoneal dialysate
32. Physicochemical characterization of an ouabain isomer isolated from bovine hypothalamus
33. Systems of reinforcement and drug dependence
34. Distribution of the endogenous digitalis-like substance (EDLS)-containing neurons labeled by digoxin antibody in hypothalamus and three circumventricular organs of dog and macaque
35. Experimental study of the abuse potential of `minor' addictive substances with special reference to alcohol
36. Reinforcing effects of ethanol (EtOH) and EtOH-associated stimuli in rodents