Endogenous anticancer mechanisms: Metastasis

Frontiers in Bioscience - Elite

Volumn 4 E, Issue 5, 2012, Pages 1888-1897

  Valastyan, Scott ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Breast cancer; Cancer; Cancer therapy; E cadherin; Epithelial mesenchymal transition; Invasion metastasis cascade; Metastasis; Metastatic colonization; MicroRNA; MiR 31; MiR 335; NM23; Review; Tumor initiating cell

Indexed keywords

ALPHA CATENIN; ALPHA5 INTEGRIN; BETA CATENIN; BIM PROTEIN; BINDING PROTEIN; C MER TYROSINE KINASE; CONNECTIVE TISSUE GROWTH FACTOR; FRIZZLED 3 PROTEIN; FRIZZLED PROTEIN; MATRIX METALLOPROTEINASE 16; MICRORNA; MICRORNA 31; MICRORNA 335; NUCLEOSIDE DIPHOSPHATE KINASE NM23; PROTEIN; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; RADIXIN; RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASE 2; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA PROTEIN 1; SPECIAL AT RICH SEQUENCE BINDING PROTEIN 2; TENASCIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX4; TRANSCRIPTION FACTOR ZEB1; TRANSCRIPTION FACTOR ZEB2; UNCLASSIFIED DRUG; UVOMORULIN; WASP FAMILY VERPROLIN HOMOLOGOUS PROTEIN 3; CADHERIN; NME1 PROTEIN, HUMAN;

ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER GROWTH; CARCINOMA CELL; CHROMOSOME DELETION; DOWN REGULATION; EPIGENETICS; GENE EXPRESSION; GENE SILENCING; HUMAN; METASTASIS INHIBITION; METASTASIS POTENTIAL; NONHUMAN; PLEIOTROPY; SIGNAL TRANSDUCTION; TUMOR INVASION; ANIMAL; CANCER INVASION; METASTASIS; PHYSIOLOGY; REVIEW;

ANIMALS; CADHERINS; HUMANS; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NM23 NUCLEOSIDE DIPHOSPHATE KINASES;

EID: 84860847314     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: 10.2741/e510     Document Type: Article

References (35)

1. G.P. Gupta and J. Massagué: Cancer metastasis: building a framework. Cell 127, 679-695 (2006) (Pubitemid 44781029)
2. I.J. Fidler: The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 3, 453-458 (2003) (Pubitemid 37328849)
3. P. Friedl and K. Wolf: Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3, 362-374 (2003) (Pubitemid 37328856)
4. J.P. Thiery, H. Acloque, R.Y.J. Huang, and M.A. Neito: Epithelial-mesenchymal transitions in development and disease. Cell 139, 871-890 (2009)
5. T.T. Onder, P.B. Gupta, S.A. Mani, J. Yang, E.S. Lander, and R.A. Weinberg: Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 68, 3645-3654 (2008)
6. P.W. Derksen, X. Liu, F. Saridin, H. van der Gulden, J. Zevenhoven, B. Evers, J.R. van Beijnum, A.W. Griffioen, J. Vink, P. Krimpenfort, J.L. Peterse, R.D. Cardiff, A. Berns, and J. Jonkers: Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell 10, 437-449 (2006) (Pubitemid 44693469)
7. T. Hao-Xiang, W. Qian, C. Lian-Zhou, H. Zhao-Hui, C. Jin-Song, F. Xin-Hui, C. Liang-Qi, C. Xi-Ling, L. Wen, and Z. Long-Juan: MicroRNA-9 reduces cell invasion and E-cadherin secretion in SK-Hep-1 cell. Med Oncol 27, 654-660 (2010)
8. L. Ma, J. Young, H. Prabhala, E. Pan, P. Mestdagh, D. Muth, J. Teruya-Feldstein, F. Reinhardt, T.T. Onder, S. Valastyan, F. Westermann, F. Speleman, J. Vandesompele, and R.A. Weinberg: miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 12, 247-256 (2010)
9. P.B. Gupta, T.T. Onder, G. Jiang, K. Tao, C. Kuperwasser, R.A. Weinberg, and E.S. Lander: Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138, 645-659 (2009)
10. S. Valastyan and R.A. Weinberg: MicroRNAs: crucial multi-tasking components in the complex circuitry of tumor metastasis. Cell Cycle 8, 3506-3512 (2009)
11. D.P. Bartel: MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009)
12. R.C. Friedman, K.K. Farh, C.B. Burge, and D.P. Bartel: Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19, 92-105 (2009)
13. G.A. Calin and C.M. Croce: MicroRNA signatures in human cancers. Nat Rev Cancer 6, 857-866 (2006) (Pubitemid 44629897)
14. S. Valastyan and R.A. Weinberg: miR-31: a crucial overseer of tumor metastasis and other emerging roles. Cell Cycle. 9, 2124-2129 (2010)
15. S. Valastyan, F. Reinhardt, N. Benaich, D. Calogrias, A.M. Szász, Z.C. Wang, J.E. Brock, A.L. Richardson, and R.A. Weinberg: A pleiotropically acting microRNA, miR- 31, inhibits breast cancer metastasis. Cell 137, 1032-1046 (2009)
16. R. Beroukhim, C.H. Mermel, D. Porter, G. Wei, S. Raychaudhuri, J. Donovan, J. Barretina, J.S. Boehm, J. Dobson, M. Urashima, K.T. McHenry, R.M. Pinchback, A.H. Ligon, Y.J. Cho, L. Haery, H. Greulich, M. Reich, W. Winckler, M.S. Lawrence, B.A. Weir, K.E. Tanaka, D.Y. Chiang, A.J. Bass, A. Loo, C. Hoffman, J. Prensner, T. Liefeld, Q. Gao, D. Yecies, S. Signoretti, E. Maher, F.J. Kaye, H. Sasaki, J.E. Tepper, J.A. Fletcher, J. Tabernero, J. Baselga, M.S. Tsao, F. Demichelis, M.A. Rubin, P.A. Janne, M.J. Daly, C. Nucera, R.L. Levine, B.L. Ebert, S. Gabriel, A.K. Rustgi, C.R. Antonescu, M. Ladanyi, A. Letai, L.A. Garraway, M. Loda, D.G. Beer, L.D. True, A. Okamoto, S.L. Pomeroy, S. Singer, T.R. Golub, E.S. Lander, G. Getz, W.R. Sellers, and M. Meyerson: The landscape of somatic copy-number alterations across human cancer. Nature 463, 899-905 (2010)
17. C. Sherr C and F. McCormick: The RB and p53 pathways in cancer. Cancer Cell 2, 103-112 (2002) (Pubitemid 41039110)
18. B.A. Weir, M.S. Woo, G. Getz, S. Perner, L. Ding, R. Beroukhim, W.M. Lin, M.A. Province, A. Kraja, L.A. Johnson, K. Shah, M. Sato, R.K. Thomas, J.A. Barletta, I.B. Borecki, S. Broderick, A.C. Chang, D.Y. Chiang, L.R. Chirieac, J. Cho, Y. Fujii, A.F. Gazdar, T. Giordano, H. Greulich, M. Hanna, B.E. Johnson, M.G. Kris, A. Lash, L. Lin, N. Linderman, E.R. Mardis, J.D. McPherson, J.D. Minna, M.B. Morgan, M. Nadel, M.B. Orringer, J.R. Osborne, B. Ozenberger, A.H. Ramos, J. Robinson, J.A. Roth, V. Rusch, H. Sasaki, F. Shepherd, C. Sougnez, M.R. Spitz, M.S. Tsao, D. Twomey, R.G. Verhaak, G.M. Weinstock, D.A. Wheeler, W. Winckler, A. Yoshizawa, S. Yu, M.F. Zakowski, Q. Zhang, D.G. Beer, I.I. Wistuba, M.A. Watson, L.A. Garraway, M. Ladanyi, W.D. Travis, W. Pao, M.A. Rubin, S.B. Gabriel, R.A. Gibbs, H.E. Varmus, R.K. Wilson, E.S. Lander, and M. Meyerson: Characterizing the cancer genome in lung adenocarcinoma. Nature 450, 893-898 (2007) (Pubitemid 350231325)
19. J. Boström, B. Meyer-Puttlitz, M. Wolter, B. Blaschke, R.G. Weber, P. Lichter, K. Ichimura, V.P Collins, and G. Reifenberger: Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas. Am J Pathol 159, 661-669 (2001) (Pubitemid 32751096)
20. E.J. Lee, M. Baek, Y. Gusev, D.J. Brackett, G.J. Nuovo, and T.D. Schmittgen: Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors. RNA 14, 35-42 (2008)
21. S. Valastyan, N. Benaich, A. Chang, F. Reinhardt, and R.A. Weinberg: Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis. Genes Dev. 23, 2592-2597 (2009)
22. S. Valastyan, A. Chang, N. Benaich, F. Reinhardt, and R.A. Weinberg: Concurrent suppression of integrin α5, radixin, and RhoA phenocopies the effects of miR- 31 on metastasis. Cancer Res. 70: 5147-5153 (2010)
23. K. Sossey-Alaoui, E. Downs-Kelly, L. Izern, R. Tubbs, and E.F. Plow: WAVE3, an actin remodeling protein, is regulated by the metastasis suppressor microRNA, miR-31, during the invasion-metastasis cascade. Int J Cancer, Epub ahead of print (2010)
24. O. Aprelikova, X. Yu, J. Palla, B.R. Wei, S. John, M. Yi, R. Stephens, R.M. Simpson, J.I. Risinger, A. Jazaeri, and J. Niederhuber: The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts. Cell Cycle 9, 4387-4398 (2010)
25. S. Braun, F.D. Vogl, B. Naume, W. Janni, M.P. Osborne, R.C. Coombes, G. Schlimok, I.J. Diel, B. Gerber, G. Gebauer, J.Y. Pierga, C. Marth, D. Oruzio, G. Wiedswang, E.F. Solomayer, G. Kundt, B. Strobel, T. Fehm, G.Y. Wong, J. Bliss, A. Vincent-Salomon, and K. Pantel: A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med 353, 793-802 (2005) (Pubitemid 41215488)
26. K. Pantel, R.H. Brakenhoff, and B. Brandt: Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer 8, 329-340 (2008) (Pubitemid 351596394)
27. S. Valastyan, A. Chang, N. Benaich, F. Reinhardt, and R.A. Weinberg: Activation of miR-31 function in alreadyestablished metastases elicits metastatic regression. Genes Dev 25, 646-657 (2011)
28. H. Clevers: The cancer stem cell: premises, promises and challenges. Nat Med 17, 313-319 (2011)
29. M. Shackleton, E. Quintana, E.R. Fearon, and S.J. Morrison: Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138, 822-829 (2009)
30. S.F. Tavazoie, C. Alarčn, T. Oskarsson, D. Padua, Q. Wang, P.D. Bos, W.L. Gerald, and J. Massagué: Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451, 147-152 (2008)
31. K.J. Png, M. Yoshida, X.H.-F. Zhang, W. Shu, H. Lee, A. Rimner, T.A. Chan, E. Comen, V.P. Andrade, S.W. Kim, T.A. King, C.A. Hudis, L. Norton, J. Hicks, J. Massagué, and S.F. Tavazoie: MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes Dev 25, 226-231 (2011)
32. M. Scarola, S. Schoeftner, C. Schneider, and R. Benetti: miR-335 directly targets Rb1 (pRb/p105) in a proximal connection to p54-depedent stress response. Cancer Res 70, 6925-6933 (2010)
33. S.C. Smith and D. Theodorescu: Learning therapeutic lessons from metastasis suppressor proteins. Nat Rev Cancer 9, 253-264 (2009)
34. P.S. Steeg, C.E. Horak, and K.D. Miller: Clinicaltranslational approaches to the Nm23-H1 metastasis suppressor. Clin Cancer Res 14, 5006-5012 (2008)
35. D. Palmeiri, D.O. Halverson, T. Ouatas, C.E. Horak, M. Salerno, J. Johnson, W.D. Figg, M. Hollingshead, S. Hursting, D. Berrigan, S.M. Steinberg, M.J. Merino, and P.S. Steeg: Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer. J Natl Cancer Inst 97, 632-642 (2005) (Pubitemid 40812627)