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Volumn 7, Issue 2, 2012, Pages 125-132

Chronic myeloid leukemia stem cell biology

Author keywords

BCR ABL; Blast crisis; Bone marrow niche; Cell cycle; Chronic myeloid leukemia; CML; Hematologic malignancies; Hematopoiesis; Hematopoietic progenitors; Leukemia stem cell; LSC; Malignant; Quiescence; Self renewal; Shh . BCL2; Signal transduction; Splicing . Microenvironment; Survival; Therapeutic resistance .RNA; TKI . Imatinib; Tyrosine kinase inhibitors

Indexed keywords

BCR ABL PROTEIN; IMATINIB; PROTEIN TYROSINE KINASE INHIBITOR;

EID: 84860834388     PISSN: 15588211     EISSN: 1558822X     Source Type: Journal    
DOI: 10.1007/s11899-012-0121-6     Document Type: Article
Times cited : (38)

References (45)
  • 1
    • 58949102105 scopus 로고    scopus 로고
    • The MLLgnant consequences of reverting to an embryonic transcriptional program
    • Jamieson C. The MLLgnant consequences of reverting to an embryonic transcriptional program. Cell Stem Cell. 2009;4 (2):97-8.
    • (2009) Cell Stem Cell , vol.4 , Issue.2 , pp. 97-8
    • Jamieson, C.1
  • 2
    • 72849159485 scopus 로고
    • Chromosome studies on normal and leukemic human leukocytes
    • Nowell PC, Hungerford DA. Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst. 1960;25:85-109.
    • (1960) J Natl Cancer Inst , vol.25 , pp. 85-109
    • Nowell, P.C.1    Hungerford, D.A.2
  • 3
    • 0022544401 scopus 로고
    • The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene
    • Ben-Neriah Y, Daley GQ, Mes-Masson AM, et al. The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science. 1986;233 (4760):212-4. (Pubitemid 16008117)
    • (1986) Science , vol.233 , Issue.4760 , pp. 212-214
    • Ben-Neriah, Y.1    Daley, G.Q.2    Mes-Masson, A.-M.3
  • 4
    • 0021802841 scopus 로고
    • Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
    • DOI 10.1038/315550a0
    • Shtivelman E, Lifshitz B, Gale RP, Canaani E. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature. 1985;315 (6020):550-4. (Pubitemid 15021190)
    • (1985) Nature , vol.315 , Issue.6020 , pp. 550-554
    • Shtivelman, E.1    Lifshitz, B.2    Gale, R.P.3    Canaani, E.4
  • 5
    • 0017653321 scopus 로고
    • Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage
    • Fialkow PJ, Jacobson RJ, Papayannopoulou T. Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am J Med. 1977;63 (1):125-30. (Pubitemid 8146659)
    • (1977) American Journal of Medicine , vol.63 , Issue.1 , pp. 125-130
    • Fialkow, P.J.1    Jacobson, R.J.2    Papayannopoulou, T.3
  • 8
    • 78049528573 scopus 로고    scopus 로고
    • Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: The prospective, multicentre stop imatinib (STIM) trial
    • This study highlights the role of therapeutically resistant LSC in progression and relapse of disease in patients with CML
    • Mahon FX, Rea D, Guilhot J, et al. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre stop imatinib (STIM) trial. Lancet Oncol. 2010;11 (11):1029-35. This study highlights the role of therapeutically resistant LSC in progression and relapse of disease in patients with CML.
    • (2010) Lancet Oncol , vol.11 , Issue.11 , pp. 1029-35
    • Mahon, F.X.1    Rea, D.2    Guilhot, J.3
  • 9
    • 33744486584 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
    • DOI 10.1182/blood-2005-07-2947
    • Copland M, Hamilton A, Elrick LJ, et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood. 2006;107 (11):4532-9. (Pubitemid 43801382)
    • (2006) Blood , vol.107 , Issue.11 , pp. 4532-4539
    • Copland, M.1    Hamilton, A.2    Elrick, L.J.3    Baird, J.W.4    Allan, E.K.5    Jordanides, N.6    Barow, M.7    Mountford, J.C.8    Holyoake, T.L.9
  • 10
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham SM, Jorgensen HG, Allan E, et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002;99 (1):319-25.
    • (2002) Blood , vol.99 , Issue.1 , pp. 319-25
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3
  • 11
    • 56649114489 scopus 로고    scopus 로고
    • BCR-ABL-transformed GMP as myeloid leukemic stem cells
    • Minami Y, Stuart SA, Ikawa T, et al. BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci U S A. 2008;105 (46):17967-72.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.46 , pp. 17967-72
    • Minami, Y.1    Stuart, S.A.2    Ikawa, T.3
  • 13
    • 77954564655 scopus 로고    scopus 로고
    • Matricellular proteins: From homeostasis to inflammation, cancer, and metastasis
    • Chiodoni C, Colombo MP, Sangaletti S. Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis. Cancer Metastasis Rev. 2010;29 (2):295-307.
    • (2010) Cancer Metastasis Rev , vol.29 , Issue.2 , pp. 295-307
    • Chiodoni, C.1    Colombo, M.P.2    Sangaletti, S.3
  • 14
    • 77956611808 scopus 로고    scopus 로고
    • Targeting leukemic stem cells by breaking their dormancy
    • Essers MA, Trumpp A. Targeting leukemic stem cells by breaking their dormancy. Mol Oncol. 2010;4 (5):443-50.
    • (2010) Mol Oncol , vol.4 , Issue.5 , pp. 443-50
    • Essers, M.A.1    Trumpp, A.2
  • 15
    • 69849104865 scopus 로고    scopus 로고
    • The leukemic stem cell niche: Current concepts and therapeutic opportunities
    • Lane SW, Scadden DT, Gilliland DG. The leukemic stem cell niche: current concepts and therapeutic opportunities. Blood. 2009;114 (6):1150-7.
    • (2009) Blood , vol.114 , Issue.6 , pp. 1150-7
    • Lane, S.W.1    Scadden, D.T.2    Gilliland, D.G.3
  • 16
    • 77950862042 scopus 로고    scopus 로고
    • Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
    • This study shows that primary stromal dysfunction due to ablation of the Dicer1 gene can result in secondary neoplastic disease, supporting the concept of nicheinduced oncogenesis. This is one of recent seminal studies that underscores the importance of the malignant niche in leukemia development and progression
    • Raaijmakers MH, Mukherjee S, Guo S, et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature. 2010;464 (7290):852-7. This study shows that primary stromal dysfunction due to ablation of the Dicer1 gene can result in secondary neoplastic disease, supporting the concept of nicheinduced oncogenesis. This is one of recent seminal studies that underscores the importance of the malignant niche in leukemia development and progression.
    • (2010) Nature , vol.464 , Issue.7290 , pp. 852-7
    • Raaijmakers, M.H.1    Mukherjee, S.2    Guo, S.3
  • 17
    • 77955646193 scopus 로고    scopus 로고
    • Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
    • This study defines the partnership between somatic and hematopoietic cells indicative of aunique niche in the bone marrow made of heterotypic stem-cell pairs. This highlights the bidirectional nature of interactions between hematopoietic cells and the cellular components of the surrounding stromal microenvironment
    • Mendez-Ferrer S, Michurina TV, Ferraro F, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010;466 (7308):829-34. This study defines the partnership between somatic and hematopoietic cells indicative of aunique niche in the bone marrow made of heterotypic stem-cell pairs. This highlights the bidirectional nature of interactions between hematopoietic cells and the cellular components of the surrounding stromal microenvironment.
    • (2010) Nature , vol.466 , Issue.7308 , pp. 829-34
    • Mendez-Ferrer, S.1    Michurina, T.V.2    Ferraro, F.3
  • 18
    • 38349086394 scopus 로고    scopus 로고
    • CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
    • Jin L, Tabe Y, Konoplev S, et al. CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells. Mol Cancer Ther. 2008;7 (1):48-58.
    • (2008) Mol Cancer Ther , vol.7 , Issue.1 , pp. 48-58
    • Jin, L.1    Tabe, Y.2    Konoplev, S.3
  • 19
    • 62649139996 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation
    • Abrahamsson AE, Geron I, Gotlib J, et al. Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation. Proc Natl Acad Sci U S A. 2009;106 (10):3925-9.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.10 , pp. 3925-9
    • Abrahamsson, A.E.1    Geron, I.2    Gotlib, J.3
  • 20
    • 33748866011 scopus 로고    scopus 로고
    • Hematopoietic stem cell biology: Too much of a Wnt thing
    • DOI 10.1038/ni1006-1021, PII NI1006-1021
    • Trowbridge JJ, Moon RT, Bhatia M. Hematopoietic stem cell biology: too much of a Wnt thing. Nat Immunol. 2006;7 (10): 1021-3. (Pubitemid 44420645)
    • (2006) Nature Immunology , vol.7 , Issue.10 , pp. 1021-1023
    • Trowbridge, J.J.1    Moon, R.T.2    Bhatia, M.3
  • 21
    • 36649002031 scopus 로고    scopus 로고
    • Loss of β-Catenin Impairs the Renewal of Normal and CML Stem Cells In Vivo
    • DOI 10.1016/j.ccr.2007.11.003, PII S1535610807003340
    • Zhao C, Blum J, Chen A, et al. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell. 2007;12 (6):528-41. (Pubitemid 350199070)
    • (2007) Cancer Cell , vol.12 , Issue.6 , pp. 528-541
    • Zhao, C.1    Blum, J.2    Chen, A.3    Kwon, H.Y.4    Jung, S.H.5    Cook, J.M.6    Lagoo, A.7    Reya, T.8
  • 22
    • 58249120738 scopus 로고    scopus 로고
    • Beta-catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia
    • Hu Y, Chen Y, Douglas L, Li S. Beta-catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia. Leukemia. 2009;23 (1):109-16.
    • (2009) Leukemia , vol.23 , Issue.1 , pp. 109-16
    • Hu, Y.1    Chen, Y.2    Douglas, L.3    Li, S.4
  • 23
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • DOI 10.1038/35077219
    • Taipale J, Beachy PA. The hedgehog and Wnt signalling pathways in cancer. Nature. 2001;411 (6835):349-54. (Pubitemid 32467044)
    • (2001) Nature , vol.411 , Issue.6835 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 24
    • 0036559186 scopus 로고    scopus 로고
    • Gli and hedgehog in cancer: Tumours, embryos and stem cells
    • Ruiz i Altaba A, Sanchez P, Dahmane N. Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer. 2002;2 (5):361-72. (Pubitemid 37328949)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.5 , pp. 361-372
    • Ruiz, I.1    Altaba, A.2    Sanchez, P.3    Dahmane, N.4
  • 25
    • 0032126734 scopus 로고    scopus 로고
    • Transducing Hedgehog: The story so far
    • DOI 10.1093/emboj/17.13.3505
    • Ingham PW. Transducing hedgehog: the story so far. EMBO J. 1998;17 (13):3505-11. (Pubitemid 28327369)
    • (1998) EMBO Journal , vol.17 , Issue.13 , pp. 3505-3511
    • Ingham, P.W.1
  • 27
    • 33644525274 scopus 로고    scopus 로고
    • Gene expression changes associated with progression and response in chronic myeloid leukemia
    • Radich JP, Dai H, Mao M, et al. Gene expression changes associated with progression and response in chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2006;103 (8):2794-9.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.8 , pp. 2794-9
    • Radich, J.P.1    Dai, H.2    Mao, M.3
  • 28
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ, et al. Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science. 2009;324 (5933):1457-61.
    • (2009) Science , vol.324 , Issue.5933 , pp. 1457-61
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3
  • 29
    • 0037118056 scopus 로고    scopus 로고
    • Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E
    • DOI 10.1038/417299a
    • Duman-Scheel M, Weng L, Xin S, Du W. Hedgehog regulates cell growth and proliferation by inducing cyclin D and cyclin E. Nature. 2002;417 (6886):299-304. (Pubitemid 34534713)
    • (2002) Nature , vol.417 , Issue.6886 , pp. 299-304
    • Duman-Scheel, M.1    Weng, L.2    Xin, S.3    Du, W.4
  • 31
    • 79957593717 scopus 로고    scopus 로고
    • CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia
    • Makishima H, Jankowska AM, McDevitt MA, et al. CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia. Blood. 2011;117 (21):e198-206.
    • (2011) Blood , vol.117 , Issue.21
    • Makishima, H.1    Jankowska, A.M.2    McDevitt, M.A.3
  • 32
    • 34250178439 scopus 로고    scopus 로고
    • From mRNA metabolism to cancer therapy: Chronic myelogenous leukemia shows the way
    • DOI 10.1158/1078-0432.CCR-06-2320
    • Perrotti D, Neviani P. From mRNA metabolism to cancer therapy: chronic myelogenous leukemia shows the way. Clin Cancer Res. 2007;13 (6):1638-42. This report provides evidence supporting the utility of targeting aberrant mRNA processing mechanisms in the development of alternative therapies for imatinib-resistant and blast crisis CML. (Pubitemid 46952928)
    • (2007) Clinical Cancer Research , vol.13 , Issue.6 , pp. 1638-1642
    • Perrotti, D.1    Neviani, P.2
  • 33
    • 80053900941 scopus 로고    scopus 로고
    • Frequent pathway mutations of splicing machinery in myelodysplasia
    • Yoshida K, Sanada M, Shiraishi Y, et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 2011;478 (7367):64-9.
    • (2011) Nature , vol.478 , Issue.7367 , pp. 64-9
    • Yoshida, K.1    Sanada, M.2    Shiraishi, Y.3
  • 34
    • 80054010617 scopus 로고    scopus 로고
    • Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
    • This is one of the first studies to identify genetic abnormalities in a component of the cellular splicing machinery that contributes to myeloid abnormalities
    • Papaemmanuil E, Cazzola M, Boultwood J, et al. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med. 2011;365 (15):1384-95. This is one of the first studies to identify genetic abnormalities in a component of the cellular splicing machinery that contributes to myeloid abnormalities.
    • (2011) N Engl J Med , vol.365 , Issue.15 , pp. 1384-95
    • Papaemmanuil, E.1    Cazzola, M.2    Boultwood, J.3
  • 35
    • 84555191727 scopus 로고    scopus 로고
    • Spliceosome mutations in hematopoietic malignancies
    • Hahn CN, Scott HS. Spliceosome mutations in hematopoietic malignancies. Nat Genet. 2011;44 (1):9-10.
    • (2011) Nat Genet , vol.44 , Issue.1 , pp. 9-10
    • Hahn, C.N.1    Scott, H.S.2
  • 36
    • 77954977940 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: Mechanisms of blastic transformation
    • Perrotti D, Jamieson C, Goldman J, Skorski T. Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest. 2010;120 (7):2254-64.
    • (2010) J Clin Invest , vol.120 , Issue.7 , pp. 2254-64
    • Perrotti, D.1    Jamieson, C.2    Goldman, J.3    Skorski, T.4
  • 37
    • 67650646082 scopus 로고    scopus 로고
    • CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
    • Jaiswal S, Jamieson CH, Pang WW, et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. 2009;138 (2):271-85.
    • (2009) Cell , vol.138 , Issue.2 , pp. 271-85
    • Jaiswal, S.1    Jamieson, C.H.2    Pang, W.W.3
  • 38
    • 77954542941 scopus 로고    scopus 로고
    • Molecular pathways to CML stem cells
    • Rice KN, Jamieson CH. Molecular pathways to CML stem cells. Int J Hematol. 2010;91 (5):748-52.
    • (2010) Int J Hematol , vol.91 , Issue.5 , pp. 748-52
    • Rice, K.N.1    Jamieson, C.H.2
  • 39
    • 0033760235 scopus 로고    scopus 로고
    • Detection of different ikaros isoforms in human leukaemias using real-time quantitative polymerase chain reaction
    • Olivero S, Maroc C, Beillard E, et al. Detection of different ikaros isoforms in human leukaemias using real-time quantitative polymerase chain reaction. Br J Haematol. 2000;110 (4):826-30.
    • (2000) Br J Haematol , vol.110 , Issue.4 , pp. 826-30
    • Olivero, S.1    Maroc, C.2    Beillard, E.3
  • 40
    • 67449164508 scopus 로고    scopus 로고
    • Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia
    • Vassen L, Khandanpour C, Ebeling P, et al. Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia. Int J Hematol. 2009;89 (4):422-30.
    • (2009) Int J Hematol , vol.89 , Issue.4 , pp. 422-30
    • Vassen, L.1    Khandanpour, C.2    Ebeling, P.3
  • 42
    • 79954769467 scopus 로고    scopus 로고
    • Three novel alternative splicing mutations in BCR-ABL1 detected in CML patients with resistance to kinase inhibitors
    • Ma W, Giles F, Zhang X, et al. Three novel alternative splicing mutations in BCR-ABL1 detected in CML patients with resistance to kinase inhibitors. Int J Lab Hematol. 2011;33 (3):326-31.
    • (2011) Int J Lab Hematol , vol.33 , Issue.3 , pp. 326-31
    • Ma, W.1    Giles, F.2    Zhang, X.3
  • 43
    • 2342565860 scopus 로고    scopus 로고
    • + hematopoietic progenitor cells
    • DOI 10.1038/sj.leu.2403310
    • Salesse S, Dylla SJ, Verfaillie CM. p210BCR/ABL-induced alteration of pre-mRNA splicing in primary human CD34+ hematopoietic progenitor cells. Leukemia. 2004;18 (4):727-33. (Pubitemid 38500190)
    • (2004) Leukemia , vol.18 , Issue.4 , pp. 727-733
    • Salesse, S.1    Dylla, S.J.2    Verfaillie, C.M.3
  • 44
    • 84855191041 scopus 로고    scopus 로고
    • Accurate identification of A-to-I RNA editing in human by transcriptome sequencing
    • Bahn JH, Lee JH, Li G, et al. Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res. 2011.
    • (2011) Genome Res
    • Bahn, J.H.1    Lee, J.H.2    Li, G.3
  • 45
    • 70349969478 scopus 로고    scopus 로고
    • Mutational evolution in alobular breast tumour profiled at single nucleotide resolution
    • Shah SP, Morin RD, Khattra J, et al. Mutational evolution in alobular breast tumour profiled at single nucleotide resolution. Nature. 2009;461 (7265):809-13.
    • (2009) Nature , vol.461 , Issue.7265 , pp. 809-813
    • Shah, S.P.1    Morin, R.D.2    Khattra, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.