Renal efflux transporter expression in pregnant mice with Type I diabetes

Toxicology Letters

Volumn 211, Issue 3, 2012, Pages 304-311

  Yacovino, Lindsay L ^a,b   Aleksunes, Lauren M ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

Diabetes; Kidney; Mrp; Pregnancy; Renal transporters

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; MULTIDRUG RESISTANCE PROTEIN 6; PREGNANE X RECEPTOR; STREPTOZOCIN; TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; LANGERHANS CELL; MALE; METABOLISM; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; TRANSCRIPTION REGULATION;

ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; CARRIER PROTEINS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; KIDNEY; MICE; MICE, INBRED C57BL; NF-E2-RELATED FACTOR 2; ORGAN SIZE; P-GLYCOPROTEINS; PANCREAS; PPAR ALPHA; PREGNANCY; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER; SIGNAL TRANSDUCTION;

MUS; RODENTIA;

EID: 84860814101     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.04.008     Document Type: Article

References (28)

1. Aleksunes L.M., Augustine L.M., Scheffer G.L., Cherrington N.J., Manautou J.E. Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment. Toxicology 2008, 250:82-88.
2. Aleksunes L.M., Cui Y., Klaassen C.D. Prominent expression of xenobiotic efflux transporters in mouse extraembryonic fetal membranes compared with placenta. Drug Metabolism and Disposition: The Biological Fate of Chemicals 2008, 36:1960-1970.
3. Aleksunes L.M., Goedken M.J., Rockwell C.E., Thomale J., Manautou J.E., Klaassen C.D. Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. Journal of Pharmacology and Experimental Therapeutics 2010, 335:2-12.
4. Aleksunes L.M., Scheffer G.L., Jakowski A.B., Pruimboom-Brees I.M., Manautou J.E. Coordinated expression of multidrug resistance-associated proteins (Mrps) in mouse liver during toxicant-induced injury. Toxicological Sciences 2006, 89:370-379.
5. Aleksunes L.M., Slitt A.L., Maher J.M., Augustine L.M., Goedken M.J., Chan J.Y., Cherrington N.J., Klaassen C.D., Manautou J.E. Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2. Toxicology and Applied Pharmacology 2008, 226:74-83.
6. Cao J., Stieger B., Meier P.J., Vore M. Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy. American Journal of Physiology-Gastrointestinal and Liver Physiology 2002, 283:G757-G766.
7. Cheng Q., Aleksunes L.M., Manautou J.E., Cherrington N.J., Scheffer G.L., Yamasaki H., Slitt A.L. Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Molecular Pharmacology 2008, 5:77-91.
8. Cheng X., Klaassen C.D. Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Drug Metabolism and Disposition: The Biological Fate of Chemicals 2009, 37:2178-2185.
9. Cornelis T., Odutayo A., Keunen J., Hladunewich M. The kidney in normal pregnancy and preeclampsia. Seminars in Nephrology 2011, 31:4-14.
10. Delmastro M.M., Piganelli J.D. Oxidative stress and redox modulation potential in type 1 diabetes. Clinical & Developmental Immunology 2011, 593863.
11. Forsbach-Sanchez G., Tamez-Perez H.E., Vazquez-Lara J. Diabetes and pregnancy. Archives of Medical Research 2005, 36:291-299.
12. He X., Kan H., Cai L., Ma Q. Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes. Journal of Molecular and Cellular Cardiology 2009, 46:47-58.
13. Hebert M.F., Easterling T.R., Kirby B., Carr D.B., Buchanan M.L., Rutherford T., Thummel K.E., Fishbein D.P., Unadkat J.D. Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study. Clinical Pharmacology and Therapeutics 2008, 84:248-253.
14. Jiang T., Huang Z., Lin Y., Zhang Z., Fang D., Zhang D.D. The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy. Diabetes 2010, 59:850-860.
15. Klaassen C.D., Aleksunes L.M. Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacological Reviews 2010, 62:1-96.
16. Maher J.M., Aleksunes L.M., Dieter M.Z., Tanaka Y., Peters J.M., Manautou J.E., Klaassen C.D. Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid. Toxicological Sciences 2008, 106:319-328.
17. Maher J.M., Cheng X., Slitt A.L., Dieter M.Z., Klaassen C.D. Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver. Drug Metabolism and Disposition: The Biological Fate of Chemicals 2005, 33:956-962.
18. Maher J.M., Cheng X., Tanaka Y., Scheffer G.L., Klaassen C.D. Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice. Biochemical Pharmacology 2006, 71:1470-1478.
19. Maher J.M., Dieter M.Z., Aleksunes L.M., Slitt A.L., Guo G., Tanaka Y., Scheffer G.L., Chan J.Y., Manautou J.E., Chen Y., Dalton T.P., Yamamoto M., Klaassen C.D. Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology 2007, 46:1597-1610.
20. Maher J.M., Slitt A.L., Callaghan T.N., Cheng X., Cheung C., Gonzalez F.J., Klaassen C.D. Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha. Biochemical Pharmacology 2006, 72:512-522.
21. More V.R., Wen X., Thomas P., Aleksunes L., Slitt A. Severe diabetes and leptin resistance causes differential hepatic and renal transporter expression in mice. Comparative Hepatology 2012, 11:1-14.
22. More V.R., Slitt A.L. Alteration of hepatic but not renal transporter expression in diet-induced obese mice. Drug Metabolism and Disposition: The Biological Fate of Chemicals 2011, 39:992-999.
23. Nowicki M.T., Aleksunes L.M., Sawant S.P., Dnyanmote A.V., Mehendale H.M., Manautou J.E. Renal and hepatic transporter expression in type 2 diabetic rats. Drug Metabolism Letters 2008, 2:11-17.
24. Powe C.E., Thadhani R. Diabetes and the kidney in pregnancy. Seminars in Nephrology 2011, 31:59-69.
25. Stanton R.C. Oxidative stress and diabetic kidney disease. Current Diabetes Reports 2011, 11:330-336.
26. Taylor R., Davison J.M. Type 1 diabetes and pregnancy. BMJ 2007, 334:742-745.
27. Vargas R., Repke J.T., Ural S.H. Type 1 diabetes mellitus and pregnancy. Reviews in Obstetrics & Gynecology 2010, 3:92-100.
28. Yves J., Valerie V., Katrien V.H., Guy M. Birth weight in type 1 diabetic pregnancy. Obstetrics and Gynecology International 2010, 2010:397623.