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Volumn 51, Issue 9, 2012, Pages 754-760

Loss of Trp53 promotes medulloblastoma development but not skin tumorigenesis in Sufu heterozygous mutant mice

Author keywords

Basal cell carcinoma; Hedgehog; P53; Suppressor of fused

Indexed keywords

REGULATOR PROTEIN; SUPPRESSOR OF FUSED PROTEIN; TRANSFORMATION RELATED PROTEIN 53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84860807392     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20852     Document Type: Article
Times cited : (9)

References (35)
  • 1
    • 52649111039 scopus 로고    scopus 로고
    • Basal cell carcinomas: Attack of the hedgehog
    • Epstein EH. Basal cell carcinomas: Attack of the hedgehog. Nat Rev Cancer 2008; 8: 743-754.
    • (2008) Nat Rev Cancer , vol.8 , pp. 743-754
    • Epstein, E.H.1
  • 2
    • 16044363842 scopus 로고    scopus 로고
    • The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
    • Gailani MR, Stahle-Backdahl M, Leffell DJ, et al. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nat Genet 1996; 14: 78-81.
    • (1996) Nat Genet , vol.14 , pp. 78-81
    • Gailani, M.R.1    Stahle-Backdahl, M.2    Leffell, D.J.3
  • 3
    • 19944433687 scopus 로고    scopus 로고
    • Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas
    • Reifenberger J, Wolter M, Knobbe CB, et al. Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. Br J Dermatol 2005; 152: 43-51.
    • (2005) Br J Dermatol , vol.152 , pp. 43-51
    • Reifenberger, J.1    Wolter, M.2    Knobbe, C.B.3
  • 4
    • 0032080853 scopus 로고    scopus 로고
    • Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    • Reifenberger J, Wolter M, Weber RG, et al. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res 1998; 58: 1798-1803.
    • (1998) Cancer Res , vol.58 , pp. 1798-1803
    • Reifenberger, J.1    Wolter, M.2    Weber, R.G.3
  • 5
    • 0031913524 scopus 로고    scopus 로고
    • Activating smoothened mutations in sporadic basal-cell carcinoma
    • Xie J, Murone M, Luoh SM, et al. Activating smoothened mutations in sporadic basal-cell carcinoma. Nature 1998; 391: 90-92.
    • (1998) Nature , vol.391 , pp. 90-92
    • Xie, J.1    Murone, M.2    Luoh, S.M.3
  • 6
    • 79955508675 scopus 로고    scopus 로고
    • Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations
    • Grachtchouk M, Pero J, Yang SH, et al. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J Clin Invest 2011; 121: 1768-1781.
    • (2011) J Clin Invest , vol.121 , pp. 1768-1781
    • Grachtchouk, M.1    Pero, J.2    Yang, S.H.3
  • 7
    • 0037844870 scopus 로고    scopus 로고
    • The magnitude of hedgehog signaling activity defines skin tumor phenotype
    • Grachtchouk V, Grachtchouk M, Lowe L, et al. The magnitude of hedgehog signaling activity defines skin tumor phenotype. EMBO J 2003; 22: 2741-2751.
    • (2003) EMBO J , vol.22 , pp. 2741-2751
    • Grachtchouk, V.1    Grachtchouk, M.2    Lowe, L.3
  • 9
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi R, Milenkovic L, Scott MP. Patched1 regulates hedgehog signaling at the primary cilium. Science 2007; 317: 372-376.
    • (2007) Science , vol.317 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 10
    • 77950463564 scopus 로고    scopus 로고
    • The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
    • Humke EW, Dorn KV, Milenkovic L, Scott MP, Rohatgi R. The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev 2010; 24: 670-682.
    • (2010) Genes Dev , vol.24 , pp. 670-682
    • Humke, E.W.1    Dorn, K.V.2    Milenkovic, L.3    Scott, M.P.4    Rohatgi, R.5
  • 11
    • 77958508124 scopus 로고    scopus 로고
    • A mechanism for vertebrate hedgehog signaling: Recruitment to cilia and dissociation of SuFu-Gli protein complexes
    • Tukachinsky H, Lopez LV, Salic A. A mechanism for vertebrate hedgehog signaling: Recruitment to cilia and dissociation of SuFu-Gli protein complexes. J Cell Biol 2010; 191: 415-428.
    • (2010) J Cell Biol , vol.191 , pp. 415-428
    • Tukachinsky, H.1    Lopez, L.V.2    Salic, A.3
  • 12
    • 15844386165 scopus 로고    scopus 로고
    • Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    • Hahn H, Wicking C, Zaphiropoulous PG, et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996; 85: 841-851.
    • (1996) Cell , vol.85 , pp. 841-851
    • Hahn, H.1    Wicking, C.2    Zaphiropoulous, P.G.3
  • 13
    • 15844381336 scopus 로고    scopus 로고
    • Human homolog of patched, a candidate gene for the basal cell nevus syndrome
    • Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996; 272: 1668-1671.
    • (1996) Science , vol.272 , pp. 1668-1671
    • Johnson, R.L.1    Rothman, A.L.2    Xie, J.3
  • 14
    • 67649869544 scopus 로고    scopus 로고
    • Identification of a SUFU germline mutation in a family with Gorlin syndrome
    • Pastorino L, Ghiorzo P, Nasti S, et al. Identification of a SUFU germline mutation in a family with Gorlin syndrome. Am J Med Genet Part A 2009; 149A: 1539-1543.
    • (2009) Am J Med Genet Part A , vol.149 A , pp. 1539-1543
    • Pastorino, L.1    Ghiorzo, P.2    Nasti, S.3
  • 15
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • Goodrich LV, Milenkovic L, Higgins KM, Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 1997; 277: 1109-1113.
    • (1997) Science , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 16
    • 0031837454 scopus 로고    scopus 로고
    • Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
    • Hahn H, Wojnowski L, Zimmer AM, Hall J, Miller G, Zimmer A. Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med 1998; 4: 619-622.
    • (1998) Nat Med , vol.4 , pp. 619-622
    • Hahn, H.1    Wojnowski, L.2    Zimmer, A.M.3    Hall, J.4    Miller, G.5    Zimmer, A.6
  • 17
    • 0032694528 scopus 로고    scopus 로고
    • Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
    • Aszterbaum M, Epstein J, Oro A, et al. Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med 1999; 5: 1285-1291.
    • (1999) Nat Med , vol.5 , pp. 1285-1291
    • Aszterbaum, M.1    Epstein, J.2    Oro, A.3
  • 18
    • 10744221671 scopus 로고    scopus 로고
    • Basal cell carcinoma and its development: Insights from radiation-induced tumors in Ptch1-deficient mice
    • Mancuso M, Pazzaglia S, Tanori M, et al. Basal cell carcinoma and its development: Insights from radiation-induced tumors in Ptch1-deficient mice. Cancer Res 2004; 64: 934-941.
    • (2004) Cancer Res , vol.64 , pp. 934-941
    • Mancuso, M.1    Pazzaglia, S.2    Tanori, M.3
  • 19
    • 31744451535 scopus 로고    scopus 로고
    • Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway
    • Svard J, Heby-Henricson K, Persson-Lek M, et al. Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway. Dev Cell 2006; 10: 187-197.
    • (2006) Dev Cell , vol.10 , pp. 187-197
    • Svard, J.1    Heby-Henricson, K.2    Persson-Lek, M.3
  • 20
    • 65649084121 scopus 로고    scopus 로고
    • Tumor suppressor gene co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice
    • Svard J, Rozell B, Toftgard R, Teglund S. Tumor suppressor gene co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice. Mol Carcinog 2009; 48: 408-419.
    • (2009) Mol Carcinog , vol.48 , pp. 408-419
    • Svard, J.1    Rozell, B.2    Toftgard, R.3    Teglund, S.4
  • 21
    • 0035935999 scopus 로고    scopus 로고
    • PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer
    • Ling G, Ahmadian A, Persson A, et al. PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer. Oncogene 2001; 20: 7770-7778.
    • (2001) Oncogene , vol.20 , pp. 7770-7778
    • Ling, G.1    Ahmadian, A.2    Persson, A.3
  • 22
    • 0035863498 scopus 로고    scopus 로고
    • Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
    • Wetmore C, Eberhart DE, Curran T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 2001; 61: 513-516.
    • (2001) Cancer Res , vol.61 , pp. 513-516
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 23
    • 34848893044 scopus 로고    scopus 로고
    • Loss of suppressor-of-fused function promotes tumorigenesis
    • Lee Y, Kawagoe R, Sasai K, et al. Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene 2007; 26: 6442-6447.
    • (2007) Oncogene , vol.26 , pp. 6442-6447
    • Lee, Y.1    Kawagoe, R.2    Sasai, K.3
  • 24
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992; 356: 215-221.
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1    Harvey, M.2    Slagle, B.L.3
  • 25
    • 2142853089 scopus 로고    scopus 로고
    • Generation and characterization of p53 mutant mice
    • Dumble ML, Donehower LA, Lu X. Generation and characterization of p53 mutant mice. Methods Mol Biol 2003; 234: 29-49.
    • (2003) Methods Mol Biol , vol.234 , pp. 29-49
    • Dumble, M.L.1    Donehower, L.A.2    Lu, X.3
  • 27
    • 0027973880 scopus 로고
    • Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development
    • Ramirez A, Bravo A, Jorcano JL, Vidal M. Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development. Differentiation 1994; 58: 53-64.
    • (1994) Differentiation , vol.58 , pp. 53-64
    • Ramirez, A.1    Bravo, A.2    Jorcano, J.L.3    Vidal, M.4
  • 28
    • 0032735482 scopus 로고    scopus 로고
    • The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis
    • Rothnagel JA, Seki T, Ogo M, et al. The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis. Differentiation 1999; 65: 119-130.
    • (1999) Differentiation , vol.65 , pp. 119-130
    • Rothnagel, J.A.1    Seki, T.2    Ogo, M.3
  • 29
    • 0032076143 scopus 로고    scopus 로고
    • Biochemical and immunohistochemical analyses of keratin expression in basal cell carcinoma
    • Yoshikawa K, Katagata Y, Kondo S. Biochemical and immunohistochemical analyses of keratin expression in basal cell carcinoma. J Dermatol Sci 1998; 17: 15-23.
    • (1998) J Dermatol Sci , vol.17 , pp. 15-23
    • Yoshikawa, K.1    Katagata, Y.2    Kondo, S.3
  • 30
    • 38449101897 scopus 로고    scopus 로고
    • Mechanisms regulating epithelial stratification
    • Koster MI, Roop DR. Mechanisms regulating epithelial stratification. Annu Rev Cell Dev Biol 2007; 23: 93-113.
    • (2007) Annu Rev Cell Dev Biol , vol.23 , pp. 93-113
    • Koster, M.I.1    Roop, D.R.2
  • 31
    • 78650811198 scopus 로고    scopus 로고
    • Subtypes of medulloblastoma have distinct developmental origins
    • Gibson P, Tong Y, Robinson G, et al. Subtypes of medulloblastoma have distinct developmental origins. Nature 2010; 468: 1095-1099.
    • (2010) Nature , vol.468 , pp. 1095-1099
    • Gibson, P.1    Tong, Y.2    Robinson, G.3
  • 32
    • 0027179908 scopus 로고
    • In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice
    • Harvey M, Sands AT, Weiss RS, et al. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 1993; 8: 2457-2467.
    • (1993) Oncogene , vol.8 , pp. 2457-2467
    • Harvey, M.1    Sands, A.T.2    Weiss, R.S.3
  • 33
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997; 88: 323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 34
    • 62649094925 scopus 로고    scopus 로고
    • A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers
    • Stecca B, Ruiz I, Altaba A. A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers. EMBO J 2009; 28: 663-676.
    • (2009) EMBO J , vol.28 , pp. 663-676
    • Stecca, B.1    Ruiz, I.2    Altaba, A.3
  • 35
    • 78651467232 scopus 로고    scopus 로고
    • Basal cell carcinomas arise from hair follicle stem cells in ptch1(+/-) mice
    • Wang GY, Wang J, Mancianti ML, Epstein EH Jr. Basal cell carcinomas arise from hair follicle stem cells in ptch1(+/-) mice. Cancer Cell 2011; 19: 114-124.
    • (2011) Cancer Cell , vol.19 , pp. 114-124
    • Wang, G.Y.1    Wang, J.2    Mancianti, M.L.3    Epstein Jr., E.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.