What ARE Parkinson disease? Non-motor features transform conception of the shaking palsy

Neurobiology of Disease

Volumn 46, Issue 3, 2012, Pages 505-507

  Jain, Samay ^a   Goldstein, David S ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN;

ALPHA SYNUCLEIN GENE; AUTONOMIC NERVOUS SYSTEM; AUTOSOMAL DOMINANT INHERITANCE; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM; CLINICAL FEATURE; COGNITIVE DEFECT; DIFFUSE LEWY BODY DISEASE; EDITORIAL; GASTROINTESTINAL SYMPTOM; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; MENTAL DISEASE; MOTOR DYSFUNCTION; NEUROPATHOLOGY; PARASOMNIA; PARKINSON DISEASE; PARKINSONISM; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; QUALITY OF LIFE; SLEEP DISORDER; SMELLING DISORDER;

ANIMALS; AUTONOMIC NERVOUS SYSTEM; DISEASE MODELS, ANIMAL; HUMANS; LEWY BODIES; NERVE DEGENERATION; NEUROTRANSMITTER AGENTS; PARALYSIS; PARKINSON DISEASE; REM SLEEP BEHAVIOR DISORDER;

EID: 84860794476     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.04.013     Document Type: Editorial

References (25)

1. Beach T.G., et al. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol. 2010, 119:689-702.
2. Bloch A., et al. Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathol. Appl. Neurobiol. 2006, 32:284-295.
3. Braak H., Del Tredici K. Invited article: nervous system pathology in sporadic Parkinson disease. Neurology 2008, 70:1916-1925.
4. Braak H., et al. Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res. 2004, 318:121-134.
5. Braak H., et al. Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons. Acta Neuropathol. 2007, 113:421-429.
6. Cersosimo M.G., Benarroch E.E. Pathological correlates of gastrointestinal dysfunction in Parkinson's disease. Neurobiol. Dis. 2012.
7. Chaudhuri K.R., et al. The metric properties of a novel non-motor symptoms scale for Parkinson's disease: results from an international pilot study. Mov. Disord. 2007, 22:1901-1911.
8. Chaudhuri K.R., et al. The non-motor symptom complex of Parkinson's disease: a comprehensive assessment is essential. Curr. Neurol. Neurosci. Rep. 2005, 5:275-283.
9. Dikiy I., Eliezer D. Folding and misfolding of alpha-synuclein on membranes. Biochim. Biophys. Acta 2011, 1818:1013-1018.
10. Doty R.L. Olfaction in Parkinson's disease. Parkinsonism Relat. Disord. 2007, 13(Suppl. 3):S225-S228.
11. Ferrer I. Neuropathology and neurochemistry of nonmotor symptoms in Parkinson's disease. Parkinsons Dis. 2011, 2011:708404.
12. Jain S., Goldstein D.S. Cardiovascular dysautonomia in Parkinson disease: from pathophysiology to pathogenesis. Neurobiol. Dis. 2011.
13. Jain S., Goldstein D.S. Cardiovascular dysautonomia in Parkinson disease: from pathophysiology to pathogenesis. Neurobiol. Dis. 2012.
14. Klos K.J., et al. Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals. Neurology 2006, 66:1100-1102.
15. Llebaria G., et al. Neuropsychological correlates of mild to severe hallucinations in Parkinson's disease. Mov. Disord. 2010, 25:2785-2791.
16. McDowell K., Chesselet M.F. Animal models of the non-motor features of Parkinson's disease. Neurobiol. Dis. 2012.
17. Orimo S., et al. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. Brain 2008, 131:642-650.
18. Parkinson J. An essay on the shaking palsy. J. Neuropsychiatry Clin. Neurosci. 2002, 14:223-236.
19. Postuma R.B., et al. REM sleep behavior disorder: from dreams to neurodegeneration 2012, Neurobiol Dis.
20. Sakakibara R., et al. Genitourinary dysfunction in Parkinson's disease. Mov. Disord. 2010, 25:2-12.
21. Schrag A. Psychiatric aspects of Parkinson's disease-an update. J. Neurol. 2004, 251:795-804.
22. Stephenson R., et al. Premotor Parkinson's disease: clinical features and detection strategies. Mov. Disord. 2009, 24(Suppl. 2):S665-S670.
23. Valente E.M., et al. Molecular pathways in sporadic PD. Parkinsonism Relat. Disord. 2011, 18(Suppl. 1):S71-S73.
24. Wakabayashi K., Takahashi H. Neuropathology of autonomic nervous system in Parkinson's disease. Eur. Neurol. 1997, 38(Suppl. 2):2-7.
25. Weintraub D., et al. Parkinson's disease-part 1: pathophysiology, symptoms, burden, diagnosis, and assessment. Am. J. Manag. Care 2008, 14:S40-S48.