Acute gentamicin-induced hypercalciuria and hypermagnesiuria in the rat: Dose-response relationship and role of renal tubular injury

British Journal of Pharmacology

Volumn 122, Issue 3, 1997, Pages 570-576

  Parsons, P P ^a   Garland, H O ^a   Harpur, E S ^b   Old, S ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b Alnwick Research Centre   (United Kingdom)

Author keywords

Calcium excretion; Enzymuria; Gentamicin; Magnesium excretion

Indexed keywords

CALCIUM ION; GENTAMICIN; MAGNESIUM ION; N ACETYL BETA GLUCOSAMINIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; ELECTROLYTE URINE LEVEL; HOMEOSTASIS; HYPERCALCIURIA; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY CLEARANCE; KIDNEY DISEASE; KIDNEY TUBULE CELL; LYSOSOME; MAGNESIUM EXCRETION; MALE; METABOLIC DISORDER; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLGLUCOSAMINIDASE; ANIMALS; ANTI-BACTERIAL AGENTS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-GLUTAMYLTRANSFERASE; GENTAMICINS; GLOMERULAR FILTRATION RATE; KIDNEY; MAGNESIUM; MALE; MICROSCOPY, ELECTRON; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY; SODIUM;

EID: 0030929393     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701403     Document Type: Article

References (28)

1. ADAMS, R.H. & DURRETT, L.R. (1978). Gentamicin blockade of slow calcium channels in atrial myocardium of guinea pigs. J. Clin. Invest., 78, 241-257.
2. BACSKAI, B.J. & FRIEDMAN, P.A. (1990). Activation of latent calcium channels in renal epithelial cells by parathyroid hormone. Nature, 347, 388-391.
3. BENNETT, W.M. (1989). Mechanisms of aminoglycoside-induced nephrotoxicity. Clin. Exp. Pharmacol. Physiol., 16, 1-6.
4. BRINKER, K.R. BULGER, R.E., DOBYAN, D.C., STACEY, T.R., SOUTHERN, P.M., HENRICH, W.L. & CRONIN, R.E. (1981). Effect of potassium depletion on gentamicin nephrotoxicity. J. Lab. Clin. Med., 98, 292-301.
5. CHAHWALA, S.B. & HARPUR, E.S. (1983). Gentamicin-induced hypercalciuria in the rat. Acta Pharmacol. Toxicol., 53, 358-362.
6. CRONIN, R.E., NIX, K.L., FERGUSON, E.R., SOUTHERN, P.M. & HENRICH, W.L. (1982). Renal cortex ion composition and Na K-ATPase activity in gentamicin nephrotoxicity. Am. J. Physiol., 242, F477-F483.
7. ELLIOTT, W.C. & PATCHIN, D.S. (1992). Aminoglycoside-mediated calciuresis. J. Pharmacol. Exp. Ther., 262, 151-156.
8. FOSTER, J.E., HARPUR, E.S. & GARLAND, H.O. (1992). An investigation of the acute effect of gentamicin on the renal handling of electrolytes in the rat. J. Pharmacol. Exp. Ther., 261, 38-43.
9. FRIEDMAN, P.A. & GESEK, F.A. (1994). Hormone-responsive calcium entry in distal convoluted tubules. J.Am.Soc.Nephrol., 4, 1396-1404.
10. GARLAND, H.O., BIRDSEY, T.J., DAVIDGE, C.G., MCLAUGHLIN, J.T., OAKES, L.M., SMITH, A.J. & HARPUR, E.S. (1994). Effects of gentamicin, neomycin and tobramycin on renal calcium and magnesium handling in two rat strains. Clin. Exp. Pharmacol. Physiol., 21, 109-115.
11. GIBEY, R., DUPOND, J.L., ALBER, D., LECONTE DES FLORIS, R. & HENRY, J.C. (1981). Predictive value of urinary N-acetyl-β-D-glucosaminidase, alanine aminopeptidase and β2-microglobulin in evaluating nephrotoxicity of gentamicin. Clin. Chim. Acta. 116, 25-34.
12. GONZALEZ-NORIEGA, A., GRUBB, J.H., TALKAD, V. & SLY, W.S. (1980). Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling. J. Cell Biol., 85, 839-852.
13. HARPUR, E.S., FATHALLA, S.A.K. & PHIPPS, D.J. (1985). Increased urinary excretion of calcium and magnesium is an early manifestation of gentamicin-induced nephrotoxicity in the rat. In Renal Heterogeneity and Target Cell Toxicity. ed. Bach, P.H. pp. 349-352. Chichester: John Wiley & Sons.
14. KACEW, S. (1990). Pathogenic factors in aminoglycoside-induced nephrotoxicity. Toxicol. Lett., 51, 241-259.
15. KELNAR. C.J.H., TAOR, W.S. REYNOLDS, D.J., SMITH, D.R., SLAVIN, B.M. & BROOK, C.G.D. (1978). Hypomagnesaemic hypocalcaemia with hypokalaemia caused by treatment with high dose gentamicin. Arch. Dis. Child, 53, 817-820.
16. KOHLEPP, S.J., PLANT, S.B., MCCARRON, D.A. & GILBERT, D.N. (1982). Gentamicin does not chelate calcium. Antimicrob. Agents Chemother., 21, 668-669.
17. MACK, M.M., ZIMÁNYI, I. & PESSAH, I.N. (1992). Discrimination of multiple binding sites for antagonists of the calcium release channel complex of skeletal and cardiac sarcoplasmic reticulum. J. Pharmacol. Exp. Ther., 262, 1028-1037.
18. MELLMAN, I., FUCHS, R. & HELENIUS, A. (1986). Acidification of the endocytotic and exocytotic pathways. Ann. Rev. Biochem., 55, 663-700.
19. PARSONS, P.P., GARLAND, H.O. & HARPUR, E.S. (1993). Acute effects of gentamicin on urinary NAG and calcium excretion in the anaesthetised rat. J. Physiol., 473, 272p.
20. PARSONS, P.P., GARLAND, H.O. & HARPUR, E.S. (1994). Assessment of the dose-response relationship and nephron site of gentamicin-induced acute hypercalciuria in the anaesthetised rat. Human Exp. Toxicol., 13, 284.
21. PARSONS, P.P., GARLAND, H.O. & HARPUR, E.S. (1995). Effect of gentamicin on urinary recoveries of 45Ca from distal tubular microperfusions in the anaesthetized rat. J. Physiol., 483, 168p.
22. RAMACHANDRAN, C. & BRUNETTE, M.G. (1989). The renal Na/Ca exchange system is located exclusively in the distal tubule. Biochem. J., 257, 259-264.
23. TULKENS, P.M. (1989). Nephrotoxicity of aminoglycoside antibiotics. Toxicol. Lett., 46, 107-123.
24. ULLRICH, K.J., RUMRICH, G. & KLOSS, C.R. (1976). Active Ca + + reabsorption in the proximal tubule of the rat kidney. Pflügers Arch., 364, 223-228.
25. WATSON, A., HOLOHAN, P.D. & ROSS, C.R. (1983). Severe hypomagnesaemia and hypocalcaemia following gentamicin therapy. Ir. Med. J., 76, 381-383.
26. WILLIAMS, P.D., HOLOHAN, P.D. & ROSS, C.R. (1981). Gentamicin nephrotoxicity 1. Acute biochemical correlates in rats. Toxicol. Appl. Pharmacol., 61, 234-242.
27. WILLIAMS, P.D., TRIMBEL, M.E., CRESPO, L., HOLOHAN, P.D., FREEDMAN, J.C. & ROSS, C.R. (1984). Inhibition of renal Na+-K+-adenosine triphosphalase by gentamicin. J. Pharmacol. Exp. Ther., 231, 248-253.
28. ZALOGA, G.P., CHERNOW, B., POCK, A., WOOD, B. & ZARITSKY, A. (1984). Hypomagnesaemia is a common complication of aminoglycoside therapy. Surg. Gynaecol. Obstet., 158, 561-565.