The functional variant V433M of the CYP4F2 and the metabolic syndrome in Swedes

Prostaglandins and Other Lipid Mediators

Volumn 98, Issue 1-2, 2012, Pages 31-36

  Fava, Cristiano ^a,b   Montagnana, Martina ^a,b   Danese, Elisa ^a,b   Sjögren, Marketa ^a   Almgren, Peter ^a   Guidi, Gian Cesare ^b   Hedblad, Bo ^a   Engström, Gunnar ^a   Minuz, Pietro ^b   Melander, Olle ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY HOSPITAL OF VERONA   (Italy)

Author keywords

20 HETE; CYP4F2; Cytochrome P450; Genetics; Metabolic syndrome; Triglycerides

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 4F2; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PHENOTYPE; POPULATION GENETICS; SWEDEN; WAIST CIRCUMFERENCE;

ADULT; AGED; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 84860721139     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2012.03.001     Document Type: Article

References (30)

1. J.C. McGiff, and J. Quilley 20-HETE and the kidney: resolution of old problems and new beginnings Am J Physiol 277 1999 R607 R623
2. P. Minuz, H. Jiang, and C. Fava Altered release of cytochrome p450 metabolites of arachidonic acid in renovascular disease Hypertension 51 2008 1379 1385 (Pubitemid 351555953)
3. N.C. Ward, I. Tsai, and A. Barden A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure Hypertension 51 2008 1393 1398 (Pubitemid 351555955)
4. C. Fava, M. Montagnana, and P. Almgren The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure Hypertension 52 2008 373 380
5. H. Ding, G. Cui, and L. Zhang Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population Pharmacogenet Genomics 20 2010 187 194
6. D.E. Stec, R.J. Roman, A. Flasch, and M.J. Rieder Functional polymorphism in human CYP4F2 decreases 20-HETE production Physiol Genomics 30 2007 74 81 (Pubitemid 47173292)
7. W. Niu, P. Gao, and D. Zhu Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects Hypertens Res 32 2009 529
8. Z. Fu, T. Nakayama, and N. Sato Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects Hypertens Res 31 2008 1719 1726
9. O. Melander, L. Groop, and U.L. Hulthén Effect of salt on insulin sensitivity differs according to gender and degree of salt sensitivity Hypertension 35 2000 827 831 (Pubitemid 30165333)
10. X. Zhang, L. Chen, and J.P. Hardwick Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells Arch Biochem Biophys 378 2000 364 376 (Pubitemid 30397637)
11. K.G. Alberti, R.H. Eckel, and S.M. Grundy Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity Circulation 120 2009 1640 1645
12. C. Fava, M. Montagnana, and M. Guerriero Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome J Hypertens 27 2009 1794 1803
13. G. Berglund, S. Elmstahl, L. Janzon, and S.A. Larsson The Malmo Diet and Cancer study design and feasibility J Intern Med 233 1993 45 51
14. B. Hedblad, P. Nilsson, L. Janzon, and G. Berglund Relation between insulin resistance and carotid intima-media thickness and stenosis in non-diabetic subjects results from a cross-sectional study in Malmo, Sweden Diabet Med 17 2000 299 307 (Pubitemid 30266125)
15. G. Berglund, K.F. Eriksson, and B. Israelsson Cardiovascular risk groups and mortality in an urban Swedish male population: the Malmo Preventive Project J Intern Med 239 1996 489 497
16. P.M. Nilsson, G. Engstrom, and B. Hedblad The metabolic syndrome and incidence of cardiovascular disease in non-diabetic subjects - a population-based study comparing three different definitions Diabet Med 24 2007 464 472 (Pubitemid 46669326)
17. K.L. Monda, K.E. North, S.C. Hunt, D.C. Rao, M.A. Province, and A.T. Kraja The genetics of obesity and the metabolic syndrome Endocr Metab Immune Disord Drug Targets 10 2010 86 108
18. H. Singh, J. Cheng, and H. Deng Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension Hypertension 50 2007 123 129 (Pubitemid 46986020)
19. K. Nakagawa, J.S. Marji, M.L. Schwartzman, M.R. Waterman, and J.H. Capdevila Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension Am J Physiol Regul Integr Comp Physiol 284 2003 R1055 R1062
20. C. Fava, M. Ricci, O. Melander, and Minuz P Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: a sex-specific relation? Prostaglandins Other Lipid Mediat 2011 November 30 [Epub ahead of print]
21. C.J. Willer, S. Sanna, and A.U. Jackson Newly identified loci that influence lipid concentrations and risk of coronary artery disease Nat Genet 40 2008 161 169 (Pubitemid 351171403)
22. S. Kathiresan, C.J. Willer, and G.M. Peloso Common variants at 30 loci contribute to polygenic dyslipidemia Nat Genet 41 2009 56 65
23. S. Kathiresan, O. Melander, and C. Guiducci Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans Nat Genet 40 2008 189 197 (Pubitemid 351171402)
24. P.A. Sarafidis, and G.L. Bakris The antinatriuretic effect of insulin: an unappreciated mechanism for hypertension associated with insulin resistance Am J Nephrol 27 2007 44 54 (Pubitemid 46364540)
25. J. Mayet, and A. Hughes Cardiac and vascular pathophysiology in hypertension Heart 89 2003 1104 1109 (Pubitemid 37046861)
26. M.G. McDonald, M.J. Rieder, M. Nakano, C.K. Hsia, and A.E. Rettie CYP4F2 is a vitamin K1 oxidase: an explanation for altered warfarin dose in carriers of the V433M variant Mol Pharmacol 75 2009 1337 1346
27. J. Cui, J. Hopper, and S. Harrap Antihypertensive treatments obscure familial contributions to blood pressure variation Hypertension 41 2003 207 210 (Pubitemid 36204890)
28. E.S. Ford The metabolic syndrome and mortality from cardiovascular disease and all-causes: findings from the National Health and Nutrition Examination Survey II Mortality Study Atherosclerosis 173 2004 309 314 (Pubitemid 38469801)
29. D. Noto, C.M. Barbagallo, and A.B. Cefalu The metabolic syndrome predicts cardiovascular events in subjects with normal fasting glucose: results of a 15 years follow-up in a Mediterranean population Atherosclerosis 197 2008 147 153 (Pubitemid 351278405)
30. J.M. Dekker, C. Girman, and T. Rhodes Metabolic syndrome and 10-year cardiovascular disease risk in the Hoorn Study Circulation 112 2005 666 673 (Pubitemid 41099045)