Blood-Brain barrier: Recent developments and clinical correlations

Neurology

Volumn 78, Issue 16, 2012, Pages 1268-1276

  Benarroch, Eduardo E ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CLAUDIN 3; CLAUDIN 5; NEUROTRANSMITTER; PEPTIDE TRANSPORTER 1;

ANGIOGENESIS; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN NERVE CELL; CELL FUNCTION; CELL MIGRATION; CORRELATION ANALYSIS; ENDOTHELIUM CELL; HOMEOSTASIS; HUMAN; ION TRANSPORT; LEUKOCYTE; MICROENVIRONMENT; MICROVASCULATURE; NERVOUS SYSTEM DEVELOPMENT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN TRANSPORT; STRUCTURE ANALYSIS; TIGHT JUNCTION;

EID: 84860715557     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e318250d8bc     Document Type: Article

References (65)

1. Huber JD, Egleton RD, Davis TP. Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci 2001;24:719-725. (Pubitemid 33097539)
2. Begley DJ, Brightman MW. Structural and functional aspects of the blood-brain barrier. Progr Drug Res Fortschritte Arzneimittelforschung 2003;61:39-78. (Pubitemid 37187402)
3. Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 2005; 57:173-185. (Pubitemid 41043883)
4. Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008;57: 178-201.
5. Abbott NJ, Ronnback L, Hansson E. Astrocyteendothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006;7:41-53.
6. Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ. Structure and function of the blood-brain barrier. Neurobiol Dis 2009;37:13-25.
7. Begley DJ, Pontikis CC, Scarpa M. Lysosomal storage diseases and the blood-brain barrier. Curr Pharmaceut Des 2008;14:1566-1580. (Pubitemid 352002984)
8. Weiss N, Miller F, Cazaubon S, Couraud PO. The bloodbrain barrier in brain homeostasis and neurological diseases. Biochim Biophys Acta 2009;1788:842-857.
9. Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 2011;12:723-738.
10. Quaegebeur A, Lange C, Carmeliet P. The neurovascular link in health and disease: Molecular mechanisms and therapeutic implications. Neuron 2011;71:406-424.
11. Neuwelt EA, Bauer B, Fahlke C, et al. Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci 2011;12:169-182.
12. Grammas P, Martinez J, Miller B. Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases. Expert Rev Mol Med 2011;13:e19.
13. Dauchy S, Dutheil F, Weaver RJ, et al. ABC transporters, cytochromes P450 and their main transcription factors: Expression at the human blood-brain barrier. J Neurochem 2008;107:1518-1528.
14. Zhang C, Kwan P, Zuo Z, Baum L. The transport of antiepileptic drugs by P-glycoprotein. Adv Drug Deliv Rev (in press 2012).
15. Aronica E, Sisodiya SM, Gorter JA. Cerebral expression of drug transporters in epilepsy. Adv Drug Deliv Rev (in press 2012).
16. Black KL, Baba T, Pardridge WM. Enzymatic barrier protects brain capillaries from leukotriene C4. J Neurosurg 1994;81:745-751. (Pubitemid 24328702)
17. Brownson EA, Abbruscato TJ, Gillespie TJ, Hruby VJ, Davis TP. Effect of peptidases at the blood brain barrier on the permeability of enkephalin. J Pharmacol Exp Ther 1994;270:675-680. (Pubitemid 24271381)
18. Greenwood J, Heasman SJ, Alvarez JI, Prat A, Lyck R, Engelhardt B. Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain. Neuropathol Appl Neurobiol 2011;37:24-39.
19. Koehler RC, Roman RJ, Harder DR. Astrocytes and the regulation of cerebral blood flow. Trends Neurosci 2009; 32:160-169.
20. Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA. Glial and neuronal control of brain blood flow. Nature 2010;468:232-243.
21. Petzold GC, Murthy VN. Role of astrocytes in neurovascular coupling. Neuron 2011;71:782-797.
22. Amiry-Moghaddam M, Frydenlund DS, Ottersen OP. Anchoring of aquaporin-4 in brain: Molecular mechanisms and implications for the physiology and pathophysiology of water transport. Neuroscience 2004;129:999-1010. (Pubitemid 39556251)
23. Albertini R, Bianchi R. Aquaporins and glia. Curr Neuropharmacol 2010;8:84-91.
24. Dohgu S, Yamauchi A, Takata F, et al. Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells. Cell Mol Neurobiol 2004;24:491-497. (Pubitemid 38988077)
25. Alvarez JI, Dodelet-Devillers A, Kebir H, et al. The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science 2011;334:1727-1731.
26. Baeten KM, Akassoglou K. Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke. Dev Neurobiol 2011;71:1018-1039.
27. Engelhardt B. β1-integrin/matrix interactions support blood-brain barrier integrity. J Cereb Blood Flow Metab 2011;31:1969 -1971.
28. Thanabalasundaram G, Schneidewind J, Pieper C, Galla HJ. The impact of pericytes on the blood-brain barrier integrity depends critically on the pericyte differentiation stage. Int J Biochem Cell Biol 2011;43:1284-1293.
29. Warth A, Kroger S, Wolburg H. Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae. Acta Neuropathol 2004;107:311-318. (Pubitemid 38477357)
30. Tomkins O, Shelef I, Kaizerman I, et al. Blood-brain barrier disruption in post-traumatic epilepsy. J Neurol Neurosurg Psychiatry 2008;79:774-777. (Pubitemid 351914722)
31. Nag S, Kapadia A, Stewart DJ. Review: Molecular pathogenesis of blood-brain barrier breakdown in acute brain injury. Neuropathol Appl Neurobiol 2011;37:3-23.
32. Yang Y, Rosenberg GA. Blood-brain barrier breakdown in acute and chronic cerebrovascular disease. Stroke 2011;42: 3323-3328.
33. Friedman A. Blood-brain barrier dysfunction, status epilepticus, seizures, and epilepsy: A puzzle of a chicken and egg? Epilepsia 2011;52(suppl 8):19-20.
34. Fabene PF, Navarro Mora G, Martinello M, et al. A role for leukocyte-endothelial adhesion mechanisms in epilepsy. Nat Med 2008;14:1377-1383.
35. Mandel I, Paperna T, Glass-Marmor L, et al. Tight junction proteins expression and modulation in immune cells and multiple sclerosis. J Cell Mol Med Epub 2011 Jul 8.
36. Simka M. Blood brain barrier compromise with endothelial inflammation may lead to autoimmune loss of myelin during multiple sclerosis. Curr Neurovasc Res 2009;6: 132-139.
37. Shimizu F, Sano Y, Takahashi T, et al. Sera from neuromyelitis optica patients disrupt the blood-brain barrier. J Neurol Neurosurg Psychiatry 2012;83:288-297.
38. Roberts TK, Buckner CM, Berman JW. Leukocyte transmigration across the blood-brain barrier: Perspectives on neuroAIDS. Front Biosci 2010;15:478-536.
39. Xu R, Feng X, Xie X, Zhang J, Wu D, Xu L. HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9. Brain Res 2012;1436: 13-19.
40. Strazza M, Pirrone V, Wigdahl B, Nonnemacher MR. Breaking down the barrier: The effects of HIV-1 on the blood-brain barrier. Brain Res 2011;1399:96-115.
41. Yang B, Akhter S, Chaudhuri A, Kanmogne GD. HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood-brain barrier: Modulatory effects of STAT1 signaling. Microvasc Res 2009;77: 212-219.
42. Eugenin EA, Osiecki K, Lopez L, Goldstein H, Calderon TM, Berman JW. CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: A potential mechanism of HIV-CNS invasion and NeuroAIDS. J Neurosci 2006;26:1098-1106. (Pubitemid 43237041)
43. Ishihara H, Kubota H, Lindberg RL, et al. Endothelial cell barrier impairment induced by glioblastomas and transforming growth factor beta2 involves matrix metalloproteinases and tight junction proteins. J Neuropathol Exp Neurol 2008;67:435-448. (Pubitemid 351653535)
44. Skowronska M, Zielinska M, Wojcik-Stanaszek L, et al. Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/ nitrosative stress and activation of matrix metalloproteinases. J Neurochem Epub 2012 Jan 19.
45. Coisne C, Engelhardt B. Tight junctions in brain barriers during central nervous system inflammation. Antioxid Redox Sig 2011;15:1285-1303.
46. Willis CL. Glia-induced reversible disruption of bloodbrain barrier integrity and neuropathological response of the neurovascular unit. Toxicol Pathol 2011;39:172-185.
47. Semple BD, Kossmann T, Morganti-Kossmann MC. Role of chemokines in CNS health and pathology: A focus on the CCL2/CCR2 and CXCL8/CXCR2 networks. J Cereb Blood Flow Metab 2010;30:459-473.
48. Takata F, Dohgu S, Matsumoto J, et al. Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-alpha, releasing matrix metalloproteinase-9 and migrating in vitro. J Neuroinflammation 2011;8:106.
49. Korn T. Pathophysiology of multiple sclerosis. J Neurol 2008;255(suppl 6):2-6.
50. Stewart TH, Eastman CL, Groblewski PA, et al. Chronic dysfunction of astrocytic inwardly rectifying K channels specific to the neocortical epileptic focus after fluid percussion injury in the rat. J Neurophysiol 2010;104:3345-3360.
51. Liu DZ, Ander BP, Xu H, et al. Blood-brain barrier breakdown and repair by Src after thrombin-induced injury. Ann Neurol 2010;67:526-533.
52. Wang D, Pascual JM, Yang H, et al. Glut-1 deficiency syndrome: Clinical, genetic, and therapeutic aspects. Ann Neurol 2005;57:111-118. (Pubitemid 40053322)
53. Vemula S, Roder KE, Yang T, Bhat GJ, Thekkumkara TJ, Abbruscato TJ. A functional role for sodium-dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation. J Pharmacol Exp Ther 2009; 328:487-495.
54. Mooradian AD, Chung HC, Shah GN. GLUT-1 expression in the cerebra of patients with Alzheimer's disease. Neurobiol Aging 1997;18:469-474. (Pubitemid 27497142)
55. Bartels AL, Willemsen AT, Kortekaas R, et al. Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA. J Neural Transm 2008;115:1001-1009.
56. Westerlund M, Belin AC, Anvret A, et al. Association of a polymorphism in the ABCB1 gene with Parkinson's disease. Parkinsonism Relat Disord 2009;15:422-424.
57. Vautier S, Fernandez C. ABCB1: The role in Parkinson's disease and pharmacokinetics of antiparkinsonian drugs. Exp Opinion Drug Metab Toxicol 2009;5:1349-1358.
58. Ifergan I, Kebir H, Alvarez JI, et al. Central nervous system recruitment of effector memory CD8 T lymphocytes during neuroinflammation is dependent on alpha4 integrin. Brain 2011;134:3557-3574.
59. Iacovetta C, Rudloff E, Kirby R. The role of aquaporin 4 in the brain. Vet Clin Pathol Epub 2012 Jan 17.
60. Badaut J, Ashwal S, Obenaus A. Aquaporins in cerebrovascular disease: A target for treatment of brain edema? Cerebrovasc Dis 2011;31:521-531.
61. Park L, Wang G, Zhou P, et al. Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta. Proc Natl Acad Sci USA 2011;108:5063-5068.
62. Forster C, Kahles T, Kietz S, Drenckhahn D. Dexamethasone induces the expression of metalloproteinase inhibitor TIMP-1 in the murine cerebral vascular endothelial cell line cEND. J Physiol 2007;580:937-949. (Pubitemid 46915250)
63. Man S, Tucky B, Bagheri N, Li X, Kochar R, Ransohoff RM. α4 Integrin/FN-CS1 mediated leukocyte adhesion to brain microvascular endothelial cells under flow conditions. J Neuroimmunol 2009;210:92-99.
64. De Fazio S, Russo E, Ammendola M, Di Paola ED, De Sarro G. Efficacy and safety of bevacizumab in glioblastomas. Curr Med Chem Epub 2012 Jan 2.
65. Biju K, Zhou Q, Li G, et al. Macrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: A therapeutic strategy for Parkinson's disease. Mol Ther 2010;18:1536-1544.