Blood-brain barrier dysfunction, status epilepticus, seizures, and epilepsy: A puzzle of a chicken and egg?

Epilepsia

Volumn 52, Issue SUPPL. 8, 2011, Pages 19-20

  Friedman, Alon ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Astrocytes; Microglia; Serum albumin; Transforming growth factor beta

Indexed keywords

CHEMOKINE; CYTOKINE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PLASMA PROTEIN; POTASSIUM; SMAD2 PROTEIN; SMAD5 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN DAMAGE; BRAIN REGION; CALCIUM TRANSPORT; CONFERENCE PAPER; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; EPILEPSY; EPILEPTIC STATE; EPILEPTOGENESIS; HOMEOSTASIS; HUMAN; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SEIZURE; SENSORIMOTOR CORTEX; SIGNAL TRANSDUCTION; VASOCONSTRICTION; VASODILATATION;

ANIMALS; BLOOD-BRAIN BARRIER; EPILEPSY; HUMANS; SEIZURES; STATUS EPILEPTICUS;

EID: 80053589297     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2011.03227.x     Document Type: Conference Paper

References (9)

1. Cacheaux LP, Ivens S, David Y, Lakhter AJ, Bar-Klein G, Shapira M, Heinemann U, Friedman A, Kaufer D,. (2009) Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis. J Neurosci 29: 8927-8935.
2. David Y, Cacheaux LP, Ivens S, Lapilover E, Heinemann U, Kaufer D, Friedman A,. (2009) Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis? J Neurosci 29: 10588-10599.
3. Dreier JP,. (2011) The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med 17: 439-447.
4. Friedman A, Kaufer D, Heinemann U,. (2009) Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy. Epilepsy Res 85: 142-149.
5. Ivens S, Kaufer D, Flores LP, Bechmann I, Zumsteg D, Tomkins O, Seiffert E, Heinemann U, Friedman A,. (2007) TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. Brain 130: 535-547. (Pubitemid 46181106)
6. Marchi N, Angelov L, Masaryk T, Fazio V, Granata T, Hernandez N, Hallene K, Diglaw T, Franic L, Najm I, Janigro D,. (2007) Seizure-promoting effect of blood-brain barrier disruption. Epilepsia 48: 732-742. (Pubitemid 46587627)
7. Tomkins O, Friedman O, Ivens S, Reiffurth C, Major S, Dreier JP, Heinemann U, Friedman A,. (2007) Blood-brain barrier disruption results in delayed functional and structural alterations in the rat neocortex. Neurobiol Dis 25: 367-377. (Pubitemid 46124017)
8. Tomkins O, Shelef I, Kaizerman I, Eliushin A, Afawi Z, Misk A, Gidon M, Cohen A, Zumsteg D, Friedman A,. (2008) Blood-brain barrier disruption in post-traumatic epilepsy. J Neurol Neurosurg Psychiatry 79: 774-777. (Pubitemid 351914722)
9. van Vliet EA, da Costa AS, Redeker S, van SR, Aronica E, Gorter JA,. (2007) Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy. Brain 130: 521-534. (Pubitemid 46181105)