Ambiguous effect of dendrimer PAMAM G3 on rat heart respiration in a model of an experimental diabetes - Objective causes of laboratory misfortune or unpredictable G3 activity?

International Journal of Pharmaceutics

Volumn 430, Issue 1-2, 2012, Pages 258-265

  Siewiera, Karolina ^a   Labieniec Watala, Magdalena ^b  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b UNIVERSITY OF LODZ   (Poland)

Author keywords

Dendrimer PAMAM G3; Experimental diabetes; Heart mitochondria; In vivo study; Mitochondrial bioenergetics

Indexed keywords

1,2 DICARBONYL DERIVATIVE; METHYLGLYOXAL; POLYAMIDOAMINE; POLYAMIDOAMINE DENDRIMER 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; BREATHING DISORDER; CONTROLLED STUDY; HEART MITOCHONDRION; HEART PROTECTION; IN VITRO STUDY; IN VIVO STUDY; MALE; METABOLIC DISORDER; METABOLIC PARAMETERS; NONHUMAN; PRIORITY JOURNAL; RAT; SEASONAL VARIATION; STREPTOZOCIN DIABETES;

ANIMALS; CELL RESPIRATION; CYTOPROTECTION; DENDRIMERS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; ENERGY METABOLISM; GLYCOSYLATION END PRODUCTS, ADVANCED; INJECTIONS, INTRAPERITONEAL; MALE; MITOCHONDRIA, HEART; PYRUVALDEHYDE; RATS; RATS, WISTAR; SEASONS;

EID: 84860710887     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.03.037     Document Type: Article

References (30)

1. K.L. Aillona, Y. Xiea, N. El-Gendya, C.J. Berklanda, and M.L. Forresta Effects of nanomaterial physicochemical properties on in vivo toxicit Adv. Drug Deliv. Rev. 61 2009 457 466
2. S. Bessman, and C. Mohan Insulin as a probe of mitochondrial metabolism in situ Mol. Cell. Biochem. 174 1997 91 96 (Pubitemid 27404174)
3. F.H. Bronson Climate change and seasonal reproduction in mammals Philos. Trans. R. Soc. Lond. B Biol. Sci. 364 2009 3331 3340
4. M.L. Carras, E. Brenowitz, and E.W. Rubel Peripheral auditory processing changes seasonally in Gambel's white-crowned sparrow J. Comp. Physiol. Neuroethol. Sens. Neural Behav. Physiol. 196 2010 581 599
5. P. Craven, M. Melhem, S. Phillis, and F. DeRubertis Over expression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice Diabetes 50 2001 2114 2125 (Pubitemid 33643680)
6. M. Ferko, D. Habodaszova, I. Waczulikova, J. Mujkosova, J. Kucharska, L. Sikurova, B. Ziegelhoffer, J. Styk, and A. Ziegelhoffer Endogenous protective mechanisms in remodeling of rat heart mitochondrial membranes in the acute phase of streptozotocin-induced diabetes Physiol. Res. 57 2008 67 73
7. E. Gnaiger Capacity of oxidative phosphorylation in human skeletal muscle: new perspectives of mitochondrial physiology Int. J. Biochem. Cell. Biol. 41 2009 1837 1845
8. S.M. Grundy, I.J. Benjamin, G.L. Burke, A. Chait, R.H. Eckel, B.V. Howard, W. Mitch, S.C. Smith Jr.; and J.R. Sowers Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association Circulation 100 1999 1134 1146 (Pubitemid 29416243)
9. Y. Kang, L. Edwards, and P. Thornalley Effect of methylglyoxal on human leukemia 60 cell growth: modification of DNA, growth arrest and induction of apoptosis Leuk. Res. 20 1996 397 405 (Pubitemid 26197249)
10. M. Labieniec, and T. Gabryelak Preliminary biological evaluation of poli(amidoamine) (PAMAM) dendrimer G3.5 on selected parameters of rat liver mitochondria Mitochondrion 8 2008 305 312
11. M. Labieniec, O. Ulicna, O. Vancova, R. Glowacki, K. Sebekova, E. Bald, T. Gabryelak, and C. Watala PAMAM G4 dendrimers lower high glucose but do not improve reduced survival in diabetic rats Int. J. Pharm. 364 2008 142 149
12. M. Labieniec, and C. Watala PAMAM dendrimers - diverse biomedical applications. Facts and unresolved questions Cent. Eur. J. Biol. 4 2009 34 451
13. M. Labieniec, and C. Watala Use of poly(amido)amine dendrimers in prevention of early non-enzymatic modifications of biomacromolecules Biochemie 92 2010 1296 1305
14. M. Labieniec, O. Ulicna, O. Vancova, J. Kucharska, T. Gabryelak, and C. Watała Effect of poly(amido)amine (PAMAM) G4 dendrimer on heart and liver mitochondria in an animal model of diabetes Cell Biol. Int. 34 2010 89 97
15. J.H. Lee, K.E. Cha, M.S. Kim, H.W. Hong, D.J. Chung, G. Ryu, and H. Myung Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction Toxicol. Lett. 190 2009 202 207
16. 125I-labelled polyamidoamine dendrimers in vivo J. Control. Release 65 2000 133 148 (Pubitemid 30122922)
17. L.B. Martin, Z.M. Weil, and R.J. Nelson Seasonal changes in vertebrate immune activity: mediation by physiological trade-offs Philos. Trans. R. Soc. Lond. B Biol. Sci. 363 2008 321 339 (Pubitemid 350249337)
18. 2+-ATPase activity, content of conjugated dienes and membrane fluidity Physiol. Res. 57 2008 S75 S82
19. S.P. Mukherjee, F.M. Lyng, A. Garcia, M. Davoren, and H.J. Byrne Mechanistic studies of in vitro cytotoxicity of poly(amidoamine) dendrimers in mammalian cells Toxicol. Appl. Pharmacol. 248 2010 259 268
20. M. Murphy, and F.J.P. Ebling The role of hypothalamic tri-iodothyronine availability in seasonal regulation of energy balance and body weight J. Thyroid Res. 2011 2011 1 7
21. P.J. Oliveira, A.P. Rolo, R. Seica, M.S. Santos, C.M. Palmeira, and A.J. Moreno Reduction in cardiac mitochondrial calcium loading capacity is observable during alpha-naphthylisothiocyanate-induced acute cholestasis: a clue for hepatic-derived cardiomyopathies? Biochim. Biophys. Acta 1637 2003 39 45 (Pubitemid 36071594)
22. P.J. Oliveira Cardiac mitochondrial alterations observed in hyperglycaemic rats - what can we learn from cell biology? Curr. Diabetes Rev. 1 2005 11 21
23. B.J. Prendergast, A. Kampf-Lassin, J.R. Yess, J. Galang, N. McMaster, and L.M. Kay Winter day lengths enhance T lymphocyte phenotypes, inhibit cytokine responses, and attenuate behavioral symptoms of infection in laboratory rats Brain Behav. Immun. 21 2007 1096 1108 (Pubitemid 47484396)
24. J.C. Roberts, M.K. Bhalgat, and R.T. Zera Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst™ dendrimers J. Biomed. Mater. Res. 30 1996 53 65
25. A.P. Rolo, and C.M. Palmeira Diabetes and mitochondrial function: role of hyperglycaemia and oxidative stress Toxicol. Appl. Pharm. 212 2006 167 178
26. G.X. Shen Oxidative stress and diabetic cardiovascular disorders: roles of mitochondria and NADPH oxidase Can. J. Physiol. Pharmacol. 88 2010 241 248
27. B. Solnica Molecular mechanisms of the damaging effect of glucose on tissues Diabetologia Doswiadczalna i Kliniczna [Experimental and Clinical Diabetology] 5 2006 1 8
28. T.P. Thomas, I. Majoros, A. Kotlyar, D. Mullen, M.M. Holl, and J.R. Baker Jr. Cationic poly(amidoamine) dendrimer induces lysosomal apoptotic pathway at therapeutically relevant concentrations Biomacromolecules 14 2009 3207 3214
29. S. Waldbaum, and M. Patel Mitochondria, oxidative stress, and temporal lobe epilepsy Epilepsy Res. 88 2009 23 45
30. D. Wallace Mitochondrial diseases in man and mouse Science 283 1999 1482 1488