메뉴 건너뛰기




Volumn 7, Issue 5, 2012, Pages

Repression of cardiac hypertrophy by KLF15: Underlying mechanisms and therapeutic implications

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 15; MYOCARDIN RELATED TRANSCRIPTION FACTOR A; MYOCARDIN RELATED TRANSCRIPTION FACTOR B; PARVOVIRUS VECTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; KLF15 PROTEIN, MOUSE; MKL1 PROTEIN, HUMAN; MUTANT PROTEIN; MYOCARDIN; MYOCARDIN RELATED TRANSCRIPTION FACTOR B, MOUSE; MYOCARDIN-RELATED TRANSCRIPTION FACTOR B, MOUSE; NUCLEAR PROTEIN; ONCOPROTEIN; TRANSACTIVATOR PROTEIN;

EID: 84860645831     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036754     Document Type: Article
Times cited : (37)

References (44)
  • 2
    • 33748323383 scopus 로고    scopus 로고
    • Regulation of cardiac hypertrophy by intracellular signalling pathways
    • Heineke J, Molkentin JD, (2006) Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 7: 589-600.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 589-600
    • Heineke, J.1    Molkentin, J.D.2
  • 3
    • 33646798121 scopus 로고    scopus 로고
    • Myocardin induces cardiomyocyte hypertrophy
    • Xing W, Zhang TC, Cao D, Wang Z, Antos CL, et al. (2006) Myocardin induces cardiomyocyte hypertrophy. Circ Res 98: 1089-1097.
    • (2006) Circ Res , vol.98 , pp. 1089-1097
    • Xing, W.1    Zhang, T.C.2    Cao, D.3    Wang, Z.4    Antos, C.L.5
  • 4
    • 80955178910 scopus 로고    scopus 로고
    • Tapping the brake on cardiac growth-endogenous repressors of hypertrophic signaling
    • Leenders JJ, Pinto YM, Creemers EE, (2011) Tapping the brake on cardiac growth-endogenous repressors of hypertrophic signaling. J Mol Cell Cardiol 51: 156-167.
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 156-167
    • Leenders, J.J.1    Pinto, Y.M.2    Creemers, E.E.3
  • 6
    • 77953015031 scopus 로고    scopus 로고
    • Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation
    • Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, et al. (2010) Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Sci Transl Med 2: 26ra26.
    • (2010) Sci Transl Med , vol.2
    • Haldar, S.M.1    Lu, Y.2    Jeyaraj, D.3    Kawanami, D.4    Cui, Y.5
  • 7
    • 77956240071 scopus 로고    scopus 로고
    • Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity
    • Leenders JJ, Wijnen WJ, Hiller M, van der Made I, Lentink V, et al. (2010) Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity. J Biol Chem 285: 27449-27456.
    • (2010) J Biol Chem , vol.285 , pp. 27449-27456
    • Leenders, J.J.1    Wijnen, W.J.2    Hiller, M.3    van der Made, I.4    Lentink, V.5
  • 8
    • 0037072874 scopus 로고    scopus 로고
    • The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4
    • Gray S, Feinberg MW, Hull S, Kuo CT, Watanabe M, et al. (2002) The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. J Biol Chem 277: 34322-34328.
    • (2002) J Biol Chem , vol.277 , pp. 34322-34328
    • Gray, S.1    Feinberg, M.W.2    Hull, S.3    Kuo, C.T.4    Watanabe, M.5
  • 9
    • 77956629432 scopus 로고    scopus 로고
    • Myocardin-related transcription factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression
    • Kuwahara K, Kinoshita H, Kuwabara Y, Nakagawa Y, Usami S, et al. (2010) Myocardin-related transcription factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression. Mol Cell Biol 30: 4134-4148.
    • (2010) Mol Cell Biol , vol.30 , pp. 4134-4148
    • Kuwahara, K.1    Kinoshita, H.2    Kuwabara, Y.3    Nakagawa, Y.4    Usami, S.5
  • 10
    • 11144250262 scopus 로고    scopus 로고
    • Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin
    • Cao D, Wang Z, Zhang CL, Oh J, Xing W, et al. (2005) Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol 25: 364-376.
    • (2005) Mol Cell Biol , vol.25 , pp. 364-376
    • Cao, D.1    Wang, Z.2    Zhang, C.L.3    Oh, J.4    Xing, W.5
  • 11
    • 26444556515 scopus 로고    scopus 로고
    • Zinc-finger domains of the transcriptional repressor KLF15 bind multiple sites in rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements
    • Otteson DC, Lai H, Liu Y, Zack DJ, (2005) Zinc-finger domains of the transcriptional repressor KLF15 bind multiple sites in rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements. BMC Mol Biol 6: 15.
    • (2005) BMC Mol Biol , vol.6 , pp. 15
    • Otteson, D.C.1    Lai, H.2    Liu, Y.3    Zack, D.J.4
  • 12
    • 3242880552 scopus 로고    scopus 로고
    • Kruppel-like factor 15, a zinc-finger transcriptional regulator, represses the rhodopsin and interphotoreceptor retinoid-binding protein promoters
    • Otteson DC, Liu Y, Lai H, Wang C, Gray S, et al. (2004) Kruppel-like factor 15, a zinc-finger transcriptional regulator, represses the rhodopsin and interphotoreceptor retinoid-binding protein promoters. Invest Ophthalmol Vis Sci 45: 2522-2530.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 2522-2530
    • Otteson, D.C.1    Liu, Y.2    Lai, H.3    Wang, C.4    Gray, S.5
  • 13
    • 78149481592 scopus 로고    scopus 로고
    • Mammalian kruppel-like factors in health and diseases
    • McConnell BB, Yang VW, (2010) Mammalian kruppel-like factors in health and diseases. Physiol Rev 90: 1337-1381.
    • (2010) Physiol Rev , vol.90 , pp. 1337-1381
    • McConnell, B.B.1    Yang, V.W.2
  • 14
    • 33845531899 scopus 로고    scopus 로고
    • Efficacy and safety of adeno-associated viral vectors based on serotype 8 and 9 vs. lentiviral vectors for hemophilia B gene therapy
    • Vandendriessche T, Thorrez L, Acosta-Sanchez A, Petrus I, Wang L, et al. (2007) Efficacy and safety of adeno-associated viral vectors based on serotype 8 and 9 vs. lentiviral vectors for hemophilia B gene therapy. J Thromb Haemost 5: 16-24.
    • (2007) J Thromb Haemost , vol.5 , pp. 16-24
    • Vandendriessche, T.1    Thorrez, L.2    Acosta-Sanchez, A.3    Petrus, I.4    Wang, L.5
  • 16
    • 34249068478 scopus 로고    scopus 로고
    • Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy
    • Schroen B, Leenders JJ, van Erk A, Bertrand AT, van Loon M, et al. (2007) Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy. J Exp Med 204: 1227-1235.
    • (2007) J Exp Med , vol.204 , pp. 1227-1235
    • Schroen, B.1    Leenders, J.J.2    van Erk, A.3    Bertrand, A.T.4    van Loon, M.5
  • 17
    • 34447324079 scopus 로고    scopus 로고
    • Nuclear localization of enhanced green fluorescent protein homomultimers
    • Seibel NM, Eljouni J, Nalaskowski MM, Hampe W, (2007) Nuclear localization of enhanced green fluorescent protein homomultimers. Anal Biochem 368: 95-99.
    • (2007) Anal Biochem , vol.368 , pp. 95-99
    • Seibel, N.M.1    Eljouni, J.2    Nalaskowski, M.M.3    Hampe, W.4
  • 18
    • 33947727502 scopus 로고    scopus 로고
    • Myocardin-related transcription factors: critical coactivators regulating cardiovascular development and adaptation
    • Parmacek MS, (2007) Myocardin-related transcription factors: critical coactivators regulating cardiovascular development and adaptation. Circ Res 100: 633-644.
    • (2007) Circ Res , vol.100 , pp. 633-644
    • Parmacek, M.S.1
  • 19
    • 0037069365 scopus 로고    scopus 로고
    • Potentiation of serum response factor activity by a family of myocardin-related transcription factors
    • Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, et al. (2002) Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci U S A 99: 14855-14860.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 14855-14860
    • Wang, D.Z.1    Li, S.2    Hockemeyer, D.3    Sutherland, L.4    Wang, Z.5
  • 20
    • 77954354238 scopus 로고    scopus 로고
    • KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding sites
    • Himeda CL, Ranish JA, Pearson RC, Crossley M, Hauschka SD, (2010) KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding sites. Mol Cell Biol 30: 3430-3443.
    • (2010) Mol Cell Biol , vol.30 , pp. 3430-3443
    • Himeda, C.L.1    Ranish, J.A.2    Pearson, R.C.3    Crossley, M.4    Hauschka, S.D.5
  • 21
    • 33645070593 scopus 로고    scopus 로고
    • Human KLF17 is a new member of the Sp/KLF family of transcription factors
    • van Vliet J, Crofts LA, Quinlan KG, Czolij R, Perkins AC, et al. (2006) Human KLF17 is a new member of the Sp/KLF family of transcription factors. Genomics 87: 474-482.
    • (2006) Genomics , vol.87 , pp. 474-482
    • van Vliet, J.1    Crofts, L.A.2    Quinlan, K.G.3    Czolij, R.4    Perkins, A.C.5
  • 22
    • 0034178250 scopus 로고    scopus 로고
    • Human Kruppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription
    • van Vliet J, Turner J, Crossley M, (2000) Human Kruppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription. Nucleic Acids Res 28: 1955-1962.
    • (2000) Nucleic Acids Res , vol.28 , pp. 1955-1962
    • van Vliet, J.1    Turner, J.2    Crossley, M.3
  • 23
    • 23944469854 scopus 로고    scopus 로고
    • The KLF2 transcription factor does not affect the formation of preadipocytes but inhibits their differentiation into adipocytes
    • Wu J, Srinivasan SV, Neumann JC, Lingrel JB, (2005) The KLF2 transcription factor does not affect the formation of preadipocytes but inhibits their differentiation into adipocytes. Biochemistry 44: 11098-11105.
    • (2005) Biochemistry , vol.44 , pp. 11098-11105
    • Wu, J.1    Srinivasan, S.V.2    Neumann, J.C.3    Lingrel, J.B.4
  • 24
  • 25
    • 0023762817 scopus 로고
    • Analysis of the upstream regions governing expression of the chicken cardiac troponin T gene in embryonic cardiac and skeletal muscle cells
    • Mar JH, Antin PB, Cooper TA, Ordahl CP, (1988) Analysis of the upstream regions governing expression of the chicken cardiac troponin T gene in embryonic cardiac and skeletal muscle cells. J Cell Biol 107: 573-585.
    • (1988) J Cell Biol , vol.107 , pp. 573-585
    • Mar, J.H.1    Antin, P.B.2    Cooper, T.A.3    Ordahl, C.P.4
  • 26
    • 48849101093 scopus 로고    scopus 로고
    • The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts
    • Wang B, Haldar SM, Lu Y, Ibrahim OA, Fisch S, et al. (2008) The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. J Mol Cell Cardiol 45: 193-197.
    • (2008) J Mol Cell Cardiol , vol.45 , pp. 193-197
    • Wang, B.1    Haldar, S.M.2    Lu, Y.3    Ibrahim, O.A.4    Fisch, S.5
  • 28
    • 0035967868 scopus 로고    scopus 로고
    • Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor
    • Wang D, Chang PS, Wang Z, Sutherland L, Richardson JA, et al. (2001) Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell 105: 851-862.
    • (2001) Cell , vol.105 , pp. 851-862
    • Wang, D.1    Chang, P.S.2    Wang, Z.3    Sutherland, L.4    Richardson, J.A.5
  • 29
    • 2942538855 scopus 로고    scopus 로고
    • Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality
    • Parlakian A, Tuil D, Hamard G, Tavernier G, Hentzen D, et al. (2004) Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality. Mol Cell Biol 24: 5281-5289.
    • (2004) Mol Cell Biol , vol.24 , pp. 5281-5289
    • Parlakian, A.1    Tuil, D.2    Hamard, G.3    Tavernier, G.4    Hentzen, D.5
  • 30
    • 77955173404 scopus 로고    scopus 로고
    • Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction
    • Small EM, Thatcher JE, Sutherland LB, Kinoshita H, Gerard RD, et al. (2010) Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction. Circ Res 107: 294-304.
    • (2010) Circ Res , vol.107 , pp. 294-304
    • Small, E.M.1    Thatcher, J.E.2    Sutherland, L.B.3    Kinoshita, H.4    Gerard, R.D.5
  • 31
    • 61849140657 scopus 로고    scopus 로고
    • Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis
    • Medjkane S, Perez-Sanchez C, Gaggioli C, Sahai E, Treisman R, (2009) Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell Biol 11: 257-268.
    • (2009) Nat Cell Biol , vol.11 , pp. 257-268
    • Medjkane, S.1    Perez-Sanchez, C.2    Gaggioli, C.3    Sahai, E.4    Treisman, R.5
  • 32
    • 37549065952 scopus 로고    scopus 로고
    • Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors
    • Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, et al. (2007) Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. J Biol Chem 282: 37244-37255.
    • (2007) J Biol Chem , vol.282 , pp. 37244-37255
    • Lagna, G.1    Ku, M.M.2    Nguyen, P.H.3    Neuman, N.A.4    Davis, B.N.5
  • 33
    • 12844273481 scopus 로고    scopus 로고
    • Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice
    • Li S, Czubryt MP, McAnally J, Bassel-Duby R, Richardson JA, et al. (2005) Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice. Proc Natl Acad Sci U S A 102: 1082-1087.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 1082-1087
    • Li, S.1    Czubryt, M.P.2    McAnally, J.3    Bassel-Duby, R.4    Richardson, J.A.5
  • 34
    • 0033830608 scopus 로고    scopus 로고
    • Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor
    • Uchida S, Tanaka Y, Ito H, Saitoh-Ohara F, Inazawa J, et al. (2000) Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor. Mol Cell Biol 20: 7319-7331.
    • (2000) Mol Cell Biol , vol.20 , pp. 7319-7331
    • Uchida, S.1    Tanaka, Y.2    Ito, H.3    Saitoh-Ohara, F.4    Inazawa, J.5
  • 35
    • 69949159381 scopus 로고    scopus 로고
    • The Kruppel traffic report: cooperative signals direct KLF8 nuclear transport
    • Rodriguez E, Martignetti JA, (2009) The Kruppel traffic report: cooperative signals direct KLF8 nuclear transport. Cell Res 19: 1041-1043.
    • (2009) Cell Res , vol.19 , pp. 1041-1043
    • Rodriguez, E.1    Martignetti, J.A.2
  • 36
    • 78650979325 scopus 로고    scopus 로고
    • Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution
    • Prasad KM, Xu Y, Yang Z, Acton ST, French BA, (2011) Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution. Gene Ther 18: 43-52.
    • (2011) Gene Ther , vol.18 , pp. 43-52
    • Prasad, K.M.1    Xu, Y.2    Yang, Z.3    Acton, S.T.4    French, B.A.5
  • 37
    • 33746874152 scopus 로고    scopus 로고
    • Adeno-associated virus serotypes: vector toolkit for human gene therapy
    • Wu Z, Asokan A, Samulski RJ, (2006) Adeno-associated virus serotypes: vector toolkit for human gene therapy. Mol Ther 14: 316-327.
    • (2006) Mol Ther , vol.14 , pp. 316-327
    • Wu, Z.1    Asokan, A.2    Samulski, R.J.3
  • 38
    • 77954173550 scopus 로고    scopus 로고
    • The expanding range of parvoviruses which infect humans
    • Brown KE, (2010) The expanding range of parvoviruses which infect humans. Rev Med Virol 20: 231-244.
    • (2010) Rev Med Virol , vol.20 , pp. 231-244
    • Brown, K.E.1
  • 39
    • 62549159967 scopus 로고    scopus 로고
    • Tailoring the AAV vector capsid for gene therapy
    • Vandenberghe LH, Wilson JM, Gao G, (2009) Tailoring the AAV vector capsid for gene therapy. Gene Ther 16: 311-319.
    • (2009) Gene Ther , vol.16 , pp. 311-319
    • Vandenberghe, L.H.1    Wilson, J.M.2    Gao, G.3
  • 40
    • 33747518710 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivo
    • Pacak CA, Mah CS, Thattaliyath BD, Conlon TJ, Lewis MA, et al. (2006) Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivo. Circ Res 99: e3-9.
    • (2006) Circ Res , vol.99
    • Pacak, C.A.1    Mah, C.S.2    Thattaliyath, B.D.3    Conlon, T.J.4    Lewis, M.A.5
  • 41
    • 33745143956 scopus 로고    scopus 로고
    • Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8
    • Inagaki K, Fuess S, Storm TA, Gibson GA, McTiernan CF, et al. (2006) Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8. Mol Ther 14: 45-53.
    • (2006) Mol Ther , vol.14 , pp. 45-53
    • Inagaki, K.1    Fuess, S.2    Storm, T.A.3    Gibson, G.A.4    McTiernan, C.F.5
  • 42
    • 62649133817 scopus 로고    scopus 로고
    • Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial
    • Jaski BE, Jessup ML, Mancini DM, Cappola TP, Pauly DF, et al. (2009) Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial. J Card Fail 15: 171-181.
    • (2009) J Card Fail , vol.15 , pp. 171-181
    • Jaski, B.E.1    Jessup, M.L.2    Mancini, D.M.3    Cappola, T.P.4    Pauly, D.F.5
  • 43
    • 2642512201 scopus 로고    scopus 로고
    • Clades of Adeno-associated viruses are widely disseminated in human tissues
    • Gao G, Vandenberghe LH, Alvira MR, Lu Y, Calcedo R, et al. (2004) Clades of Adeno-associated viruses are widely disseminated in human tissues. J Virol 78: 6381-6388.
    • (2004) J Virol , vol.78 , pp. 6381-6388
    • Gao, G.1    Vandenberghe, L.H.2    Alvira, M.R.3    Lu, Y.4    Calcedo, R.5
  • 44
    • 78751507979 scopus 로고    scopus 로고
    • Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart
    • Creemers EE, Pinto YM, (2011) Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart. Cardiovasc Res 89: 265-272.
    • (2011) Cardiovasc Res , vol.89 , pp. 265-272
    • Creemers, E.E.1    Pinto, Y.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.