Different protocols of physical exercise produce different effects on synaptic and structural proteins in motor areas of the rat brain

Brain Research

Volumn 1456, Issue , 2012, Pages 36-48

  Garcia, Priscila C ^a   Real, Caroline C ^b   Ferreira, Ana F B ^b   Alouche, Sandra R ^a   Britto, Luiz R G ^b   Pires, Raquel S ^a  

^a MASTERS AND DOCTORAL PROGRAMS IN PHYSICAL THERAPY   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Acrobatic exercise; Cerebellum; Motor cortex; Striatum; Structural plasticity; Synaptic plasticity; Treadmill exercise

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN 2; SYNAPSIN I; SYNAPTOPHYSIN;

ANIMAL BEHAVIOR; ARTICLE; BRAIN FUNCTION; BRAIN REGION; CEREBELLUM; CEREBELLUM CORTEX; CLINICAL PROTOCOL; CORPUS STRIATUM; EXERCISE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOTOR CORTEX; MOTOR PERFORMANCE; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; SEDENTARY LIFESTYLE; SYNAPTIC TRANSMISSION; TREADMILL EXERCISE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN; IMMUNOHISTOCHEMISTRY; MALE; NERVE TISSUE PROTEINS; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR; SYNAPSES;

RATTUS; RATTUS NORVEGICUS;

EID: 84860626087     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.03.059     Document Type: Article

References (48)

1. D.L. Adkins, J. Boychuk, M.S. Remple, and J.A. Kleim Motor training induces experience-specific patterns of plasticity across motor cortex and spinal cord J. Appl. Physiol. 101 2006 1776 1782 (Pubitemid 44904501)
2. E.T. Ang, G.S. Dawe, P.T. Wong, S. Moochhala, and Y.K. Ng Alterations in spatial learning and memory after forced exercise Brain Res. 1113 2006 186 193 (Pubitemid 44396947)
3. R.M. Arida, F.A. Scorza, S. Gomes da Silva, R.M. Cysneiros, and E.A. Cavalheiro Exercise paradigms to study brain injury recovery in rodents Am. J. Phys. Med. Rehabil. 90 2011 452 465
4. J.E. Black, K.R. Isaacs, B.J. Anderson, A.A. Alcantara, and W.T. Greenough Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats Proc. Natl. Acad. Sci. U. S. A. 87 1990 5568 5572
5. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
6. T.O. Brock, and J.P. O'Callaghan Quantitative changes in the synaptic vesicle proteins synapsin I and p38 and the astrocyte-specific protein glial fibrillary acidic protein are associated with chemical-induced injury to the rat central nervous system J. Neurosci. 7 4 1987 931 942 (Pubitemid 17055338)
7. S.P. Brooks, and S.B. Dunnett Tests to assess motor phenotype in mice: a user's guide Nat. Rev. Neurosci. 10 2009 519 529
8. C.W. Cotman, and N.C. Berchtold Physical activity and the maintenance of cognition: learning from animal models Alzheimers Dement. 3 2007 S30 S37
9. A. Del Arco, G. Segovia, J.J. Canales, P. Garrido, M. de Blas, J.M. Garcia-Verdugo, and F. Mora Environmental enrichment reduces the function of D1 dopamine receptors in the prefrontal cortex of the rat J. Neural Transm. 114 2007 43 48 (Pubitemid 46018674)
10. A. Del Arco, G. Segovia, P. Garrido, M. de Blas, and F. Mora Stress, prefrontal cortex and environmental enrichment: studies on dopamine and acetylcholine release and working memory performance in rats Behav. Brain Res. 176 2007 267 273 (Pubitemid 44880088)
11. M.J. Derksen, N.L. Ward, K.D. Hartle, and T.L. Ivanco MAP2 and synaptophysin protein expression following motor learning suggests dynamic regulation and distinct alterations coinciding with synaptogenesis Neurobiol. Learn. Mem. 87 2007 404 415 (Pubitemid 46137010)
12. Q. Ding, S. Vaynman, P. Souda, J.P. Whitelegge, and F. Gomez-Pinilla Exercise affects energy metabolism and neural plasticity-related proteins in the hippocampus as revealed by proteomic analysis Eur. J. Neurosci. 24 2006 1265 1276 (Pubitemid 44401649)
13. R.E. Dustman, R.Y. Emmerson, R.O. Ruhling, D.E. Shearer, L.A. Steinhaus, S.C. Johnson, H.W. Bonekat, and J.W. Shigeoka Age and fitness effects on EEG, ERPs, visual sensitivity, and cognition Neurobiol. Aging 11 1990 193 200 (Pubitemid 20181896)
14. A.F. Ferreira, C.C. Real, A.C. Rodrigues, A.S. Alves, and L.R. Britto Moderate exercise changes synaptic and cytoskeletal proteins in motor regions of the rat brain Brain Res. 1361 2010 31 42
15. A.F. Ferreira, C.C. Real, A.C. Rodrigues, A.S. Alves, and L.R. Britto Short-term, moderate exercise is capable of inducing structural, bdnf-independent hippocampal plasticity Brain Res. 1425 2011 111 122
16. E.F. Fornasiero, D. Bonanomi, F. Benfenati, and F. Valtorta The role of synapsins in neuronal development Cell. Mol. Life Sci. 67 9 2010 1383 1396
17. M.M. Holmes, L.A. Galea, R.E. Mistlberger, and G. Kempermann Adult hippocampal neurogenesis and voluntary running activity: circadian and dose-dependent effects J. Neurosci. Res. 76 2 2004 216 222 (Pubitemid 38451209)
18. D.P. Holschneider, J. Yang, Y. Guo, and J.M. Maarek Reorganization of functional brain maps after exercise training: importance of cerebellar-thalamic-cortical pathway Brain Res. 1184 2007 96 107 (Pubitemid 350160587)
19. D.P. Holschneider, and J.M. Maarek Brain maps on the go: functional imaging during motor challenge in animals Methods 45 2008 255 261
20. T.A. Jones, C.J. Chu, L.A. Grande, and A.D. Gregory Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats J. Neurosci. 19 1999 10153 10163 (Pubitemid 30226687)
21. J.A. Kleim, E. Lussnig, E.R. Schwarz, T.A. Comery, and W.T. Greenough Synaptogenesis and Fos expression in the motor cortex of the adult rat after motor skill learning J. Neurosci. 16 1996 4529 4535 (Pubitemid 26242294)
22. J.A. Kleim, K. Vij, D.H. Ballard, and W.T. Greenough Learning-dependent synaptic modifications in the cerebellar cortex of the adult rat persist for at least four weeks J. Neurosci. 17 1997 717 721 (Pubitemid 27024583)
23. J.A. Kleim, S. Barbay, and R.J. Nudo Functional reorganization of the rat motor cortex following motor skill learning J. Neurophysiol. 80 1998 3321 3325 (Pubitemid 29029253)
24. J.A. Kleim, R.A. Swain, K.A. Armstrong, R.M. Napper, T.A. Jones, and W.T. Greenough Selective synaptic plasticity within the cerebellar cortex following complex motor skill learning Neurobiol. Learn. Mem. 69 1998 274 289 (Pubitemid 28374561)
25. J.A. Kleim, S. Barbay, N.R. Cooper, T.M. Hogg, C.N. Reidel, M.S. Remple, and R.J. Nudo Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex Neurobiol. Learn. Mem. 77 2002 63 77 (Pubitemid 34971544)
26. A.Y. Klintsova, R.M. Cowell, R.A. Swain, R.M. Napper, C.R. Goodlett, and W.T. Greenough Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats. I. Behavioral results Brain Res. 800 1998 48 61 (Pubitemid 28361921)
27. A.Y. Klintsova, E. Dickson, R. Yoshida, and W.T. Greenough Altered expression of BDNF and its high-affinity receptor TrkB in response to complex motor learning and moderate exercise Brain Res. 1028 2004 92 104 (Pubitemid 39429465)
28. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
29. T.J. Lambert, S.M. Fernandez, and K.M. Frick Different types of environmental enrichment have discrepant effects on spatial memory and synaptophysin levels in female mice Neurobiol. Learn. Mem. 83 2005 206 216 (Pubitemid 40488808)
30. M.M. Lewis, C.G. Slagle, A.B. Smith, Y. Truong, P. Bai, M.J. McKeown, R.B. Mailman, A. Belger, and X. Huang Task specific influences of Parkinson's disease on the striato-thalamo-cortical and cerebello-thalamo-cortical motor circuitries Neuroscience 147 2007 224 235 (Pubitemid 46873847)
31. N.S. Lupinacci, R.E. Rikli, C.J. Jones, and D. Ross Age and physical activity effects on reaction time and digit symbol substitution performance in cognitively active adults Res. Q. Exerc. Sport 64 1993 144 150
32. R. Meeusen, I. Smolders, S. Sarre, K. de Meirleir, H. Keizer, M. Serneels, G. Ebinger, and Y. Michotte Endurance training effects on neurotransmitter release in rat striatum: an in vivo microdialysis study Acta Physiol. Scand. 159 1997 335 341 (Pubitemid 27193342)
33. S. Miyachi, O. Hikosaka, and X. Lu Differential activation of monkey striatal neurons in the early and late stages of procedural learning Exp. Brain Res. 146 2002 122 126 (Pubitemid 34985335)
34. R. Molteni, Z. Ying, and F. Gomez-Pinilla Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray Eur. J. Neurosci. 16 2002 1107 1116 (Pubitemid 35463560)
35. F. Mora, G. Segovia, and A. del Arco Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain Brain Res. Rev. 55 2007 78 88 (Pubitemid 47422232)
36. G. Paxinos, and C. Watson The Rat Brain - In Stereotaxic Coordinates fifth ed. 2005 Elsevier Academic Press Burlington
37. R. Perrot, R. Berges, A. Bocquet, and J. Eyer Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration Mol. Neurobiol. 38 1 2008 27 65
38. P. Rasmussem, P. Brassard, H. Adser, M.V. Pedersen, L. Leick, E. Hart, N.H. Secher, B.K. Pedersen, and H. Pilegaard Evidence for a release of brain-derived neurotrophic factor from the brain during exercise Exp. Physiol. 94 10 2009 1062 1069
39. C.C. Real, A.F. Ferreira, M.S. Hernandes, L.R. Britto, and R.S. Pires Exercise-induced plasticity of AMPA-type glutamate receptor subunits in the rat brain Brain Res. 1363 2010 63 71
40. R. Salgado-Delgado, M. Angeles-Castellanos, M.R. Buijs, and C. Escobar Internal desynchronization in a model of night-work by forced activity in rats Neuroscience 154 2008 922 931
41. C. Sanchez, J. Diaz-Nido, and J. Avila Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function Prog. Neurobiol. 61 2000 133 168 (Pubitemid 30110476)
42. N. Tajiri, T. Yasuhara, T. Shingo, A. Kondo, W. Yuan, T. Kadota, F. Wang, T. Baba, J.T. Tayra, T. Morimoto, M. Jing, Y. Kikuchi, S. Kuramoto, T. Agari, Y. Miyoshi, H. Fujino, F. Obata, I. Takeda, T. Furuta, and I. Date Exercise exerts neuroprotective effects on Parkinson's disease model of rats Brain Res. 1310 2010 200 207
43. R.P. Tucker, C.C. Garner, and A. Matus In situ localization of microtubule-associated protein mRNA in the developing and adult rat brain Neuron 2 3 1989 1245 1256
44. H. van Praag, B.R. Christie, T.J. Sejnowski, and F.H. Gage Running enhances neurogenesis, learning, and long-term potentiation in mice Proc. Natl. Acad. Sci. U. S. A. 96 1999 13427 13431
45. H. van Praag, G. Kempermann, and F.H. Gage Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus Nat. Neurosci. 2 1999 266 270 (Pubitemid 30491298)
46. S. Vaynman, Z. Ying, and F. Gomez-Pinilla Exercise induces BDNF and synapsin I to specific hippocampal subfields J. Neurosci. Res. 76 2004 356 362 (Pubitemid 38580130)
47. S.S. Vaynman, Z. Ying, D. Yin, and F. Gomez-Pinilla Exercise differentially regulates synaptic proteins associated to the function of BDNF Brain Res. 1070 2006 124 130 (Pubitemid 43247751)
48. H.H. Yin The sensorimotor striatum is necessary for serial order learning J. Neurosci. 30 2010 14719 14723