Learning-dependent synaptic modifications in the cerebellar cortex of the adult rat persist for at least four weeks

Journal of Neuroscience

Volumn 17, Issue 2, 1997, Pages 717-721

  Kleim, Jeffrey A ^a   Vij, Kapil ^a   Ballard, David H ^a   Greenough, William T ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

cerebellum; motor learning; persistence; rat; synaptic plasticity; synaptogenesis

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CEREBELLUM CORTEX; CONTROLLED STUDY; FEMALE; LEARNING; MEMORY; MOTOR ACTIVITY; MOTOR PERFORMANCE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RAT; SYNAPTOGENESIS;

EID: 0031012167     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-02-00717.1997     Document Type: Article

References (22)

1. Anderson BJ, Li X, Alcantara AA, Isaacs KR, Black JE, Greenough WT (1994) Glial hypertrophy is associated with synaptogenesis following motor skill learning, but not with angiogenesis following exercise. Glia 11:73-80.
2. Anderson BJ, Alcantara AA, Greenough WT (1996) Motor skill learning: changes in synaptic organization of the rat cerebellar cortex. Neurobiol Learn Mem, in press.
3. Anker RL, Cragg BG (1974) Estimation of the number of synapses in a volume of nervous tissue from counts in thin sections by electron microscopy. J Neurocytol 3:725-735.
4. Bailey CH, Chen M (1983) Morphological basis of long-term habituation and sensitization in Aplysia. Science 220:91-93.
5. Bailey CH, Chen M (1989) Time course of structural changes at identified sensory neuron synapses during long-term sensitization in Aplysia. J Neurosci 9:1774-1780.
6. Bailey CH, Kandel ER (1993) Structural changes accompanying memory storage. Annu Rev Physiol 16:397-426.
7. Bendre AA, Swain RS, Wheeler BC, Greenough WT (1995) Augmentation of cerebellar responses to parallel fiber activation following skilled motor acquisition in rats. Soc Neurosci Abstr 21:444.
8. Berthier NE, Moore JW (1986) Cerebellar Purkinje cell activity related to the classically conditioned nictitating membrane response. Exp Brain Res 63:341-350.
9. Bhide PG, Bedi KS (1984) The effects of a lengthy period of environmental diversity on well-fed and previously undernourished rats. II. Synapse-to-neuron ratios. J Comp Neurol 227:305-310.
10. Black JE, Isaacs KR, Anderson BJ, Alcantara AA, Greenough WT (1990) Learning causes synaptogenesis whereas motor activity causes angiogenesis in cerebellar cortex of adult rats. Proc Natl Acad Sci USA 87:5568-5572.
11. Camel JE, Withers GS, Greenough WT (1986) Persistence of visual cortex dendritic alterations induced by postweaning exposure to a "superenriched" environment in rats. Behav Neurosci 100:810-813.
12. Chang FLF, Greenough WT (1982) Lateralized effects of monocular training on dendritic branching in adult split-brain rats. Brain Res 232:283-292.
13. Diamond MC, Krech D, Rosenzweig MR (1964) The effects of an enriched environment on the histology of the rat cerebral cortex. J Comp Neurol 123:111-120.
14. Federmeier K, Kleim JA, Anderson BJ, Greenough WT (1994) Formation of double synapses in the cerebellar cortex of the rat following motor learning. Soc Neurosci Abstr 20:1435.
15. Forgays DG, Read JM (1962) Crucial periods for free environmental experience in the rat. J Comp Physiol Psychol 45:322-328.
16. Gilbert PFC, Thach WT (1977) Purkinje cell activity during motor learning. Brain Res 128:309-328.
17. Globus A, Rosenzweig MR, Bennett EL, Diamond MC (1973) Effects of differential experience on dendritic spine counts in rat cerebral cortex. J Comp Physiol Psychol 82:175-181.
18. Greenough WT, Bailey CH (1988) Anatomy of memory: convergence of results across a diversity of tests. Trends Neurosci 11:142-147.
19. Greenough WT, Juraska JM, Volkmar FR (1979) Maze training effects on dendritic branching in occipital cortex of adult rats. Behav Neural Biol 26:287-297.
20. Turner AM, Greenough WT (1985) Differential rearing effects on rat visual cortex synapses. I. Synaptic and neuronal density and synapses per neuron. Brain Res 329:195-203.
21. Volkmar FR, Greenough WT (1972) Rearing complexity affects branching of dendrites in the visual cortex of the rat. Science 176:1445-1447.
22. Withers GS, Greenough WT (1989) Reach training selectively alters dendritic branching in subpopulations of layer II-III pyramidals in rat motor-somatosensory forelimb cortex. Neuropsychologia 27:61-69.