Evaluation of salivary cortisol measurements for the diagnosis of subclinical Cushing's syndrome

Endocrine Journal

Volumn 59, Issue 4, 2012, Pages 283-289

  Tateishi, Yuko ^a   Kouyama, Ryuji ^a   Mihara, Masatomo ^a   Doi, Masaru ^a   Yoshimoto, Takanobu ^a   Hirata, Yukio ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Adrenal incidentaloma; Salivary cortisol; Subclinical Cushing's syndrome

Indexed keywords

ALDOSTERONE; CORTICOTROPIN; DEXAMETHASONE; HYDROCORTISONE;

ADRENAL INCIDENTALOMA; ADULT; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CUSHING SYNDROME; DEXAMETHASONE SUPPRESSION TEST; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; JAPAN; LIMIT OF DETECTION; MALE; NIGHT; NONFUNCTIONING PITUITARY ADENOMA; PHEOCHROMOCYTOMA; PRIMARY HYPERALDOSTERONISM; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SALIVA ANALYSIS; SENSITIVITY AND SPECIFICITY;

ADENOMA; ADRENAL GLAND NEOPLASMS; ADULT; AGED; CIRCADIAN RHYTHM; CUSHING SYNDROME; DEXAMETHASONE; FEMALE; HUMANS; HYDROCORTISONE; HYPERALDOSTERONISM; MALE; MIDDLE AGED; PHEOCHROMOCYTOMA; ROC CURVE; SALIVA; SENSITIVITY AND SPECIFICITY;

EID: 84860622035     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.EJ11-0204     Document Type: Article

References (31)

1. Nieman LK (2010) Approach to the patient with an adrenal incidentaloma. J Clin Endocrinol Metab 95:4106-4113.
2. Mansmann G, Lau J, Balk E, Rothberg M, Miyachi Y, Bornstein SR (2004) The clinically inapparent adrenal mass: update in diagnosis and management. Endocr Rev 25:309-340.
3. Young WF Jr (2007) Clinical practice. The incidentally discovered adrenal mass. N Engl J Med 356:601-610.
4. Rossi R, Tauchmanova L, Luciano A, Di Martino M, Battista C, Del Viscovo L, Nuzzo V, Lombardi G (2000) Subclinical Cushing's syndrome in patients with adrenal incidentaloma: clinical and biochemical features. J Clin Endocrinol Metab 85:1440-1448.
5. Chiodini I (2011) Diagnosis and Treatment of Subclinical Hypercortisolism. J Clin Endocrinol Metab 96:1223- 1236.
6. Zeiger MA, Siegelman SS, Hamrahian AH (2011) Medical and surgical evaluation and treatment of adrenal incidentalomas. J Clin Endocrinol Metab 96:2004-2015.
7. Tauchmanova L, Rossi R, Biondi B, Pulcrano M, Nuzzo V, Palmieri EA, Fazio S, Lombardi G (2002) Patients with subclinical Cushing's syndrome due to adrenal adenoma have increased cardiovascular risk. J Clin Endocrinol Metab 87:4872-4878.
8. Chiodini I, Morelli V, Salcuni AS, Eller-Vainicher C, Torlontano M, Coletti F, Iorio L, Cuttitta A, Ambrosio A, Vicentini L, Pellegrini F, Copetti M, Beck-Peccoz P, Arosio M, Ambrosi B, Trischitta V, Scillitani A (2010) Beneficial metabolic effects of prompt surgical treatment in patients with an adrenal incidentaloma causing biochemical hypercortisolism. J Clin Endocrinol Metab 95:2736-2745.
9. Morelli V, Eller-Vainicher C, Salcuni AS, Coletti F, Iorio L, Muscogiuri G, Della Casa S, Arosio M, Ambrosi B, Beck-Peccoz P, Chiodini I (2011) Risk of new vertebral fractures in patients with adrenal incidentaloma with and without subclinical hypercortisolism: a multicenter longitudinal study. J Bone Miner Res 26:1816-1821.
10. Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM (2008) The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 93:1526-1540.
11. Nawata H, Demura H, Suda T, Takayanagi R (1996) Adrenal preclinical Cushing's syndrome in Annual Report of the Ministry of Health and Welfare "Disorders of Adrenal Hormones" Research Committee, Japan, 223-226 (In Japanese).
12. Morelli V, Masserini B, Salcuni AS, Eller-Vainicher C, Savoca C, Viti R, Coletti F, Guglielmi G, Battista C, Iorio L, Beck-Peccoz P, Ambrosi B, Arosio M, Scillitani A, Chiodini I (2010) Subclinical hypercortisolism: correlation between biochemical diagnostic criteria and clinical aspects. Clin Endocrinol (Oxf) 73:161-166.
13. Raff H, Raff JL, Findling JW (1998) Late-night salivary cortisol as a screening test for Cushing's syndrome. J Clin Endocrinol Metab 83:2681-2686.
14. Papanicolaou DA, Mullen N, Kyrou I, Nieman LK (2002) Nighttime salivary cortisol: a useful test for the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab 87:4515-4521.
15. Yaneva M, Mosnier-Pudar H, Dugue MA, Grabar S, Fulla Y, Bertagna X (2004) Midnight salivary cortisol for the initial diagnosis of Cushing's syndrome of various causes. J Clin Endocrinol Metab 89:3345-3351.
16. Viardot A, Huber P, Puder JJ, Zulewski H, Keller U, Muller B (2005) Reproducibility of nighttime salivary cortisol and its use in the diagnosis of hypercortisolism compared with urinary free cortisol and overnight dexamethasone suppression test. J Clin Endocrinol Metab 90:5730-5736.
17. Lewis JG (2006) Steroid analysis in saliva: an overview. Clin Biochem Rev 27:139-146.
18. Doi M, Sekizawa N, Tani Y, Tsuchiya K, Kouyama R, Tateno T, Izumiyama H, Yoshimoto T, Hirata Y (2008) Late-night salivary cortisol as a screening test for the diagnosis of Cushing's syndrome in Japan. Endocr J 55:121-126.
19. Kidambi S, Raff H, Findling JW (2007) Limitations of nocturnal salivary cortisol and urine free cortisol in the diagnosis of mild Cushing's syndrome. Eur J Endocrinol 157:725-731.
20. Masserini B, Morelli V, Bergamaschi S, Ermetici F, Eller-Vainicher C, Barbieri AM, Maffini MA, Scillitani A, Ambrosi B, Beck-Peccoz P, Chiodini I (2009) The limited role of midnight salivary cortisol levels in the diagnosis of subclinical hypercortisolism in patients with adrenal incidentaloma. Eur J Endocrinol 160:87-92.
21. Nunes ML, Vattaut S, Corcuff JB, Rault A, Loiseau H, Gatta B, Valli N, Letenneur L, Tabarin A (2009) Latenight salivary cortisol for diagnosis of overt and subclinical Cushing's syndrome in hospitalized and ambulatory patients. J Clin Endocrinol Metab 94:456-462.
22. Sereg M, Toke J, Patocs A, Varga I, Igaz P, Szucs N, Horanyi J, Pusztai P, Czirjak S, Glaz E, Racz K, Toth M (2011) Diagnostic performance of salivary cortisol and serum osteocalcin measurements in patients with overt and subclinical Cushing's syndrome. Steroids 76:38-42.
23. Barzon L, Fallo F, Sonino N, Boscaro M (2002) Development of overt Cushing's syndrome in patients with adrenal incidentaloma. Eur J Endocrinol 146:61-66.
24. Beko G, Varga I, Glaz E, Sereg M, Feldman K, Toth M, Racz K, Patocs A (2010) Cutoff values of midnight salivary cortisol for the diagnosis of overt hypercortisolism are highly influenced by methods. Clin Chim Acta 411:364-367.
25. Carrozza C, Corsello SM, Paragliola RM, Ingraudo F, Palumbo S, Locantore P, Sferrazza A, Pontecorvi A, Zuppi C (2010) Clinical accuracy of midnight salivary cortisol measured by automated electrochemiluminescence immunoassay method in Cushing's syndrome. Ann Clin Biochem 47:228-232.
26. Zerikly RK, Amiri L, Faiman C, Gupta M, Singh RJ, Nutter B, Kennedy L, Hatipoglu B, Weil RJ, Hamrahian AH (2010) Diagnostic characteristics of late-night salivary cortisol using liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metab 95:4555-4559.
27. Baid SK, Sinaii N, Wade M, Rubino D, Nieman LK (2007) Radioimmunoassay and tandem mass spectrometry measurement of bedtime salivary cortisol levels: a comparison of assays to establish hypercortisolism. J Clin Endocrinol Metab 92:3102-3107.
28. van Aken MO, Romijn JA, Miltenburg JA, Lentjes EG (2003) Automated measurement of salivary cortisol. Clin Chem 49:1408-1409.
29. Deutschbein T, Unger N, Hinrichs J, Walz MK, Mann K, Petersenn S (2009) Late-night and low-dose dexamethasone- suppressed cortisol in saliva and serum for the diagnosis of cortisol-secreting adrenal adenomas. Eur J Endocrinol 161:747-753.
30. Golden SH, Malhotra S, Wand GS, Brancati FL, Ford D, Horton K (2007) Adrenal gland volume and dexamethasone- suppressed cortisol correlate with total daily salivary cortisol in African-American women. J Clin Endocrinol Metab 92:1358-1363.
31. Castro M, Elias PC, Quidute AR, Halah FP, Moreira AC (1999) Out-patient screening for Cushing's syndrome: the sensitivity of the combination of circadian rhythm and overnight dexamethasone suppression salivary cortisol tests. J Clin Endocrinol Metab 84:878-882.