Stimulus response latency of cough and expiration reflex depends on breathing in the rabbit

Pulmonary Pharmacology and Therapeutics

Volumn 25, Issue 3, 2012, Pages 242-247

  Varechova, S ^a   Poussel, M ^a   Schweitzer, C ^a   Demoulin, B ^a   Chenuel, B ^a   Marchal, F ^a  

^a laboratoire de Physiologie   (France)

Author keywords

Animal model of cough; Cough; Expiration; Expiration reflex; Inspiration; Stimulus response latency

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN STEM; BREATHING; BREATHING REFLEX; CONTROLLED STUDY; COUGHING; EXPERIMENTAL RABBIT; EXPIRATION REFLEX; LATENT PERIOD; MECHANICAL STIMULATION; NONHUMAN; PRIORITY JOURNAL; STIMULUS RESPONSE; TRACHEA;

ANIMALS; BRAIN STEM; COUGH; EXHALATION; INHALATION; RABBITS; REFLEX; RESPIRATION; TIME FACTORS; TRACHEA;

EID: 84860617873     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2012.03.006     Document Type: Article

References (42)

1. Korpas J., Kalocsayova G. The expiration reflex from the vocal folds of the rabbit. Physiol Bohemoslov 1974, 23:333-340.
2. Korpas J., Tomori Z. Cough and other respiratory reflexes basel 1979, Karger, Switzerland.
3. Tomori Z., Stransky A. Electroneurographic and pneumotachographic analysis of the expiration reflex. Physiol Bohemoslov 1973, 22:589-601.
4. Fontana G.A., Lavorini F. Cough motor mechanisms. Respir Physiol Neurobiol 2006, 152:266-281.
5. Fontana G.A., Widdicombe J. What is cough and what should be measured?. Pulm Pharmacol Ther 2007, 20:307-312.
6. Bolser D.C., Poliacek I., Jakus J., Fuller D.D., Davenport P.W. Neurogenesis of cough, other airway defensive behaviors and breathing: a holarchical system?. Respir Physiol Neurobiol 2006, 152:255-265.
7. Sullivan C.E., Murphy E., Kozar L.F., Phillipson E.A. Waking and ventilatory responses to laryngeal stimulation in sleeping dogs. J Appl Physiol 1978, 45:681-689.
8. Sullivan C.E., Kozar L.F., Murphy E., Phillipson E.A. Arousal, ventilatory, and airway responses to bronchopulmonary stimulation in sleeping dogs. J Appl Physiol 1979, 47:17-25.
9. Poliacek I., Rose M.J., Corrie L.W., Wang C., Jakus J., Barani H., et al. Short reflex expirations (expiration reflexes) induced by mechanical stimulation of the trachea in anesthetized cats. Cough 2008, 4:1.
10. Tatar M., Korpas J. Expiration reflex in wakeful cats (author's transl). Bratisl Lek Listy 1977, 67:138-144.
11. Ivanco I., Korpas J., Tomori Z. Studies on interoception in the respiratory tract. Cesk Fysiol 1956, 5:87-92.
12. Widdicombe J., Fontana G. Cough: what's in a name?. Eur Respir J 2006, 28:10-15.
13. Tomori Z. Pleural, tracheal and abdominal pressure variations in defensive and pathologic reflexes of the respiratory tract. Physiol Bohemoslov 1965, 14:84-95.
14. Kuhn H.F., Friebel H. On the arrangement of the cough impulse into the respiratory rhythm. Med Exp Int J Exp Med 1960, 3:329-335.
15. Engelhorn R., Weller E. Action potentials of respiration-synchronous discharged neurons of the medulla oblongata during coughing. Pflugers Arch Gesamte Physiol Menschen Tiere 1961, 273:614-635.
16. Addington W.R., Stephens R.E., Widdicombe J.G., Ockey R.R., Anderson J.W., Miller S.P. Electrophysiologic latency to the external obliques of the laryngeal cough expiration reflex in humans. Am J Phys Med Rehabil 2003, 82:370-373.
17. Fontana G.A. Before we get started: what is a cough?. Lung 2008, 186(Suppl. 1):S3-S6.
18. Mutolo D., Bongianni F., Fontana G.A., Pantaleo T. The role of excitatory amino acids and substance P in the mediation of the cough reflex within the nucleus tractus solitarii of the rabbit. Brain Res Bull 2007, 74:284-293.
19. Baekey D.M., Morris K.F., Nuding S.C., Segers L.S., Lindsey B.G., Shannon R. Ventrolateral medullary respiratory network participation in the expiration reflex in the cat. J Appl Physiol 2004, 96:2057-2072.
20. Varechova S., Poussel M., Demoulin B., Chenuel B., Schweitzer C., Marchal F. Within breath ventilatory responses to mechanical tracheal stimulation in anaesthetised rabbits. Pulm Pharmacol Ther 2010, 23:397-402.
21. Varechova S., Demoulin B., Poussel M., Chenuel B., Marchal F. Cough threshold and reactivity to mechanical stimulation of the trachea in the rabbit preliminary observations. Bratisl Lek Listy 2011, 112:136-139.
22. Basmajian J.V., Stecko G. The role of muscles in arch support of the foot. J Bone Jt Surg Am 1963, 45:1184-1190.
23. SYSTAT Software I SYSTAT 12 statistics 2007, 1735 Technomogy Drive, Suite 430, San Jose, CA 95110 USA, SYSTAT Software, Inc, Chicago.
24. Davies A., Roumy M. The effect of transient stimulation of lung irritant receptors on the pattern of breathing in rabbits. J Physiol 1982, 324:389-401.
25. Canning B.J., Mazzone S.B., Meeker S.N., Mori N., Reynolds S.M., Undem B.J. Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs. J Physiol 2004, 557:543-558.
26. Morelot-Panzini C., Fournier E., Donzel-Raynaud C., Dubourg O., Willer J.C., Similowski T. Conduction velocity of the human phrenic nerve in the neck. J Electromyogr Kinesiol 2009, 19:122-130.
27. Mazzone S.B. An overview of the sensory receptors regulating cough. Cough 2005, 1:2.
28. Mazzone S.B., McGovern A.E. Immunohistochemical characterization of nodose cough receptor neurons projecting to the trachea of guinea pigs. Cough 2008, 4:9.
29. Riccio M.M., Myers A.C., Undem B.J. Immunomodulation of afferent neurons in guinea-pig isolated airway. J Physiol 1996, 491(Pt 2):499-509.
30. Kajekar R., Proud D., Myers A.C., Meeker S.N., Undem B.J. Characterization of vagal afferent subtypes stimulated by bradykinin in guinea pig trachea. J Pharmacol Exp Ther 1999, 289:682-687.
31. Undem B.J., Carr M.J., Kollarik M. Physiology and plasticity of putative cough fibres in the Guinea pig. Pulm Pharmacol Ther 2002, 15:193-198.
32. Kollarik M., Undem B.J. Mechanisms of acid-induced activation of airway afferent nerve fibres in guinea-pig. J Physiol 2002, 543:591-600.
33. Adcock J.J., Douglas G.J., Garabette M., Gascoigne M., Beatch G., Walker M., et al. RSD931, a novel anti-tussive agent acting on airway sensory nerves. Br J Pharmacol 2003, 138:407-416.
34. Reynolds S.M., Mackenzie A.J., Spina D., Page C.P. The pharmacology of cough. Trends Pharmacol Sci 2004, 25:569-576.
35. Mazzone S.B. Sensory regulation of the cough reflex. Pulm Pharmacol Ther 2004, 17:361-368.
36. Korpas J., Jakus J. The expiration reflex from the vocal folds. Acta Physiol Hung 2000, 87:201-215.
37. Bolser D.C., Davenport P.W. Functional organization of the central cough generation mechanism. Pulm Pharmacol Ther 2002, 15:221-225.
38. Ainsworth D.M., Smith C.A., Eicker S.W., Henderson K.S., Dempsey J.A. The effects of locomotion on respiratory muscle activity in the awake dog. Respir Physiol 1989, 78:145-162.
39. Ellenberger H.H., Feldman J.L. Monosynaptic transmission of respiratory drive to phrenic motoneurons from brainstem bulbospinal neurons in rats. J Comp Neurol 1988, 269:47-57.
40. Merrill E.G., Fedorko L. Monosynaptic inhibition of phrenic motoneurons: a long descending projection from Botzinger neurons. J Neurosci 1984, 4:2350-2353.
41. Schreihofer A.M., Stornetta R.L., Guyenet P.G. Evidence for glycinergic respiratory neurons: Botzinger neurons express mRNA for glycinergic transporter 2. J Comp Neurol 1999, 407:583-597.
42. Widdicombe J., Tatar M., Fontana G., Hanacek J., Davenport P., Lavorini F., et al. Workshop: Tuning the 'cough center'. Pulm Pharmacol Ther 2011.