Cough motor mechanisms

Respiratory Physiology and Neurobiology

Volumn 152, Issue 3, 2006, Pages 266-281

  Fontana, Giovanni A ^a   Lavorini, Federico ^a  

^a Dipartimento di Area Critica Medico Chirurgica   (Italy)

Author keywords

Bronchoconstriction; Cardiovascular changes; Changes in breathing pattern; Cough; Laryngeal muscles; Lower oesophageal sphincter; Mucus secretion; Perineal muscles; Respiratory muscles

Indexed keywords

ABDOMINAL WALL MUSCULATURE; ARTICLE; BLOOD PRESSURE; BREATHING MUSCLE; BREATHING PATTERN; BRONCHOSPASM; CARDIOVASCULAR EFFECT; COUGHING; DEFENSE MECHANISM; DIAPHRAGM; ELECTROMYOGRAM; GASTROESOPHAGEAL REFLUX; HEART OUTPUT; HEART RATE; HUMAN; INTERCOSTAL MUSCLE; LARYNX MUSCLE; LOWER ESOPHAGUS SPHINCTER; MECHANICAL STRESS; MOTONEURON; MUCUS SECRETION; NERVE FIBER C; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; RESPIRATORY NERVE CELL; TRACHEOBRONCHIAL TREE;

ANIMALS; COUGH; HUMANS; RESPIRATORY MUSCLES; RESPIRATORY SYSTEM;

EID: 33745831886     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2006.02.016     Document Type: Article

References (74)

1. Amarenco G., Ismael S.S., Lagauche D., Raibaut P., Rene-Corail P., Wolff N., Thoumie P., and Haab F. Cough anal reflex: strict relationship between intravesical pressure and pelvic floor muscle electromyographic activity during cough. Urodynamic and electrophysiological study. J. Urol. 1 (2005) 149-152
2. Banner A.S. Cough: physiology, evaluation, and treatment. Lung 164 (1986) 79-92
3. Benditt D.G., Samniah N., Pham S., Sakaguchi S., Lu F., Lurie K.G., and Ermis C. Effect of cough on heart rate and blood pressure in patients with cough syncope. Heart Rhythm 2 (2005) 807-813
4. Bongianni F., Corda M., Fontana G.A., and Pantaleo T. Influences of superior laryngeal afferent stimulation on expiratory activity in cats. J. Appl. Physiol. 65 (1988) 385-392
5. Bongianni F., Mutolo D., Fontana G.A., and Pantaleo T. Discharge patterns of Botzinger complex neurons during cough in the cat. Am. J. Physiol. 274 (1998) R1015-R1024
6. Bongianni F., Mutolo D., Nardone F., and Pantaleo T. Ionotropic glutamate receptors mediate excitatory drive to caudal medullary expiratory neurons in the rabbit. Brain Res. 1056 (2005) 145-157
7. Cardone C., Bellavere F., Ferri M., and Fedele D. Autonomic mechanisms in the heart response to coughing. Clin. Sci. 72 (1987) 55-60
8. Chang A.B., McKean M., and Morris P. Inhaled anti-cholinergics for prolonged non-specific cough in children. Cochrane Database Syst. Rev. (2004) CD004358
9. Colebatch H.J.H., and Halmagyi D.F.J. Effect of vagotomy and vagal stimulation on lung mechanics and circulation. J. Appl. Physiol. 18 (1963) 881-887
10. Coleridge H.M., and Coleridge J.C.G. Reflexes evoked from tracheobronchial tree and lungs. In: Cherniack N.S., and Widdicombe J.G. (Eds). Handbook of Physiology. Section 3: The Respiratory System, vol. II: Control of Breathing, Part 1 (1986), American Physiological Society, Washington, DC 395-429
11. Criley J.M., Bloufuss A.H., and Kissell G.K. Cough-induced cardiac compression. Self-administered from of cardiopulmonary resuscitation. J. Am. Med. Assoc. 263 (1976) 1246-1250
12. Daly M.B., and Kirkman E. Differential modulation by pulmonary stretch afferents of some reflex cardioinhibitory responses in the cat. J. Physiol. 417 (1989) 323-341
13. D'Angelo E., Prandi E., D'Angelo E., and Pecchiari M. Lung-deflating ability of rib cage and abdominal muscles in rabbits. Respir. Physiol. Neurobiol. 135 (2003) 17-24
14. Davenport P.W., Sapienza C.M., and Bolser D.C. Psychophysical assessment of the urge-to-cough. Eur. Respir. Rev. 12 (2002) 249-253
15. Davis B., Roberts A.M., Coleridge H.M., and Coleridge J.C. Reflex tracheal gland secretion evoked by stimulation of bronchial C-fibers in dogs. J. Appl. Physiol. 53 (1982) 985-991
16. De Troyer A., Kirkwood P.A., and Wilson T.A. Respiratory action of the intercostals muscles. Physiol. Rev. 85 (2005) 717-756
17. Di Marco A.F., Romaniuk J.R., Kowalski K.E., and Supinski G. Mechanical contribution of expiratory muscles to pressure generation during spinal cord stimulation. J. Appl. Physiol. 87 (1999) 1433-1439
18. Evans K.C., Shea S.A., and Saykin A.J. Functional MRI localisation of central nervous system regions associated with volitional inspiration in humans. J. Physiol. 520 (1999) 383-392
19. Floyd W.F., and Silver P.H.S. Electromyographic study of patterns of activity of the anterior abdominal wall muscles in man. J. Anat. 84 (1950) 132-145
20. Fontana G.A., Pantaleo T., Lavorini F., Mutolo D., Polli G., and Pistolesi M. Coughing in laryngectomized patients. Am. J. Respir. Crit. Care Med. 160 (1999) 1578-1584
21. Fontana G.A., and Pistolesi M. Cough 3: chronic cough and gastro-oesophageal reflux. Thorax 58 (2003) 1092-1095
22. Fontana G.A. Motor mechanisms and the mechanics of cough. In: Chung K.F., Widdicombe J.G., and Boushey H. (Eds). Cough: Causes, Mechanisms and Therapy (2003), Blackwell Publishing 193-205
23. Fontana G.A., Lavorini F., and Pistolesi M. Water aerosols and cough. In: Redington A.E., and Morice A.H. (Eds). Acute and Chronic Cough (2005), Taylor & Francis Group 195-214
24. Foster W.M. Mucociliary transport and cough in humans. Pulm. Pharmacol. 15 (2002) 277-282
25. German V.F., Ueki I.F., and Nadel J.A. Micropipette measurements of airway submucosal glands secretion: laryngeal reflex. Am. Rev. Respir. Dis. 122 (1980) 413-416
26. Grélot L., and Milano S. Diaphragmatic and abdominal muscle activity during coughing in the decerebrate cat. Neuroreport 2 (1991) 165-168
27. Hainsworth R. Pathophysiology of syncope. Clin. Autonom. Res. 14 Suppl. 1 (2004) 18-24
28. Holstege G., and Tan J. Supraspinal control of motoneurons innervating the striated muscles of the pelvic floor including urethral and anal sphincters in the cat. Brain 110 (1987) 1323-1344
29. Ing A.J. Cough and gastroesophageal reflux. Am. J. Med. 103 (1997) 91S-96S
30. Iscoe S., and Grélot L. Regional intercostal activity during coughing and vomiting in decerebrate cats. Can. J. Physiol. Pharmacol. 70 (1992) 1195-1199
31. Iscoe S. Control of abdominal muscles. Prog. Neurobiol. 56 (1998) 433-506
32. Jordan D. Central nervous pathways and control of the airways. Respir. Physiol. 125 (2001) 67-81
33. Karlsson J.-A., Sant'Ambrogio G., and Widdicombe J.G. Afferent neural pathways in cough and reflex bronchoconstriction. J. Appl. Physiol. 65 (1988) 1007-1023
34. Kase Y., Kito G., Miyata T., and Takahama K. Influence of cerebral cortex stimulation upon cough-like spasmodic expiratory responses (SER) and cough in the cat. Brain Res. 306 (1984) 293-298
35. Kobayashi I., Kondo T., Suzuki H., Ohta Y., and Yamabayashi H. Expiratory activity of the inspiratory muscles during cough. Jpn. J. Physiol. 42 (1992) 905-916
36. Korpas J., and Tomori Z. Cough and other respiratory reflexes. In: Herzog H. (Ed). Progress in Respiratory Research vol. 12 (1979), Karger, Basel
37. Lavorini F., Fontana G.A., Pantaleo T., Camiciottoli G., Castellani W., Maluccio N.M., and Pistolesi M. Fog-induced respiratory responses are attenuated by nedocromil sodium in humans. Am. J. Respir. Crit. Care Med. 163 (2001) 1117-1120
38. Leith D.E., Butler J., Sneddon P., Brain S.L., and Cough J.D. In: Macklem P.T., and Mead J. (Eds). Handbook of Physiology, Section 3: The Respiratory System, vol. III: Mechanics of Breathing, Part 1 (1986), American Physiological Society, Washington, DC 315-336
39. Mazzone S.B., and Canning B.J. Central nervous system control of the airways: pharmacological implications. Curr. Opin. Pharmacol. 2 (2002) 220-228
40. Mead J., and Reid M.B. Respiratory muscle activity during repeated airflow interruption. J. Appl. Physiol. 64 (1988) 2314-2317
41. McIntosh H.D., Estes E.H., and Warren J.V. The mechanism of cough syncope. Am. Heart J. 52 (1956) 70-82
42. Miller A.D., Nonaka S., Siniaia M.S., and Jakus J. Multifunctional ventral respiratory group: bulbospinal expiratory neurons play a role in pudendal discharge during vomiting. J. Auton. Nerv. Syst. 54 (1995) 253-260
43. Mills J.E., Sellick H., and Widdicombe J.G. Epithelial irritant receptors in the lungs. In: Porter R. (Ed). Breathing, Hering-Breuer Centenary Symposium (1970), Churchill, London 77-92
44. Nishino T., Tagaito Y., and Isono S. Cough and other reflexes on irritation of airway mucosa in man. Pulm. Pharmacol. 9 (1996) 285-292
45. Phipps R.J., and Richardson P.S. The effects of irritation at various levels of the airway upon tracheal mucus secretion in the cat. J. Physiol. 261 (1976) 563-581
46. Pisarri T.E., Jonzon A., Coleridge H.M., and Coleridge J.C.G. Vagal afferents and reflex responses to changes in surface osmolarity in lower airways of dogs. J. Appl. Physiol. 73 (1992) 2305-2313
47. Poletto C.J., Verdun L.P., Strominger R., and Ludlow C.L. Correspondence between laryngeal vocal fold movement and muscle activity during speech and nonspeech gestures. J. Appl. Physiol. 97 (2004) 858-866
48. Poliacek I., Stransky A., Jakus J., Barani H., Tomori Z., and Halasova E. Activity of the laryngeal abductor and adductor muscles during cough, expiration and aspiration reflexes in cats. Physiol Res. 52 (2003) 749-762
49. Poliacek, I., Stransky, A., Szereda-Przestaszewska, M., Akus, J., Barani, H., Tomori, Z., Halasova, E., 2005. Cough and laryngeal muscle discharges in brainstem lesioned anesthetized cats. Physiol Res. [Epub ahead of print].
50. Richardson P.S., and Peatfield A.C. Reflexes concerned in the defence of the lungs. Bull. Eur. Physiopat. Resp. 17 (1981) 979-1012
51. Rogers D.F. Motor control of airway goblet cells and glands. Respir. Physiol. 125 (2001) 129-144
52. Salerno F.G., Shinozuka N., Fredberg J.J., and Ludwig M.S. Tidal volume amplitude affects the degree of induced bronchoconstriction in dogs. J. Appl. Physiol. 87 (1999) 1674-1677
53. Sant'Ambrogio G., Kuna S.T., Vanoye C.R., and Sant'Ambrogio F. Activation of intrinsic laryngeal muscles during cough. Am. J. Respir. Crit. Care Med. 155 (1997) 637-641
54. Sasaki S.I., Uchino H., Imagawa M., Miyake T., and Uchino Y. Lower lumbar branching of caudal medullary expiratory neurons of the cat. Brain Res. 553 (1991) 159-162
55. Schultz H.D., Roberts A.M., Bratcher C., Coleridge H.M., Coleridge J.C.G., and Davis B. Pulmonary C-fibres reflexly increase secretion by tracheal submucosal glands in dogs. J. Appl. Physiol. 58 (1985) 907-910
56. Shafik A., El-Sibai O., Shafik A.A., Mostafa R., and Shafik I. Effect of straining on the lower esophageal sphincter: identification of the "straining-esophageal reflex" and its role in gastroesophageal competence mechanism. J. Invest. Surg. 17 (2004) 191-196
57. Shannon R., Beakey D.M., Morris K.F., Nuding S.C., Segers L.S., and Lindsey B.G. Production of reflex cough by brainstem respiratory networks. Pulm. Pharmacol. Ther. 17 (2004) 369-376
58. Sharpey-Shafer E.P. Effects of coughing on intrathoracic pressure, arterial pressure and peripheral blood flow. J. Physiol. 122 (1953) 351-357
59. Sharpey-Shafer E.P. The mechanism of syncope after coughing. Br. Med. J. 2 (1953) 860-863
60. Shepherd J.T. The lungs as receptor sites for cardiovascular regulation. Circulation 63 (1981) 1-10
61. Simonyan K., and Jurgens U. Afferent subcortical connections into the motor cortical larynx area in the rhesus monkey. Neuroscience 130 (2005) 119-131
62. Smucny J., Flynn C., Becker L., and Glazier R. Beta2-agonists for acute bronchitis. Cochrane Database Syst. Rev. (2004) CD001726
63. Strohl K.P., Mead J., Banzett R.B., Loring S., and Kosch P. Regional differences in abdominal muscle activity during various maneuvres in humans. J. Appl. Physiol. 51 (1981) 1471-1476
64. Sun Q.J., Berkowitz R.G., and Pilowsky P.M. Response of laryngeal motoneurons to hyperventilation induced apnea in the rat. Respir. Physiol. Neurobiol. 146 (2005) 155-163
65. Tomori Z., and Widdicombe J.G. Muscular, bronchomotor and cardiovascular reflexes elicited by mechanical stimulation of the respiratory tract. J. Physiol. 200 (1969) 25-49
66. Van Lunteren E., Daniels R., Chandler Deal R., and Haxhiou M. Role of costal and crural diaphragm and parasternal intercostals during coughing in cats. J. Appl. Physiol. 66 (1989) 135-141
67. Wei J.W., and Harris W.S. Heart rate response to cough. J. Appl. Physiol. 53 (1982) 1039-1043
68. Widdicombe J.G., and Nadel J.A. Reflex effects of lung inflation on tracheal volume. J. Appl. Physiol. 18 (1963) 681-686
69. Widdicombe J.G. Action potentials in parasympathetic and sympathetic efferent fibers to the trachea and lungs in dogs and cats. J. Physiol. 186 (1966) 56-88
70. Widdicombe J.G. Reflexes from the upper respiratory tract. Handbook of Physiology. The Respiratory System. Control of Breathing. Section 3, vol. II, Part 1 (1986), American Physiological Society, Washington, DC pp. 363-394 (Chapter 11)
71. Widdicombe J.G. Airway receptors. Respir. Physiol. 125 (2001) 3-15
72. Widdicombe J.G. Overview of neural pathways in allergy and asthma. Pulm. Pharmacol. Ther. 16 (2003) 23-30
73. Widdicombe, J.G., Fontana, G.A., in press. Cough: what is in a name? Eur. Respir. J.
74. Yu J., Zhang J.F., and Fletcher E.C. Stimulation of breathing by activation of pulmonary peripheral afferents in rabbits. J. Appl. Physiol. 85 (1998) 1485-1492