High dose methotrexate treatment in childhood ALL: Pilot study on the impact of the MTHFR 677C>T and 1298A>C polymorphisms on MTX-related toxicity

Klinische Padiatrie

Volumn 224, Issue 3, 2012, Pages 156-159

  Haase, R ^a   Elsner, K ^a   Merkel, N ^a   Stiefel, M ^a   Mauz Korholz C ^a   Kramm, C M ^a   Korholz D ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

methotrexate; MTHFR; polymorphism; toxicity

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); METHOTREXATE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; BONE MARROW TOXICITY; CANCER CHEMOTHERAPY; CANCER GRADING; CHILD; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DOSE RESPONSE; DRUG MEGADOSE; DRUG SAFETY; ENZYME POLYMORPHISM; GASTROINTESTINAL TOXICITY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INFECTION RATE; LIVER TOXICITY; MULTIPLE CYCLE TREATMENT; PILOT STUDY; RETROSPECTIVE STUDY;

ALLELES; ANTIMETABOLITES, ANTINEOPLASTIC; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; GENOTYPE; HETEROZYGOTE DETECTION; HOMOZYGOTE; HUMANS; LEUKOPENIA; MALE; METHOTREXATE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PILOT PROJECTS; POLYMORPHISM, GENETIC; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84860584894     PISSN: 03008630     EISSN: 14393824     Source Type: Journal    
DOI: 10.1055/s-0032-1304623     Document Type: Article

References (25)

1. Aggarwal P, Naik S, Mishra K P et al. Correlation between methotrexate efficacy & toxicity with C677T polymorphism of the methylenetetrahydrofolate gene in rheumatoid arthritis patients on folate supplementation. Indian J Med Res: 2006; 124 521 526 (Pubitemid 46157711)
2. Aplenc R, Thompson J, Han P et al. Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemia. Cancer Res: 2005; 65 2482 2487 (Pubitemid 40490161)
3. Botto L D, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol: 2000; 151 862 877 (Pubitemid 30461127)
4. de Jonge R, Tissing W J, Hooijberg J H et al. Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. Blood: 2009; 113 2284 2289
5. Faganel Kotnik B, Grabnar I, Bohanec Grabar P et al. Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma. Eur J Clin Pharmacol: 2011; 67 993 1006
6. Franco R F, Simoes B P, Tone L G et al. The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol: 2001; 115 616 618 (Pubitemid 34015653)
7. Gemmati D, Ongaro A, Scapoli G L et al. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol Biomarkers Prev: 2004; 13 787 794 (Pubitemid 38737868)
8. Gilbody S, Lewis S, Lightfoot T. Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. Am J Epidemiol: 2007; 165 1 13 (Pubitemid 46026203)
9. Hainmann I, Korinthenberg R, Oldenburg J et al. Compound heterozygosity of the protein S-gene as a cause of severe cerebral sinovenous thrombosis in a 7-year-old child. Klin Padiatr: 2010; 222 194 195
10. Imanishi H, Okamura N, Yagi M et al. Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma. J Hum Genet: 2007; 52 166 171 (Pubitemid 46188292)
11. Kantar M, Kosova B, Cetingul N et al. Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma. Leuk Lymphoma: 2009; 50 912 917
12. Karathanasis N V, Choumerianou D M, Kalmanti M. Gene polymorphisms in childhood ALL. Pediatr Blood Cancer: 2009; 52 318 323
13. Koppen I J, Hermans F J, Kaspers G J. Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. Br J Haematol: 2010; 148 3 14
14. Krajinovic M, Lamothe S, Labuda D et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood: 2004; 103 252 257 (Pubitemid 38029946)
15. Liu S G, Li Z G, Cui L et al. Effects of methylenetetrahydrofolate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population. Leuk Lymphoma: 2011; 52 1030 1040
16. Meinicke H, Moske-Eick O, Sitzberger A N et al. Anterior spinal artery syndrome in a 13-year-old boy 8 days after taekwondo-fight: vascular obliteration due to vessel lesion or thrombophilia? Klin Padiatr: 2011; 223 182 186
17. Pakakasama S, Kanchanakamhaeng K, Kajanachumpol S et al. Genetic polymorphisms of folate metabolic enzymes and toxicities of high dose methotrexate in children with acute lymphoblastic leukemia. Ann Hematol: 2007; 86 609 611 (Pubitemid 47018479)
18. Robien K, Ulrich C M. 5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview. Am J Epidemiol: 2003; 157 571 582 (Pubitemid 36368527)
19. Ruiz-Arguelles G J, Coconi-Linares L N, Garces-Eisele J et al. Methotrexate-induced mucositis in acute leukemia patients is not associated with the MTHFR 677T allele in Mexico. Hematology: 2007; 12 387 391 (Pubitemid 47487846)
20. Seidemann K, Book M, Zimmermann M et al. MTHFR 677 (C - >T) polymorphism is not relevant for prognosis or therapy-associated toxicity in pediatric NHL: results from 484 patients of multicenter trial NHL-BFM 95. Ann Hematol: 2006; 85 291 300 (Pubitemid 43732651)
21. Shimasaki N, Mori T, Samejima H et al. Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia or lymphoma. J Pediatr Hematol Oncol: 2006; 28 64 68
22. Tantawy A A, El-Bostany E A, Adly A A et al. Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia. Blood Coagul Fibrinolysis: 2010; 21 28 34
23. Thompson P A, Murry D J, Rosner G L et al. Methotrexate pharmacokinetics in infants with acute lymphoblastic leukemia. Cancer Chemother Pharmacol: 2007; 59 847 853 (Pubitemid 46440608)
24. Wallot I W, Leonhardt A, Geks A et al. Thrombose der Vena cava unter hormoneller Kontrazeption bei MTHFR-Mutation. Klin Padiatr: 2010; 222: 109
25. Woessmann W, Seidemann K, Mann G et al. The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95. Blood: 2005; 105 948 958 (Pubitemid 40170860)