Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering

European Cells and Materials

Volumn 23, Issue , 2012, Pages 170-181

  Huang, Yen Jang ^a   Shiau, Ai Li ^a   Chen, Shih Yao ^a   Chen, Yuh Ling ^a   Wang, Chrong Reen ^a   Tsai, Chiau Yuang ^a   Chang, Meng Ya ^a   Li, Yuan Tsung ^a   Leu, Chia Hsing ^a   Wu, Chao Liang ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Ankle joint; Apoptosis; Cell surface receptors; Galectin 1; Gold; Inflammation; Nanoparticles; Rheumatoid arthritis

Indexed keywords

CASPASE; CD45 ANTIGEN; CELL SURFACE RECEPTOR; GALECTIN 1; GOLD NANOPARTICLE; PHOSPHATASE; CYTOKINE; GOLD; METAL NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; INTRACELLULAR SIGNALING; LEUKEMIA CELL LINE; LIGAND BINDING; MALE; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PARTICLE SIZE; PROTEIN CROSS LINKING; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; RHEUMATOID ARTHRITIS; STRUCTURE ANALYSIS; ANIMAL; ANKLE; ARTHRITIS; CELL CULTURE; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; HUMAN; INTRAARTICULAR DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; RADIOGRAPHY; SPRAGUE DAWLEY RAT;

ANIMALS; ANKLE JOINT; APOPTOSIS; ARTHRITIS, EXPERIMENTAL; CD4-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; GALECTIN 1; GOLD; HUMANS; INJECTIONS, INTRA-ARTICULAR; JURKAT CELLS; MALE; METAL NANOPARTICLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE;

EID: 84860574130     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: 10.22203/eCM.v023a13     Document Type: Article

References (30)

1. Amano M, Galvan M, He J, Baum LG (2003) The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death. J Biol Chem 278: 7469-7475.
2. Brandt B, Büchse T, Abou-Eladab EF, Tiedge M, Krause E, Jeschke U, Walzel H (2008) Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes. Histochem Cell Biol 129: 599-609.
3. Camby I, Le Mercier M, Lefranc F, Kiss R (2006) Galectin-1: a small protein with major functions. Glycobiology 16: 137R-157R.
4. + T cell apoptosis and synovial interleukin-17 reduction by indoleamine 2,3-dioxygenase gene therapy. Hum Gene Ther 22: 145-154.
5. Earl LA, Bi S, Baum LG (2010) N- and O-glycans modulate galectin-1 binding, CD45 signaling, and T cell death. J Biol Chem 285: 2232-2244.
6. Fouillit M, Joubert-Caron R, Poirier F, Bourin P, Monostori E, Levi-Strauss M, Raphael M, Bladier D, Caron M (2000) Regulation of CD45-induced signaling by galectin-1 in burkitt lymphoma B cells. Glycobiology 10: 413-419.
7. Garner OB, Baum LG (2008) Galectin-glycan lattices regulate cell-surface glycoprotein organization and signalling. Biochem Soc Trans 36: 1472-1477.
8. Gestwicki JE, Cairo CW, Strong LE, Oetjen KA, Kiessling LL (2002) Influencing receptor-ligand binding mechanisms with multivalent ligand architecture. J Am Chem Soc 124: 14922-14933.
9. Hermiston ML, Xu Z, Weiss A (2003) CD45: a critical regulator of signaling thresholds in immune cells. Annu Rev Immunol 21: 107-137
10. Hong S, Leroueil PR, Majoros IJ, Orr BG, Baker JR Jr, Banaszak Holl MM (2007) The binding avidity of a nanoparticle-based multivalent targeted drug delivery platform. Chem Biol 14: 107-115.
11. Huang YF, Liu H, Xiong X, Chen Y, Tan W (2009) Nanoparticle-mediated IgE-receptor aggregation and signaling in RBL mast cells. J Am Chem Soc 131: 17328-17334.
12. Inagaki Y, Sohma Y, Horie H, Nozawa R, Kadoya T (2000) Oxidized galectin-1 promotes axonal regeneration in peripheral nerves but does not possess lectin properties. Eur J Biochem 267: 2955-2964.
13. Jiang W, Kim BY, Rutka JT, Chan WC (2008) Nanoparticle-mediated cellular response is size-dependent. Nat Nanotechnol 3: 145-150.
14. Lange F, Brandt B, Tiedge M, Jonas L, Jeschke U, Pöhland R, Walzel H (2009) Galectin-1 induced activation of the mitochondrial apoptotic pathway: evidence for a connection between death-receptor and mitochondrial pathways in human Jurkat T lymphocytes. Histochem Cell Biol 132: 211-223.
15. Liu Y, Miyoshi H, Nakamura M (2007) Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles. Int J Cancer 120: 2527-2537.
16. Motran CC, Molinder KM, Liu SD, Poirier F, Miceli MC (2008) Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function. Eur J Immunol 38: 3015-3027.
17. Nguyen JT, Evans DP, Galvan M, Pace KE, Leitenberg D, Bui TN, Baum LG (2001) CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans. J Immunol 167: 5697-5707.
18. Pang M, He J, Johnson P, Baum LG (2009) CD45-mediated fodrin cleavage during galectin-1 T cell death promotes phagocytic clearance of dying cells. J Immunol 182: 7001-7008.
19. Rabinovich GA, Daly G, Dreja H, Tailor H, Riera CM, Hirabayashi J, Chernajovsky Y (1999) Recombinant galectin-1 and its genetic delivery suppress collageninduced arthritis via T cell apoptosis. J Exp Med 190: 385-398.
20. Rabinovich GA, Toscano MA, Jackson SS, Vasta GR (2007) Functions of cell surface galectin-glycoprotein lattices. Curr Opin Struct Biol 17: 513-520.
21. Shankaran H, Resat H, Wiley HS (2007) Cell surface receptors for signal transduction and ligand transport: a design principles study. PLoS Comput Biol 3: e101.
22. Shiau AL, Chen SY, Chang MY, Su CH, Chung SY, Yo YT, Wang CR, Wu CL (2007) Prothymosin α lacking the nuclear localization signal as an effective gene therapeutic strategy in collagen-induced arthritis. J Immunol 178: 4688-4694.
23. Shokeen M, Pressly ED, Hagooly A, Zheleznyak A, Ramos N, Fiamengo AL, Welch MJ, Hawker CJ, Anderson CJ (2011) Evaluation of multivalent, functional polymeric nanoparticles for imaging applications. ACS Nano 5: 738-747.
24. Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA (2007) Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol 8: 825-834.
25. Trowbridge IS and Thomas ML (1994) CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Annu Rev Immunol 12: 85-116.
26. Tsai CY, Shiau AL, Chen SY, Chen YH, Cheng PC, Chang MY, Chen DH, Chou CH, Wang CR, Wu CL (2007) Amelioration of collagen-induced arthritis in rats by nanogold. Arthritis Rheum 56: 544-554.
27. van der Heijde DM (1995) Joint erosions and patients with early rheumatoid arthritis. Br J Rheumatol 34 (suppl 2): 74-78.
28. Walzel H, Schulz U, Neels P, Brock J (1999) Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45. Immunol Lett 67: 193-202.
29. Wang CR, Chen SY, Wu CL, Liu MF, Jin YT, Chao L, Chao J (2005) Prophylactic adenovirus-mediated human kallistatin gene therapy suppresses rat arthritis by inhibiting angiogenesis and inflammation. Arthritis Rheum 52: 1319-1324.
30. Wang CR, Shiau AL, Chen SY, Cheng ZS, Li YT, Lee CH, Yo YT, Lo CW, Lin YS, Juan HY, Chen YL, Wu CL (2010) Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis. Gene Ther 17: 1225-1233.