Cysteamine prevents the development of lens opacity in a rat model of selenite-induced cataract

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 3, 2012, Pages 1452-1459

  Lee, Sang Mok ^a,b   Jeong, Eui Man ^a   Jeong, Jinho ^a,c   Shin, Dong Myung ^a   Lee, Hyun Ju ^a,b   Kim, Hyo Jun ^a   Lim, Jisun ^a   Lee, Jin Haeng ^a   Cho, Sung Yup ^a   Kim, Mee Kum ^a,b   Wee, Won Ryang ^a,b   Lee, Jin Hak ^a,b   Kim, In Gyu ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Biomedical Research Institute   (South Korea)

^c Jeju National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; MALONALDEHYDE; MERCAPTAMINE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; RADIOPROTECTIVE AGENT; SODIUM SELENITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CATARACTOGENESIS; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; LENS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WESTERN BLOTTING; ANIMAL; CELL LINE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; NEWBORN; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; CATARACT; CELL LINE; CYSTEAMINE; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; EPITHELIAL CELLS; FEMALE; GLUTATHIONE; GTP-BINDING PROTEINS; HUMANS; LENS, CRYSTALLINE; MALE; RADIATION-PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM SELENITE; TRANSGLUTAMINASES;

EID: 84860570356     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8636     Document Type: Article

References (46)

1. Wong TY, Hyman L. Population-based studies in ophthalmology. Am J Ophthalmol. 2008;146:656-663.
2. Brian G, Taylor H. Cataract blindness-challenges for the 21st century. Bull World Health Organ. 2001;79:249-256.
3. Robman L, Taylor H. External factors in the development of cataract. Eye. 2005;19:1074-1082.
4. West S. Epidemiology of cataract: accomplishments over 25 years and future directions. Ophthalmic Epidemiol. 2007;14:173-178.
5. Sekimoto M, Imanaka Y, Kitano N, Ishizaki T, Takahashi O. Why are physicians not persuaded by scientific evidence? A grounded theory interview study. BMC Health Serv Res. 2006;6:92.
6. Bloemendal H, de Jong W, Jaenicke R, Lubsen NH, Slingsby C, Tardieu A. Ageing and vision: structure, stability and function of lens crystallins. Prog Biophys Mol Biol. 2004;86:407-485.
7. Benedek GB. Cataract as a protein condensation disease: the Proctor Lecture. Invest Ophthalmol Vis Sci. 1997;38:1911-1921.
8. Shin DM, Jeon JH, Kim CW, et al. TGFβ mediates activation of transglutaminase 2 in response to oxidative stress that leads to protein aggregation. FASEB J. 2008;22:2498-2507.
9. Lorand L, Graham RM. Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol. 2003;4:140-156.
10. Ientile R, Caccamo D, Griffin M. Tissue transglutaminase and the stress response. Amino Acids. 2007;33:385-394.
11. Shin DM, Jeon JH, Kim CW, et al. Cell type-specific activation of intracellular transglutaminase 2 by oxidative stress or ultraviolet irradiation. J Biol Chem. 2004;279:15032-15039.
12. Jeon JH, Lee HJ, Jang GY, et al. Different inhibition characteristics of intracellular transglutaminase activity by cystamine and cysteamine. Exp Mol Med. 2004;36:576-581.
13. Cooper AJ, Jeitner TM, Gentile V, Blass JP. Cross linking of polyglutamine domains catalyzed by tissue transglutaminase is greatly favored with pathological-length repeats: does transglutaminase activity play a role in (CAG)(n) /Q(n) -expansion diseases? Neurochem Int. 2002;40:53-67.
14. Pitari G, Malergue F, Martin F, et al. Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice. FEBS Lett. 2000;483:149-154.
15. -/- mice exhibit a glutathione-mediated tissue resistance to oxidative stress. Mol Cell Biol. 2004;24:7214-7224.
16. Vecsei L, Widerlov E. Preclinical and clinical studies with cysteamine and pantethine related to the central nervous system. Prog Neuropsychopharmacol Biol Psychiatry. 1990;14:835-862.
17. Saransaari P, Oja SS. Taurine and neural cell damage. Amino Acids. 2000;19:509-526.
18. Lesort M, Lee M, Tucholski J, Johnson GV. Cystamine inhibits caspase activity: implications for the treatment of polyglutamine disorders. J Biol Chem. 2003;278:3825-3830.
19. Jang GY, Jeon JH, Cho SY, et al. Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells. Oncogene. 2010;29:356-367.
20. Berruyer C, Pouyet L, Millet V, et al. Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. J Exp Med. 2006;203:2817-2827.
21. Nesterova G, Gahl W. Nephropathic cystinosis: late complications of a multisystemic disease. Pediatr Nephrol. 2008;23:863-878.
22. Shearer TR, Ma H, Fukiage C, Azuma M. Selenite nuclear cataract: review of the model. Mol Vis. 1997;3:8-16.
23. 2+-induced protein loss, vimentin cleavage and opacification. Invest Ophthalmol Vis Sci. 2000;41:2255-2261.
24. Jeon JH, Choi KH, Cho SY, et al. Transglutaminase 2 inhibits Rb binding of human papillomavirus E7 by incorporating polyamine. EMBO J. 2003;22:5273-5282.
25. Elanchezhian R, Ramesh E, Sakthivel M, et al. Acetyl-L-carnitine prevents selenite-induced cataractogenesis in an experimental animal model. Curr Eye Res. 2007;32:961-971.
26. 2 and photochemically induced cataract. Curr Eye Res. 1993; 12:163-179.
27. Neal R, Cooper K, Gurer H, Ercal N. Effects of N-acetylcysteine and 2,3-dimercaptosuccinic acid on lead induced oxidative stress in rat lenses. Toxicology. 1998;130:167-174.
28. Biju PG, Devi VG, Lija Y, Abraham A. Protection against selenite cataract in rat lens by drevogenin D, a triterpenoid aglycone from Dregea volubilis. J Med Food. 2007;10:308-315.
29. Hankinson SE, Stampfer MJ, Seddon JM, et al. Nutrient intake and cataract extraction in women: a prospective study. BMJ. 1992;305: 335-339.
30. Rouhiainen P, Rouhiainen H, Salonen JT. Association between low plasma vitamin E concentration and progression of early cortical lens opacities. Am J Epidemiol. 1996;144:496-500.
31. Lorand L, Hsu LK, Siefring GE Jr, Rafferty NS. Lens transglutaminase and cataract formation. Proc Natl Acad Sci U S A. 1981;78: 1356-1360.
32. 2+-treated lens: a model for cataract. Biochemistry. 1985;24:1525-1531.
33. 2+-treated lens. Invest Ophthalmol Vis Sci. 1987;28:1218-1222.
34. Shridas P, Sharma Y, Balasubramanian D. Transglutaminase-mediated cross-linking of alpha-crystallin: structural and functional consequences. FEBS Lett. 2001;499:245-250.
35. Graw J, Gopinath PM, Bors W, Michel C, Summer HK. Biochemical analysis of young rats homozygous for the cataract mutation cat. Exp Eye Res. 1989;48:1-9.
36. Ashida Y, Takeda T, Hosokawa M. Protein alterations in age-related cataract associated with a persistent hyaloid vascular system in senescence-accelerated mouse (SAM). Exp Eye Res. 1994;59:467-473.
37. Takeuchi N, Kamei A. Crystallin proteins in lenses of hereditary cataractous rat, ICR/f. Biol Pharm Bull. 2000;23:283-290.
38. Wan XH, Lee EH, Koh HJ, et al. Enhanced expression of transglutaminase 2 in anterior polar cataracts and its induction by TGF-beta in vitro. Br J Ophthalmol. 2002;86:1293-1298.
39. Ganea E, Harding JJ. Glutathione-related enzymes and the eye. Curr Eye Res. 2006;31:1-11.
40. O'Brian CA, Chu F. Post-translational disulfide modifications in cell signaling-role of inter-protein, intra-protein, S-glutathionyl, and S-cysteaminyl disulfide modifications in signal transmission. Free Radic Res. 2005;39:471-480.
41. Di Leandro L, Maras B, Schininà ME, et al. Cystamine restores GSTA3 levels in Vanin-1 null mice. Free Radic Biol Med. 2008;44:1088-1096.
42. Nakajima T, Belusko PB, Walkup RD, Azuma M, Shearer TR. Involvement of Egr-1 in lens epithelial cell death induced by selenite. Exp Eye Res. 2006;82:874-878.
43. Geraldine P, Sneha BB, Elanchezhian R, et al. Prevention of selenite-induced cataractogenesis by acetyl-L-carnitine: an experimental study. Exp Eye Res. 2006;83:1340-1349.
44. Boscia F, Grattagliano I, Vendemiale G, Micelli-Ferrari T, Altomare E. Protein oxidation and lens opacity in humans. Invest Ophthalmol Vis Sci. 2000;41:2461-2465.
45. Spallholz JE. Free radical generation by selenium compounds and their prooxidant toxicity. Biomed Environ Sci. 1997;10:260-270.
46. Stark WJ, Sommer A, Smith RE. Changing trends in intraocular lens implantation. Arch Ophthalmol. 1989;107:1441-1444.