Protein kinase C-α mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct

American Journal of Physiology - Renal Physiology

Volumn 302, Issue 9, 2012, Pages

  Klein, Janet D ^a   Martin, Christopher F ^a   Kent, Kimilia J ^a   Sands, Jeff M ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Urine concentrating mechanism; Vasopressin

Indexed keywords

CARRIER PROTEIN; CHELERYTHRINE; HYPERTONIC SOLUTION; ISOPROTEIN; PHORBOL ESTER; PHOSPHORUS 32; PROTEIN KINASE C ALPHA; PROTEIN UREA TRANSPORTER A1; SERINE; UNCLASSIFIED DRUG; VASOPRESSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTINYLATION; CELL MEMBRANE; CONTROLLED STUDY; KIDNEY COLLECTING TUBULE; KIDNEY TUBULE FUNCTION; KNOCKOUT MOUSE; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; RAT; WILD TYPE;

EID: 84860521744     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00664.2011     Document Type: Article

References (24)

1. Blessing NW, Blount MA, Sands JM, Martin CF, Klein JD. Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity. Am J Physiol Renal Physiol 295: F1336-F1341, 2008.
2. Blount MA, Klein JD, Martin CF, Tchapyjnikov D, Sands JM. Forskolin stimulates phosphorylation and membrane accumulation of UT-A3. Am J Physiol Renal Physiol 293: F1308-F1313, 2007.
3. Blount MA, Mistry AC, Fröhlich O, Price SR, Chen G, Sands JM, Klein JD. Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation. Am J Physiol Renal Physiol 295: F295-F299, 2008.
4. Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, Robbins J, Hewett TE, Bibb JA, Westfall MV, Kranias EG, Molkentin JD. PKC-α regulates cardiac contractility and propensity toward heart failure. Nat Med 10: 248-254, 2004.
5. Chen G, Huang H, Fröhlich O, Yang Y, Klein JD, Price SR, Sands JM. MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiq-uitination and degradation. Am J Physiol Renal Physiol 295: F1528-F1534, 2008.
6. Fenton RA, Chou CL, Stewart GS, Smith CP, Knepper MA. Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct. Proc Natl Acad Sci USA 101: 7469-7474, 2004.
7. Fenton RA, Knepper MA. Mouse models and the urinary concentrating mechanism in the new millennium. Physiol Rev 87: 1083-1112, 2007.
8. Gillin AG, Sands JM. Characteristics of osmolarity-stimulated urea transport in rat IMCD. Am J Physiol Renal Fluid Electrolyte Physiol 262: F1061-F1067, 1992.
9. Gillin AG, Star RA, Sands JM. Osmolarity-stimulated urea transport in rat terminal IMCD: role of intracellular calcium. Am J Physiol Renal Fluid Electrolyte Physiol 265: F272-F277, 1993.
10. Kato A, Klein JD, Zhang C, Sands JM. Angiotensin II increases vasopressin-stimulated facilitated urea permeability in rat terminal IM-CDs. Am J Physiol Renal Physiol 279: F835-F840, 2000.
11. Klein JD, Blount MA, Fröhlich O, Denson C, Tan X, Sim J, Martin CF, Sands JM. Phosphorylation of UT-A1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells. Am J Physiol Renal Physiol 298: F935-F940, 2010.
12. Klein JD, Blount MA, Sands JM. Urea transport in the kidney. Comp Physiol 1: 699-729, 2011.
13. Klein JD, Fröhlich O, Blount MA, Martin CF, Smith TD, Sands JM. Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts. J Am Soc Nephrol 17: 2680-2686, 2006.
14. Klein JD, Price SR, Bailey JL, Jacobs JD, Sands JM. Glucocorticoids mediate a decrease in the AVP-regulated urea transporter in diabetic rat inner medulla. Am J Physiol Renal Physiol 273: F949-F953, 1997.
15. Kokko JP, Rector FC. Countercurrent multiplication system without active transport in inner medulla. Kidney Int 2: 214-223, 1972.
16. Redling S, Pfaff IL, Leitges M, Vallon V. Immunolocalization of protein kinase C isozymes a, bI, bII, d and e in mouse kidney. Am J Physiol Renal Physiol 287: F289-F298, 2004.
17. Sands JM, Layton HE. The physiology of urinary concentration: an update. Semin Nephrol 29: 178-195, 2009.
18. Sands JM, Schrader DC. An independent effect of osmolality on urea transport in rat terminal IMCDs. J Clin Invest 88: 137-142, 1991.
19. Snedecor GW, Cochran WG. Statistical Methods. Ames, IA: Iowa State Univ., 1980.
20. Stephenson JL. Concentration of urine in a central core model of the renal counterflow system. Kidney Int 2: 85-94, 1972.
21. Wang Y, Liedtke CM, Klein JD, Sands JM. Protein kinase C regulates urea permeability in the rat inner medullary collecting duct. Am J Physiol Renal Physiol 299: F1401-F1406, 2010.
22. Yao LJ, Wang JQ, Zhao H, Liu JS, Deng AG. Effect of telmisartan on expression of protein kinase C-a in kidneys of diabetic mice. Acta Pharmacol Sin 28: 829-838, 2007.
23. Yao LJ, Huang DY, Pfaff IL, Nie X, Leitges M, Vallon V. Evidence for a role of protein kinase C-alpha in urine concentration. Am J Physiol Renal Physiol 287: F299-F304, 2004.
24. Zhang C, Sands JM, Klein JD. Vasopressin rapidly increases the phosphorylation of the UT-A1 urea transporter activity in rat IMCDs through PKA. Am J Physiol Renal Physiol 282: F85-F90, 2002.