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Volumn 302, Issue 9, 2012, Pages

Combined inhibition of aromatase activity and dihydrotestosterone supplementation attenuates renal injury in male streptozotocin (STZ)-induced diabetic rats

Author keywords

Diabetes; Estrogen; Testosterone

Indexed keywords

ANASTROZOLE; ANDROSTANOLONE; AROMATASE; CD68 ANTIGEN; CHLORDANE; COLLAGEN TYPE 4; ESTRADIOL; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84860517474     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00569.2011     Document Type: Article
Times cited : (14)

References (46)
  • 1
    • 0023710588 scopus 로고
    • A comparison of body and organ weights, physiologic parameters, and pathologic changes in target organs of rats given combinations of exercise, anabolic hormone, and protein supplementation
    • Bauman DH, Richerson JT, Britt AL. A comparison of body and organ weights, physiologic parameters, and pathologic changes in target organs of rats given combinations of exercise, anabolic hormone, and protein supplementation. Am J Sports Med 16: 397-402, 1988.
    • (1988) Am J Sports Med , vol.16 , pp. 397-402
    • Bauman, D.H.1    Richerson, J.T.2    Britt, A.L.3
  • 3
    • 33645450441 scopus 로고    scopus 로고
    • Enhancing the predictive value of urinary albumin for diabetic nephropathy
    • Caramori ML, Fioretto P, Mauer M. Enhancing the predictive value of urinary albumin for diabetic nephropathy. J Am Soc Nephrol 17: 339-352, 2006.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 339-352
    • Caramori, M.L.1    Fioretto, P.2    Mauer, M.3
  • 6
    • 79551599216 scopus 로고    scopus 로고
    • The protective role of Smad7 in diabetic kidney disease: Mechanism and therapeutic potential
    • Chen HY, Huang XR, Wang W, Li JH, Heuchel RL, Chung AC, Lan HY. The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential. Diabetes 60: 590-601, 2011.
    • (2011) Diabetes , vol.60 , pp. 590-601
    • Chen, H.Y.1    Huang, X.R.2    Wang, W.3    Li, J.H.4    Heuchel, R.L.5    Chung, A.C.6    Lan, H.Y.7
  • 8
    • 0033773105 scopus 로고    scopus 로고
    • Different roles for androgens and estrogens in the susceptibility to autoimmune rheumatic diseases
    • Cutolo M, Wilder RL. Different roles for androgens and estrogens in the susceptibility to autoimmune rheumatic diseases. Rheum Dis Clin North Am 26: 825-839, 2000.
    • (2000) Rheum Dis Clin North Am , vol.26 , pp. 825-839
    • Cutolo, M.1    Wilder, R.L.2
  • 10
    • 79551510741 scopus 로고    scopus 로고
    • Testosterone and 17beta-estradiol have opposite effects on podocyte apoptosis that precedes glomerulosclerosis in female estrogen receptor knockout mice
    • Doublier S, Lupia E, Catanuto P, Periera-Simon S, Xia X, Korach K, Berho M, Elliot SJ, Karl M. Testosterone and 17beta-estradiol have opposite effects on podocyte apoptosis that precedes glomerulosclerosis in female estrogen receptor knockout mice. Kidney Int 79: 404-413, 2011.
    • (2011) Kidney Int , vol.79 , pp. 404-413
    • Doublier, S.1    Lupia, E.2    Catanuto, P.3    Periera-Simon, S.4    Xia, X.5    Korach, K.6    Berho, M.7    Elliot, S.J.8    Karl, M.9
  • 14
    • 84859131983 scopus 로고    scopus 로고
    • Gonadal dysfunction in men with chronic kidney disease: Clinical features, prognostic implications and therapeutic options
    • Iglesias P, Carrero JJ, Diez JJ. Gonadal dysfunction in men with chronic kidney disease: clinical features, prognostic implications and therapeutic options. J Nephrol 25: 31-42, 2012.
    • (2012) J Nephrol , vol.25 , pp. 31-42
    • Iglesias, P.1    Carrero, J.J.2    Diez, J.J.3
  • 15
    • 0031970237 scopus 로고    scopus 로고
    • Estrogen induces glomeruloscle-rosis in analbuminemic rats
    • Joles JA, van Goor H, Koomans HA. Estrogen induces glomeruloscle-rosis in analbuminemic rats. Kidney Int 53: 862-868, 1998.
    • (1998) Kidney Int , vol.53 , pp. 862-868
    • Joles, J.A.1    van Goor, H.2    Koomans, H.A.3
  • 17
    • 34548028733 scopus 로고    scopus 로고
    • Hormonal status affects the progression of STZ-induced diabetes and diabetic renal damage in the VCD mouse model of menopause
    • Keck M, Romero-Aleshire MJ, Cai Q, Hoyer PB, Brooks HL. Hormonal status affects the progression of STZ-induced diabetes and diabetic renal damage in the VCD mouse model of menopause. Am J Physiol Renal Physiol 293: F193-F199, 2007.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Keck, M.1    Romero-Aleshire, M.J.2    Cai, Q.3    Hoyer, P.B.4    Brooks, H.L.5
  • 20
    • 84860531024 scopus 로고    scopus 로고
    • Long-term mineralocorticoid receptor blockade ameliorates progression of experimental diabetic renal disease
    • Lian M, Hewitson TD, Wigg B, Samuel CS, Chow F, Becker GJ. Long-term mineralocorticoid receptor blockade ameliorates progression of experimental diabetic renal disease. Nephrol Dial Transplant 27: 906-912, 2011.
    • (2011) Nephrol Dial Transplant , vol.27 , pp. 906-912
    • Lian, M.1    Hewitson, T.D.2    Wigg, B.3    Samuel, C.S.4    Chow, F.5    Becker, G.J.6
  • 25
    • 3242667701 scopus 로고    scopus 로고
    • The effect of testosterone replacement on endogenous inflammatory cy-tokines and lipid profiles in hypogonadal men
    • Malkin CJ, Pugh PJ, Jones RD, Kapoor D, Channer KS, Jones TH. The effect of testosterone replacement on endogenous inflammatory cy-tokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab 89: 3313-3318, 2004.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3313-3318
    • Malkin, C.J.1    Pugh, P.J.2    Jones, R.D.3    Kapoor, D.4    Channer, K.S.5    Jones, T.H.6
  • 26
    • 80052410207 scopus 로고    scopus 로고
    • Inhibition of estradiol synthesis attenuates renal injury in male streptozotocin (STZ)-induced diabetic rats
    • Manigrasso MB, Sawyer RT, Marbury DC, Flynn ER, Maric C. Inhibition of estradiol synthesis attenuates renal injury in male streptozotocin (STZ)-induced diabetic rats. Am J Physiol Renal Physiol 301: F634-F640, 2011.
    • (2011) Am J Physiol Renal Physiol , vol.301
    • Manigrasso, M.B.1    Sawyer, R.T.2    Marbury, D.C.3    Flynn, E.R.4    Maric, C.5
  • 27
    • 13744262844 scopus 로고    scopus 로고
    • 17fj-Estradiol replacement improves renal function and pathology associated with diabetic nephropathy
    • Mankhey RW, Bhatti F, Maric C. 17fj-Estradiol replacement improves renal function and pathology associated with diabetic nephropathy. Am J Physiol Renal Physiol 288: F399-F405, 2005.
    • (2005) Am J Physiol Renal Physiol , vol.288
    • Mankhey, R.W.1    Bhatti, F.2    Maric, C.3
  • 28
    • 33846787010 scopus 로고    scopus 로고
    • 17fj-Estradiol supplementation reduces tubulointerstitial fibrosis by increasing MMP activity in the diabetic kidney
    • Mankhey RW, Wells CC, Bhatti F, Maric C. 17fj-Estradiol supplementation reduces tubulointerstitial fibrosis by increasing MMP activity in the diabetic kidney. Am J Physiol Regul Integr Comp Physiol 292: R769-R777, 2007.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.292
    • Mankhey, R.W.1    Wells, C.C.2    Bhatti, F.3    Maric, C.4
  • 29
    • 77955926673 scopus 로고    scopus 로고
    • Association between testosterone, estradiol and sex hormone binding globulin levels in men with type 1 diabetes with nephropathy
    • Maric C, Forsblom C, Thorn L, Waden J, Groop PH. Association between testosterone, estradiol and sex hormone binding globulin levels in men with type 1 diabetes with nephropathy. Steroids 75: 772-778, 2010.
    • (2010) Steroids , vol.75 , pp. 772-778
    • Maric, C.1    Forsblom, C.2    Thorn, L.3    Waden, J.4    Groop, P.H.5
  • 30
    • 26844524966 scopus 로고    scopus 로고
    • Effect of troglitazone on the excess testosterone and LH secretion in thyroidectomized, insulin-resistant, type 2 diabetic Goto-Kakizaki rats
    • Matsushita M, Tamura K, Osada S, Kogo H. Effect of troglitazone on the excess testosterone and LH secretion in thyroidectomized, insulin-resistant, type 2 diabetic Goto-Kakizaki rats. Endocrine 27: 301-305, 2005.
    • (2005) Endocrine , vol.27 , pp. 301-305
    • Matsushita, M.1    Tamura, K.2    Osada, S.3    Kogo, H.4
  • 31
    • 0026166625 scopus 로고
    • Marked cell-type-specific differences in glycosylation of human interleukin-6
    • May LT, Shaw JE, Khanna AK, Zabriskie JB, Sehgal PB. Marked cell-type-specific differences in glycosylation of human interleukin-6. Cytokine 3: 204-211, 1991.
    • (1991) Cytokine , vol.3 , pp. 204-211
    • May, L.T.1    Shaw, J.E.2    Khanna, A.K.3    Zabriskie, J.B.4    Sehgal, P.B.5
  • 32
    • 38949122729 scopus 로고    scopus 로고
    • Testosterone exacerbates obstructive renal injury by stimulating TNF-alpha production and increasing proapoptotic and profibrotic signaling
    • Metcalfe PD, Leslie JA, Campbell MT, Meldrum DR, Hile KL, Meldrum KK. Testosterone exacerbates obstructive renal injury by stimulating TNF-alpha production and increasing proapoptotic and profibrotic signaling. Am J Physiol Endocrinol Metab 294: E435-E443, 2008.
    • (2008) Am J Physiol Endocrinol Metab , vol.294
    • Metcalfe, P.D.1    Leslie, J.A.2    Campbell, M.T.3    Meldrum, D.R.4    Hile, K.L.5    Meldrum, K.K.6
  • 34
    • 0036433260 scopus 로고    scopus 로고
    • Estradiol reverses TGF-beta1-induced mesangial cell apoptosis by a casein kinase 2-dependent mechanism
    • Negulescu O, Bognar I, Lei J, Devarajan P, Silbiger S, Neugarten J. Estradiol reverses TGF-beta1-induced mesangial cell apoptosis by a casein kinase 2-dependent mechanism. Kidney Int 62: 1989-1998, 2002.
    • (2002) Kidney Int , vol.62 , pp. 1989-1998
    • Negulescu, O.1    Bognar, I.2    Lei, J.3    Devarajan, P.4    Silbiger, S.5    Neugarten, J.6
  • 35
    • 77649268137 scopus 로고    scopus 로고
    • The protective effect of testosterone on streptozotocin-induced apoptosis in beta cells is sex specific
    • Palomar-Morales M, Morimoto S, Mendoza-Rodriguez CA, Cerbon MA. The protective effect of testosterone on streptozotocin-induced apoptosis in beta cells is sex specific. Pancreas 39: 193-200, 2010.
    • (2010) Pancreas , vol.39 , pp. 193-200
    • Palomar-Morales, M.1    Morimoto, S.2    Mendoza-Rodriguez, C.A.3    Cerbon, M.A.4
  • 36
    • 67651113994 scopus 로고    scopus 로고
    • Rat mesangial cells exhibit sex-specific profibrotic and proinflammatory phenotypes
    • Pawluczyk IZ, Tan EK, Harris KP. Rat mesangial cells exhibit sex-specific profibrotic and proinflammatory phenotypes. Nephrol Dial Transplant 24: 1753-1758, 2009.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 1753-1758
    • Pawluczyk, I.Z.1    Tan, E.K.2    Harris, K.P.3
  • 40
    • 34447632467 scopus 로고    scopus 로고
    • Testosterone treatment promotes tubular damage in experimental diabetes in prepubertal rats
    • Sun J, Devish K, Langer WJ, Carmines PK, Lane PH. Testosterone treatment promotes tubular damage in experimental diabetes in prepubertal rats. Am J Physiol Renal Physiol 292: F1681-F1690, 2007.
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Sun, J.1    Devish, K.2    Langer, W.J.3    Carmines, P.K.4    Lane, P.H.5
  • 41
    • 68149138117 scopus 로고    scopus 로고
    • The dark side of testosterone deficiency. III. Cardiovascular disease
    • Traish AM, Saad F, Feeley RJ, Guay A. The dark side of testosterone deficiency. III. Cardiovascular disease. J Androl 30: 477-494, 2009.
    • (2009) J Androl , vol.30 , pp. 477-494
    • Traish, A.M.1    Saad, F.2    Feeley, R.J.3    Guay, A.4
  • 42
    • 77950323382 scopus 로고    scopus 로고
    • Low testosterone and sex hormone-binding globulin levels and high estradiol levels are independent predictors of type 2 diabetes in men
    • Vikan T, Schirmer H, Njolstad I, Svartberg J. Low testosterone and sex hormone-binding globulin levels and high estradiol levels are independent predictors of type 2 diabetes in men. Eur J Endocrinol 162: 747-754, 2010.
    • (2010) Eur J Endocrinol , vol.162 , pp. 747-754
    • Vikan, T.1    Schirmer, H.2    Njolstad, I.3    Svartberg, J.4
  • 43
    • 68049111587 scopus 로고    scopus 로고
    • Dose-dependent effects of dihydrotestosterone in the streptozotocin-induced diabetic rat kidney
    • Xu Q, Prabhu A, Xu S, Manigrasso MB, Maric C. Dose-dependent effects of dihydrotestosterone in the streptozotocin-induced diabetic rat kidney. Am J Physiol Renal Physiol 297: F307-F315, 2009.
    • (2009) Am J Physiol Renal Physiol , vol.297
    • Xu, Q.1    Prabhu, A.2    Xu, S.3    Manigrasso, M.B.4    Maric, C.5
  • 46
    • 85171950841 scopus 로고    scopus 로고
    • Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats
    • Epub ahead of print
    • Yim HE, Ha KS, Bae IS, Yoo KH, Hong YS, Lee JW. Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats. J Nutr Biochem [Epub ahead of print].
    • J Nutr Biochem
    • Yim, H.E.1    Ha, K.S.2    Bae, I.S.3    Yoo, K.H.4    Hong, Y.S.5    Lee, J.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.