Oncolytic effects of a novel influenza a virus expressing interleukin-15 from the NS reading frame

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  van Rikxoort, Marijke ^a   Michaelis, Martin ^a,c   Wolschek, Markus ^b   Muster, Thomas ^b   Egorov, Andrej ^b   Seipelt, Joachim ^b   Doerr, Hans Wilhelm ^a   Cinatl, Jindrich ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b Avir Green Hills Biotechnology AG   (Austria)

^c UNIVERSITY OF KENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CISPLATIN; INTERLEUKIN 15; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MYXOVIRUS RESISTANCE PROTEIN A; ONCOLYTIC INFLUENZA A VIRUS WITH DELETED NS1 GENE; ONCOLYTIC INFLUENZA A VIRUS WITH DELETED NS1 GENE WITH INTERLEUKIN 15 INSERTION; ONCOLYTIC VIRUS; STAT1 PROTEIN; STAT2 PROTEIN; UNCLASSIFIED DRUG; VIROTHERAPY AGENT; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASPASE; CYSTEINE PROTEINASE INHIBITOR; MAPK1 PROTEIN, HUMAN; PEPTIDE CHLOROMETHYL KETONE; VIRUS PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE DELETION; GENE INSERTION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INTRACELLULAR SIGNALING; MELANOMA CELL; MOLECULAR DYNAMICS; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NON STRUCTURAL PROTEIN 1 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOLYTIC VIROTHERAPY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; TUMOR CELL CULTURE; TUMOR CELL DESTRUCTION; VIRUS GENE; VIRUS REPLICATION; ANIMAL; CELL CULTURE; CELL SURVIVAL; CERCOPITHECUS; DRUG ANTAGONISM; GENETICS; GROWTH, DEVELOPMENT AND AGING; INFLUENZA VIRUS A H1N1; MELANOMA; METABOLISM; PATHOLOGY; TUMOR CELL LINE; VERO CELL; VIROLOGY; WESTERN BLOTTING;

INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CISPLATIN; CYSTEINE PROTEINASE INHIBITORS; GENE DELETION; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INTERLEUKIN-15; MELANOMA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; ONCOLYTIC VIRUSES; RNA INTERFERENCE; VERO CELLS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84860515231     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036506     Document Type: Article

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