5-HTTLPR polymorphism impacts task-evoked and resting-state activities of the amygdala in han Chinese

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Li, Sufang ^a   Zou, Qihong ^b   Li, Jun ^a   Li, Jin ^a   Wang, Deyi ^a   Yan, Chaogan ^a   Dong, Qi ^a   Zang, Yu Feng ^a,c  

^a BEIJING NORMAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c HANGZHOU NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 HTTLPR GENE; ADULT; AMYGDALOID NUCLEUS; ARTICLE; BOLD SIGNAL; BRAIN DEPTH STIMULATION; BRAIN ELECTROPHYSIOLOGY; CHINESE; CONTROLLED STUDY; CORTICAL SYNCHRONIZATION; DNA POLYMORPHISM; EMOTIONALITY; EVOKED RESPONSE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE; HAN CHINESE; HUMAN; HUMAN EXPERIMENT; MALE; MENTAL TASK; NORMAL HUMAN; POPULATION GENETICS; STEADY STATE; ASIAN; BASAL METABOLIC RATE; BEHAVIOR; CAUCASIAN; EMOTION; ETHNIC GROUP; ETHNOLOGY; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; METABOLISM; PHYSIOLOGY;

SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

AMYGDALA; ASIAN CONTINENTAL ANCESTRY GROUP; BASAL METABOLISM; BEHAVIOR; EMOTIONS; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; YOUNG ADULT;

EID: 84860508720     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036513     Document Type: Article

References (75)

1. Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA, (2004) Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 306: 879-881.
2. Gaspar P, Cases O, Maroteaux L, (2003) The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 4: 1002-1012.
3. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, et al. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1531.
4. Lotrich FE, Pollock BG, (2004) Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatr Genet 14: 121-129.
5. Joo YH, Oh HB, Kim B, Jung SH, Chung JK, et al. (2007) No association between 5-HTTLPR and harm avoidance in Korean college students. J Korean Med Sci 22: 138-141.
6. Heils A, Teufel A, Petri S, Stober G, Riederer P, et al. (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66: 2621-2624.
7. Hauser J, Leszczynska A, Samochowiec J, Czerski PM, Ostapowicz A, et al. (2003) Association analysis of the insertion/deletion polymorphism in serotonin transporter gene in patients with affective disorder. Eur Psychiatry 18: 129-132.
8. Dorado P, Penas-Lledo EM, Gonzalez AP, Caceres MC, Cobaleda J, et al. (2007) Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele. Fundam Clin Pharmacol 21: 451-453.
9. Hoefgen B, Schulze TG, Ohlraun S, von Widdern O, Hofels S, et al. (2005) The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder. Biol Psychiatry 57: 247-251.
10. Kiyohara C, Yoshimasu K, (2010) Association between major depressive disorder and a functional polymorphism of the 5-hydroxytryptamine (serotonin) transporter gene: a meta-analysis. Psychiatr Genet 20: 49-58.
11. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, et al. (2001) Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 98: 6917-6922.
12. Canli T, Omura K, Haas BW, Fallgatter A, Constable RT, et al. (2005) Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proc Natl Acad Sci U S A 102: 12224-12229.
13. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, et al. (2002) Serotonin transporter genetic variation and the response of the human amygdala. Science 297: 400-403.
14. Heinz A, Braus DF, Smolka MN, Wrase J, Puls I, et al. (2005) Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci 8: 20-21.
15. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, et al. (2005) 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 8: 828-834.
16. Canli T, Qiu M, Omura K, Congdon E, Haas BW, et al. (2006) Neural correlates of epigenesis. Proc Natl Acad Sci U S A 103: 16033-16038.
17. Rao H, Gillihan SJ, Wang J, Korczykowski M, Sankoorikal GM, et al. (2007) Genetic variation in serotonin transporter alters resting brain function in healthy individuals. Biol Psychiatry 62: 600-606.
18. Lee BT, Ham BJ, (2008) Serotonergic genes and amygdala activity in response to negative affective facial stimuli in Korean women. Genes Brain Behav 7: 899-908.
19. Munafo MR, Brown SM, Hariri AR, (2008) Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry 63: 852-857.
20. Goldman N, Glei DA, Lin YH, Weinstein M, (2010) The serotonin transporter polymorphism (5-HTTLPR): allelic variation and links with depressive symptoms. Depress Anxiety 27: 260-269.
21. Shi M, Hu J, Dong X, Gao Y, An G, et al. (2008) Association of unipolar depression with gene polymorphisms in the serotonergic pathways in Han Chinese. Acta Neuropsychiatrica 20: 139-144.
22. Kim DK, Lim SW, Lee S, Sohn SE, Kim S, et al. (2000) Serotonin transporter gene polymorphism and antidepressant response. Neuroreport 11: 215-219.
23. Kim JM, Stewart R, Kim SW, Yang SJ, Shin IS, et al. (2007) Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biol Psychiatry 62: 423-428.
24. Kunugi H, Hattori M, Kato T, Tatsumi M, Sakai T, et al. (1997) Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. Mol Psychiatry 2: 457-462.
25. Ohara K, Nagai M, Tsukamoto T, Tani K, Suzuki Y, (1998) Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders. Biol Psychiatry 44: 550-554.
26. Zhang K, Xu Q, Xu Y, Yang H, Luo J, et al. (2009) The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population. J Affect Disord 114: 224-231.
27. Mrazek DA, Rush AJ, Biernacka JM, O'Kane DJ, Cunningham JM, et al. (2009) SLC6A4 variation and citalopram response. Am J Med Genet B Neuropsychiatr Genet 150B: 341-351.
28. Pollock BG, Ferrell RE, Mulsant BH, Mazumdar S, Miller M, et al. (2000) Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology 23: 587-590.
29. Smeraldi E, Zanardi R, Benedetti F, Di Bella D, Perez J, et al. (1998) Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol Psychiatry 3: 508-511.
30. Kim H, Lim SW, Kim S, Kim JW, Chang YH, et al. (2006) Monoamine transporter gene polymorphisms and antidepressant response in koreans with late-life depression. JAMA 296: 1609-1618.
31. Yoshida K, Ito K, Sato K, Takahashi H, Kamata M, et al. (2002) Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 26: 383-386.
32. Heinz A, Smolka MN, Braus DF, Wrase J, Beck A, et al. (2007) Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation. Biol Psychiatry 61: 1011-1014.
33. Viviani R, Sim EJ, Lo H, Beschoner P, Osterfeld N, et al. (2010) Baseline brain perfusion and the serotonin transporter promoter polymorphism. Biol Psychiatry 67: 317-322.
34. Collier DA, Stober G, Li T, Heils A, Catalano M, et al. (1996) A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1: 453-460.
35. Beck AT, Steer RA, Ball R, Ranieri W, (1996) Comparison of Beck Depression Inventories-IA and-II in psychiatric outpatients. J Pers Assess 67: 588-597.
36. Beck A, Steer R, (1990) Manual for the Beck Anxiety Inventory: Psychological Corporation: San Antonio, TX.
37. Cloninger CR, Svrakic DM, Przybeck TR, (1993) A psychobiological model of temperament and character. Arch Gen Psychiatry 50: 975-990.
38. Zang Y, Jiang T, Lu Y, He Y, Tian L, (2004) Regional homogeneity approach to fMRI data analysis. Neuroimage 22: 394-400.
39. Long XY, Zuo XN, Kiviniemi V, Yang Y, Zou QH, et al. (2008) Default mode network as revealed with multiple methods for resting-state functional MRI analysis. J Neurosci Methods 171: 349-355.
40. Hariri AR, Tessitore A, Mattay VS, Fera F, Weinberger DR, (2002) The amygdala response to emotional stimuli: a comparison of faces and scenes. Neuroimage 17: 317-323.
41. Kensinger EA, Corkin S, (2003) Effect of negative emotional content on working memory and long-term memory. Emotion 3: 378-393.
42. Yamasaki H, LaBar KS, McCarthy G, (2002) Dissociable prefrontal brain systems for attention and emotion. Proc Natl Acad Sci U S A 99: 11447-11451.
43. Beevers CG, Gibb BE, McGeary JE, Miller IW, (2007) Serotonin transporter genetic variation and biased attention for emotional word stimuli among psychiatric inpatients. J Abnorm Psychol 116: 208-212.
44. Fox E, Ridgewell A, Ashwin C, (2009) Looking on the bright side: biased attention and the human serotonin transporter gene. Proc Biol Sci 276: 1747-1751.
45. Kwang T, Wells TT, McGeary JE, Swann WB Jr, Beevers CG, (2010) Association of the serotonin transporter promoter region polymorphism with biased attention for negative word stimuli. Depress Anxiety 27: 746-751.
46. Leopold DA, Murayama Y, Logothetis NK, (2003) Very slow activity fluctuations in monkey visual cortex: implications for functional brain imaging. Cereb Cortex 13: 422-433.
47. Mankinen K, Long XY, Paakki JJ, Harila M, Rytky S, et al. (2011) Alterations in regional homogeneity of baseline brain activity in pediatric temporal lobe epilepsy. Brain Res 1373: 221-229.
48. Zhong Y, Lu G, Zhang Z, Jiao Q, Li K, et al. (2011) Altered regional synchronization in epileptic patients with generalized tonic-clonic seizures. Epilepsy Res 97: 83-91.
49. Zou Q, Wu CW, Stein EA, Zang Y, Yang Y, (2009) Static and dynamic characteristics of cerebral blood flow during the resting state. Neuroimage 48: 515-524.
50. Salvador R, Sarro S, Gomar JJ, Ortiz-Gil J, Vila F, et al. (2010) Overall brain connectivity maps show cortico-subcortical abnormalities in schizophrenia. Hum Brain Mapp 31: 2003-2014.
51. Cullen KR, Vizueta N, Thomas KM, Han GJ, Lim KO, et al. (2011) Amygdala Functional Connectivity in Young Women with Borderline Personality Disorder. Brain Connectivity 1: 61-71.
52. Tian C, Plenge RM, Ransom M, Lee A, Villoslada P, et al. (2008) Analysis and application of European genetic substructure using 300 K SNP information. PLoS Genet 4: e4.
53. Goldberg TE, Weinberger DR, (2004) Genes and the parsing of cognitive processes. Trends Cogn Sci 8: 325-335.
54. Lesch KP, Gutknecht L, (2005) Pharmacogenetics of the serotonin transporter. Prog Neuropsychopharmacol Biol Psychiatry 29: 1062-1073.
55. Beitchman JH, Baldassarra L, Mik H, De Luca V, King N, et al. (2006) Serotonin transporter polymorphisms and persistent, pervasive childhood aggression. Am J Psychiatry 163: 1103-1105.
56. Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, et al. (2006) Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78: 815-826.
57. Lowe MJ, Mock BJ, Sorenson JA, (1998) Functional connectivity in single and multislice echoplanar imaging using resting-state fluctuations. Neuroimage 7: 119-132.
58. Dannlowski U, Ohrmann P, Bauer J, Kugel H, Baune BT, et al. (2007) Serotonergic genes modulate amygdala activity in major depression. Genes Brain Behav 6: 672-676.
59. Smolka MN, Buhler M, Schumann G, Klein S, Hu XZ, et al. (2007) Gene-gene effects on central processing of aversive stimuli. Mol Psychiatry 12: 307-317.
60. Zhang JL, Yang JF, Chan P, (2009) No association between polymorphism of serotonin transporter gene and depression in Parkinson's disease in Chinese. Neurosci Lett 455: 155-158.
61. Lang PJ, Bradley MM, Cuthbert BN, (2005) International affective picture system (IAPS): Affective ratings of pictures and instruction manual. Technical Report A-6. University of Florida: Gainesville, FL.
62. Huang YX, Luo YJ, (2004) Native assessment of international affective picture system. Chinese Mental Health Journal 18: 631-634.
63. Chao-Gan Y, Yu-Feng Z, (2010) DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. Front Syst Neurosci 4: 13.
64. Song XW, Dong ZY, Long XY, Li SF, Zuo XN, et al. (2011) REST: a toolkit for resting-state functional magnetic resonance imaging data processing. PLoS ONE 6: e25031.
65. Biswal B, Yetkin FZ, Haughton VM, Hyde JS, (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34: 537-541.
66. Kendall M, Gibbons JD, (1990) Rank Correlation Methods Oxford Oxford Univ. Press.
67. Liu Z, Xu C, Xu Y, Wang Y, Zhao B, et al. (2010) Decreased regional homogeneity in insula and cerebellum: a resting-state fMRI study in patients with major depression and subjects at high risk for major depression. Psychiatry Res 182: 211-215.
68. Paakki JJ, Rahko J, Long X, Moilanen I, Tervonen O, et al. (2010) Alterations in regional homogeneity of resting-state brain activity in autism spectrum disorders. Brain Res 1321: 169-179.
69. Shukla DK, Keehn B, Muller RA, (2010) Regional homogeneity of fMRI time series in autism spectrum disorders. Neurosci Lett 476: 46-51.
70. Wu T, Long X, Zang Y, Wang L, Hallett M, et al. (2009) Regional homogeneity changes in patients with Parkinson's disease. Hum Brain Mapp 30: 1502-1510.
71. Yang T, Cheng Y, Li H, Jiang H, Luo C, et al. (2010) Abnormal regional homogeneity of drug-naive obsessive-compulsive patients. Neuroreport 21: 786-790.
72. Yao Z, Wang L, Lu Q, Liu H, Teng G, (2009) Regional homogeneity in depression and its relationship with separate depressive symptom clusters: a resting-state fMRI study. J Affect Disord 115: 430-438.
73. Yuan Y, Zhang Z, Bai F, Yu H, Shi Y, et al. (2008) Abnormal neural activity in the patients with remitted geriatric depression: a resting-state functional magnetic resonance imaging study. J Affect Disord 111: 145-152.
74. Zhu CZ, Zang YF, Cao QJ, Yan CG, He Y, et al. (2008) Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder. Neuroimage 40: 110-120.
75. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, et al. (2002) Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15: 273-289.