Properties of 7NDCCL2 are modulated upon fusion to Fc

Protein Engineering, Design and Selection

Volumn 25, Issue 5, 2012, Pages 213-222

  Severin, India C ^a   Souza, Adriano L S ^a   Davis, Jonathan H ^b,d   Musolino, Najia ^a   MacK, Matthias ^c   Power, Christine A ^a   Proudfoot, Amanda E I ^a  

^a MERCK SERONO S A   (Switzerland)

^b EMD SERONO INC   (United States)

^c UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^d BRISTOL MYERS SQUIBB RESEARCH AND DEVELOPMENT   (United States)

Author keywords

anti inflammatory; chemokine receptor antagonist; Fc fusion protein

Indexed keywords

AGONIST ACTIVITY; ANTAGONISTIC ACTIVITY; ANTI-INFLAMMATORIES; CHEMOKINE RECEPTORS; CHEMOKINES; CHEMOTACTIC RESPONSE; DISEASE MODELS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FUSION PROTEINS; IN-VITRO; IN-VIVO; MULTIPLE SCLEROSIS; MURINE MODEL; SIGNALING PATHWAYS; TRUNCATED VERSIONS;

BIOCHEMISTRY; BIOTECHNOLOGY;

AMINO ACIDS;

7ND; 7ND FC FUSION PROTEIN; CHEMOKINE RECEPTOR ANTAGONIST; MONOCYTE CHEMOTACTIC PROTEIN 1; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; CALCIUM; CHEMOKINE RECEPTOR CCR2; CHIMERIC PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE FRAGMENT;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN; CHEMOTAXIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; RAT; TREATMENT RESPONSE; ANIMAL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; C57BL MOUSE; CELL LINE; CHEMISTRY; DISEASE MODEL; HALF LIFE TIME; IMMUNOLOGY; LYMPHOCYTE; METABOLISM; MIGRATION INHIBITION; MOLECULAR CLONING; MOUSE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

MURINAE;

ANIMALS; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CALCIUM; CELL LINE; CELL LINE, TUMOR; CELL MIGRATION INHIBITION; CHEMOKINE CCL2; CLONING, MOLECULAR; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HALF-LIFE; IMMUNOGLOBULIN FC FRAGMENTS; LYMPHOCYTES; MICE; MICE, INBRED C57BL; MUTANT CHIMERIC PROTEINS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; RECEPTORS, CCR2; SIGNAL TRANSDUCTION;

EID: 84860486463     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzs008     Document Type: Article

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