In vitro and in vivo properties of a dimeric bispecific single-chain antibody IgG-fusion protein for depletion of CCR2+ target cells in mice

European Journal of Immunology

Volumn 35, Issue 3, 2005, Pages 987-995

  Schneider, Martin A ^a   Brühl, Hilke ^a   Wechselberger, Alexandra ^a   Cihak, Josef ^a   Stangassinger, Manfred ^a   Schlöndorff, Detlef ^a   Mack, Matthias ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Antibody engineering; Bispecific single chain antibody; Cell depletion; Chemokine receptor CCR2

Indexed keywords

BISPECIFIC ANTIBODY; CHEMOKINE RECEPTOR CCR2; IMMUNOGLOBULIN G;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; CELL ACTIVITY; CELL INTERACTION; CELL ISOLATION; CELL MIGRATION; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HYPOTHESIS; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; TARGET CELL;

ANIMALS; ANTIBODIES, BISPECIFIC; CHO CELLS; COCULTURE TECHNIQUES; CRICETINAE; CRICETULUS; DNA PRIMERS; FLOW CYTOMETRY; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN G; LEUKOCYTE REDUCTION PROCEDURES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MICE; RECEPTORS, CHEMOKINE; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 15844362718     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425512     Document Type: Article

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